The exquisite cellular uniformity of the central neurocytoma
Intraoperative ThinPrep smear demonstrates the striking cellular uniformityPermanent section of the same tumor (Source: neuropathology blog)
Source: neuropathology blog - November 21, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Perforating injury of globe
Ocular perforation caused by BB gun is a through-and-through injury with entrance and exit wounds in limbus and sclera, respectively. The track of the BB is marked by fresh blood. Posteriorly detached vitreous also contains ochre-colored degenerated blood.(Source: Eagle R. Eye Pathology: An Atlas and Text. Second Edition. 2011) (Source: neuropathology blog)
Source: neuropathology blog - November 19, 2018 Category: Radiology Tags: eye Source Type: blogs

Q & A with Dr Peter Cummings, co-author of “Brainwashed: The Bad Science Behind CTE and the Plot to Destroy Football”
Peter Cummings, MD1.   Chronic traumatic encephalopathy has been considered by many to be a distinct nosologic entity since 1928, when Dr. Harrison Martland published the article“Punch Drunk ” in JAMA. Do you believe that CTE is a distinct entity? If so, what, in your opinion, defines CTE?That's a good question! If you look at the totality of the literature in a historical context, you see the'classic'boxers neuropathological changes followed by the Omalu cases and then the McKee cases. Looking at all of these cases you can see that there is a wide spectrum of changes considered to be "...
Source: neuropathology blog - November 14, 2018 Category: Radiology Tags: trauma Source Type: blogs

Dr. Fausto Rodriguez to deliver live online presentation this Wednesday
Wednesday, November 14th  - 8 AM ESTTopic: Surgical Neuropathology Pearls: Sellar LesionsPresented by Fausto Rodriguez, MD, Associate Professor of Pathology, JHUSOMThis seminar can be accessed livethrough the following links at 8 AM on Wednesday:Facebook:https://www.facebook.com/pathCast/YouTube:https://www.youtube.com/channel/UCVxosS9hPP3ikMQXAE9PamwWebsite:http://pathologycast.com/This hour-long PathCast seminar presented by Dr. Fausto Rodriguez will be broadcast live on both Facebook and YouTube. Live chat will be available for you to discuss the presentation with Dr. Rodriguez during the...
Source: neuropathology blog - November 12, 2018 Category: Radiology Tags: neuropathologists websites Source Type: blogs

SF-1 immunohistochemistry for detecting gonadotroph adenomas
Adenomas driven by the transcription factor SF-1, which are exclusively gonadotroph adenomas, are a common subtype encountered by the surgical pathologist. Traditionally, gonadotroph adenomas have been defined by positive immunostaining for luteinizing hormone (LH) and/or follicle stimulating hormone (FSH) with or without alpha-subunit ( αSU). However, SF-1 alone can detect gonadotrophin adenomas. Further, the majority of previously classified " null cell " adenomas -- negative for all hormonal markers including LH, FSH and αSU -- are in fact positive for SF-1 and therefore better classified as gonado...
Source: neuropathology blog - November 7, 2018 Category: Radiology Tags: pituitary Source Type: blogs

The appendix is implicated in Parkinson ’s disease
Clumps of alpha-synuclein (red) in the appendix of a healthy individual suggests the possibilitythat the gut plays a role in the pathogenesis of Parkinson diseaseThe appendix may contribute to a person ’s chances of developing Parkinson’s disease. An analysis of data from nearly 1.7 million Swedes found that those who’d had their appendix removed had a lower overall risk of Parkinson’s disease. Also, samples of appendix tissue from healthy individuals revealed protein clumps similar to those found in the brains of Parkinson ’s patients, researchers report online October 31 in Sc...
Source: neuropathology blog - November 5, 2018 Category: Radiology Tags: parkinson disease Source Type: blogs

AANP announces Special Course topic for 2019 meeting
The Special Course topic is:Unintended Consequences: The Iatrogenic Neuropathology of Systemic Therapies.Register for the meetinghere. (Source: neuropathology blog)
Source: neuropathology blog - November 2, 2018 Category: Radiology Source Type: blogs

