Guest Post from Dr. Mike Lawlor: Audentes Announces Positive Interim Data from First Dose Cohort of ASPIRO, a Phase 1/2 Clinical Trial of AT132 in Patients With X-Linked Myotubular Myopathy
Dr. Mike LawlorRegular contributor Mike Lawlor, MD, PhD passed this development along from the X-linked myotubular myopathy clinical research front:Audentes Therapeutics has released an interim data update on the ASPIRO gene therapy clinical trial for X-linked myotubular myopathy. In the 4thquarter of 2017, three patients were given a single dose of an adeno-associated virus containing the human myotubularin gene. To quote the press release:" The early AT132 efficacy data observed in our first dose cohort of patients have exceeded our expectations, " stated Dr. Suyash Prasad, Senior Vice President and Chief Med...
Source: neuropathology blog - January 16, 2018 Category: Radiology Tags: muscle Source Type: blogs
Best Post of October 2017: Neuropathologist Hannes Vogel featured in New York Times for examining brain of Las Vegas mass murderer
The next in our " Best of the Month " series is from Friday, October 27, 2017:Prominent neuropathologist Hannes Vogel of Stanford University was featured in the New York Times yesterday as he is examining the brain of Stephen Paddock, who killed 58 concertgoers in Las Vegas this month in a rampage without any clear motive. Here ' s the link to the NYT article.Hannes Vogel, MD (Source: neuropathology blog)
Source: neuropathology blog - December 22, 2017 Category: Radiology Tags: Best of the Month series neuropathologists Source Type: blogs
A message from American Association of Neuropathologists President Elizabeth Cochran
Louisville, KYAANP members are already prepping for the 94th Annual Meeting, to be held in Louisville, KY, June 7-10, 2018. Annual Meeting registration and theabstract submission site have launched, and the call for DSS cases has been sent. We are looking forward to seeing you in Kentucky! (Source: neuropathology blog)
Source: neuropathology blog - December 18, 2017 Category: Radiology Tags: meetings Source Type: blogs
Best Post of September 2017 -- Guest Post from Dr. PJ Cimino: Blue discoloration of the gray matter in a patient who received methylene blue for respiratory distress prior to death
The next in our " Best Post of the Month " series is from Monday, September 11, 2017:Dr. PJ Cimino, whom we profiled when he was a fellow back in November of 2013, is a now faculty member at the University of Washington. I was delighted to receive this email from him today:" I had an autopsy case with interesting gross pathology findings, which made for some nice clinical images (below). The patient received therapeutic methylene blue in the setting of respiratory distress prior to death. The gross pathology showed striking widespread green-blue gray matter discoloration. I thought these images might be of intere...
Source: neuropathology blog - December 14, 2017 Category: Radiology Tags: anatomy Best of the Month series Source Type: blogs
Best Post of August 2017: Choroid plexus carcinoma in an infant
The next in our " Best of the Month " Series is from August 1, 2017:Some papillary architecture is maintained (Source: neuropathology blog)
Source: neuropathology blog - December 1, 2017 Category: Radiology Tags: Best of the Month series neoplasms Source Type: blogs
Best Post of June 2017: Remarkable en bloc dissection of human central and peripheral nervous system accomplished at University of Colorado
Discussion is underway about loaning the specimen to the Denver Museum of Nature and Science for community health education.CNS en bloc dissection with extensive portion of PNSConnection to the eyeballs is maintained, with plans to dissect away extraocular musclesDetail showing maintained connection with digital nerves of the left hand (Source: neuropathology blog)
Source: neuropathology blog - November 28, 2017 Category: Radiology Tags: anatomy Best of the Month series Source Type: blogs
Choroidal hemangioma in a patient with Stuge-Weber Syndrome
Sclera is at bottom of picture; retinal pigment epithelium is at top right. Between them is choroid with cavernous hemangioma (Source: neuropathology blog)
Source: neuropathology blog - November 6, 2017 Category: Radiology Tags: eye Source Type: blogs
Guest Post from Sandro Santagata, MD, PhD: Papillary Craniopharyngioma Trial
I am pleased to present a guest post from Dr. Sandro Santagata of Brigham and Women ’s Hospital/Dana Farber Cancer Center, who writes:Our group of collaborators has recently opened a Phase II Trial of BRAF/MEK Inhibitors in Papillary Craniopharyngiomas that is sponsored by the Alliance for Clinical Trials in Oncology.The eligibility criteria are listed here:https://clinicaltrials.gov/ct2/show/NCT03224767The trial is based on work published in these two papers:https://www.ncbi.nlm.nih.gov/pubmed/24413733https://www.ncbi.nlm.nih.gov/pubmed/26498373I am happy to answer any questions that our colleagues may have about this t...
