Single-dose Administration of Recombinant Human Thrombopoietin Enhances Survival and Hematopoietic Reconstruction in Canines Irradiated with 3 Gy Gamma Radiation
Radiat Res. 2024 Apr 29. doi: 10.1667/RADE-23-00206.1. Online ahead of print.ABSTRACTWe conducted this study to investigate the radioprotective effects of recombinant human thrombopoietin (rhTPO) on beagle dogs irradiated with 3.0 Gy 60Co gamma rays. Fifteen healthy adult beagles were randomly assigned to a control group with alleviating care, and 5 and 10 μg/kg rhTPO treatment group. All animals received total-body irradiation using 60Co γ-ray source at a dose of 3.0 Gy (dose rate was 69.1 cGy/min). The treatment group received intramuscular injection of rhTPO 5 and 10 μg/kg at 2 h postirradiation, and the control grou...
Source: Radiation Research - April 28, 2024 Category: Physics Authors: Jinkun Yang Hao Luan Xing Shen Guolin Xiong Xun Wang Xuewen Zhang Wenyu Ji Ying Jiang Yangyang Dai Enqi Zhang Hongling Ou Yuwen Cong Xinru Wang Shuang Xing Zuyin Yu Source Type: research
Drug-coated balloon in the treatment of coronary artery de-novo large lesions angiography
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):196-201. doi: 10.14715/cmb/2024.70.4.31.ABSTRACTThe superiority of drug-coated balloon (DCB) in treating small vessels, branching lesions, and high-risk bleeding lesions in coronary heart disease patients has been confirmed. However, its safety and efficacy in large vessels are still unclear. We aimed to investigate whether the efficacy of DCB in large vessels is not inferior to that of drug-eluting stent (DES). From November 2019 to April 2022, a total of 88 patients in our hospital who underwent coronary angiography for the first time and decided to receive DCB or DES tre...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Xingyou Cai Xin Hong Yuli Wang Yafei Li Guidong Xu Source Type: research
Comparison of the efficacy and safety of warfarin anticoagulation and left atrial appendage transcatheter occlusion in the treatment of non-valvular atrial fibrillation and investigation of ET-1, hs-CRP and PDGFs
This study compared the therapeutic effect and safety between warfarin anticoagulation and percutaneous left atrial appendage transcatheter occlusion (PLAATO) in non-valvular atrial fibrillation (NVAF). A total of 110 patients were selected and assigned to Control group (n=55) and Observation group (n=55). The control patients were used warfarin, while the observation patients were performed PLAATO. The coagulation function, stroke and bleeding scores were compared between the two groups at different times. Left ventricular function before therapy and 1 year after therapy and adverse events during follow-up were compared b...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yujie Zhang Yali Yao Ling Tao Tao Du Binbin Jia Mi Zhou Zhen Zhang Source Type: research
Variant mapping using mass spectrometry-based proteotyping as a diagnostic tool in Von Willebrand Disease
CONCLUSIONS: This study highlights how VWF proteotyping from plasma could be the first step to bridge the gap between genotyping and functional testing in VWD.PMID:38679335 | DOI:10.1016/j.jtha.2024.04.011 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 28, 2024 Category: Hematology Authors: Iris C Kreft Tirsa T van Duijl Calvin van Kwawegen Ferdows Atiq Winny Phan Margo B P Schuller Mari ëtte Boon-Spijker Carmen van der Zwaan Alexander B Meijer Arie J Hoogendijk Ruben Bierings Jeroen C J Eikenboom Frank W G Leebeek Maartje van den Biggelaar Source Type: research
DIREN mitigates DSS-induced colitis in mice and attenuates collagen deposition via inhibiting the Wnt/ β-catenin and focal adhesion pathways
CONCLUSION: DIREN exerts a protective effect against DSS-induced UC by ameliorating colonic fibrosis via regulation of focal adhesion and the WNT/β-catenin signaling pathway, thereby inhibiting fibroblast migration and reducing collagen secretion.PMID:38678963 | DOI:10.1016/j.biopha.2024.116671 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Weizhi Lai Yingying Wang Chen Huang Hao Xu Xunjie Zheng Ke Li Jue Wang Zhaohuan Lou Source Type: research
