Aldape Takes on Role as Chief of the Laboratory of Pathology at NCI
Kenneth Aldape, MDKenneth Aldape, MD, has joined the National Cancer Institute ’s Center for Cancer Research as chief of theLaboratory of Pathology, an integral component of the research and clinical community at the National Institutes of Health.Prior to his current role, Aldape was a professor and department chair of pathology at the MD Anderson Cancer in Houston, Texas. He was later recruited to Toronto General Hospital and Research Institute to develop a brain tumor program and conduct clinical-translational research in neuro-oncology. (Source: neuropathology blog)
Source: neuropathology blog - February 26, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs
Tau accumulations in the brains of woodpeckers
Dr. Peter Cummings makes another appearance on the blog, this time as senior author on a paper entitled:Tau Accumulations in the Brains of Woodpeckers. Eight of ten woodpeckers examined showed cerebral tau accumulations, whereas no control brains (red-winged blackbirds) were positive.This is significant in that there has been some research interest in developing football helmets based on the protective design that has evolved to protect the brains of woodpeckers.But maybe the relatively short life of the woodpecker (average less than 10 years) precludes the need to this protective adaptation. Thanks toDr. Mark Cohen for al...
Source: neuropathology blog - February 21, 2018 Category: Radiology Tags: trauma Source Type: blogs
AANP meeting abstract submission deadline extended
American Association of Neuropathologists annual meeting abstract submission deadline has been EXTENDED to March 6, 2018 at 11:59 EST. (Source: neuropathology blog)
Source: neuropathology blog - February 20, 2018 Category: Radiology Tags: meetings Source Type: blogs
Pineal Parenchymal Tumor of Intermediate Differentiation, WHO grade II-III
Small rosettes can be seen in PPTID (Source: neuropathology blog)
Source: neuropathology blog - February 19, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Pineocytoma, WHO grade I in a young adult
Pineocytomatous rosettes are evident (Source: neuropathology blog)
Source: neuropathology blog - February 19, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Las Vegas gunman had unusually high burden of corpora amylacea, but no other significant findings, at autopsy
TheNew York Times reports that brain autopsy results on Las Vegas gunman Stephen Paddock show that he " had not had a stroke, brain tumor or a number of other neurological disorders that might have helped explain his actions " . Paddock, 64-years-old, did have an unusually high burden of corpora amylacea, the significance of which is not known.In the article, Stanford neuropathologist Hannes Vogel commented on the corpora amylacea as follows: “Most people would have them at that age, but not in that profusion,” Dr. Vogel said. “It’s a striking exaggeration of an age-related finding.”I put up apost a few mont...
Source: neuropathology blog - February 14, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs
Registration and Abstract Submission for 19th International Congress of Neuropathology (ICN2018 Tokyo) now open
The organizing committees for the 19th International Congress of Neuropathology (ICN2018 Tokyo) have announced that registration and abstract submission for the meeting have officially opened as of Wednesday, February 7, 2018. ICN2018 Tokyo will take place September 23-27, 2018. For more information, clickhere. (Source: neuropathology blog)
Source: neuropathology blog - February 9, 2018 Category: Radiology Tags: meetings Source Type: blogs
Meningioma involved by mantle cell lymphoma
70-year-old female with a right frontal lobe mass. Before the meningioma presented itself, the patient already carried the diagnosis of mantle cell lymphoma on peripheral blood analysis.meningiomalymphoma (Source: neuropathology blog)
Source: neuropathology blog - February 7, 2018 Category: Radiology Tags: lymphoma neoplasms Source Type: blogs
Best Post of December 2017: A message from American Association of Neuropathologists President Elizabeth Cochran
The next in our " Best of the Month " series is form Monday, December 18, 2017. Good to be reminded of the upcoming meeting:Louisville, KYAANP members are already prepping for the 94th Annual Meeting, to be held in Louisville, KY, June 7-10, 2018. Annual Meeting registration and the abstract submission site have launched, and the call for DSS cases has been sent. We are looking forward to seeing you in Kentucky! (Source: neuropathology blog)
Source: neuropathology blog - February 6, 2018 Category: Radiology Tags: Best of the Month series meetings Source Type: blogs
TBI Linked to Increased Dementia Risk Over Several Years
The following is adapted from arecent post on practiceupdate.com:Traumatic brain injury (TBI) is associated with persistently increased risk of dementia, according to a study published online Jan. 30 in PLOS Medicine.Anna Nordstr öm, M.D., Ph.D., and Peter Nordström, M.D., Ph.D., both from Umeå University in Sweden, tracked dementia and TBI diagnoses among all 3,329,360 individuals in SwedenThe correlation was strongest in the first year after TBI (odds ratio, 3.52) and persisted at>30 years (odds ratio, 1.25). A weaker association with dementia was seen for single mild TBI versus more severe TBI or multiple TBI...