Best Post of October 2018: Young adult with an iridic mass extending into the ciliary body
The next in our " Best of the Month " series comes from October 9, 2018:Melanoma markers were negative. Smooth muscle markers were positive. This case was determined to be an epithelioid leiomyoma. I didn't do electron microscopy to look for mitochondia, but it may well be what Ursula Schlotzer-Schredhardt et al. have called a mitochondria-rich epithelioid leiomyoma (Arch Ophthalmol, Vol 120, January 2002). (Source: neuropathology blog)
Source: neuropathology blog - November 1, 2018 Category: Radiology Tags: Best of the Month series eye ophthalmic pathology Source Type: blogs

Nowinski rebuts book which questions football's role in chronic traumatic encephalopathy
On Tuesday, I posted about a new book out which questions the conclusions drawn by Boston University researchers regarding the connections between football and chronic traumatic encephalopathy (CTE). Today, BU's Chris Nowinskiresponded in the pages of USA Today.Chris Nowinski, PhD, CEO of the Concussion Legacy Foundation which has connections to Boston University researchers, said the following in the USA Today article: " I'm happy to ask Merril Hoge who to draft No. 1 next year, but we shouldn't be asking him how to design research studies. "Chris Nowinski, PhD (Source: neuropathology blog)
Source: neuropathology blog - October 25, 2018 Category: Radiology Tags: trauma Source Type: blogs

Neuropathologist teams up with former NFL player to write provocative book questioning the extent and cause of CTE among football players
Dr. Peter CummingsIn an Op-Ed piece published today onYahoo! Sports, neuropathologistPeter Cummings and former NFL playerMerril Hoge discuss their skepticism about the science behind the connection between chronic traumatic encephalopathy (CTE) and football. Cummings and Hoge just released a book entitled “Brainwashed: The Bad Science Behind CTE and the Plot to Destroy Football” (Amplify, Oct. 23, 2018), describing their take on the conclusions that have been drawn regarding the connection between football and CTE. " We believe that when people know what we know, they ’ll start asking tough...
Source: neuropathology blog - October 23, 2018 Category: Radiology Tags: trauma Source Type: blogs

The Ivy League reduces concussion rates in football by moving the kickoff ball just five yards toward opposing team's goalpost
Following an experimental 2016 change to kickoff rules designed to encourage more touchbacks,  Ivy League schools saw reduced rates of concussions on the football field.A recent study in which Brown University and the seven other Ivy League institutions participated showed that reducing kickoff returns in which players actively try to advance the ball during football games could lessen the number of concussions players suffer on the field.Results from the study, published this month in the Journal of the American Medical Association, show a sharp decrease in the rate of concussions following the Ivy League &rsquo...
Source: neuropathology blog - October 14, 2018 Category: Radiology Tags: trauma Source Type: blogs

True rosette situated within an Embryonal Tumor with Multilayered Rosettes, C19MC-altered, WHO grade IV
This aggressive tumor was located in the frontoparietal lobe of a young child. It had alterations in the C19MC locus at 19q13.42. (Source: neuropathology blog)
Source: neuropathology blog - October 12, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Xanthic cell in a pleomorphic xanthastrocytoma
(Source: neuropathology blog)
Source: neuropathology blog - October 11, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Young adult with an iridic mass extending into the ciliary body
Melanoma markers were negative. Smooth muscle markers were positive. This case was determined to be anepithelioid leiomyoma. I didn't do electron microscopy to look for mitochondia, but it may well be whatUrsula Schlotzer-Schredhardtet al. have called amitochondria-rich epithelioid leiomyoma(Arch Ophthalmol, Vol 120, January 2002). (Source: neuropathology blog)
Source: neuropathology blog - October 9, 2018 Category: Radiology Tags: eye ophthalmic pathology Source Type: blogs

Best Post of September 2018: A Case of Posterior Cortical Atrophy
The next in our " Best of the Month " series is from September 7, 2018:Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills. The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer's disease in most patients. However, alternative underlying causes, including dementia with Lewy bodies, corticobasal degeneration, and prion disease, have also been identified, and not all patients with PCA have atrophy on clinical ...
Source: neuropathology blog - October 8, 2018 Category: Radiology Tags: Alzheimer ' s disease Best of the Month series neurodegen dz (other) Source Type: blogs

Mesoectodermal Leiomyoma of the Ciliary Body
A 47-year-old woman is suspected of having a ciliary body melanoma (A). Histologic sections (B and C) show large ciliary body tumor composed of tumor cells in a fibrillar cytoplasmic matrix. Electron microscopy (D) shows a dense osmophiliic structure known as askeinoid fiber.Immunohistochemistry helped to confirm that this was a leiomyoma.(Case reported by J. Campbell et al. Ultrastruct Pathol 28:559, 1997.) (Source: neuropathology blog)
Source: neuropathology blog - October 5, 2018 Category: Radiology Tags: eye Source Type: blogs

