Anhydroicaritin suppresses tumor progression via the PI3K/AKT signaling pathway in hepatocellular carcinoma
CONCLUSIONS: The Bushen Huayu Decoction and its active ingredient AHI could fight HCC. The potential mechanism may be associated with inhibiting the activation of PI3K/AKT signal pathway, which may serve as a potential treatment for HCC therapy.PMID:37556351 | DOI:10.18632/aging.204948 (Source: Aging)
Source: Aging - August 9, 2023 Category: Biomedical Science Authors: Houhong Wang Wenli Chen Yayun Cui Huihui Gong Amao Tang Source Type: research
Molecules, Vol. 28, Pages 5913: Antioxidant, Volatile Compounds; Antimicrobial, Anti-Inflammatory, and Dermatoprotective Properties of Cedrus atlantica (Endl.) Manetti Ex Carriere Essential Oil: In Vitro and In Silico Investigations
Kawtar Fikri-Benbrahim
Cedrus atlantica (Endl.) Manetti ex Carriere is an endemic tree possessing valuable health benefits which has been widely used since time immemorial in international traditional pharmacopoeia. The aim of this exploratory investigation is to determine the volatile compounds of C. atlantica essential oils (CAEOs) and to examine their in vitro antimicrobial, antioxidant, anti-inflammatory, and dermatoprotective properties. In silico simulations, including molecular docking and pharmacokinetics absorption, distribution, metabolism, excretion, and toxicity (ADMET), and drug-likeness prediction were...
Source: Molecules - August 6, 2023 Category: Chemistry Authors: Naoufal El Hachlafi Hanae Naceiri Mrabti Samiah Hamad Al-Mijalli Mohamed Jeddi Emad M. Abdallah Nesrine Benkhaira Hanine Hadni Hamza Assaggaf Ahmed Qasem Khang Wen Goh Ammar AL-Farga Abdelhakim Bouyahya Kawtar Fikri-Benbrahim Tags: Article Source Type: research
Mitochondrial DNA Fragmentation and Risk of Non-Hodgkin Lymphoma
CONCLUSIONS AND RELEVANCE: This study's findings suggest that increased mtDNAfb is associated with an increased future risk of NHL. Additional studies are needed to confirm these findings, particularly among women and nonsmokers.PMID:37531109 | DOI:10.1001/jamanetworkopen.2023.26885 (Source: Cancer Control)
Source: Cancer Control - August 2, 2023 Category: Cancer & Oncology Authors: H Dean Hosgood Meghan Davitt Richard Cawthon Stephanie J Weinstein Batel Blechter Jason Y Y Wong Mohammad L Rahman Wei Hu Satu M ännistö Demetrius Albanes Nathaniel Rothman Qing Lan Source Type: research
Molecules, Vol. 28, Pages 5438: Carotenoids and Fatty Acids Obtained from Paprika Capsicum annuum by Supercritical Carbon Dioxide and Ethanol as Co-Extractant
³Åºwik
Paprika Capsicum annuum L. contains useful molecules such as carotenoids and polyunsaturated fatty acids, which are considered high-value functional and health ingredients. To obtain these compounds, paprika was extracted using different methods (Soxhlet, SC-CO2, and SC-CO2 with co-extractant) and at different parameters. The results showed that the carotenoid content decreased with the addition of the co-extractant while the fatty acid content and yield increased. It was found that the highest carotenoid content (capsanthin > β-carotene > capsorubin > zeaxanthin &am...
