9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models
In this study, we investigated whether the administration of 9-cis beta-carotene (9CBC)-rich powder of the alga Dunaliella bardawil, the best-known source of βC in nature, inhibits the development of AD-like neuropathology and cognitive deficits. We demonstrated that in 3 AD mouse models, Tg2576, 5xFAD, and apoE4, 9CBC treatment improved long- and short-term memory, decreased neuroinflammation, and reduced the prevalence of β-amyloid plaques and tau hyperphosphorylation. These findings suggest that 9CBC has the potential to be an effective preventive and symptomatic AD therapy.PMID:38381472 | DOI:10.1016/j.neurobiolaging...
Source: Neurobiology of Aging - February 21, 2024 Category: Geriatrics Authors: Rachel Twitto-Greenberg Sigal Liraz-Zaltsman Daniel M Michaelson Ori Liraz Irit Lubitz Dana Atrakchi-Baranes Chen Shemesh Uri Ashery Itzik Cooper Ayelet Harari Dror Harats Michal Schnaider-Beeri Aviv Shaish Source Type: research
Molecules, Vol. 29, Pages 917: Bioactive Potential of Carrot-Based Products Enriched with Lactobacillus plantarum
rămioara Lisă
The primary goal of this study was to generate different kinds of functional products based on carrots that were supplemented with lactic acid bacteria. The fact that carrots (Daucus carota sp.) rank among the most popular vegetables in our country led to the convergence of the research aim. Their abundance of bioactive compounds, primarily polyphenols, flavonoids, and carotenoids, offers numerous health benefits. Among the obtained products, the freeze-dried carrot powder (FDCP) variation presented the highest concentrations of total carotenoids (TCs) and β-carotene (BC) of 26.977 &...
Source: Molecules - February 19, 2024 Category: Chemistry Authors: Monica Boev Cristina St ănescu Mihaela Turturic ă Mihaela Cot ârleţ Denisa Bat îr-Marin Nicoleta Maftei Carmen Chi ţescu Leontina Grigore-Gurgu Vasilica Barbu Elena Enachi Elena L ăcrămioara Lisă Tags: Article Source Type: research
Molecules, Vol. 29, Pages 807: Assessment of Popcorn & rsquo;s Bioactive Status in Response to Popping
Molecules, Vol. 29, Pages 807: Assessment of Popcorn’s Bioactive Status in Response to Popping
Molecules doi: 10.3390/molecules29040807
Authors:
Jelena Vukadinović
Jelena Srdić
Natalija Kravić
Snežana Mladenović Drinić
Milena Simić
Milan Brankov
Vesna Dragičević
Popcorn is a specialty maize variety with popping abilities. Although considered a snack, popcorn flakes provide a variety of benefits for the human diet. To evaluate the change in content of bioactive compounds in response to microwave popping, the kernels and flakes of twelve popcorn hybrids were assayed. Accordingly, the co...
Source: Molecules - February 9, 2024 Category: Chemistry Authors: Jelena Vukadinovi ć Jelena Srdi ć Natalija Kravi ć Sne žana Mladenović Drinić Milena Simi ć Milan Brankov Vesna Dragi čević Tags: Article Source Type: research
Development of a diet quality score and adherence to the Swiss dietary recommendations for vegans
CONCLUSION: The newly developed DQS-V provides a single score for estimating diet quality among vegan adults. Further validation studies examining the DQS-V in relation to an independent dietary assessment method and to biomarkers of nutritional intake and status are still needed before the general application of the DQS-V.PMID:38291526 | PMC:PMC10829326 | DOI:10.1186/s41043-024-00498-3 (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - January 30, 2024 Category: International Medicine & Public Health Authors: Natalie S Bez Joyce Haddad Giulia S Tedde Karolin Rose Aljoscha V Ivanov Marina Milazzo Jo ëlle Wickart Giulia Casale Michele D'Ascanio Klazine Van der Horst Isabelle Herter-Aeberli Leonie H Bogl Source Type: research
Effect of type and concentration of antioxidant on sperm motility, viability, and DNA integrity of climbing perch Anabas testudineus Bloch, 1792 (Pisces: Anabantidae) post-cryopreservation
Cryobiology. 2024 Jan 17;114:104851. doi: 10.1016/j.cryobiol.2024.104851. Online ahead of print.ABSTRACTSperm quality is preserved through the crucial involvement of antioxidants, which play a vital role in minimizing the occurrence of reactive oxygen species (ROS) during the cryopreservation process. The suitability of the type and concentration of antioxidants are species-dependent, and this study is crucial in order to improve the quality of the climbing perch sperm post-cryopreservation. Therefore, this study aimed to determine the best type and concentration of antioxidants for cryopreservation of climbing perch Anaba...
Source: Cryobiology - January 18, 2024 Category: Biology Authors: Siti Maulida Kartini Eriani Nur Fadli Mohd N Siti-Azizah Filiz K Kocabas Mehmet Kocabas Martin Wilkes Luvi S Handayani Sri R Rahayu Zainal A Muchlisin Source Type: research
Molecules, Vol. 29, Pages 487: Effect of Novel Processing Techniques on the Carotenoid Release during the Production of Red Guava Juice
This study systematically evaluates the impact of diverse processing techniques on the efficient release of carotenoids. The primary objective is to facilitate the transfer of carotenoids into the juice fraction, yielding carotenoid-enriched juice seamlessly integrable into aqueous-based food matrices. The untreated guava puree exhibited a modest release of carotenoids, with only 66.26% of β-carotene and 57.08% of lycopene reaching the juice. Contrastly, both high-pressure homogenization (HPH) at 25 Mpa and enzyme (EM) treatment significantly enhanced carotenoid release efficiency (p < 0.05), while ...