Source: neuropathology blog - February 5, 2018 Category: Radiology Tags: Alzheimer ' s disease trauma Source Type: blogs
Best Post of November 2017: Choroidal hemangioma in a patient with Stuge-Weber Syndrome
The next in our " Best of the Month " series is from Monday, November 6, 2017:Sclera is at bottom of picture; retinal pigment epithelium is at top right. Between them is choroid with cavernous hemangioma (Source: neuropathology blog)
Source: neuropathology blog - February 2, 2018 Category: Radiology Tags: Best of the Month series eye Source Type: blogs
Uveal Melanoma: The Basics
The uvea of the eye is a vascular tunic comprised of the iris, ciliary body, and choroid. Located between the sclera and the retina, the uvea contains dendritic pigmented melanocytes which have the potential to give rise to malignant melanoma. Patients with choroidal melanoma typically present as adults with painless monocular vision loss, while a cataract or glaucoma may be the presenting feature of an anterior segment melanoma.Approximately half of patients with choroidal and ciliochoroidal melanomas eventually die from their tumors. Prognosis is better in cases localized to the iris, presumably because they are recogniz...
Source: neuropathology blog - February 1, 2018 Category: Radiology Tags: eye Source Type: blogs
Choroidal ganglioneuronal hamartoma in an NF1 patient
Thanks to Dr. Ahmed Gilani (pediatric pathology fellow at the University of Colorado) for providing me with slides of an enucleation specimen from a patient with Von Recklinghausen Neurofibromatosis (NF-1). The specimen exhibits a region of choroidal expansion with hamartomatous neuroglial tissue. Distributed throughout this choroidal expansion are non-pigmented ovoid bodies, which have a delicately laminated appearance reflecting the presence of concentric Schwann cell processes. One might conceive of these choroidal expansions as cousins of iridic Lisch nodules.Choroidal expansion in an enucleation specimen from a child ...
Source: neuropathology blog - January 30, 2018 Category: Radiology Tags: eye Source Type: blogs
What is amyloid?
The following is adapted fromPhenomena, the Phenopath newsletter, Winter 2018 (21:1):Rudolph Virchow, introduced the term “amyloid” to refer to extracellular deposits in human tissues that exhibited a positive blue-violet staining reaction to iodine and dilute acid. Based on this reaction, Virchow mistakenly identified these aggregates as composed of starch (amylum is Latin for starch). Subsequent microscopic studies have shown that amyloid deposits exhibit an affinity for Congo red dyes, which also yield a property known as “dichroic birefringence” in which crossed polarizing filters produce apple-green...
Source: neuropathology blog - January 29, 2018 Category: Radiology Tags: nerve Source Type: blogs
Today's Google Doodle Honors Neurosurgeon Wilder Penfield
Quoted fromKN Smith ofForbes:Today ' s Google Doodle celebrates the 127th birthday of Canadian neurosurgeon Wilder Penfield, who developed a groundbreaking epilepsy treatment called the Montreal Procedure.In the 1930s, while working as a neurosurgeon at the Montreal Neurological Institute at McGill University, Penfield had a patient who reported smelling burned toast just before her seizures. He realized that he could use that hallucinatory scent to pinpoint the part of the brain that was seizing - and put a stop to it.With the patient wide awake, but under local anesthetic, he used electrodes to stimulate parts of her exp...
Source: neuropathology blog - January 26, 2018 Category: Radiology Tags: neurosurgery Source Type: blogs
