A Jungian Approach to Individual Neuropathological Specimens
I was readingThe Undiscovered Self (1958) by Carl Jung today, and noted that Jung ' s description of individual patients could also be applied to individual tumors:" The statistical method shows the facts in the light of the ideal average but does not give us a picture of their empirical reality.... The distinctive thing about real facts, however, is their individuality.... There is and can be no self-knowledge based on theoretical assumptions, for the object of this knowledge is an individual - a relative exception and an irregular phenomenon. Hence, it is not the universal and the regular that characterize the individual...
Source: neuropathology blog - May 1, 2019 Category: Radiology Tags: people Source Type: blogs
Live PathCast Tomorrow: Rodriguez on Meningomas
Tuesday, April 30th - 8 AM ESTTopic: MeningiomasPresented by Fausto Rodriguez, M.D., Associate Professor of Pathology, JHUSOMThis seminar can be accessed livethrough the following links at 8 AM on Tuesdsay:Facebook:https://www.facebook.com/events/355454475302665/YouTube:https://www.youtube.com/channel/UCVxosS9hPP3ikMQXAE9Pamw/videosWebsite:http://pathologycast.com/ (Source: neuropathology blog)
Source: neuropathology blog - April 29, 2019 Category: Radiology Tags: websites Source Type: blogs
Sclerosing orbital lesions: broadening the differential diagnosis of " idiopathic sclerosing pseudotumor "
Sclerosing orbital lesion(the biopsy revealed it to be Erdheim-Chester disease)Sclerosing lesions of the orbit can present a diagnostic conundrum. Often submitted with a differential diagnosis that includes idiopathic sclerosing pseudotumor, it is incumbent upon the pathologist to rule out other diagnostic possibilities before designating the lesion as idiopathic. In order to survey the range of diagnoses for such specimens, we searched over a 10-year period for specimens submitted to the University of Colorado pathology department which either clinically or pathologically raised the possibility of idiopathic sclerosing ps...
Source: neuropathology blog - April 19, 2019 Category: Radiology Tags: ophthalmic pathology Source Type: blogs
cIMPACT-NOW Update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAFV600E mutation
This cIMPACT-NOW update was published this month:Summary:cIMPACT (Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) has reviewed the status of WHO grade II IDH-wt/H3-wt diffuse gliomas, focusing on those with a BRAFV600E mutation, FGFR1 alteration, or a MYB or MYBL1 rearrangement, and recommends the use of an integrated diagnosis to combine their histologic and genetic features. The consortium ecommends the use of an integrated diagnosis to combine their histologic and genetic features, as suggested in the following:Diffuse glioma, MYB...
Source: neuropathology blog - April 16, 2019 Category: Radiology Tags: molecular studies neoplasms Source Type: blogs
PML in a patient with idiopathic CD4 lymphopenia
My last post prompted the inimitableDr. Murat Gokden to write to me about an interesting case he published in 2015 of a 33-year-old man who with idiopathic CD4 lymphopenia (ICL) who was ultimately diagnosed with progressive multifocal leukoencephalopathy (PML).Image from Dr. Gikden ' s paper: A and B are MRI FLAIR images showing hyperintense areas with gyral swelling and sulcal effacement (curved arrows). Image C depicts MR spectroscopy with abnormally elevated choline peak. Image D shows multifocal punctate enhancement in white matter.Murat Gokden, MD (Source: neuropathology blog)
Source: neuropathology blog - April 15, 2019 Category: Radiology Tags: infectious disease Source Type: blogs
Progressive Multifocal Leukoencephalopathy in patients without obvious immunosuppression
I recently received a case in consultation which turned out to be progressive multifocal leukoencephalopathy (PML). Reading the clinical history, it was not entirely clear what predisposed the patient to PML. It wasn ' t clear, that is, until my mentor (the illustrious BK DeMasters) to a nine-year-old paper by Sarah Gheuens, Gerald Pierone, Patrick Peeters, and Igor J. Koralnik entitled Progressive Multifocal Leukoencephalopathy in individuals with minimal or occult immunosuppression (J Neurol Neurosurg Psychiatry 2010;81:247-254). In this series, hepatic cirrhosis -- which was what my patient had -- was among the more com...
