The exquisite cellular uniformity of the central neurocytoma
Intraoperative ThinPrep smear demonstrates the striking cellular uniformityPermanent section of the same tumor (Source: neuropathology blog)
Source: neuropathology blog - November 20, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Perforating injury of globe
Ocular perforation caused by BB gun is a through-and-through injury with entrance and exit wounds in limbus and sclera, respectively. The track of the BB is marked by fresh blood. Posteriorly detached vitreous also contains ochre-colored degenerated blood.(Source: Eagle R. Eye Pathology: An Atlas and Text. Second Edition. 2011) (Source: neuropathology blog)
Source: neuropathology blog - November 19, 2018 Category: Radiology Tags: eye Source Type: blogs

Q & A with Dr Peter Cummings, co-author of “Brainwashed: The Bad Science Behind CTE and the Plot to Destroy Football”
Peter Cummings, MD1.   Chronic traumatic encephalopathy has been considered by many to be a distinct nosologic entity since 1928, when Dr. Harrison Martland published the article“Punch Drunk ” in JAMA. Do you believe that CTE is a distinct entity? If so, what, in your opinion, defines CTE?That ' s a good question! If you look at the totality of the literature in a historical context, you see the ' classic ' boxers neuropathological changes followed by the Omalu cases and then the McKee cases. Looking at all of these cases you can see that there is a wide spectrum of changes considered to be " CTE " ...
Source: neuropathology blog - November 14, 2018 Category: Radiology Tags: trauma Source Type: blogs

Dr. Fausto Rodriguez to deliver live online presentation this Wednesday
Wednesday, November 14th  - 8 AM ESTTopic: Surgical Neuropathology Pearls: Sellar LesionsPresented by Fausto Rodriguez, MD, Associate Professor of Pathology, JHUSOMThis seminar can be accessed livethrough the following links at 8 AM on Wednesday:Facebook:https://www.facebook.com/pathCast/YouTube:https://www.youtube.com/channel/UCVxosS9hPP3ikMQXAE9PamwWebsite:http://pathologycast.com/This hour-long PathCast seminar presented by Dr. Fausto Rodriguez will be broadcast live on both Facebook and YouTube. Live chat will be available for you to discuss the presentation ...
Source: neuropathology blog - November 12, 2018 Category: Radiology Tags: neuropathologists websites Source Type: blogs

SF-1 immunohistochemistry for detecting gonadotroph adenomas
Adenomas driven by the transcription factor SF-1, which are exclusively gonadotroph adenomas, are a common subtype encountered by the surgical pathologist. Traditionally, gonadotroph adenomas have been defined by positive immunostaining for luteinizing hormone (LH) and/or follicle stimulating hormone (FSH) with or without alpha-subunit ( αSU). However, SF-1 alone can detect gonadotrophin adenomas. Further, the majority of previously classified " null cell " adenomas -- negative for all hormonal markers including LH, FSH and αSU -- are in fact positive for SF-1 and therefore better classified as gonadotroph adenomas.A gon...
Source: neuropathology blog - November 7, 2018 Category: Radiology Tags: pituitary Source Type: blogs

The appendix is implicated in Parkinson ’s disease
Clumps of alpha-synuclein (red) in the appendix of a healthy individual suggests the possibilitythat the gut plays a role in the pathogenesis of Parkinson diseaseThe appendix may contribute to a person ’s chances of developing Parkinson’s disease. An analysis of data from nearly 1.7 million Swedes found that those who’d had their appendix removed had a lower overall risk of Parkinson’s disease. Also, samples of appendix tissue from healthy individuals revealed protein clumps similar to those found in the brains of Parkinson ’s patients, researchers report online October 31 in Science Translational ...
Source: neuropathology blog - November 5, 2018 Category: Radiology Tags: parkinson disease Source Type: blogs

AANP announces Special Course topic for 2019 meeting
The Special Course topic is:Unintended Consequences: The Iatrogenic Neuropathology of Systemic Therapies.Register for the meetinghere. (Source: neuropathology blog)
Source: neuropathology blog - November 2, 2018 Category: Radiology Source Type: blogs

