Primary PCI and its silent encounter with “ myocardial neutrophilia ”
Myocardial infarction, a gross pathological entity renamed now as STEMI for clinical purposes, is the most famous medical emergency that triggers a series of calls. Right from 911/First medical contact, the ER, that ends up in CCU or a 24/7 cath lab. The heart, can’t wait for all these external responses when it is challenged with a vascular accident. The moment ATO occurs, two things happen. The endogenous fibrinolytic led by native tissue PA (Tpa) tries to get rid of the thrombotic plug by all its means. It succeeds in 15%. We call it spontaneous lysis or aborted MI. Many lives are lost in the remaining before th...
Source: Dr.S.Venkatesan MD - February 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized myocardial neutrophilia Source Type: blogs
Got Calcium?
Someone’s hand moving to scroll through this blog post is possible because of a mineral that both gives bones their strength and allows muscles to move: calcium. As the most abundant mineral in our bodies, it’s essential for lots of important functions. It’s found in many foods, medicines, and dietary supplements.
Calcium keeps your bones strong, allows your muscles to move, and is important for many other bodily functions. The element is found in foods, medicines, and the world around us. Credit: Compound Interest CC BY-NC-ND 4.0. Click to enlarge.
Committed to Critical Duties
For athletes, calc...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 1, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Diseases Proteins Source Type: blogs
A Discussion of the Biochemistry of Cardiac Fibrosis
Fibrosis is a malfunction of tissue maintenance, in which excessive amounts of extracellular matrix structure are created, forming scar-like features that disrupt normal tissue function. Fibrosis is a feature of aging and can rise to the level of life-threatening issue in organs such as the lung, liver, kidneys, and heart. This is particularly the case because there are no truly effective therapies to treat fibrosis; it is an inexorable condition that leads towards organ failure. Progress towards the reversal of fibrosis has been slow, unfortunately, despite the comparatively recent discovery that senescent cells appear to...
Source: Fight Aging! - January 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.
Communication Between Blood and Brain in Aging and Rejuvenation
https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inte...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Investigating the Comparative Biology of Variations in Rockfish Species Life Spans
The comparative biology of aging, the study of aging in species with widely divergent life spans, is hoped to improve the catalog and understanding of important mechanisms of aging. It may or may not turn out to be the case that the biochemistry of long-lived species can give rise to practical therapies that slow aspects of human aging, at least in the near future of the next few decades. Engineering a human that ages more slowly seems a far more daunting task than the production of rejuvenation therapies that repair the known forms of cell and tissue damage that drive aging.
An alternative to comparing other specie...
Source: Fight Aging! - January 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity.
Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Tau Aggregation Drives Neuroinflammation via Transposable Element Activation
Evidence suggests that there is a bidirectional relationship between tau aggregation and inflammation in the aging brain. Both occur in all brains, and when present to a greater degree contribute to the neurodegenerative conditions termed tauopathies. The most well known of these is Alzheimer's disease, in which tau aggregates and their surrounding toxic biochemistry cause the widespread cell death and severe symptoms that characterize the final stages of the condition.
Various studies individually support each of the two directions of the relationship between tau and inflammation. Removing senescent cells from the ...
Source: Fight Aging! - January 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Wanted: Pharmacological and Physiological Sciences Program Director
We’re recruiting for a position in the Pharmacological and Physiological Sciences (PPS) Branch of the Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). Scientific responsibilities of the position include any or all of the following research subjects, depending on the applicant’s experience: cellular signaling, drug-receptor interactions, drug metabolism and transport, drug delivery, and wound healing. The successful hire will be responsible for management of a portfolio of research grants and research training and/or career development awards, and will collaboratively stimulate, plan, advise, and d...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 18, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Mentoring: It ’s In Our Genes
Anyone who’s spent time in an academic science lab has probably heard about lab culture. Many labs boast long, rigorous working hours, while others require graduate students and postdoctoral trainees (postdocs) to meet often-unattainable experiment quotas each week. But is sheer quantity really the gold standard we want to hold ourselves to when it comes to training the next generation of scientists?
The #MentorFirst logo. Credit: www.MentorFirst.org.
Neil Garg, Ph.D., Distinguished Professor and chair of the department of chemistry and biochemistry at the University of California Los Angeles (UCLA), and Jen Heemstr...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 18, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Training Source Type: blogs
New year, new you! 10 Steps to Change Your Life!
Are you setting goals for this year? Did you decide to get fit? Eat healthier? Spend more time with your family? Be more mindful? Read on for my famous 10 steps to change your life!
Bah, humbug!
Reflect for a moment on what you’ve just read. Head to Google and do a search using the terms “New Year” and see what you come up with. My search page showed, amongst all the horrific news of car smashes and events for the holiday season, topics like “New Year Bootcamp: Get rid of your debt”, “cook something new every week”, “read more books”, “create a cleaning sch...
Source: HealthSkills Weblog - January 8, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Coping strategies Motivation Occupational therapy Research Science in practice biopsychosocial contentment goals Health healthcare New Year Source Type: blogs
Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Search of Early Biomarkers of LATE, a Form of Dementia Related to TDP-43 Aggregation
LATE is a comparatively recently discovered form of dementia, connected to aggregation of misfolded TDP-43, one of the few proteins in the body capable of taking on an altered form that encourages other molecules of the same protein to also adopt that form and join together to form clumps. Aggregates are disruptive of cell function, but it is a slow process to understand exactly why this is the case. Researchers have been working on understanding amyloid-β aggregates for decades now, and continue to find that the present state of knowledge is incomplete regarding how the toxic halo of biochemistry that surrounds aggregate...
Source: Fight Aging! - December 21, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
So Much to Do, So Little Selenium Needed
You may know that antioxidants can help protect your cells from oxidative damage, but do you know about selenium—an element often found in special proteins called antioxidant enzymes? Selenium is essential to your body, which means you must get it from the food you eat. But it’s a trace element so you only need a small amount to benefit from its effects. In addition to its antioxidant properties, it’s also important for reproduction, DNA synthesis, and hormone metabolism.
In our bodies, selenium works in antioxidant enzymes to help protect us from oxidative damage. The element is also found in antidandruf...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 21, 2022 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Proteins Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A High Level Survey of Mechanisms of Brain Aging
Ultimately, we live and die as the brain lives and dies. The rest of the body is a support system, a complex one to be sure, but probably not as complex as the brain. Repairing the cell and tissue damage of aging in the body seems a more tractable challenge, in that replacement is always an option. Replace cells, replace the gut microbiome, add new tissues grown in a lab to organs like the liver and thymus, or grow a new body and transplant the brain. A path of ever increasing control over cells, cell signaling, and regeneration implies a future in which all damaged tissue can be replaced in one way or another ... except f...
Source: Fight Aging! - December 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