Source: neuropathology blog - April 12, 2019 Category: Radiology Tags: infectious disease Source Type: blogs
Psychiatrist Hand-Knits an Anatomically Correct Textile Sculpture of the Human Brain
A psychiatrist from the National Bureau of Economic Research in Cambridge, MA,Dr. Karen Norberg spent an entire year knitting detailed replica of the central organ. (Source: neuropathology blog)
Source: neuropathology blog - April 1, 2019 Category: Radiology Tags: anatomy Source Type: blogs
Miller selected as division director of neuropathology at University of Alabama
C. Ryan Miller, MD, PhDThe University of Alabama at Birmingham Department of Pathology has recently named C. Ryan Miller, MD, PhD as director of the neuropathology division. He starts in that position on April 1.Miller was most recently a professor in the Department of Pathology and Laboratory Medicine at the University of North Carolina-Chapel Hill. Miller also served as faculty director of the UNC Translational Pathology Laboratory in conjunction with the Lineberger Comprehensive Cancer Center“We are excited to have Dr. Miller back at UAB in the Department of Pathology, where his experience in research on tumors of the...
Source: neuropathology blog - March 27, 2019 Category: Radiology Tags: neuropathologists Source Type: blogs
Polymer coating embolism from intravascular medical devices
The deaths of at least three people who had hospital procedures in Vancouver were caused by coatings that sloughed off medical devices like catheters and scattered through blood vessels to major organs,a recent study has found.Here ' s a link to the relevant news article.Rupal I. Mehta, MDThanks toDr. Rupal I. Mehta of the University of Rochester for alerting me to this article. Dr. Mehta herself has published on this increasing recognized phenomenon.Here ' s a link to her update on the topic.Dr. Harry Vintershad this to say about the new study coming out of Canada: “Their study is especially intriguing in that...
Source: neuropathology blog - March 26, 2019 Category: Radiology Tags: vascular disease Source Type: blogs
Glial cytoplasmic inclusions filling putaminal pencillary fibers in a case of multiple system atrophy (striatonigral type)
Putamen (alpha-synuclein immunohistochemistry) (Source: neuropathology blog)
Source: neuropathology blog - March 14, 2019 Category: Radiology Tags: multiple system atrophy Source Type: blogs
Best Post of December 2018: Giant cell GBM masquerading as an anaplastic PXA
The next in our " Best of the Month " series is from December 4, 2018:At first glance, this tumor with pleomorphic cells and prominent perivascular lymphocytic cuffing strikes one as a pleomorphic xanthoastrocytoma (PXA).The relative circumscription, as demonstrated by the stark difference in tumor burden in adjacent gyri depicted above also suggests the possibility of PXA.The presence of mitotic figures (center of picture above) and a small amount of necrosis and microvascular proliferation (not pictured) suggests the possibility of anaplastic PXA.However, perivascular lymphocytes and relative circumscription can be...
Source: neuropathology blog - March 12, 2019 Category: Radiology Tags: Best of the Month series neoplasms Source Type: blogs
Best Post of December 2018: Giant cell GBM masquerading as an anaplastic PCA
The next in our " Best of the Month " series is from December 4, 2018:At first glance, this tumor with pleomorphic cells and prominent perivascular lymphocytic cuffing strikes one as a pleomorphic xanthoastrocytoma (PXA).The relative circumscription, as demonstrated by the stark difference in tumor burden in adjacent gyri depicted above also suggests the possibility of PXA.The presence of mitotic figures (center of picture above) and a small amount of necrosis and microvascular proliferation (not pictured) suggests the possibility of anaplastic PXA.However, perivascular lymphocytes and relative circumscription can be...
Source: neuropathology blog - March 12, 2019 Category: Radiology Tags: Best of the Month series neoplasms Source Type: blogs
Donahue does it again: a case of type 2 myotonic dystrophy from Providence, Rhode Island
A case from Dr. John Donahue, inimitable neuropathologist and neuropathology fellowship program director at Brown University:" This is a fast myosin immunostain on a gluteus maximus biopsy from a 45-year-old woman who went on to have genetically-proven myotonic dystrophy, type 2 (DM2; proximal myotonic myopathy; PROMM). The type 2 muscle fibers are EXTREMELY atrophic. " (Source: neuropathology blog)
Source: neuropathology blog - March 1, 2019 Category: Radiology Tags: muscle Source Type: blogs
Dr. Fausto Rodriguez presents on the topic of tumefactive pseudoneoplasms on PathCast
Here ' s a linkto the whole PathCast series on YouTube. Great lectures from prominent pathologists -- completely free!Dr. Rodriguez has another lecture uploaded on the site, andDr. Arie Perry has two. (Source: neuropathology blog)
Source: neuropathology blog - February 28, 2019 Category: Radiology Tags: websites Source Type: blogs
Primum non nocere
Dr. Edward LeeDr. Edward Leeis among several others who have authored an interesting commentary on CTE entitled:Primum non nocere: a call for balance when reporting on CTE. It ' s worth a read! (Source: neuropathology blog)
Source: neuropathology blog - February 15, 2019 Category: Radiology Tags: neuropathologists trauma Source Type: blogs