Alzheimer Society International Congress (ASIC 2019): Call for Abstracts
Abstracts are being accepted for theAlzheimer Society International Congress(ASIC 2019), which will be held on February 18-21, 2019 in San Francisco.The ASIC 2019 is sponsored bythe Alzheimer International Society, a non-profit organization with a mission to support patient care and foster research to find a cure for Alzheimer ’s disease. The Society is a professional international society for individuals interested in Alzheimer's and dementia science —including scientists, physicians and other professionals involved in the research and treatments of Alzheimer's disease and other dementias.ASIC 2019is a leading...
Source: neuropathology blog - October 3, 2018 Category: Radiology Tags: meetings Source Type: blogs

“Rising Star Award” in Neurodegenerative Research: Call for Submissions
TheMahoney Institute for Neurosciences (MINS) at the  University of Pennsylvania is has announced a call for submissions for its annualRising Star Award in neuroscience research. To highlight the “Year of Neurodegenerative Research” on Penn’s campus, the award honors a young researcher for outstanding contributions to neurodegenerative research with a $10,000 personal honorarium at theMINS 35th Annual Retreat and Symposium on April 3, 2019.Dr. Virginia Lee“Neurodegenerative disorders are major health problems for the elderly, and there are currently no treatments for any of these diseases,&rdqu...
Source: neuropathology blog - October 2, 2018 Category: Radiology Tags: neurodegen dz (other) Source Type: blogs

Dr. Doug Miller named interim pathology chair at University of Missouri
Dr. Miller (note the " brain in a jar " lapel pin)Douglas C. Miller, MD, PhD was recently named interim chair of pathology at theUniversity of Missouriin Columbia. Dr. Miller joins several other department chairs who are neuropathologists:Douglas Anthony at Brown (pathologist-in-chief at Rhode Island Hospital)Dan Bratat NorthwesternSteven Carroll at Medical University of South CarolinaRobert Corona at SUNY UpstateJeffrey Golden at Brigham and Women's HospitalEyas Hattab at University of LouisvilleAlex Judkins at Children's Hospital Los Angeles (pathologist-in-chief)David Louis a...
Source: neuropathology blog - September 28, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs

Crooke cell change in a normal pituitary of a patient with ectopic ACTH producing tumor
CK20 immunohistochemistry highlights Crooke cells (Source: neuropathology blog)
Source: neuropathology blog - September 27, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Subcortical band heterotopia
Also known as double cortex syndrome, subcortical band heterotopia is a rare congenital abnormality. Patients can live into adulthood, but seizures, cognitive disability, and behavioral problems can occur. (Picture courtesy of Dr. Nathaniel B. Patterson) (Source: neuropathology blog)
Source: neuropathology blog - September 25, 2018 Category: Radiology Tags: malformations Source Type: blogs

Neuropathologist combines music composition with brain research
Dr. Elaine BearerUniversity of New Mexico neuropathologist Elaine Bearer, MD, PhD was featured today on a radio interview with KUNM. You can listen to the interview on the University of New Mexicoradio station web site. Dr. Bearer's work includes studying biomarkers of trauma and abuse in children and whether the cause of Alzheimer's disease may come from infections. Dr. Bearer is also a composer and it was music that spurred her interest in studying the brain. (Source: neuropathology blog)
Source: neuropathology blog - September 24, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs

Multinodular and vacuolating neuronal tumor,WHO grade I
The patient is a middle-aged male with a temporal lobe mass. Histopathology shows a low-grade ganglion cell tumor with clustered ganglion cells with a vacuolated neuropil background. The fragmented nature of the specimen precludes identification of a nodular architecture. The diagnosis is multinodular and vacuolating neuronal tumor, WHO grade I. This entity is a cousin of gangliocytoma. (Source: neuropathology blog)
Source: neuropathology blog - September 21, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

