Mesoectodermal Leiomyoma of the Ciliary Body
A 47-year-old woman is suspected of having a ciliary body melanoma (A). Histologic sections (B and C) show large ciliary body tumor composed of tumor cells in a fibrillar cytoplasmic matrix. Electron microscopy (D) shows a dense osmophiliic structure known as askeinoid fiber.Immunohistochemistry helped to confirm that this was a leiomyoma.(Case reported by J. Campbell et al. Ultrastruct Pathol 28:559, 1997.) (Source: neuropathology blog)
Source: neuropathology blog - October 5, 2018 Category: Radiology Tags: eye Source Type: blogs

Alzheimer Society International Congress (ASIC 2019): Call for Abstracts
Abstracts are being accepted for theAlzheimer Society International Congress(ASIC 2019), which will be held on February 18-21, 2019 in San Francisco.The ASIC 2019 is sponsored bythe Alzheimer International Society, a non-profit organization with a mission to support patient care and foster research to find a cure for Alzheimer ’s disease. The Society is a professional international society for individuals interested in Alzheimer ' s and dementia science —including scientists, physicians and other professionals involved in the research and treatments of Alzheimer ' s disease and other dementias.ASIC 2019is a leading for...
Source: neuropathology blog - October 3, 2018 Category: Radiology Tags: meetings Source Type: blogs

“Rising Star Award” in Neurodegenerative Research: Call for Submissions
TheMahoney Institute for Neurosciences (MINS) at the  University of Pennsylvania is has announced a call for submissions for its annualRising Star Award in neuroscience research. To highlight the “Year of Neurodegenerative Research” on Penn’s campus, the award honors a young researcher for outstanding contributions to neurodegenerative research with a $10,000 personal honorarium at theMINS 35th Annual Retreat and Symposium on April 3, 2019.Dr. Virginia Lee“Neurodegenerative disorders are major health problems for the elderly, and there are currently no treatments for any of these diseases,” saidVirginia Lee,...
Source: neuropathology blog - October 2, 2018 Category: Radiology Tags: neurodegen dz (other) Source Type: blogs

Dr. Doug Miller named interim pathology chair at University of Missouri
Dr. Miller (note the " brain in a jar " lapel pin)Douglas C. Miller, MD, PhD was recently named interim chair of pathology at theUniversity of Missouriin Columbia. Dr. Miller joins several other department chairs who are neuropathologists:Douglas Anthony at Brown (pathologist-in-chief at Rhode Island Hospital)Dan Bratat NorthwesternSteven Carroll at Medical University of South CarolinaRobert Corona at SUNY UpstateJeffrey Golden at Brigham and Women ' s HospitalEyas Hattab at University of LouisvilleAlex Judkins at Children ' s Hospital Los Angeles (pathologist-in-chief)David Louis at Mass...
Source: neuropathology blog - September 28, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs

Crooke cell change in a normal pituitary of a patient with ectopic ACTH producing tumor
CK20 immunohistochemistry highlights Crooke cells (Source: neuropathology blog)
Source: neuropathology blog - September 27, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Subcortical band heterotopia
Also known as double cortex syndrome, subcortical band heterotopia is a rare congenital abnormality. Patients can live into adulthood, but seizures, cognitive disability, and behavioral problems can occur. (Picture courtesy of Dr. Nathaniel B. Patterson) (Source: neuropathology blog)
Source: neuropathology blog - September 25, 2018 Category: Radiology Tags: malformations Source Type: blogs

Neuropathologist combines music composition with brain research
Dr. Elaine BearerUniversity of New Mexico neuropathologist Elaine Bearer, MD, PhD was featured today on a radio interview with KUNM. You can listen to the interview on the University of New Mexicoradio station web site. Dr. Bearer ' s work includes studying biomarkers of trauma and abuse in children and whether the cause of Alzheimer ' s disease may come from infections. Dr. Bearer is also a composer and it was music that spurred her interest in studying the brain. (Source: neuropathology blog)
Source: neuropathology blog - September 24, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs

Multinodular and vacuolating neuronal tumor,WHO grade I
The patient is a middle-aged male with a temporal lobe mass. Histopathology shows a low-grade ganglion cell tumor with clustered ganglion cells with a vacuolated neuropil background. The fragmented nature of the specimen precludes identification of a nodular architecture. The diagnosis is multinodular and vacuolating neuronal tumor, WHO grade I. This entity is a cousin of gangliocytoma. (Source: neuropathology blog)
Source: neuropathology blog - September 21, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

A WHO grade IV diagnosis in the face of a low-grade histophenotype: a difficult situation for the surgical neuropathologist
This midbrain mass in a 33-year-old patient has low-grade histology (minimal mitoses, low MIB-1 cell cycling index, and a single Rosenthal fiber), yet it harbors the H3 K27M mutation. Perivascular lymphocytes were present, but ganglioglioma was ruled out. So, the following diagnosis was rendered:diffuse midline glioma, H3 K27M mutant, WHO grade IV. Other molecular changes included loss of p16 (CDKN2a) and loss of PTEN and 10 centromere, consistent with monosomy for chromosome 10. The discordance between histopathology and molecular findings can make the diagnostician squeamish about rendering a high-grade diagnos...
Source: neuropathology blog - September 20, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Handy reference photo for orienting an enucleation specimen
(Source: Eagle, RC Jr., Eye Pathology: An Atlas and Text, second edition (2011) p. 291. (Source: neuropathology blog)
Source: neuropathology blog - September 18, 2018 Category: Radiology Tags: eye Source Type: blogs

Best Post of August 2018 - Omalu puts a religious spin on his assessment of the football: " It is not of God. "
The next in our " Best of the Month " series comes from August 8, 2018:“We shouldn’t let children play [football] because we are damaging their brains and robbing them of their humanity. That is a fact.” That ' s what Dr. Bennet Omalu had to say to a reporter associate with Sojourners, a faith-based organization. In the recently released article from Sojourners, Omalu said that football is a sport " not of God " . A committed Catholic, Omalu  says that he lets "the Spirit of God percolate into my being... Everything I do, I do through the eyes of faith. ”Bennet Omalu, MDOmalu is best known for t...
Source: neuropathology blog - September 17, 2018 Category: Radiology Tags: Best of the Month series trauma Source Type: blogs

Best Post of July 2018: What is the nodulus?
The next in our " Best of the Month " series come from July 16, 2018:The nodulus is the lobule of the cerebellar vermis that, together with the flocculus of each hemisphere, forms the flocculonodular lobe. (Source: neuropathology blog)
Source: neuropathology blog - September 12, 2018 Category: Radiology Tags: anatomy Best of the Month series Source Type: blogs

Circadian Rhythm Gene May Serve as Target for Glioblastoma Therapies
Scientists from the Virginia Tech Carilion Research Institute say a gene involved in the body ' s circadian rhythms is a potential target for therapies for glioblastoma.Their discovery ( “Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival”), published in Scientific Reports, points to a subtype of a particular gene that apparently is enabling the survival of cancer cells, although it is more commonly associated with circadian rhythms.“In our previous work, we identified casein kinase 1 ε (CK1ε, also known as CSNK1E) as a potential survival factor in glioblastoma. However, how CK1ε controls cell ...
Source: neuropathology blog - September 11, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

A case of posterior cortical atrophy
Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills. The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer ' s disease in most patients. However, alternative underlying causes, including dementia with Lewy bodies, corticobasal degeneration, and prion disease, have also been identified, and not all patients with PCA have atrophy on clinical imaging.(Crutch, S. J., Lehmann, M., Schott, J. M., Rabinovici, G. D., Rossor, ...
Source: neuropathology blog - September 7, 2018 Category: Radiology Tags: neurodegen dz (other) Source Type: blogs

A case of Alexander disease
Alexander disease is a progressive and often fatal leukodystrophy wherein innumerableRosenthal fibers form. Caused by mutation in the gene encoding GFAP, Alexander disease can be inherited in an autosomal dominant manner, but typically arisesde novo.CerebrumCerebrumCerebellum (Source: neuropathology blog)
Source: neuropathology blog - August 23, 2018 Category: Radiology Tags: neurodegen dz (other) Source Type: blogs