Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei

Antimicrob Agents Chemother. 2023 May 3:e0017123. doi: 10.1128/aac.00171-23. Online ahead of print.ABSTRACTCefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.PMID:37133377 | DOI:10.1128/aac.00171-23

Source: Antimicrobial Agents and Chemotherapy - May 3, 2023 Category: Microbiology Authors: Carina M Hall Nawarat Somprasong Johannah P Hagen Roxanne Nottingham Jason W Sahl Jessica R Webb Mark Mayo Bart J Currie Yuwana Podin David M Wagner Paul Keim Herbert P Schweizer Source Type: research