A WHO grade IV diagnosis in the face of a low-grade histophenotype: a difficult situation for the surgical neuropathologist
This midbrain mass in a 33-year-old patient has low-grade histology (minimal mitoses, low MIB-1 cell cycling index, and a single Rosenthal fiber), yet it harbors the H3 K27M mutation. Perivascular lymphocytes were present, but ganglioglioma was ruled out. So, the following diagnosis was rendered:diffuse midline glioma, H3 K27M mutant, WHO grade IV. Other molecular changes included loss of p16 (CDKN2a) and loss of PTEN and 10 centromere, consistent with monosomy for chromosome 10. The discordance between histopathology and molecular findings can make the diagnostician squeamish about rendering a high-grade diagnos...
Source: neuropathology blog - September 20, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Handy reference photo for orienting an enucleation specimen
(Source: Eagle, RC Jr., Eye Pathology: An Atlas and Text, second edition (2011) p. 291. (Source: neuropathology blog)
Source: neuropathology blog - September 18, 2018 Category: Radiology Tags: eye Source Type: blogs

Best Post of August 2018 - Omalu puts a religious spin on his assessment of the football: " It is not of God. "
The next in our " Best of the Month " series comes from August 8, 2018:“We shouldn’t let children play [football] because we are damaging their brains and robbing them of their humanity. That is a fact.” That's what Dr. Bennet Omalu had to say to a reporter associate with Sojourners, a faith-based organization. In the recently released article from Sojourners, Omalu said that football is a sport " not of God " . A committed Catholic, Omalu  says that he lets "the Spirit of God percolate into my being... Everything I do, I do through the eyes of faith. ”Be...
Source: neuropathology blog - September 17, 2018 Category: Radiology Tags: Best of the Month series trauma Source Type: blogs

Best Post of July 2018: What is the nodulus?
The next in our " Best of the Month " series come from July 16, 2018:The nodulus is the lobule of the cerebellar vermis that, together with the flocculus of each hemisphere, forms the flocculonodular lobe. (Source: neuropathology blog)
Source: neuropathology blog - September 12, 2018 Category: Radiology Tags: anatomy Best of the Month series Source Type: blogs

Circadian Rhythm Gene May Serve as Target for Glioblastoma Therapies
Scientists from the Virginia Tech Carilion Research Institute say a gene involved in the body's circadian rhythms is a potential target for therapies for glioblastoma.Their discovery ( “Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival”), published in Scientific Reports, points to a subtype of a particular gene that apparently is enabling the survival of cancer cells, although it is more commonly associated with circadian rhythms.“In our previous work, we identified casein kinase 1 ε (CK1ε, also known as CSNK1E) as a potential survival factor in glioblastoma. However, ...
Source: neuropathology blog - September 11, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

A case of posterior cortical atrophy
Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills. The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer's disease in most patients. However, alternative underlying causes, including dementia with Lewy bodies, corticobasal degeneration, and prion disease, have also been identified, and not all patients with PCA have atrophy on clinical imaging.(Crutch, S. J., Lehmann, M., Schott, J. M., Rabinovici, G. D., Rossor, M....
Source: neuropathology blog - September 7, 2018 Category: Radiology Tags: neurodegen dz (other) Source Type: blogs

A case of Alexander disease
Alexander disease is a progressive and often fatal leukodystrophy wherein innumerableRosenthal fibers form. Caused by mutation in the gene encoding GFAP, Alexander disease can be inherited in an autosomal dominant manner, but typically arisesde novo.CerebrumCerebrumCerebellum (Source: neuropathology blog)
Source: neuropathology blog - August 23, 2018 Category: Radiology Tags: neurodegen dz (other) Source Type: blogs

New Channel on YouTube: Adventures in Neuropathology
There's a new channel on YouTube calledAdventures in Neuropathology. The intended audience appears to be medical students or beginning residents. The channel offers brief reviews of individual topics in bite-size chunks. It looks as though the channel just got underway, with fifteen short videos having been posted with the past two months. (Source: neuropathology blog)
Source: neuropathology blog - August 22, 2018 Category: Radiology Tags: websites Source Type: blogs

A gaggle of Rosenthal fibers forming at the pushing border of an ependymoma
Ependymoma (left) pushing on adjacent brain induces numerous Rosenthal fibers,particularly around a blood vessel (Source: neuropathology blog)
Source: neuropathology blog - August 18, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Tumours of the CNS Dataset is now published to the ICCR website
TheInternational Collaboration on Cancer Reporting has published theTumours of the CNS Dataset.According to the published document, the " dataset has been developed for the histological assessment of benign and malignant tumours of the central nervous system (CNS) and its coverings, as well as tumours from those aspects of the peripheral nervous system immediately adjacent to the CNS. This dataset applies to both biopsy and resection specimens. Haematological lesions that may originate in the brain are included. Tumours of the anterior pituitary gland are included as the majority of these tumours are reported by neuro...
Source: neuropathology blog - August 17, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