Source: Molecules - January 18, 2024 Category: Chemistry Authors: Xiaoxue Zheng Ziting Chen Ziming Guo Mengting Chen Bijun Xie Zhida Sun Kai Hu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 469: Essential Oil from the Leaves, Fruits and Twigs of Schinus terebinthifolius: Chemical Composition, Antioxidant and Antibacterial Potential
The objective of this work was to analyze the chemical composition and the antioxidant and antibacterial potential of essential oils (EOs) from the leaves, fruits and twigs of S. terebinthifolius, aiming for their application in food safety. EOs were obtained by hydrodistillation and the chemical composition was determined by gas chromatography coupled to mass spectrometry. Phenolic compounds were quantified and antioxidant activity was evaluated using three different methods. The antibacterial activity was determined by the broth microdilution method against foodborne bacteria. In the chemical analysis, 22 compounds were ...
Source: Molecules - January 17, 2024 Category: Chemistry Authors: K átia C. Oliveira Lidaiane M. S. S. Franciscato Suelen S. Mendes Francielly M. A. Barizon Daniela D. Gon çalves Lidiane N. Barbosa Maria G. I. Faria Juliana S. Valle Rhaira F. A. Casalvara Jos é E. Gonçalves Zilda C. Gazim Suelen P. Ruiz Tags: Article Source Type: research
Genetically predicted circulating concentrations of micronutrients and risk of hypertensive disorders of pregnancy: a Mendelian randomization study
ConclusionThere is no strong evidence to support the causation between circulating micronutrients and hypertensive disorder during pregnancy. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - January 9, 2024 Category: OBGYN Source Type: research
Development of safe and antioxidant COX-2 inhibitors; Synthesis, molecular docking analysis and biological evaluation of novel pyrrolizine 5-carboxamides
Bioorg Chem. 2024 Jan 5;143:107098. doi: 10.1016/j.bioorg.2024.107098. Online ahead of print.ABSTRACTIn the current study, a series of new pyrrolizine-5-carboxamide derivatives (5-8, 9a-d, 10a-d, 11a,b and 12a,b) were developed, synthesized and evaluated in terms of in vitro COX-2 enzyme inhibition. The in vivo anti-inflammatory evaluation was conducted on the most selective compounds (9a,b,d, 10b,c and 11a,b). For the most active five compounds (9a, 10b,c and 11a,b), ulcerogenic liability, histopathological examinations, physicochemical properties study and antioxidant activity were investigated. Also, nitric oxide donor ...
Source: Bioorganic Chemistry - January 7, 2024 Category: Chemistry Authors: Eman K A Abdelall Heba A H Elshemy John N Philoppes Maha M Abdel-Fattah El-Shaymaa El-Nahaas Rabab R Mahmoud Source Type: research
Development of safe and antioxidant COX-2 inhibitors; Synthesis, molecular docking analysis and biological evaluation of novel pyrrolizine 5-carboxamides
Bioorg Chem. 2024 Jan 5;143:107098. doi: 10.1016/j.bioorg.2024.107098. Online ahead of print.ABSTRACTIn the current study, a series of new pyrrolizine-5-carboxamide derivatives (5-8, 9a-d, 10a-d, 11a,b and 12a,b) were developed, synthesized and evaluated in terms of in vitro COX-2 enzyme inhibition. The in vivo anti-inflammatory evaluation was conducted on the most selective compounds (9a,b,d, 10b,c and 11a,b). For the most active five compounds (9a, 10b,c and 11a,b), ulcerogenic liability, histopathological examinations, physicochemical properties study and antioxidant activity were investigated. Also, nitric oxide donor ...
Source: Bioorganic Chemistry - January 7, 2024 Category: Chemistry Authors: Eman K A Abdelall Heba A H Elshemy John N Philoppes Maha M Abdel-Fattah El-Shaymaa El-Nahaas Rabab R Mahmoud Source Type: research
Association of Serum Beta-Carotene with Metabolic Risk Factors among a Work Cohort in Malaysia
J Nutr Sci Vitaminol (Tokyo). 2023;69(6):463-470. doi: 10.3177/jnsv.69.463.ABSTRACTMetabolic syndrome (MetS) poses increased risks for non-communicable diseases, increasing all-cause mortality, disability, and healthcare costs. Beta-carotene as the major carotenoid is identified to play an important role in the pathophysiology of MetS. The present study aimed to investigate the association between serum beta-carotene levels with metabolic syndrome and metabolic risk factors among a cohort of teachers in Peninsular Malaysia. This cross-sectional study investigated a sub-sample of 645 serum samples which were randomly select...
Source: Journal of Nutritional Science and Vitaminology - January 3, 2024 Category: Nutrition Authors: Foong Ming Moy Yit Han Ng Seok Shin Tan Source Type: research