Efficacy of acupuncture as adjunct therapy for sleep disorders in Parkinson's disease: A systematic review and meta-analysis
CONCLUSION: This study provides initial evidence that acupuncture as an adjunct therapy might be associated with improvement of sleep disorders in PD. Due to the lack of high-quality studies, larger sample size studies with sham acupuncture groups should be conducted in future.REGISTRATION NUMBER: CRD42022364249 (PROSPERO).PMID:38679147 | DOI:10.1016/j.ctim.2024.103044 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - April 28, 2024 Category: Complementary Medicine Authors: Wenjing Mi Miaomiao Meng Fenghua Xu Lingzhi Sun Source Type: research
Association between Covishield vaccine and menstrual disturbance. Findings from a cross-sectional study among participants of Zero TB cohort in India
CONCLUSION: Menstrual problems were reported by Covishield vaccinees, but they were minor and reversible within three months and do not constitute a ground for vaccine hesitancy. Studies designed to assess causal link taking care to avoid selection bias or confounding are needed.PMID:38679512 | DOI:10.1016/j.vaccine.2024.04.063 (Source: Vaccine)
Source: Vaccine - April 28, 2024 Category: Allergy & Immunology Authors: Kunchok Dorjee Tenzin Namdon Sonam Topgyal Ugen Gyatso Tenzin Tsundue Tashi Dolma Vipan Kumar Dekyi Lhadon Tenzin Yangkyi Tenzin Khachoe Sangyal Dorjee R C Sadoff David Peters Amita Gupta Zorba Paster Richard E Chaisson Dawa Phunkyi Tsetan D Sadutshang Source Type: research
Single-dose Administration of Recombinant Human Thrombopoietin Enhances Survival and Hematopoietic Reconstruction in Canines Irradiated with 3 Gy Gamma Radiation
Radiat Res. 2024 Apr 29. doi: 10.1667/RADE-23-00206.1. Online ahead of print.ABSTRACTWe conducted this study to investigate the radioprotective effects of recombinant human thrombopoietin (rhTPO) on beagle dogs irradiated with 3.0 Gy 60Co gamma rays. Fifteen healthy adult beagles were randomly assigned to a control group with alleviating care, and 5 and 10 μg/kg rhTPO treatment group. All animals received total-body irradiation using 60Co γ-ray source at a dose of 3.0 Gy (dose rate was 69.1 cGy/min). The treatment group received intramuscular injection of rhTPO 5 and 10 μg/kg at 2 h postirradiation, and the control grou...
Source: Radiation Research - April 28, 2024 Category: Physics Authors: Jinkun Yang Hao Luan Xing Shen Guolin Xiong Xun Wang Xuewen Zhang Wenyu Ji Ying Jiang Yangyang Dai Enqi Zhang Hongling Ou Yuwen Cong Xinru Wang Shuang Xing Zuyin Yu Source Type: research
Comparison of the efficacy and safety of warfarin anticoagulation and left atrial appendage transcatheter occlusion in the treatment of non-valvular atrial fibrillation and investigation of ET-1, hs-CRP and PDGFs
This study compared the therapeutic effect and safety between warfarin anticoagulation and percutaneous left atrial appendage transcatheter occlusion (PLAATO) in non-valvular atrial fibrillation (NVAF). A total of 110 patients were selected and assigned to Control group (n=55) and Observation group (n=55). The control patients were used warfarin, while the observation patients were performed PLAATO. The coagulation function, stroke and bleeding scores were compared between the two groups at different times. Left ventricular function before therapy and 1 year after therapy and adverse events during follow-up were compared b...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Yujie Zhang Yali Yao Ling Tao Tao Du Binbin Jia Mi Zhou Zhen Zhang Source Type: research
Drug-coated balloon in the treatment of coronary artery de-novo large lesions angiography
