An oddball sellar region mass
In the last post, it was noted that Dr. Peter Burger presented a series of sellar region "oddball lesions" at the recent USCAP meeting. The esteemed Dr. Mark Cohen was good enough to provide photographs (above) of one particular lesion that was discussed at the meeting: an osteolipoma of the tuber cinereum. Thank you, Dr. Cohen! (Source: neuropathology blog)
Source: neuropathology blog - March 15, 2013 Category: Pathologists Tags: neoplasms Source Type: blogs

Dr. Thomasina Bailey reviews pituitary session at recent USCAP meeting
A guest post from Thomasina Bailey, MD: I spent Saturday night, March 9,  up late in Baltimore at the AANP session at USCAP.  The talks focused on sellar lesions. The panel consisted of  Drs. Lopez, Kleinschmidt-DeMasters, and Burger.  Dr. Lopez  from UVA gave a really great overview of sellar lesions focusing in on pituitary adenomas.  She discussed the things that are clinically significant in the work-up of pituitary adenomas along with the controversies over atypical adenomas and carcinomas of the pituitary.  At the end of her talk, she listed her own WHO classification of pituit...
Source: neuropathology blog - March 14, 2013 Category: Pathologists Tags: meetings Source Type: blogs

Review by Dr. Mark Cohen of "Neuropathology: A Volume in the High Yield Pathology Series", edited by Yachnis and Rivera-Zengotita
Mark L. Cohen, MDI am honored to present a guest post by the inimitable Dr. Mark Cohen of the illustrious Case Western Reserve University. Dr. Cohen not only reviews a great new neuropathology textbook, but illustrates yet again why he is widely known as the Maxwell Smart of Neuropathology. (Not really) Full disclosureSelf-annihilating conflicts of interest, as follows:Long-standing professional relationship with unbridled admiration for lead editor Tony Yachnis, both as a person and as a pathologist (he's not the Moderator of the world-famous Diagnostic Slides Session of the American Association of Neuropathologis...
Source: neuropathology blog - February 26, 2013 Category: Pathologists Tags: books Source Type: blogs

A Primer on Perinatal Telencephalic Leukoencephalopathy
In my last post, it was correctly pointed out by two astute readers that the Netter figure demonstrating brain malformations included an entity which is NOT a brain malformation: perinatal telencephalic leukoencephalopathy (PTL). PTL results from a perinatal hypoxic insult and is not a malformation per se, as the term "malformation" should really be reserved for anatomic abnormalities resulting from developmental defects. The cerebral white matter in the fetus and neonate is particularly susceptible to injury as it is metabolically highly active. Ischemia of the germinal matrix, subependymal region, and periventr...
Source: neuropathology blog - February 13, 2013 Category: Pathologists Tags: developmental disorders vascular disease Source Type: blogs

Brain Malformations
(Source: neuropathology blog)
Source: neuropathology blog - February 1, 2013 Category: Pathologists Tags: malformations Source Type: blogs

Best Post of August 2012: A case of renal cell carcinoma metastatic to a meningioma
The next in our "Best of the Month" series is from August 9, 2012:A 74-year-old woman with a history of a seizure disorder had been followed for several years with a stable and unsymptomatic left parasagittal dural-based brain tumor presumed to be a benign meningioma. Recently, though, the lesion increased in size and hemorrhaged, leaving her significantly paretic on the right side. Neurosurgery thereupon performed a craniotomy for tumor removal. Intraoperative frozen section diagnosis was meningioma. But, upon receipt of the permanent sections, I was impressed by the staghorn vessels at low power and hemangioper...
Source: neuropathology blog - January 25, 2013 Category: Pathologists Tags: neoplasms Best of the Month series Source Type: blogs

Yachnis and Rivera-Zengotita team up to bring us some high-yield neuropathology
Who doesn't love the feel of a brand new textbook in your hands, and that first subtle crack of the binder as you open the cover releasing the synthetic fragrance of smooth new paper? We will get to re-live that feeling when Dr. Anthony Yachnis' Neuropathology: A Volume in the High-Yield Pathology Series is released. The book has a copyright year of 2014, so we may have to wait a while before it is released. But, if the good Dr. Yachnis is the principal author, it will surely be worth the wait. In his preface, written with co-author Dr. Marie L Rivera-Zengotita, Dr. Yachnis writes: "Our intent in producing this volume...
Source: neuropathology blog - January 17, 2013 Category: Pathologists Tags: books neuropathologists Source Type: blogs

The biggest Alzheimer Disease discovery in 2012
Kári StefánssonPerhaps the biggest discovery in the Alzheimer research world last year was the identification of a mutation in APP that significantly decreases its cleavage by β-secretase, leading to 40% less production of amyloidogenic peptides in vitro. The researchers found the mutation (A673T) in the APP gene protects against Alzheimer’s disease and cognitive decline in the elderly without Alzheimer’s disease.Future drugs that can recreate this Aβ-reducing effect “should perhaps be given not only to people at risk of Alzheimer’s but to all elderly people,” says K&aa...
Source: neuropathology blog - January 4, 2013 Category: Pathologists Tags: Alzheimer's disease Source Type: blogs

Best Post of July 2012: "Chasing The Dragon": A Cause of Toxic Spongiform Leukoencephalopathy
The next in our "Best of the Month" series comes from July 10, 2012:My favorite case from the 2012 AANP Diagnostic Slide Session in Chicago last month featured an autopsy slide from the brain of a 25-year-old man with a history of polysubstance abuse found unresponsive at a New Year's Eve party. Toxicology screening was positive for methadone, lorazepam, and cocaine. The patient died after three weeks in the intensive care unit. Attendees were provided glass slides in advance of the session demonstrating the following findings:Low Power: Marked white matter pallorHigh Power: White matter virtually replaced by lip...
Source: neuropathology blog - January 1, 2013 Category: Pathologists Tags: toxic encephalopathy meetings Best of the Month series neuropathologists Source Type: blogs