The Lack of Consensus on Approaches to Aging as a Flaw to be Fixed
It can be argued that the largest challenge facing the development of means to treat aging as a medical condition is that there is, as of yet, no useful consensus position on how to measure aging, how to define aging, or which of the countless measurable aspects of biochemistry that change with age are the most appropriate targets for therapy. This means that any given research group or biotech startup has a lot of leeway to argue that their approach is the right one - and it might take twenty years to establish the effects of their therapies on long-term health and life span, even given a successful development program. T...
Source: Fight Aging! - September 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chronic Pain Conditions in the Context of Aging
Chronic pain conditions are poorly understood, often incorrectly diagnosed or dismissed by medical practitioners, and, generally, have only poor and unreliable options for treatment. Given that aging degrades the function of all bodily systems, it is no surprise to find a significant incidence of chronic pain in older adults. It is an open question as to the degree to which similar mechanisms are at play to those causing chronic pain in younger adults, and whether useful information can be obtained by comparing the biochemistry of similar conditions in old and young individuals. Unfortunately there remains a lack of unders...
Source: Fight Aging! - September 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wanted: Division of Pharmacology, Physiology, and Biological Chemistry Branch Chief
We’re seeking a highly qualified scientist to serve as a branch chief in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three branches. Applicants should have significant interest and experience in the scientific areas managed by the Division, which will continue to encompass all the existing research portfolios and will generally be arranged into branches covering physiology and clinical sciences, biochemistry and molecular pharmacology, and chemistry and chemical biology. For a listing of the current scientifi...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 11, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
All Too Short Comments on the 10th Aging Research and Drug Discovery (ARDD) Meeting
I attended the 10th Aging Research and Drug Discovery (ARDD) conference in Copenhagen recently, alongside my Chief Scientific Officer at Repair Biotechnologies, Mourad Topors. If one wanted to take in all of the presentations and take notes, as I've done in the past, ARDD would be much more of a test of endurance than other longevity industry conferences. It is five 12 hour days, starting with networking at 8am, the last presentations going on past 8pm, and then socializing at nearby bars afterwards for the truly dedicated. This on top of jet lag for those coming in from the US in direction and Asia in the other. The inten...
Source: Fight Aging! - September 11, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
What Happens to Medicine in Your Body?
Medicines administered orally, by inhaler, and intravenously enter the stomach, lungs, and veins, respectively. They’re absorbed, then circulate throughout the body in the blood, are processed by the liver, and excreted by the kidneys and intestines. Credit: NIGMS.
Have you ever wondered what happens inside your body when you take a medicine? An area of pharmacology called pharmacokinetics is the study of precisely that. Here, we follow a medicine as it enters the body, finds its therapeutic target (also called the active site), and then eventually leaves the body.
To begin, a person takes or is given a dose of medi...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 11, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Medicines Miniseries Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Suppression of Transposable Element Activity Extends Life in Nematode Worms
There is a growing interest in the role of transposable elements in aging. These are sections of the genome, remnants of ancient viral infections, that are capable of copying themselves when active, causing mutational damage in the process. Transposable elements are suppressed in youth, their portions of the genome folded away and hidden from transcriptional machinery, but this suppression fails with age as epigenetic markers that determine the structure of the genome change. Any mechanism that increases mutational damage in large numbers of cells might be suspected to contribute to degenerative aging, but definitive proof...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cardiolipin Oxidation in Mitochondrial Dysfunction
An interesting question is posed here by some of the researchers responsible for creating plastoquinone mitochondrially-targeted antioxidants. To what degree do mitochondrially-targeted antioxidants improve mitochondrial function and modestly slow aging by preventing cardiolipin oxidation? Past a certain level of detail, less is known of mitochondrial biochemistry than one might think. This organelle is very well studied, but it is still the case that many approaches known to improve mitochondrial function are incompletely understood, or only understood in outline. It is clear that the mitochondrial generation of reactive ...
Source: Fight Aging! - September 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
We examined whether adult neurogenesis sustains hippocampal connections cumulatively across the life span. Long-term suppression of neurogenesis as occurs during stress and aging resulted in an accelerated decline in hippocampal acetylcholine signaling and a slow and progressing emergence of profound working memory deficits.
These deficits were accompanied by compensatory reorganization of cholinergic dentate gyrus inputs with increased cholinergic innervation to the ventral hippocampus and recruitment of ventrally projecting neurons by the dorsal projection. While increased cholinergic innervation was dysfunctional...
Source: Fight Aging! - September 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Wanted: Division of Pharmacology, Physiology, and Biological Chemistry Branch Chief
We’re seeking a highly qualified scientist to serve as a branch chief in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three branches. Applicants should have significant interest and experience in the scientific areas managed by the Division, which will continue to encompass all the existing research portfolios and will generally be arranged into branches covering physiology and clinical sciences, biochemistry and molecular pharmacology, and chemistry and chemical biology. For a listing of the current scientifi...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - August 30, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Distinct Signatures for Human Microglia in Alzheimer's Disease
This study identified 10 distinct microglia clusters from aged human brain. These included previously described homeostatic, senescent, and inflammatory microglia transcriptional phenotypes as well as additional clusters of transcriptional specification, which may give insight into AD pathogenesis, providing a platform for hypothesis generation. We describe the diversity of microglia clusters with endolysosomal gene signatures, one of which is enriched with nucleic acid recognition and interferon regulation genes. Inferred gene networks predict that individual clusters are driven by distinct transcription factors, lending ...
Source: Fight Aging! - August 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
