Anaplastic Gangliocytoma in the frontal lobe of a 35-year-old female
This is the latest in several resections and follows two rounds of chemotherapy. Immunomarkers positive for neurofilament, and negative for S100, GFAP, synaptophysin, chromogranin, NeuN, HMB45, and MelanA.Anaplastic Gangliocytoma (note the necrosis in the lower right corner) (Source: neuropathology blog)
Source: neuropathology blog - April 16, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Colloid cyst of the third ventricle
Modified by compressive atrophy, the cyst lining cells would otherwise be columnar with obvious ciliaA different area of the same cyst which more clearly demonstrates cilia (Source: neuropathology blog)
Source: neuropathology blog - April 12, 2018 Category: Radiology Tags: cysts Source Type: blogs

There is a neuropathology museum in Lima, Peru
The Institute of Neurological Science (INCN) in Lima houses the only " Brain Museum " in Latin America. The  collection contains over 3000 samples from which around 300 are on permanent display, including brains with diverse cerebral diseases and anomalies as well as fetal brains with abnormalities.  Unique photomicrographs and other items are also on display. (Source: neuropathology blog)
Source: neuropathology blog - April 11, 2018 Category: Radiology Tags: history Source Type: blogs

Posterior fossa tumor in a 5-month-old girl
The tumor was GAB1 positive (a marker for the SHH pathway).Desmoplastic./nodular medulloblastoma (Source: neuropathology blog)
Source: neuropathology blog - April 9, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Exuberant endothelial reactive hyperplasia next to a subacute infarct biopsied to rule out neoplasia
Endothelial hyperplasia next to an infarct, not to be confused with microvascular proliferation in a glioma (Source: neuropathology blog)
Source: neuropathology blog - April 3, 2018 Category: Radiology Tags: vascular disease Source Type: blogs

Best Post of January 2018: Choroidal ganglioneuronal hamartoma in an NF1 patient
The next in our " Best of the Month " series is from January 30, 2018:Thanks to Dr. Ahmed Gilani (pediatric pathology fellow at the University of Colorado) for providing me with slides of an enucleation specimen from a patient with Von Recklinghausen Neurofibromatosis (NF-1). The specimen exhibits a region of choroidal expansion with hamartomatous neuroglial tissue. Distributed throughout this choroidal expansion are non-pigmented ovoid bodies, which have a delicately laminated appearance reflecting the presence of concentric Schwann cell processes. One might conceive of these choroidal expansions as cousins of iridic Lisc...
Source: neuropathology blog - March 21, 2018 Category: Radiology Tags: Best of the Month series eye Source Type: blogs

Epigenomics to Enhance Tumor Classification
The Neuropathology Department at Heidelberg University Hospital led by Professor Andreas von Deimling, have developed a new computer-based method. “We hope that our new molecular classification method will help improve diagnostic accuracy in CNS tumors and, thus, also improve the chances for successful treatment,” said von Deimling.The researchers analyzed specific DNA methylations. Different cell types exhibit characteristic patterns of DNA methylation which enable scientists to draw conclusions about a tumor ’s cellular origin. " We have developed computer-based algorithms that reliably differentiate 82 types of CN...
Source: neuropathology blog - March 19, 2018 Category: Radiology Tags: molecular studies Source Type: blogs

On Einstein's Birthday, We Take a Second Look at His Brain
On this date 139 years ago, Albert Einstein was born inUlm, Germany. We take this occasion to republish a post from November 21, 2012 entitled:Photos reveal unique features of Einstein ' s cerebral cortex:Photographs taken shortly after his death, but never before analysed in detail, have now revealed that Einstein ’s brain had several unusual features, providing clues about the neural basis of his extraordinary mental reports that, while doing Einstein ' s autopsy, the pathologist Thomas Harvey removed the physicist ' s brain and preserved it in formalin. He then took dozens of black and white ...
Source: neuropathology blog - March 14, 2018 Category: Radiology Tags: anatomy history Source Type: blogs

