Exposure to ambient air pollution and chronic bronchitis: Findings from over 6.6 million adults in northwestern China
CONCLUSION: Long-term exposure to ambient air pollutants may increase the odds of CB, especially among younger people and those with unhealthy lifestyles.PMID:38141672 | DOI:10.1016/j.chemosphere.2023.140993 (Source: Chemosphere)
Source: Chemosphere - December 23, 2023 Category: Chemistry Authors: Weidong Ji Yushan Wang Xiao-Xuan Liu Lin Li Hua Yao Yi Zhou Bo-Yi Yang Source Type: research
Exposure to ambient air pollution and chronic bronchitis: Findings from over 6.6 million adults in northwestern China
CONCLUSION: Long-term exposure to ambient air pollutants may increase the odds of CB, especially among younger people and those with unhealthy lifestyles.PMID:38141672 | DOI:10.1016/j.chemosphere.2023.140993 (Source: Chemosphere)
Source: Chemosphere - December 23, 2023 Category: Chemistry Authors: Weidong Ji Yushan Wang Xiao-Xuan Liu Lin Li Hua Yao Yi Zhou Bo-Yi Yang Source Type: research
Avian coronavirus infectious bronchitis virus Beaudette strain NSP9 interacts with STAT1 and inhibits its phosphorylation to facilitate viral replication
In this study, we uncovered a function of NSP9 in immune regulation. First, the host proteins that interacted with NSP9 were screened. The immune-related protein signal transducer and activator of transcription 1 (STAT1) was identified and the interaction between NSP9 and STAT1 was further confirmed. Furthermore, IBV replication was inhibited in STAT1-overexpressing cells but inversely affected in STAT1 knock-down cells. Importantly, NSP9 inhibited STAT1 phosphorylation. Finally, the expression of JAK/STAT pathway downstream genes IRF7 and ISG20 was significantly decreased in NSP9-overexpressing cells. These results showed...
Source: Virology - December 23, 2023 Category: Virology Authors: Ting Xia Shengkui Xu Xueyan Li Wenke Ruan Source Type: research
Avian coronavirus infectious bronchitis virus Beaudette strain NSP9 interacts with STAT1 and inhibits its phosphorylation to facilitate viral replication
In this study, we uncovered a function of NSP9 in immune regulation. First, the host proteins that interacted with NSP9 were screened. The immune-related protein signal transducer and activator of transcription 1 (STAT1) was identified and the interaction between NSP9 and STAT1 was further confirmed. Furthermore, IBV replication was inhibited in STAT1-overexpressing cells but inversely affected in STAT1 knock-down cells. Importantly, NSP9 inhibited STAT1 phosphorylation. Finally, the expression of JAK/STAT pathway downstream genes IRF7 and ISG20 was significantly decreased in NSP9-overexpressing cells. These results showed...
Source: Virology - December 23, 2023 Category: Virology Authors: Ting Xia Shengkui Xu Xueyan Li Wenke Ruan Source Type: research
Integration of lipidomics and metabolomics reveals plasma and urinary profiles associated with pediatric Mycoplasma pneumoniae infections and its severity
In this study, lipidomics and metabolomics analyses were conducted using UHPLC-LTQ-Orbitrap XL mass spectrometry and gas chromatography-triple quadrupole mass spectrometry on plasma (n = 65) and urine (n = 65) samples. MS-DIAL software, in combination with LipidBlast and Fiehn BinBase DB, identified 163 lipids and 104 metabolites in plasma samples, as well as 208 metabolites in urine samples. Perturbed lipid species (adjusted p < 0.05) were observed, including lysophosphatidylethanolamines, phosphatidylinositols, phosphatidylcholines, phosphatidylethanol amines, and triglycerides. Additionally, differential metabolites ...
