Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Other Words: Some Antagonists Are Heroes
Many of us learned in English class that an antagonist is a person or thing that a hero fights. But in biomedical science, an antagonist is a molecule that binds to a cellular receptor to prevent a response, such as a muscle contraction or hormone release. Antagonists can be important medical treatments, like the antagonist naloxone—also known as
Narcan —that can reverse an opioid overdose.
Credit: NIGMS; Yekaterina Kadyshevskaya, The Scripps Research Institute.
The two main types of antagonists—competitive and noncompetitive—are named for their relationships to agonists, which are molecules th...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 13, 2022 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology In Other Words Medicines Source Type: blogs
Systematic Screening of Cell Death Pathways in Search of New Senolytics
Senolytic drugs capable of clearing senescent cells from the bodies of older people will be a very important part of the medicine of tomorrow. A burden of senescent cells contributes significantly to aging, and removing them produces quite rapid and profound rejuvenation in animal models. If taking the small molecule drug approach, a diversity of senolytics will likely be needed in order to clear most senescent cells from most tissues, due to differences in drug biodistribution and biochemistry of senescence between tissue types. The search for new senolytic drug targets and drug compounds has been underway in earnest for ...
Source: Fight Aging! - April 11, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 11th 2022
In conclusion, plasma levels of IGHA2, APOA and HPT are associated with subclinical atherosclerosis independently of traditional risk factors and offers potential to predict this disease. The panel could improve primary prevention strategies in areas where imaging is not available.
A Lesser Diversity of Circulating Antibodies in the Aging Killifish Immune System
https://www.fightaging.org/archives/2022/04/a-lesser-diversity-of-circulating-antibodies-in-the-aging-killifish-immune-system/
Short-lived killifish are one of the more recently adopted animal models of aging. All such models are a trade-off bet...
Source: Fight Aging! - April 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Proteases in the Biochemistry of Aging
Proteases are an important category of molecular machinery in the cell, one of several responsible for breaking down proteins and other molecules into component parts that can be recycled. Proteases operate as a part of the cellular maintenance processes that remove excess or damaged and potentially damaging structures and proteins. The quality of this cellular maintenance influences cell and tissue function, and improved maintenance is a feature of many interventions, genetic and otherwise, that modestly slow aging in short-lived laboratory species. Looking at all proteases in the context of aging is a little broad for on...
Source: Fight Aging! - April 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Lesser Diversity of Circulating Antibodies in the Aging Killifish Immune System
Short-lived killifish are one of the more recently adopted animal models of aging. All such models are a trade-off between the cost of running studies and the relevance of their biochemistry to long-lived mammals such as our own species. Fortunately, a lot of the cellular biochemistry of aging is similar enough to make such models useful; unfortunately the differences are often significant enough to sink specific attempts to discover mechanisms and build new therapies. Here, researchers look at the aging immune system in killifish, finding a feature known to exist in humans, and further digging in to the details.
...
Source: Fight Aging! - April 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Discovering Better Ways to Build Medicinal Molecules
Dr. Phil Baran. Credit: Scripps Research.
“I love the mystery of chemistry. It explores the great unknown of the universe,” says Phil Baran, Ph.D., a professor of chemistry at Scripps Research, La Jolla, California. His passion for the subject catalyzed a successful career in organic synthesis—building molecules that are the foundation of living things and can be developed as medicines.
Setting His Sights on Science
School didn’t interest Dr. Baran until he found chemistry in 10th grade. “From there, the mission was clear: do whatever was required to do chemistry for the rest of my life,” he says. At t...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 30, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Medicines Profiles Source Type: blogs
Dibs on a RNA Computer
BY KIM BELLARD
I’ve given DNA a lot of love over the years — DNA as a storage medium, as a computing platform, as the basis for robots, as the tool for synthetic biology/biohacking, even used for the DNA-of-Things (DoT). DNA is the basis for all life as we know it, in every category of life we’ve found anywhere on earth. That we are now using it to achieve technological goals seems like one of humankind’s greatest accomplishments.
But where’s the love for RNA, DNA’s putative ancestor and still-partner? A few recent developments in RNA caught my eye that I wanted to give their due.
...
Source: The Health Care Blog - March 29, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Partially Inhibiting Mitochondrial Complex I as an Approach to Therapy
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 21, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 21st 2022
This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions.
"This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise."
Variations in Biological Age Across Organs in Younger Individuals
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Source: Fight Aging! - March 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The (sort of, partial) Father mRNA Vaccines Who Now Spreads Vaccine Misinformation (Part 2)
By DAVID WARMFLASH, MD
This is part 2 of David Warmlash’s takedown of Robert W. Malone’s appearance (transcript) on the Rogan podcast. Part 1 is here
Menstruation and Fertility
Much more than the line about reproductive damage in the Wisconsin News clip that we used to open the story, Malone used the Rogan interview to dive more deeply into the topic, starting with:
…there’s a huge number of dysmenorrhea and menometrorrhagia…
By that, he meant excessive menstrual cramping and very heavy, often irregular, bleeding, which he followed up with:
…they DENY it…
Judging by other parts ...
Source: The Health Care Blog - March 18, 2022 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Health Policy antivaxxer COVID-19 vaccine David Warmflash Joe Rogan Robert Malone Source Type: blogs
Variations in Biological Age Across Organs in Younger Individuals
Systems of measuring biological age are multiplying rapidly. There are many ways of going about this, from epigenetic clocks to weighted combinations of simple measures such as grip strength. Researchers here build their own assessments for the purpose of looking at aging in younger adults, 20s to 40s, a part of aging that is not well studied at all. The interesting outcome is that there appears to be a significant variation in assessed biological age between different organs and systems in the body. It is a little early to talk about why this arises, whether an artifact of the tools used, or reflects some underlying truth...
Source: Fight Aging! - March 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Mechanisms that Allow Senescent Cells to Resist Apoptosis
A large portion of research into senescent cells in the context of degenerative aging is focused on how these cells fail to destroy themselves. Senescent cells are primed to enter the programmed cell death process of apoptosis, but various mechanisms hold this off. Sabotaging some of those mechanisms is an effective way to clear a sizable fraction of senescent cells in many old tissues, as demonstrated by the initial small molecule senolytic treatments, such as the dasatinib and quercetin combination.
As the authors of today's open access paper note, the fact that these apoptosis-inducing senolytics are only partial...
Source: Fight Aging! - March 16, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
