Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: Am J Trop Med Hyg - May 15, 2023 Category: Infectious Diseases Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: The American Journal of Tropical Medicine and Hygiene - May 15, 2023 Category: Tropical Medicine Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Case Report: Vagal Nerve Neuritis Associated with Pulmonary Melioidosis Provides Potential Insights into the Pathophysiology of Neuromelioidosis
Am J Trop Med Hyg. 2023 May 15:tpmd220694. doi: 10.4269/ajtmh.22-0694. Online ahead of print.ABSTRACTEncephalomyelitis is the most frequent manifestation of neuromelioidosis in Australia. It is hypothesized that Burkholderia pseudomallei causes encephalomyelitis after entering the brain directly, if complicating a scalp infection, or after traveling to the brain within peripheral or cranial nerves. A 76-year-old man presented with fever, dysphonia, and hiccups. Chest imaging demonstrated extensive bilateral pneumonia with mediastinal lymphadenopathy, blood cultures isolated B. pseudomallei, and nasendoscopy confirmed a lef...
Source: Am J Trop Med Hyg - May 15, 2023 Category: Infectious Diseases Authors: Rosie J Matthews Simon Smith Ian Wilson Richard Tjahjono Soon Young Josh Hanson Source Type: research
Using a multi-omic approach to investigate the mechanism of 12-bis-THA activity against Burkholderia thailandensis
In this study, we examine the antimicrobial activity of 12-bis-THA against strains of Burkholderia thailandensis. As B. pseudomallei produces a polysaccharide capsule we first examined if this extra barrier influenced the activity of 12-bis-THA which is known to act on the bacterial envelope. Therefore two strains of B. thailandensis were selected for further testing, strain E264 which does not produce a capsule and strain E555 which does produce a capsule that is chemically similar to that found in B. pseudomallei. In this study no difference in the minimum inhibitory concentration (MIC) was observed when capsulated (E555...
Source: Frontiers in Microbiology - May 12, 2023 Category: Microbiology Source Type: research
A unique AA5 alcohol oxidase fused with a catalytically inactive CE3 domain from the bacterium Burkholderia pseudomallei
Copper radical oxidases (CROs) from Auxiliary Activities family 5 can oxidize various alcohol substrates. Bacterial CROs are less studied than eukaryotic enzymes. Here we have characterized an unusual bacterial CRO that acts only on primary alcohols and is fused to a carbohydrate esterase domain, which was completely inactive due to substitutions of key amino acid residues in the active site. Copper radical oxidases (CROs) are redox enzymes able to oxidize alcohols or aldehydes, while only requiring a single copper atom as cofactor. Studied CROs are found in one of two subfamilies within the Auxiliary Activities family 5 (...
Source: FEBS Letters - May 11, 2023 Category: Biochemistry Authors: Scott Mazurkewich,
Andrea Seveso,
Johan Larsbrink Tags: Research Letter Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
The Expanding Global Footprint of Burkholderia pseudomallei and Melioidosis
Am J Trop Med Hyg. 2023 May 9:tpmd230223. doi: 10.4269/ajtmh.23-0223. Online ahead of print.NO ABSTRACTPMID:37160279 | DOI:10.4269/ajtmh.23-0223 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Bart J Currie Ella M Meumann Mirjam Kaestli Source Type: research
Expanding the Geographic Boundaries of Melioidosis in Queensland, Australia
This study suggests an association between climate change and an increased incidence of melioidosis. In addition, this is the first report of environmental sampling and whole-genome analysis to prove endemicity and local acquisition in this region.PMID:37160276 | DOI:10.4269/ajtmh.23-0002 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Ian Gassiep Victoria Grey Li Jun Thean Drew Farquhar Julia E Clark Lawrence Ariotti Rikki Graham Amy V Jennison Haakon Bergh Satyamurthy Anuradha Wendy Dyer Christian James Andrea Huang Elise Putt Veenaa Pakeerathan Paul M Griffin Patrick N A Harris Source Type: research