Source: Biomedical Chromatography : BMC - December 22, 2023 Category: Biomedical Science Authors: Hui Chen Jia-Bin Chen Li-Na Du Hai-Xia Yuan Jin-Jun Shan Shou-Chuan Wang Jin Ye Li-Li Lin Source Type: research
Integration of lipidomics and metabolomics reveals plasma and urinary profiles associated with pediatric Mycoplasma pneumoniae infections and its severity
In this study, lipidomics and metabolomics analyses were conducted using UHPLC-LTQ-Orbitrap XL mass spectrometry and gas chromatography-triple quadrupole mass spectrometry on plasma (n = 65) and urine (n = 65) samples. MS-DIAL software, in combination with LipidBlast and Fiehn BinBase DB, identified 163 lipids and 104 metabolites in plasma samples, as well as 208 metabolites in urine samples. Perturbed lipid species (adjusted p < 0.05) were observed, including lysophosphatidylethanolamines, phosphatidylinositols, phosphatidylcholines, phosphatidylethanol amines, and triglycerides. Additionally, differential metabolites ...
Source: Biomedical Chromatography : BMC - December 22, 2023 Category: Biomedical Science Authors: Hui Chen Jia-Bin Chen Li-Na Du Hai-Xia Yuan Jin-Jun Shan Shou-Chuan Wang Jin Ye Li-Li Lin Source Type: research
Integration of lipidomics and metabolomics reveals plasma and urinary profiles associated with pediatric Mycoplasma pneumoniae infections and its severity
In this study, lipidomics and metabolomics analyses were conducted using UHPLC-LTQ-Orbitrap XL mass spectrometry and gas chromatography-triple quadrupole mass spectrometry on plasma (n = 65) and urine (n = 65) samples. MS-DIAL software, in combination with LipidBlast and Fiehn BinBase DB, identified 163 lipids and 104 metabolites in plasma samples, as well as 208 metabolites in urine samples. Perturbed lipid species (adjusted p < 0.05) were observed, including lysophosphatidylethanolamines, phosphatidylinositols, phosphatidylcholines, phosphatidylethanol amines, and triglycerides. Additionally, differential metabolites ...
Source: Biomedical Chromatography : BMC - December 22, 2023 Category: Biomedical Science Authors: Hui Chen Jia-Bin Chen Li-Na Du Hai-Xia Yuan Jin-Jun Shan Shou-Chuan Wang Jin Ye Li-Li Lin Source Type: research
Integration of lipidomics and metabolomics reveals plasma and urinary profiles associated with pediatric Mycoplasma pneumoniae infections and its severity
In this study, lipidomics and metabolomics analyses were conducted using UHPLC-LTQ-Orbitrap XL mass spectrometry and gas chromatography-triple quadrupole mass spectrometry on plasma (n = 65) and urine (n = 65) samples. MS-DIAL software, in combination with LipidBlast and Fiehn BinBase DB, identified 163 lipids and 104 metabolites in plasma samples, as well as 208 metabolites in urine samples. Perturbed lipid species (adjusted p < 0.05) were observed, including lysophosphatidylethanolamines, phosphatidylinositols, phosphatidylcholines, phosphatidylethanol amines, and triglycerides. Additionally, differential metabolites ...
Source: Biomedical Chromatography : BMC - December 22, 2023 Category: Biomedical Science Authors: Hui Chen Jia-Bin Chen Li-Na Du Hai-Xia Yuan Jin-Jun Shan Shou-Chuan Wang Jin Ye Li-Li Lin Source Type: research
The Expression of Semaphorin3E in Vagal Ganglion and Lung Tissue Is Related to Airway Hyperresponsiveness in Murine Asthma Model
CONCLUSION: Sema3E in lungs and vagal ganglia is related to eosinophilic inflammation and has a protective effect on OVA-induced AHR in asthma.PMID:38111650 | PMC:PMC10727799 | DOI:10.1155/2023/6459234 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - December 19, 2023 Category: Allergy & Immunology Authors: Liyan Chen Xiaohui Yuan Yaowei He Zichuan Fan Ya Guan Qiuying Li Yaying Chen Lianglan Bao Yidan Huang Kefang Lai Source Type: research
Potential systemic effects of acquired CFTR dysfunction in COPD
Respir Med. 2023 Dec 15:107499. doi: 10.1016/j.rmed.2023.107499. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is characterized by airflow limitation, respiratory symptoms, inflammation of the airways, and systemic manifestations of the disease. Genetic susceptibility and environmental factors are important in the development of the disease, particularly exposure to cigarette smoke which is the most notable risk factor. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are the cause of cystic fibrosis (CF), which shares several pathophysiological pulmonary feature...