2019 Annual Meeting of AANP: Save the Date!
(Source: neuropathology blog)
Source: neuropathology blog - August 15, 2018 Category: Radiology Tags: meetings Source Type: blogs

Salzmann nodular degeneration of the cornea
Histopathology of Salzmann nodules (*). Disruption of the Bowman membrane is demarcated in each photomicrograph by the area between the left and right arrows: (A) hematoxylin and eosin stain; (B) periodic acid-Schiff stain; (C) immunohistochemistry with antibody against pan-cytokeratin; and (D) immunohistochemistry with antibody against vimentin. (From Stone DU, et al. Histopathology of Saltzmann Nodular Corneal Degeneration.Cornea. Volume 27(2), February 2008, pp 148-151)Salzmann nodular degeneration  was once called  Salzmann nodular dystrophy. It is now recognized that this typically unilateral disor...
Source: neuropathology blog - August 13, 2018 Category: Radiology Tags: ophthalmic pathology Source Type: blogs

Best Post of June 2018: Who was Rosenthal?
Of the ten posts from June 2018, my favorite was " Who was Rosenthal? " from June 22. So, here's the next in our " Best of the Month " series:A Rosenthal fiber in pilocytic astrocytoma" In 1898, the German pathologist Werner Rosenthal noted elongated inclusions within the gliotic edge of a syringeal cavity of an ependymoma. Assigned to write the case report by a senior mentor while serving as a “first assistant” at the University of Erlangen, Rosenthal colorfully described these inclusions as a “glossy formation of little bulbs or wavy sausages with one thick and on...
Source: neuropathology blog - August 11, 2018 Category: Radiology Tags: Best of the Month series history Source Type: blogs

Omalu puts a religious spin on his assessment of the football: " It is not of God. "
“We shouldn’t let children play [football] because we are damaging their brains and robbing them of their humanity. That is a fact.” That's what Dr. Bennet Omalu had to say to a reporter associate withSojourners, a faith-based organization. In therecently released article from Sojourners, Omalu said that football is a sport " not of God " . A committed Catholic, Omalu  says that he lets "the Spirit of God percolate into my being... Everything I do, I do through the eyes of faith. ”Bennet Omalu, MDOmalu is best known for the startling discovery he made after performing an aut...
Source: neuropathology blog - August 8, 2018 Category: Radiology Tags: trauma Source Type: blogs

CAP Neuropathology Committee meets in Montreal
The College of American PathologistsNeuropathology Committee met this past weekend in Montreal. It marked the end of my six-year term as a member of the committee. It was an honor to have served with such a wonderful collection of neuropathologists over the years. I'll miss working with these great colleagues.In Montreal, committee members (left to right) Kara Jones, Arie Perry, myself, Eyas Hattab, Andrea Wiens, and junior member Lindsey LowderAt dinner after a day of committee work (left to iight): CAP staffer Annabel Dizon, Karra Jones, Eyas Hattab, Andrea Weins, myself, Arie Perry, Lindsey Lowder, and Lindsey's husband...
Source: neuropathology blog - August 7, 2018 Category: Radiology Tags: meetings Source Type: blogs

Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports
Dr. Ann McKee's group last week published anarticle in the Journal of Neuropathology and Experimental Neurology supporting the theory that contact sports increases the risk of developing neocortical Lewy body disease, which may in part explain the extrapyramidal motor symptoms sometimes observed in patients with chronic traumatic encephalopathy. Dr. Thor Stein is the senior author on the paper, entitledLewy Body Pathology and Chronic Traumatic Encephalopathy Asssociated with Contact Sports.  (Source: neuropathology blog)
Source: neuropathology blog - August 1, 2018 Category: Radiology Tags: Lewy body disease trauma Source Type: blogs

A ganglion of neuropathologists spontaneously coalesces at a this week's Association of Pathology Chairs meeting
Neuropathologists serve many roles aside from signing out surgical specimens and performing brain autopsies. That fact was in full display at this week's Association of Pathology Chairs meeting where, at a reception on Monday, a group of neuropathologists found themselves standing together at an afternoon reception. (Perhaps this coalescence was not so much by chance as it occurred directly adjacent to the bar.) It was nice to see old friends.Left to right: Drs. Douglas Miller, Kymberly Gyure, Jennifer Baccon, Eyas Hattab, and Brian Moore (Source: neuropathology blog)
Source: neuropathology blog - July 20, 2018 Category: Radiology Tags: meetings neuropathologists Source Type: blogs

