A gaggle of Rosenthal fibers forming at the pushing border of an ependymoma
Ependymoma (left) pushing on adjacent brain induces numerous Rosenthal fibers,particularly around a blood vessel (Source: neuropathology blog)
Source: neuropathology blog - August 18, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Tumours of the CNS Dataset is now published to the ICCR website
TheInternational Collaboration on Cancer Reporting has published theTumours of the CNS Dataset.According to the published document, the " dataset has been developed for the histological assessment of benign and malignant tumours of the central nervous system (CNS) and its coverings, as well as tumours from those aspects of the peripheral nervous system immediately adjacent to the CNS. This dataset applies to both biopsy and resection specimens. Haematological lesions that may originate in the brain are included. Tumours of the anterior pituitary gland are included as the majority of these tumours are reported by neuropatho...
Source: neuropathology blog - August 17, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
2019 Annual Meeting of AANP: Save the Date!
(Source: neuropathology blog)
Source: neuropathology blog - August 15, 2018 Category: Radiology Tags: meetings Source Type: blogs
Salzmann nodular degeneration of the cornea
Histopathology of Salzmann nodules (*). Disruption of the Bowman membrane is demarcated in each photomicrograph by the area between the left and right arrows: (A) hematoxylin and eosin stain; (B) periodic acid-Schiff stain; (C) immunohistochemistry with antibody against pan-cytokeratin; and (D) immunohistochemistry with antibody against vimentin. (From Stone DU, et al. Histopathology of Saltzmann Nodular Corneal Degeneration.Cornea. Volume 27(2), February 2008, pp 148-151)Salzmann nodular degeneration was once called Salzmann nodular dystrophy. It is now recognized that this typically unilateral disor...
Source: neuropathology blog - August 13, 2018 Category: Radiology Tags: ophthalmic pathology Source Type: blogs
Best Post of June 2018: Who was Rosenthal?
Of the ten posts from June 2018, my favorite was " Who was Rosenthal? " from June 22. So, here ' s the next in our " Best of the Month " series:A Rosenthal fiber in pilocytic astrocytoma" In 1898, the German pathologist Werner Rosenthal noted elongated inclusions within the gliotic edge of a syringeal cavity of an ependymoma. Assigned to write the case report by a senior mentor while serving as a “first assistant” at the University of Erlangen, Rosenthal colorfully described these inclusions as a “glossy formation of little bulbs or wavy sausages with one thick and one pointed end.”…. His supp...
Source: neuropathology blog - August 10, 2018 Category: Radiology Tags: Best of the Month series history Source Type: blogs
Omalu puts a religious spin on his assessment of the football: " It is not of God. "
“We shouldn’t let children play [football] because we are damaging their brains and robbing them of their humanity. That is a fact.” That ' s what Dr. Bennet Omalu had to say to a reporter associate withSojourners, a faith-based organization. In therecently released article from Sojourners, Omalu said that football is a sport " not of God " . A committed Catholic, Omalu says that he lets "the Spirit of God percolate into my being... Everything I do, I do through the eyes of faith. ”Bennet Omalu, MDOmalu is best known for the startling discovery he made after performing an autopsy on former NFL player Mik...
Source: neuropathology blog - August 8, 2018 Category: Radiology Tags: trauma Source Type: blogs
CAP Neuropathology Committee meets in Montreal
The College of American PathologistsNeuropathology Committee met this past weekend in Montreal. It marked the end of my six-year term as a member of the committee. It was an honor to have served with such a wonderful collection of neuropathologists over the years. I ' ll miss working with these great colleagues.In Montreal, committee members (left to right) Kara Jones, Arie Perry, myself, Eyas Hattab, Andrea Wiens, and junior member Lindsey LowderAt dinner after a day of committee work (left to iight): CAP staffer Annabel Dizon, Karra Jones, Eyas Hattab, Andrea Weins, myself, Arie Perry, Lindsey Lowder, and Lindsey ' s hus...
Source: neuropathology blog - August 7, 2018 Category: Radiology Tags: meetings Source Type: blogs
Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports
Dr. Ann McKee ' s group last week published anarticle in the Journal of Neuropathology and Experimental Neurology supporting the theory that contact sports increases the risk of developing neocortical Lewy body disease, which may in part explain the extrapyramidal motor symptoms sometimes observed in patients with chronic traumatic encephalopathy. Dr. Thor Stein is the senior author on the paper, entitledLewy Body Pathology and Chronic Traumatic Encephalopathy Asssociated with Contact Sports. (Source: neuropathology blog)
Source: neuropathology blog - August 1, 2018 Category: Radiology Tags: Lewy body disease trauma Source Type: blogs
A ganglion of neuropathologists spontaneously coalesces at a this week's Association of Pathology Chairs meeting
Neuropathologists serve many roles aside from signing out surgical specimens and performing brain autopsies. That fact was in full display at this week ' s Association of Pathology Chairs meeting where, at a reception on Monday, a group of neuropathologists found themselves standing together at an afternoon reception. (Perhaps this coalescence was not so much by chance as it occurred directly adjacent to the bar.) It was nice to see old friends.Left to right: Drs. Douglas Miller, Kymberly Gyure, Jennifer Baccon, Eyas Hattab, and Brian Moore (Source: neuropathology blog)
Source: neuropathology blog - July 20, 2018 Category: Radiology Tags: meetings neuropathologists Source Type: blogs
What is the nodulus?
The lobule of the cerebellar vermis that, together with the flocculus of each hemisphere, forms the flocculonodular lobe. (Source: neuropathology blog)
Source: neuropathology blog - July 16, 2018 Category: Radiology Tags: anatomy Source Type: blogs
Hyperbrain: a great resource for learning neuroanatomy
HyperBrain is an online tutorial for human neuroanatomy from the University of Utah. HyperBrain includes thousand of images and hundreds of linked illustrated glossary terms, as well as movies, quizzes and interactive animations. (Source: neuropathology blog)
Source: neuropathology blog - July 13, 2018 Category: Radiology Tags: anatomy websites Source Type: blogs
Best Post of May 2018: Moving beyond histologic grading of IDH-wildtype diffuse astrocytic gliomas
The next in our " Best of the Month " series comes fromMay, 30, 2018:Despite the fact that the most recent update of the World Health Organization (WHO) classification of central nervous system tumors was published only two years ago, the data is already showing that we are moving beyond that classification system when if comes to IDH-wildtype diffuse astrocytomas. The concept of an " integrated diagnosis " in the setting of IDH-wildtype histologic grade II and III tumors has already been eclipsed in the literature by the primacy of the genetic signature over histologic appearance in predicting outcome. In the near future,...
Source: neuropathology blog - July 12, 2018 Category: Radiology Tags: Best of the Month series molecular studies neoplasms Source Type: blogs
CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids
These lesions histologically demonstrate a lymphocytic perivascular inflammatory pattern (Source: neuropathology blog)
Source: neuropathology blog - July 11, 2018 Category: Radiology Tags: vascular disease Source Type: blogs
The 2018 CANP annual meeting will be in Halifax October 3-6, 2018
TheCanadian Association of Neuropathologists is gearing up for its a 58th annual meeting this fall. (Source: neuropathology blog)
Source: neuropathology blog - July 10, 2018 Category: Radiology Tags: meetings Source Type: blogs
Atypical teratoid/rhabdoid tumor (AT/RT) in an infant
Rhabdoid cells (such as those circled above) frequently are seen in AT/RTs (Source: neuropathology blog)
Source: neuropathology blog - July 9, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
