Educating Physicians About Firearm Safety and Injury Prevention
On this episode of the Academic Medicine Podcast, guests Katherine Hoops, MD, MPH, Andra Blomkalns, MD, MBA, and Allison Augustus-Wallace, PhD, MS, MNS, join host Toni Gallo to talk about firearm safety and injury prevention education. They discuss the role of physicians in engaging patients and communities in firearm injury risk reduction, the current state of firearm injury prevention education, and where the academic medicine community needs to go from here.
This episode is now available through Apple Podcasts, Spotify, and anywhere else podcasts are available.
A transcript is below.
Read the articles d...
Source: Academic Medicine Blog - August 22, 2022 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast firearm injury prevention firearm safety medical education Source Type: blogs
Suggesting that the Unguarded X Chromosome is not Important in Gender Longevity Differences
Researchers here discuss the unguarded X hypothesis in the context of gender differences in life span. That these differences exist across species strongly suggests evolutionary, biological origins, rather than the lifestyle and behavioral origins sometimes suggested to explain life span differences in our species. It seems likely that the interaction between evolutionary pressures and mating strategies drives a great deal of the differences between genders, and life span may be included in that list, but exactly how that difference in longevity is produced at the level of cellular biochemistry remains up for discussion, a...
Source: Fight Aging! - August 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period. (Source: Fight Aging!)
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Epigenetic Aging Slows During Hiberation in a Common Bat Species
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period.
Link: https://doi.org/10.1098/rspb.2022.0635 (Source: Fight Aging!)
Source: Fight Aging! - August 19, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Combining BCL-2 Family Inhibitors May Yield More Effective Senolytic Therapies
In this study, we aimed to search for synergistic selective senolytic effects. We found that combining selective MCL-1 inhibitors with non-MCL1 BCL-2 inhibitors results in marked synergistic effects with higher sensitivity of senescent compared to proliferating cells. These findings indicate that a combination of drugs targeting different BCL-2 family members can benefit for senolytic therapies. (Source: Fight Aging!)
Source: Fight Aging! - August 17, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Career Conversations: Q & A with Organic Chemist Elizabeth Parkinson
Dr. Elizabeth Parkinson. Credit: Courtesy of Dr. Elizabeth Parkinson.
“Being able to discover new, unexpected things is why you wake up every day and go to work as a scientist. The other part is hopefully to have a positive impact on human health—through combatting conditions ranging from antibiotic resistance to cancer,” says Elizabeth Parkinson, Ph.D., an assistant professor of organic chemistry at Purdue University in West Lafayette, Indiana. In an interview, Dr. Parkinson shared with us her path to a scientific career, research on natural products made by soil-dwelling bacteria, and advice for students.
Q: W...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 17, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Bacteria Medicines Microbes Profiles Source Type: blogs
Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is.
Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?
https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/
Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Continuing the Debate Over Viral Contributions to Alzheimer's Disease
Persistent viral infection may be an important contributing cause of Alzheimer's disease, either because the amyloid-β associated with Alzheimer's disease is a part of the innate immune response, and infection thereby increases production, or because persistent infection drives the chronic inflammation that disrupts the biochemistry of brain tissue. If viral infection does drive Alzheimer's disease, it may go some way towards explaining why the disease doesn't correlate with lifestyle factors such as weight, activity, and so forth, anywhere near as well as is the case for other common age-related conditions. It all sounds...
Source: Fight Aging! - August 5, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Correlating Epigenetic Age Acceleration with Survival in Older Individuals
An epigenetic clock produces an epigenetic age from a patient blood or tissue sample. These clocks are trained on data from many individuals at varying ages. When the measured epigenetic age is greater than chronological age, in other words that their biochemistry looks more like that of older people from the training data, this is referred to as epigenetic age acceleration, and is thought to represent a more rapid progression of degenerative aging. Numerous studies have correlated epigenetic age acceleration with risk of specific age-related conditions. Here, researchers correlate it with odds of survival to late life. Th...
Source: Fight Aging! - August 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Career Conversations: Q & A with Biochemist Alexis Komor
Dr. Alexis Komor. Credit: Michelle Fredricks.
“DNA is an amazingly beautiful molecule, and it’s so important. Each of our cells has only one copy of DNA, and if it gets damaged, that messes up everything else in the cell,” says Alexis Komor, Ph.D., an assistant professor of chemistry and biochemistry at the University of California, San Diego (UCSD). Check out the highlights of our interview with Dr. Komor to learn about her scientific journey, research on DNA, and advice for students.
Q: How did you decide to study chemistry?
A: I really enjoyed math and science in middle and high school. When I applied to c...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 3, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Genes DNA Gene Editing Genomics Profiles Source Type: blogs
Changes in the Behavior of Lipid Rafts in Aging
It is fair to say that everything changes with age, every aspect of cellular biochemistry. That doesn't mean that researchers can point to any specific change and say that it is important, however. It could be far downstream from underlying causes. It could be hard to fix in comparison to those causes. It may be shown to detrimentally affect a range of vital cellular processes, but those mechanisms could turn out to be minor and unimportant in comparison to others. The major challenge in aging research is exactly that everything changes. It is thus very hard to determine the importance of any given change, given that it ta...
Source: Fight Aging! - August 1, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Doubling Down on the Failure of Amyloid- β Clearance
After decades of work, researchers have finally achieved therapies that can effectively clear amyloid-β aggregates from the brains of patients with Alzheimer's disease. Unfortunately clinical trials have shown no robust benefit to patients as a result. As illustrated by today's open access paper, a sizable contingent in the research community feel that the evidence for amyloid-β aggregation to be the root of the condition remains convincing. Failure means, in their eyes, that the challenge is more difficult than hoped, and the answer should be an increased effort to run longer clinical trials, find more and better anti-a...
Source: Fight Aging! - July 28, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mitrix Bio Works on the Production of Mitochondria for Transplantation
One of the more practical near term approaches to address the age-related decline of mitochondrial function is transplantation of functional mitochondria. As an approach, it bypasses all of the remaining unknowns relating to the biochemistry of mitochondrial aging. Cells will take up whole mitochondria and make use of them, and early studies suggest that providing new mitochondria can improve tissue function when native mitochondria are impaired. It is likely that this improvement will last for only a limited time, as the same processes that degrade the function of mitochondria, such as a lack of effective mitophagy, will ...
Source: Fight Aging! - July 27, 2022 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Science Snippet: Lipids in the Limelight
This study could inform the advancement of new antibiotics.Developing new imaging technologies to track lipid droplet formation and breakdown in cancer cells. Understanding this phenomenon could shed light on why lipid droplets accumulate in these cells, which could aid in creating new therapies.
Learn about other scientific terms with the NIGMS glossary. (Source: Biomedical Beat Blog - National Institute of General Medical Sciences)
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 27, 2022 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes COVID-19 Medicines Science-snippet Source Type: blogs