What is the nodulus?
The lobule of the cerebellar vermis that, together with the flocculus of each hemisphere, forms the flocculonodular lobe. (Source: neuropathology blog)
Source: neuropathology blog - July 16, 2018 Category: Radiology Tags: anatomy Source Type: blogs

Hyperbrain: a great resource for learning neuroanatomy
HyperBrain is an online tutorial for human neuroanatomy from the University of Utah.  HyperBrain includes thousand of images and hundreds of linked illustrated glossary terms, as well as movies, quizzes and interactive animations. (Source: neuropathology blog)
Source: neuropathology blog - July 13, 2018 Category: Radiology Tags: anatomy websites Source Type: blogs

Best Post of May 2018: Moving beyond histologic grading of IDH-wildtype diffuse astrocytic gliomas
The next in our " Best of the Month " series comes fromMay, 30, 2018:Despite the fact that the most recent update of the World Health Organization (WHO) classification of central nervous system tumors was published only two years ago, the data is already showing that we are moving beyond that classification system when if comes to IDH-wildtype diffuse astrocytomas. The concept of an " integrated diagnosis " in the setting of IDH-wildtype histologic grade II and III tumors has already been eclipsed in the literature by the primacy of the genetic signature over histologic appearance in predicting outcome....
Source: neuropathology blog - July 12, 2018 Category: Radiology Tags: Best of the Month series molecular studies neoplasms Source Type: blogs

CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids
These lesions histologically demonstrate a lymphocytic perivascular inflammatory pattern  (Source: neuropathology blog)
Source: neuropathology blog - July 11, 2018 Category: Radiology Tags: vascular disease Source Type: blogs

The 2018 CANP annual meeting will be in Halifax October 3-6, 2018
TheCanadian Association of Neuropathologists is gearing up for its a 58th annual meeting this fall. (Source: neuropathology blog)
Source: neuropathology blog - July 10, 2018 Category: Radiology Tags: meetings Source Type: blogs

Atypical teratoid/rhabdoid tumor (AT/RT) in an infant
Rhabdoid cells (such as those circled above) frequently are seen in AT/RTs (Source: neuropathology blog)
Source: neuropathology blog - July 9, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Malignant astroblastoma in a 23-year-old female
Headaches prompted imaging which showed a large right parieto-occipital tumor. Astroblastic pseudorossettes are prominent, with cells that are fairly monotonous. GFAP was only focally positive, not unusual for this diagnosis. Mitotic rate ranged up to 8 per 10 HPF, with a MIB1 cell cycling index reaching 40%. (Source: neuropathology blog)
Source: neuropathology blog - July 6, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

More on Rosenthal
Thanks toDr. Gregg B. Wells from Texas A&M University for directing me to an article authored byDr. Hans Goebel of Charite-Universit ätsmedizin in Berlin regarding the life and accomplishments of neuropathologist Werner Rosenthal (1870-1942). Dr. Wells was prompted to write to me by my recent post entitled "Who was Rosenthal? " . For those who are interested in Dr. Rosethal's travails as a Jew in Nazi Germany forced into exile in India, I encourage you to read Dr. Goebel's open-access article.Dr. Werner Rosenthal with his wife and daughter in 1917.(Taken from Dr. Goebel's article in Clinical Neuropa...
Source: neuropathology blog - July 5, 2018 Category: Radiology Tags: history Source Type: blogs

Diffuse intracranial dolichoectasia in a 68 yo man with thoracic arterial dissection
Picture courtesy of Mark Cohen, MD of Case Western Reserve University (Source: neuropathology blog)
Source: neuropathology blog - June 29, 2018 Category: Radiology Tags: vascular disease Source Type: blogs

Embryonal tumor with multilayered rosettes, C19MC-altered
Embryonal tumor with multlayered rosettes, C19MC-altered, is a WHO grade IV tumor with alterations -- including amplifications and fusions -- in the C19MC locus at 19q13.42. (Source: neuropathology blog)
Source: neuropathology blog - June 25, 2018 Category: Radiology Tags: neoplasms Source Type: blogs