104 Adverse maternal obstetric outcomes by HIV status in Botswana: Data from the ‘Treat-All’ HIV Era
This study aimed to evaluate maternal outcomes in a large cohort with high HIV prevalence after implementation of a ‘treat-all’ policy. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: J. Sroda Agudogo, Maya Jackson-Gibson, Annliz Macharia, Indira Ranaweera, Katlego Boikanyo, Modiegi Diseko, Judith Mabuta, Sarah Hanson, Dudu Rubgega, Bridgette Wamakima, Joseph Makhema, Michele R. Hacker, Rebecca Zash, Justus Hofmeyr, Roger L. Shapiro, R Source Type: research
Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes
We report 27.7 million single nucleotide variations (SNVs) in the complete genomes of Botswana nationals, of which 2.8 million were missing in public databases. Our population structure analysis revealed a largely homogenous structure in the Botswana population. Admixture analysis showed elevated components shared between the Botswana population and the Niger-Congo (65.9%), Khoe-San (32.9%), and Europeans (1.1%) ancestries in the population of Botswana. Statistical significance of the mutational burden of deleterious and loss-of-function variants per gene against a null model was estimated. The most deleterious variants we...
Source: Frontiers in Genetics - December 20, 2023 Category: Genetics & Stem Cells Source Type: research
Regional anaesthesia practice in public hospitals in Botswana: A cross-sectional study
ConclusionsThe results of this study suggest that spinal anesthesia is the most common regional anesthesia technique performed by anesthesia providers working in public hospitals in Botswana followed by few upper limb blocks. However, most public hospitals lack enough training capacity, equipment, and supplies for regional anesthesia. More engagement of the hospital management, investment in regional anesthesia resources, and training are needed in order to improve the regional anesthesia capacity and provide safe surgery and anesthesia in Botswana. (Source: PLoS One)
Source: PLoS One - December 19, 2023 Category: Biomedical Science Authors: Mamo Kassa Source Type: research
Author Correction: Pilot Test of Mopati, a Multi-Level Adherence Intervention for People Living with HIV and Their Treatment Partners in Botswana
(Source: International Journal of Behavioral Medicine)
Source: International Journal of Behavioral Medicine - December 13, 2023 Category: Psychiatry Source Type: research
African animals prefer to graze in spots once inhabited by Iron Age humans
Survey a savanna bush in southern Africa, where a sea of tall grasses sways in the wind, dotted with herds of antelope, shrubs, and acacia trees, and you might think you were in a pristine landscape untouched by humans. But the continent’s grazing animals know better. Impala and greater kudu, African antelope species, prefer to forage on land once covered by 1800-year-old Iron Age homes and cattle enclosures, because more kinds of nutrient-rich grasses grow there today, a team of researchers based in Zimbabwe and Botswana
reports
this month in the
Journal of Arid Environments
. The work adds to...
Source: Science of Aging Knowledge Environment - December 12, 2023 Category: Geriatrics Source Type: research
Awareness of diabetic retinopathy among patients with type 2 diabetes mellitus attending Donga Clinic in Francistown, Botswana
CONCLUSION: The need arises to raise DR awareness to increase case detection thus reduce the strain of DR's sight-threatening complications.PMID:38074255 | PMC:PMC10706529 | DOI:10.4103/jfmpc.jfmpc_121_23 (Source: Primary Care)
Source: Primary Care - December 11, 2023 Category: Primary Care Authors: Tshegofatso Kgame Huiqun Wu Jinsong Geng Source Type: research
Awareness of diabetic retinopathy among patients with type 2 diabetes mellitus attending Donga Clinic in Francistown, Botswana
CONCLUSION: The need arises to raise DR awareness to increase case detection thus reduce the strain of DR's sight-threatening complications.PMID:38074255 | PMC:PMC10706529 | DOI:10.4103/jfmpc.jfmpc_121_23 (Source: Primary Care)
Source: Primary Care - December 11, 2023 Category: Primary Care Authors: Tshegofatso Kgame Huiqun Wu Jinsong Geng Source Type: research
Long-term non-progression and risk factors for disease progression among children living with HIV in Botswana and Uganda: a retrospective cohort study
Africa remains the global epicenter of the HIV epidemic; more than 70% of all people living with HIV/AIDS are in Africa. In 2021, UNAIDS estimates indicated that 150,000 new HIV infections and 99,000 deaths occurred among African children [1]. Before the initiative of universal antiretroviral therapy (ART), it was widely noted that some children would remain AIDS-free for more than ten years and could maintain normal-for-age CD4+ T-cell counts [2] – so-called long-term nonprogressors (LTNP). Children capable of controlling HIV infection present the opportunity for unique insights into the natural host immune responses, w...
Source: International Journal of Infectious Diseases - November 27, 2023 Category: Infectious Diseases Authors: Samuel Kyobe, Grace Kisitu, Savannah Mwesigwa, John Farirai, Eric Katagirya, Gaone Retshabile, Lesedi Williams, Angela Mirembe, Lesego Ketumile, Misaki Wayengera, John Mukisa, Gaseene Sebetso, Thabo Diphoko, Marion Amujal, Edgar Kigozi, Fred Katabazi, Ron Source Type: research
Standard of care in advanced HIV disease: review of HIV treatment guidelines in six sub-Saharan African countries
CONCLUSION: National guidelines addressing the care of advanced HIV disease in sub-Saharan Africa are available. Besides optimal timing for start of ART in presence of tuberculosis, most national recommendations are in line with the 2021 WHO standards.PMID:37996881 | DOI:10.1186/s12981-023-00581-5 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - November 23, 2023 Category: Infectious Diseases Authors: Thomas C Scheier Nabila Youssouf Mosepele Mosepele Cecilia Kanyama Olukemi Adekanmbi Sulaiman Lakoh Conrad K Muzoora Graeme Meintjes Dominik Mertz John W Eikelboom Sean Wasserman Source Type: research
Standard of care in advanced HIV disease: review of HIV treatment guidelines in six sub-Saharan African countries
CONCLUSION: National guidelines addressing the care of advanced HIV disease in sub-Saharan Africa are available. Besides optimal timing for start of ART in presence of tuberculosis, most national recommendations are in line with the 2021 WHO standards.PMID:37996881 | PMC:PMC10668471 | DOI:10.1186/s12981-023-00581-5 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - November 23, 2023 Category: Infectious Diseases Authors: Thomas C Scheier Nabila Youssouf Mosepele Mosepele Cecilia Kanyama Olukemi Adekanmbi Sulaiman Lakoh Conrad K Muzoora Graeme Meintjes Dominik Mertz John W Eikelboom Sean Wasserman Source Type: research