Source: neuropathology blog - November 1, 2017 Category: Radiology Tags: molecular studies Source Type: blogs
Neuropathology Blog is Ten Years Old Today
Ten years ago today, I put up thefirst post to neuropathology blog. At the time, I didn ' t intend for anyone to actually read any of this stuff. I thought the blog would be a convenient way of taking searchable notes on various neuropathology topics I came across. Ten years (and 703 posts!) later, the blog has thus far had more than 850,000 page views. I ' d like to particularly thank two early supporters: Drs. John Donahue and Mark Cohen. Thanks to both of you for your encouragement early on. And thanks to all the readers and contributors who have participated in making this blog a success over the last decade. Her...
Source: neuropathology blog - October 31, 2017 Category: Radiology Source Type: blogs
Neuropathologist Hannes Vogel featured in New York Times for examining brain of Las Vegas mass murderer
Prominent neuropathologist Hannes Vogel of Stanford University was featured in the New York Times yesterday as he is examining the brain of Stephen Paddock, who killed 58 concertgoers in Las Vegas this month in a rampage without any clear motive.Here ' s the link to the NYT article.Hannes Vogel, MD (Source: neuropathology blog)
Source: neuropathology blog - October 27, 2017 Category: Radiology Tags: forensics neuropathologists Source Type: blogs
Audentes Therapeutics Announces Dosing of First Patient in ASPIRO, a Phase 1/2 Clinical Trial of AT132 for the Treatment of X-Linked Myotubular Myopathy
Following up on the last post, Dr. Mike Lawlor sent me this in an email:"Audentes Therapeutics officially announced the dosing of the first patient for the X-linked myotubular myopathy treatment trial that we ’ve been working on over the past few years. We ’ve been very involved in the translation from dogs to humans, and will be doing the human pathology work for the trial. Here ’s a link to that press release. " (Source: neuropathology blog)
Source: neuropathology blog - October 11, 2017 Category: Radiology Tags: muscle Source Type: blogs
Lawlor featured in video about his work in myotubular myopathy
Michael Lawlor, MD, PhDMedical College of Wisconsin is highlighting the work of our colleagueDr. Michael Lawlor in the area of gene therapy for myotubular myopathy. Check out this wonderful 4-minute video! (Source: neuropathology blog)
Source: neuropathology blog - October 2, 2017 Category: Radiology Tags: muscle neuropathologists Source Type: blogs
Murat Gokden releases " Neuropathologic and Neuroradiologic Correlations: A Differential Diagnostic Text and Atlas "
I got this email from medical student extraordinaire Stephen Nix:Murat Gokden, MD" I ' m not sure if this would be something to feature on the neuropathology blog or not, but Murat Gokden just edited and released a book with Cambridge Press entitled " Neuropathologic and Neuroradiologic Correlations " (link below) focusing on combining neuropathology and neuroradiology information/findings into one resource. I just got my copy today and the images and text look great. Pathology contributors include Travis Danielsen, Robin Elliott, Bret Evers, Theodore Friedman, Melissa Gener, Humayun Gultekin, Eyas...
Source: neuropathology blog - September 28, 2017 Category: Radiology Tags: books Source Type: blogs
Aaron Hernandez Had Severe C.T.E. When He Died at Age 27
The New York Timesreported yesterday that an autopsy report on 27-year-old Aaron Hernandez, the former New England Patriots tight end and convicted murderer, showed evidence of severe chronic traumatic encephalopathy (CTE). Hernandez committed suicide earlier this year. Excerpts from the article:"Dr. Ann McKee, chief of neuropathology at the VA Boston Healthcare System and director of the CTE Center at Boston University, examined his brain and said in a statement that Mr. Hernandez had “early brain atrophy” and “large perforations in the septum pellucidum, a central membrane” of the brain. The slides also show...
Source: neuropathology blog - September 22, 2017 Category: Radiology Tags: trauma Source Type: blogs
" I'm a brain scientist and I let my son play football " -- Peter Cummings, MD
Peter Cummings, MD with his sonDr. Peter Cummings, an accomplished forensic neuropathologist, just posted an article on Yahoo Sports giving his perspective on the controversial question of whether we should let our children play football given the risk for chronic traumatic encephalopathy.Here is the link. Thanks toDr. John Donahue of Brown University for alerting me to this article. (Source: neuropathology blog)
Source: neuropathology blog - September 19, 2017 Category: Radiology Tags: trauma Source Type: blogs