Best Post of October 2018: Young adult with an iridic mass extending into the ciliary body
The next in our " Best of the Month " series comes from October 9, 2018:Melanoma markers were negative. Smooth muscle markers were positive. This case was determined to be an epithelioid leiomyoma. I didn ' t do electron microscopy to look for mitochondia, but it may well be what Ursula Schlotzer-Schredhardt et al. have called a mitochondria-rich epithelioid leiomyoma (Arch Ophthalmol, Vol 120, January 2002). (Source: neuropathology blog)
Source: neuropathology blog - November 1, 2018 Category: Radiology Tags: Best of the Month series eye ophthalmic pathology Source Type: blogs

Nowinski rebuts book which questions football's role in chronic traumatic encephalopathy
On Tuesday, I posted about a new book out which questions the conclusions drawn by Boston University researchers regarding the connections between football and chronic traumatic encephalopathy (CTE). Today, BU ' s Chris Nowinskiresponded in the pages of USA Today.Chris Nowinski, PhD, CEO of the Concussion Legacy Foundation which has connections to Boston University researchers, said the following in the USA Today article: " I ' m happy to ask Merril Hoge who to draft No. 1 next year, but we shouldn ' t be asking him how to design research studies. "Chris Nowinski, PhD (Source: neuropathology blog)
Source: neuropathology blog - October 25, 2018 Category: Radiology Tags: trauma Source Type: blogs

Neuropathologist teams up with former NFL player to write provocative book questioning the extent and cause of CTE among football players
Dr. Peter CummingsIn an Op-Ed piece published today onYahoo! Sports, neuropathologistPeter Cummings and former NFL playerMerril Hoge discuss their skepticism about the science behind the connection between chronic traumatic encephalopathy (CTE) and football. Cummings and Hoge just released a book entitled “Brainwashed: The Bad Science Behind CTE and the Plot to Destroy Football” (Amplify, Oct. 23, 2018), describing their take on the conclusions that have been drawn regarding the connection between football and CTE. " We believe that when people know what we know, they ’ll start asking tougher, smarter quest...
Source: neuropathology blog - October 23, 2018 Category: Radiology Tags: trauma Source Type: blogs

The Ivy League reduces concussion rates in football by moving the kickoff ball just five yards toward opposing team's goalpost
Following an experimental 2016 change to kickoff rules designed to encourage more touchbacks,  Ivy League schools saw reduced rates of concussions on the football field.A recent study in which Brown University and the seven other Ivy League institutions participated showed that reducing kickoff returns in which players actively try to advance the ball during football games could lessen the number of concussions players suffer on the field.Results from the study, published this month in the Journal of the American Medical Association, show a sharp decrease in the rate of concussions following the Ivy League ’s d...
Source: neuropathology blog - October 14, 2018 Category: Radiology Tags: trauma Source Type: blogs

True rosette situated within an Embryonal Tumor with Multilayered Rosettes, C19MC-altered, WHO grade IV
This aggressive tumor was located in the frontoparietal lobe of a young child. It had alterations in the C19MC locus at 19q13.42. (Source: neuropathology blog)
Source: neuropathology blog - October 12, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Xanthic cell in a pleomorphic xanthastrocytoma
(Source: neuropathology blog)
Source: neuropathology blog - October 11, 2018 Category: Radiology Tags: neoplasms Source Type: blogs

Young adult with an iridic mass extending into the ciliary body
Melanoma markers were negative. Smooth muscle markers were positive. This case was determined to be anepithelioid leiomyoma. I didn ' t do electron microscopy to look for mitochondia, but it may well be whatUrsula Schlotzer-Schredhardtet al. have called amitochondria-rich epithelioid leiomyoma(Arch Ophthalmol, Vol 120, January 2002). (Source: neuropathology blog)
Source: neuropathology blog - October 9, 2018 Category: Radiology Tags: eye ophthalmic pathology Source Type: blogs

Best Post of September 2018: A Case of Posterior Cortical Atrophy
The next in our " Best of the Month " series is from September 7, 2018:Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills. The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer ' s disease in most patients. However, alternative underlying causes, including dementia with Lewy bodies, corticobasal degeneration, and prion disease, have also been identified, and not all patients with PCA have atrophy on clinical imaging....
Source: neuropathology blog - October 8, 2018 Category: Radiology Tags: Alzheimer ' s disease Best of the Month series neurodegen dz (other) Source Type: blogs