Source: Molecules - July 16, 2023 Category: Chemistry Authors: Dorota Kostrzewa Barbara Mazurek Marcin Kostrzewa Emilia J óźwik Tags: Article Source Type: research
Circulating hormones and risk of gastric cancer by subsite in three cohort studies
ConclusionsSome obesity-related hormones influence CGC and NCGC risk. (Source: Gastric Cancer)
Source: Gastric Cancer - July 16, 2023 Category: Gastroenterology Source Type: research
Fabricating pectin and chitosan double layer coated liposomes to improve physicochemical stability of beta-carotene and alter its gastrointestinal fate
Int J Biol Macromol. 2023 Jul 9:125780. doi: 10.1016/j.ijbiomac.2023.125780. Online ahead of print.ABSTRACTTo improve storage stability and gastrointestinal (GI) stability of liposomes, pectin and chitosan double layer coated liposome (P-C-L) was proposed and optimized using electrostatic deposition technique. The physical-chemical properties and GI fate of the carrier were then investigated in comparison to that of chitosan coated liposomes (C-L) and un-coated liposomes (L). The results showed P-C-L was successfully prepared at 0.2 % chitosan and 0.06 % pectin. It was hydrogen bonds between the amino groups in chitosan an...
Source: International Journal of Biological Macromolecules - July 11, 2023 Category: Biochemistry Authors: Yin Wang Qing Zhou Jingxia Zheng Hua Xiong Li Zhao Yan Xu Chunqing Bai Source Type: research
Evaluation of the constituent compounds, antioxidant, anticancer, and antimicrobial potential of Prangos ferulacea plant extract and its effect on Listeria monocytogenes virulence gene expression
Prangos ferulacea plant is very popular in Iran due to its unique properties in treating diseases and its special flavor. To check the characteristics of this plant, first, its extract was extracted using the maceration method. Its chemical composition was investigated using high-performance liquid chromatography (HPLC) that p-coumaric was identified as its main compound, and Fourier-transform infrared spectroscopy (FTIR) showed the presence of functional groups related to phenolic, flavonoid, tannins, and carboxylic acids such as caffeic acid and coumaric acid composition. Total phenol content (TPC), total flavonoid conte...
Source: Frontiers in Microbiology - July 10, 2023 Category: Microbiology Source Type: research
Lipidomics and pancreatic cancer risk in two prospective studies
AbstractPancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC in two prospective studies. We measured 904 lipid species and 252 fatty acids across 15 lipid classes in pre-diagnostic serum (up to 24  years) in a PDAC nested-case control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO,NCT00002540) with 332 matched case –control sets including 272 having serial blood samples and Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study ...
Source: European Journal of Epidemiology - June 30, 2023 Category: Epidemiology Source Type: research
Molecules, Vol. 28, Pages 5096: Wild Vitex agnus-castus L.: Phytochemical Characterization, Acute Toxicity, and Bioactive Properties
This study aimed to validate, for the first time, the beneficial use of VAC fruits and fruit decoctions (VFDs) through in vitro and in vivo trials. Forty-one volatile components were detected in VAC fruits, with 1,8-cineole (30.3%) comprising the majority. The antioxidant activity of VFD was measured by using different in vitro methods (EC50 of 0.16 mg/mL by β-carotene bleaching inhibition assay) and by measuring the DNA protection power. Using the disc diffusion assay, the antimicrobial activity of VFD was evaluated, and it exhibited a noticeable anticandidal activity. VFD did not cause any toxicity or mortal...