Source: Respiratory Care - December 17, 2023 Category: Respiratory Medicine Authors: Marc Miravitlles Gerard J Criner Marcus A Mall Steven M Rowe Claus F Vogelmeier Bettina Hederer Matthias Schoenberger Pablo Altman Source Type: research
Potential systemic effects of acquired CFTR dysfunction in COPD
Respir Med. 2023 Dec 15:107499. doi: 10.1016/j.rmed.2023.107499. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is characterized by airflow limitation, respiratory symptoms, inflammation of the airways, and systemic manifestations of the disease. Genetic susceptibility and environmental factors are important in the development of the disease, particularly exposure to cigarette smoke which is the most notable risk factor. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are the cause of cystic fibrosis (CF), which shares several pathophysiological pulmonary feature...
Source: Respiratory Care - December 17, 2023 Category: Respiratory Medicine Authors: Marc Miravitlles Gerard J Criner Marcus A Mall Steven M Rowe Claus F Vogelmeier Bettina Hederer Matthias Schoenberger Pablo Altman Source Type: research
Adjuvant effects of novel water/oil emulsion formulations on immune responses against infectious bronchitis (IB) vaccine in mice
Biologicals. 2023 Dec 14;85:101736. doi: 10.1016/j.biologicals.2023.101736. Online ahead of print.ABSTRACTVaccines have long made use of adjuvants to boost the immune response of the body and reduce the amount of vaccine needed as well as the expense of producing the vaccine. Many vaccine adjuvants are in development, but their application in veterinary vaccinations is restricted due to their lack of efficacy or undesirable side effects. For this reason, it is essential to develop novel adjuvants. To address the issue that the currently available infectious bronchitis (IB) vaccine often fails to produce sufficient immune r...
Source: Biologicals : Journal of the International Association of Biological Standardization - December 15, 2023 Category: Biotechnology Authors: Karrar Ali Mohammed Hasan Alsakini Furkan Ozan Çöven Ayse Nalbantsoy Source Type: research
Adjuvant effects of novel water/oil emulsion formulations on immune responses against infectious bronchitis (IB) vaccine in mice
Biologicals. 2023 Dec 14;85:101736. doi: 10.1016/j.biologicals.2023.101736. Online ahead of print.ABSTRACTVaccines have long made use of adjuvants to boost the immune response of the body and reduce the amount of vaccine needed as well as the expense of producing the vaccine. Many vaccine adjuvants are in development, but their application in veterinary vaccinations is restricted due to their lack of efficacy or undesirable side effects. For this reason, it is essential to develop novel adjuvants. To address the issue that the currently available infectious bronchitis (IB) vaccine often fails to produce sufficient immune r...
Source: Biologicals : Journal of the International Association of Biological Standardization - December 15, 2023 Category: Biotechnology Authors: Karrar Ali Mohammed Hasan Alsakini Furkan Ozan Çöven Ayse Nalbantsoy Source Type: research
Retracted: Nursing Progress of Hypertonic Saline Inhalation in the Treatment of Infantile Bronchitis Based on Image Enhancement
Comput Math Methods Med. 2023 Dec 6;2023:9867927. doi: 10.1155/2023/9867927. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/5092969.].PMID:38094455 | PMC:PMC10718776 | DOI:10.1155/2023/9867927 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - December 14, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
