Career Conversations: Q & A with Medicinal Inorganic Chemist Eszter Boros
Dr. Eszter Boros. Credit: Courtesy of Dr. Eszter Boros. “As a researcher, you get to learn something new every day, and that knowledge feeds more questions. It’s this eternal learning process, and I find that really enticing about being in science,” says Eszter Boros, Ph.D., an assistant professor of chemistry at Stony Brook University in Stony Brook, New York. Our interview with Dr. Boros highlights her journey of becoming a scientist and her research on biomedical applications of metals. Q: What drew you to science? A: I was born and raised in Switzerland, and I went to a linguistics-focused high school the...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 22, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles Source Type: blogs

Fight Aging! Newsletter, June 13th 2022
In conclusion, long-term cumulative BP was associated with subsequent cognitive decline, dementia risk, and all-cause mortality in cognitively healthy adults aged ≥50 years. Efforts are required to control long-term systolic BP and pulse pressure and to maintain adequate diastolic BP. Longer-Lived Mammals Tend to Have Lower Expression of Inflammation-Related Genes https://www.fightaging.org/archives/2022/06/longer-lived-mammals-tend-to-have-lower-expression-of-inflammation-related-genes/ Researchers here make a few interesting observations on gene expression data from a range of mammalian species with...
Source: Fight Aging! - June 12, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

More Evidence for Chloroquine to Modestly Slow Aging in Rodents
We report that, surprisingly, daily treatment with chloroquine extended the median life span by 11.4% and the maximum life span of the middle-aged male NMRI mice by 11.8%. Subsequent experiments show that the chloroquine-induced lifespan elevation is associated with dose-dependent increase in LC3B-II, a marker of autophagosomes, in the liver and heart that was confirmed by transmission electron microscopy. This supports the hypothesis that long-term treatment led to an accumulation of autophagosomes due to impaired autophagosome fusion with lysosomes. Quite intriguingly, chloroquine treatment was also associated wit...
Source: Fight Aging! - June 7, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Differentially Expressed Circular RNAs in Long Lived Individuals
In this study, we investigated the circRNAs expression pattern of longevous families, from a Chinese cohort of longevity. Based on weighted circRNA co-expression network analysis, we found that longevous elders (98.3 ± 3.4 years) specifically gained eight but lost seven conserved circRNA-circRNA co-expression modules compared with normal elder controls (spouses of offspring of long-lived individuals, age = 59.3 ± 5.8 years). Both the gained and lost module-related genes were enriched in infectious disease-related pathways. This suggests that these elders might have a history of infection, which could be related to life i...
Source: Fight Aging! - June 6, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology. Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Slower Protein Turnover in the Aged Brain
Metabolic activity slows down in late life, perhaps in large part because this reduces the risk of cancer. In an environment of pervasive molecular damage, a growing burden of nuclear DNA mutations, inflammation, and a declining immune system, more cellular replication and activity implies an ever greater risk of cancer. Longevity in our species appears to be a trade-off that selects for a slow decline in tissue function coupled to a lower cancer risk, rather than maintained tissue function coupled to a higher cancer risk. Greater human longevity relative to other primates is a comparatively recent development in ev...
Source: Fight Aging! - June 3, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, May 30th 2022
In conclusion, fisetin supplementation may be a novel strategy to target excess cellular senescence and thereby reduce mitochondrial ROS to improve NO-mediated endothelial function with aging. Exercise Upregulates BDNF Expression to Promote Dopamine Release and Brain Function https://www.fightaging.org/archives/2022/05/exercise-upregulates-bdnf-expression-to-promote-dopamine-release-and-brain-function/ Researchers have in the past shown that exercise results in greater amounts of BDNF, which in turn promotes neurogenesis. Here, this line of research is extended to show that exercise results in an increa...
Source: Fight Aging! - May 29, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Evaluating Intermittent Hypoxia as a Basis for Therapy
Many forms of mild, intermittent stress produce an overall net benefit to cell and tissue function: low nutrient intake; heat; cold; excessive oxidative molecules; some toxins; and the topic of today's open access paper, hypoxia. When under stress, cells react with increased maintenance efforts aimed at removing damaged molecules and structures. If the stress is mild or of short duration, then the damage done it outweighed by the ongoing repair carried out. Work on the biochemistry of the beneficial response to calorie restriction suggests that autophagy is the most important of these processes, but there are others. In au...
Source: Fight Aging! - May 26, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Constraints Due to the Interconnected Nature of Cellular Biochemistry in the Evolution of Aging
Why is degenerative aging near universal in the animal kingdom? The present consensus explanation is that natural selection acts most strongly on early reproductive life, selecting for mechanisms that are beneficial at the outset of life, heedless of later life harms when those mechanisms run awry over time. Yet why is it the case that so many of the mechanisms beneficial in young animals are also harmful in older animals? Why is this inevitable? Here it is argued that this is an outcome of the highly interconnected nature of cellular biochemistry. Every protein has many functions and influences the function of many other ...
Source: Fight Aging! - May 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan. Naked Mole-Rat Skin Shows Fewer Signs of Aging https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/ Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem ...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Naked Mole-Rat Skin Shows Fewer Signs of Aging
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem cell populations and regenerative capacity, as well as a near immunity to cancer. Accordingly, the research community is very interested in uncovering the genetic and biochemical differences that allow naked mole-rats to achieve these desirable outcomes. In today's open access paper, the authors report on their investigation of the biochemistry a...
Source: Fight Aging! - May 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, May 16th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 15, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

SIRT6 in Aging, Immunity, and Cancer
A lot of work has gone into better understanding the roles of sirtuin 1 (SIRT1) in aging, ultimately something of a dead end, not a large enough influence on relevant areas of cellular biochemistry to produce viable treatments to slow aging. Sirtuin 6 (SIRT6), on the other hand is less well explored, but somewhat more interesting, even though it is likely still only a path towards therapies that can do not more than modestly slow aging over time. Overexpression of SIRT6 extends life in mice. One of the possible mechanisms for that extension of life is promotion of DNA repair, and a startup biotech company is working on a S...
Source: Fight Aging! - May 10, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 9th 2022
In conclusion, although several favorable effects are obtained in our heterochronic non-myeloablative transplantation model, additional optimization is needed for better rejuvenation effects. More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells https://www.fightaging.org/archives/2022/05/more-on-gpnmb-as-a-target-for-senolytic-therapies-to-clear-senescent-cells/ You might recall that researchers recently demonstrated that vaccination against GPNMB is a senolytic strategy, reducing the harmful burden of senescent cells in aged tissues by directing the immune system to destroy these ...
Source: Fight Aging! - May 8, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Three Brothers Are Making Research a Family Affair
Caleb, Paul, and Adam Worsley. Credit: Pittsburg State University. “You’re doing something really important with people who are important to you,” Paul Worsley remarks when asked about having his younger brothers Caleb and Adam as lab mates. The trio are undergraduate students working in the lab of Santimukul Santra, Ph.D., at Pittsburg State University in Pittsburg, Kansas. Paul seated at his chemistry fume hood. Credit: Pittsburg State University. All three brothers are part of the Kansas IDeA Networks of Biomedical Research Excellence (K-INBRE). Paul is currently a junior majoring in biology a...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 4, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Cancer Medicines Precision Medicine Training Source Type: blogs