Featured Neuropathologist: Michael Punsoni, MD
On occasion, we profile a prominent or rising neuropathologist. In the past, we ' ve featured the likes of Craig Horbinski, Roger McLendon,Jan Leestma, and Karra Jones. Today we featureMichael Punsoni, MD, a 2016 graduate of the Brown University Neuropathology Fellowship Program and now on faculty at the University of Nebraska in Omaha. Dr. Punsoni agreed to engage in a little Q&A:1. Why did you decide to become a neuropathologist?I have always had a strong interest in science and medicine, particularly the neurosciences. After college I worked in two research labs, which fueled my interest in basic...
Source: neuropathology blog - March 12, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs

Cerebral malaria in a young woman who had traveled to Africa
A young woman became sick after visiting Zambia. She died a few weeks after onset of headache and flu-like symptoms. The slide is not dirty! The dirty-looking stuff in the picture below is birefringent pigment called hemozoin. This is typical of a falciparum infection. There are ring hemorrhages and D ürck granulomas present as well. Dürck granulomas are accumulations of mononuclear cells, predominantly macrophages, probably related to resorption of ring hemorrhages.Hemozoin pigmentD ürck granuloma (Source: neuropathology blog)
Source: neuropathology blog - March 8, 2018 Category: Radiology Tags: infectious disease Source Type: blogs

The meticulously extracted nervous system of a 19th-century woman on display at Hahnemann Medical College
Last summer I put up apostabout a remarkable whole nervous system dissection that was carried out at the University of Colorado School of Medicine. The inimitable Dr. Mark Cohen recently sent mean article about a similar dissection performed at Hahnemann Medical College in Philadelphia by Dr. Rufus B. Weaver. The dissection, which took place in 1888 over the course of five months, was performed on a 35-year-old woman who had given permission for her body to be used for the furtherance of science.Dr. Rufus B. Weaver and the nervous system of Harriet ColeAn excerpt from the article appearing inAtlas Obscura:According to the&...
Source: neuropathology blog - March 7, 2018 Category: Radiology Tags: anatomy history Source Type: blogs

Dr. Mary Fowkes featured in YouTube Video
Dr. Mary FowkesDr. Mary Fowkes, neuropathologist at Mount Sinai, is featured in a one-hour neuropathology review session on YouTube! (Source: neuropathology blog)
Source: neuropathology blog - March 5, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs

Course being offered at March 2018 USCAP annual meeting: Non-neoplastic surgical neuropathology that can be mistaken for neoplasia
SC07 - Surgical Neuropathology - The Other StuffThursday, March 22, 2018 - 8:00 am - 11:30 amThis Short Course session includes up to a half-hour break.Session Credits:3 CME and 3 SAMsFacultyBette K. Kleinschmidt-DeMasters, MD, University of Colorado, Aurora, CORichard A. Prayson, MD, Cleveland Clinic, Cleveland, OHAnthony T. Yachnis, MD, University of Florida, Gainesville, FLCourse DescriptionThe majority of cases encountered in surgical neuropathology represent neoplasms. Subsequently, most pathologist, when confronted with a surgical neuropathology case, are usually “thinking tumor” and conjuring up differential dia...
Source: neuropathology blog - February 28, 2018 Category: Radiology Tags: meetings Source Type: blogs

McLean Hospital Launches the National Eating Disorders Brain Bank
This article was adapted from a press release issued by McLean and FREED) (Source: neuropathology blog)
Source: neuropathology blog - February 27, 2018 Category: Radiology Tags: Brain Banking Source Type: blogs

Aldape Takes on Role as Chief of the Laboratory of Pathology at NCI
Kenneth Aldape, MDKenneth Aldape, MD, has joined the National Cancer Institute ’s Center for Cancer Research as chief of theLaboratory of Pathology, an integral component of the research and clinical community at the National Institutes of Health.Prior to his current role, Aldape was a professor and department chair of pathology at the MD Anderson Cancer in Houston, Texas. He was later recruited to Toronto General Hospital and Research Institute to develop a brain tumor program and conduct clinical-translational research in neuro-oncology. (Source: neuropathology blog)
Source: neuropathology blog - February 26, 2018 Category: Radiology Tags: neuropathologists Source Type: blogs