Choroidal ganglioneuronal hamartoma in an NF1 patient

Thanks to Dr. Ahmed Gilani (pediatric pathology fellow at the University of Colorado) for providing me with slides of an enucleation specimen from a patient with Von Recklinghausen Neurofibromatosis (NF-1). The specimen exhibits a region of choroidal expansion with hamartomatous neuroglial tissue. Distributed throughout this choroidal expansion are non-pigmented ovoid bodies, which have a delicately laminated appearance reflecting the presence of concentric Schwann cell processes. One might conceive of these choroidal expansions as cousins of iridic Lisch nodules.Choroidal expansion in an enucleation specimen from a child with NF1Ganglion-like cells within the choroidal expansionOvoid body within choroidal expansion

Source: neuropathology blog - January 30, 2018 Category: Radiology Tags: eye Source Type: blogs