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):196-201. doi: 10.14715/cmb/2024.70.4.31.ABSTRACTThe superiority of drug-coated balloon (DCB) in treating small vessels, branching lesions, and high-risk bleeding lesions in coronary heart disease patients has been confirmed. However, its safety and efficacy in large vessels are still unclear. We aimed to investigate whether the efficacy of DCB in large vessels is not inferior to that of drug-eluting stent (DES). From November 2019 to April 2022, a total of 88 patients in our hospital who underwent coronary angiography for the first time and decided to receive DCB or DES tre...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Xingyou Cai Xin Hong Yuli Wang Yafei Li Guidong Xu Source Type: research
Conversion rate to open surgery during transanal total mesorectal excision (TaTME) for rectal cancer: a single-center experience
AbstractMinimally invasive techniques for rectal cancer have demonstrated considerable advantages in terms of faster recovery and less post-operative complications. However, due to the complex anatomy and a limited surgical field, conversion to open surgery is still sometimes required, with a negative impact on the short-and long-term outcomes. The purpose of this study was to analyse the conversion rate to open abdominal surgery during laparoscopic transanal total mesorectal excision (TaTME) procedures performed at a high-volume Italian referral center. All consecutive TaTME performed for mid-to-low rectal cancer between ...
Source: Updates in Surgery - April 28, 2024 Category: Surgery Source Type: research
Association between Antenatal Vaginal Bleeding and Adverse Perinatal Outcomes in Placenta Accreta Spectrum
Conclusions: Antenatal vaginal bleeding in the setting of PAS is associated with increased emergent deliveries, earlier gestational ages, and maternal composite morbidity. This important antenatal event may aid in not only counseling patients but also in the coordination of multidisciplinary teams caring for these complex patients.PMID:38674323 | PMC:PMC11052054 | DOI:10.3390/medicina60040677 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: J Connor Mulhall Kayla E Ireland John J Byrne Patrick S Ramsey Georgia A McCann Jessian L Munoz Source Type: research
Postoperative Morbidity after Dental Treatment under General Anesthesia in Children with and without Disabilities
Conclusions: CD more frequently reported complications like oral bleeding, fever, and diarrhea. In contrast, the CTL group more often reported pain-related symptoms. The conclusion underscores the need for a pain control protocol for CD and emphasizes the importance of frequent monitoring to prevent unwanted consequences during tooth restoration under general anesthesia.PMID:38674314 | PMC:PMC11051803 | DOI:10.3390/medicina60040668 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Marija Šimunović-Erpušina Danko Bakar čić Odri Cicvari ć Luka Šimunović Vlatka Soto šek Dorotea Petrovi ć Nata ša Ivančić Jokić Source Type: research
Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection
Conclusions: A patient-tailored strategy for cerebral perfusion should be considered in obese patients, considering the high atheromatous burden of the supra-aortic vessels in these patients and the potential risk of atheromatous embolization associated with this technique.PMID:38674307 | PMC:PMC11052173 | DOI:10.3390/medicina60040661 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mircea Robu Bogdan Radulescu Irina Maria Margarint Cornel Robu Ovidiu Stiru Andrei Iosifescu Silvia Preda Mihai Cacoveanu Cristian Voica Vlad Anton Iliescu Horatiu Moldovan Source Type: research
The Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipients
Conclusions: Although the histological scoring of hepatocyte damage was found to be higher in the Pringle maneuver group, the Pringle maneuver did not augment ischemia-reperfusion injury in donors and recipients that was evaluated by clinical and laboratory analyses.PMID:38674295 | PMC:PMC11051728 | DOI:10.3390/medicina60040649 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Yasin Dalda Sami Akbulut Tevfik Tolga Sahin Adem Tuncer Zeki Ogut Basri Satilmis Ozlem Dalda Mehmet Gul Sezai Yilmaz Source Type: research