Source: Molecules - June 29, 2023 Category: Chemistry Authors: Mohamed Ali Boujbiha Hassiba Chahdoura Khaoula Adouni Borhane Eddine Cherif Ziani Mejdi Snoussi Yasmine Chakroun Mar Ãa Ciudad-Mulero Virginia Fern ández-Ruiz Lotfi Achour Boulbaba Selmi Patricia Morales Guido Flamini Habib Mosbah Tags: Article Source Type: research
Dietary quality and circulating lipidomic profiles in two cohorts of middle-aged and older male Finnish smokers and American populations
CONCLUSIONS: Adherence to HEI-2015, AHEI-2010 and aMED are associated with serum lipidomic profiles, mostly triacylglycerols or FA22:6-containing species, which are related to seafood and plant proteins, EPA-DHA, fish, or fat ratio index components.PMID:37328109 | DOI:10.1016/j.tjnut.2023.06.010 (Source: Cancer Control)
Source: Cancer Control - June 16, 2023 Category: Cancer & Oncology Authors: Ting Zhang Sabine Naudin Hyokyoung G Hong Demetrius Albanes Satu M ännistö Stephanie J Weinstein Steven C Moore Rachael Z Stolzenberg-Solomon Source Type: research
Mechanism associated with changes in male reproductive functions during ageing process
Exp Gerontol. 2023 Jun 12:112232. doi: 10.1016/j.exger.2023.112232. Online ahead of print.ABSTRACTAgeing is a natural process with physiological changes in different body parts and has been associated with decreased reproductive capacity. Factors such as imbalance in the antioxidant defence system, vascular diseases, diabetes mellitus, accessory reproductive glands infection, obesity as well as buildup of toxic substances play a role in age-related male reproductive malfunction. Age is inversely proportional to volume of semen, sperm count, sperm progressive motility, sperm viability, normal sperm morphology. The observed ...
Source: Experimental Gerontology - June 14, 2023 Category: Geriatrics Authors: Ajayi Folorunsho Ayodeji Onaolapo Comfort Moyinoluwa Omole Ayomide Isaac Adeyemi Wale Johnson Oluwole David Tolulope Source Type: research
Mechanism associated with changes in male reproductive functions during ageing process
Exp Gerontol. 2023 Jun 12:112232. doi: 10.1016/j.exger.2023.112232. Online ahead of print.ABSTRACTAgeing is a natural process with physiological changes in different body parts and has been associated with decreased reproductive capacity. Factors such as imbalance in the antioxidant defence system, vascular diseases, diabetes mellitus, accessory reproductive glands infection, obesity as well as buildup of toxic substances play a role in age-related male reproductive malfunction. Age is inversely proportional to volume of semen, sperm count, sperm progressive motility, sperm viability, normal sperm morphology. The observed ...
Source: Experimental Gerontology - June 14, 2023 Category: Geriatrics Authors: Ajayi Folorunsho Ayodeji Onaolapo Comfort Moyinoluwa Omole Ayomide Isaac Adeyemi Wale Johnson Oluwole David Tolulope Source Type: research
Is beta-carotene consumption associated with thyroid hormone levels?
The thyroid hormones play a pivotal role in various physiological processes, including growth, metabolism regulation, and reproduction. While non-modifiable factors are known to impact thyroid function, such as genetics and age, nutritional factors are also important. Diets rich in selenium and iodine are conventionally acknowledged to be beneficial for the production and release of thyroid hormones. Recent studies have suggested a potential link between beta-carotene, a precursor to vitamin A (retinol), and thyroid function. Beta-carotene is known for its antioxidant properties and has been shown to play a role in the pre...
Source: Frontiers in Endocrinology - May 26, 2023 Category: Endocrinology Source Type: research
Molecules, Vol. 28, Pages 4358: In Silico and In Vitro Methods in the Characterization of Beta-Carotene as Pharmaceutical Material via Acetylcholine Esterase Inhibitory Actions
hian Giap Lim
Molecular docking is widely used in the assessment of the therapeutic potential of pharmaceutical agents. The binding properties of beta-carotene (BC) to acetylcholine esterase (AChE) proteins were characterized using the molecular docking method. The mechanism of AChE inhibition was assessed by an experimental in vitro kinetic study. In addition, the role of BC action was tested by the zebrafish embryo toxicity test (ZFET). The results of the docking ability of BC to AChE showed significant ligand binding mode. The kinetic parameter, i.e., the low AICc value shown as the compound was the competitive type...
Source: Molecules - May 26, 2023 Category: Chemistry Authors: Arunachalam Muthuraman Muthusamy Ramesh Fazlina Mustaffa Ahmed Nadeem Shamama Nishat Nallupillai Paramakrishnan Khian Giap Lim Tags: Article Source Type: research
