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Molecules, Vol. 28, Pages 4190: Xanthophyll-Rich Extract of Phaeodactylum tricornutum Bohlin as New Photoprotective Cosmeceutical Agent: Safety and Efficacy Assessment on In Vitro Reconstructed Human Epidermis Model
In this study, the Phaeodactylum tricornutum Bohlin (Phaeodactylaceae), a pleiomorphic diatom commonly found in marine ecosystems, was investigated. The in vitro culture conditions used favoured the fusiform morphotype, characterized by a high accumulation of neutral lipids, as detected by fluorescence microscopy after BODIPY staining. These data were confirmed by HPLC-DAD-APCI-MS/MS analyses carried out on the ethanolic extract (PTE), which showed a high content of xanthophylls (98.99%), and in particular of fucoxanthin (Fx, 6.67 g/100 g PTE). The antioxidant activity (ORAC, FRAP, TEAC and &beta;-carotene bleachin...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Antonella Smeriglio Joseph Lionti Mariarosaria Ingegneri Bruno Burlando Laura Cornara Federica Grillo Luca Mastracci Domenico Trombetta Tags: Article Source Type: research

Lipidomics and pancreatic cancer risk in two prospective studies
AbstractPancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC in two prospective studies. We measured 904 lipid species and 252 fatty acids across 15 lipid classes in pre-diagnostic serum (up to 24 years) in a PDAC nested-case control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO,NCT00002540) with 332 matched case –control sets including 272 having serial blood samples and Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study ...
Source: European Journal of Epidemiology - May 12, 2023 Category: Epidemiology Source Type: research

Lipidomics and pancreatic cancer risk in two prospective studies
Eur J Epidemiol. 2023 May 12. doi: 10.1007/s10654-023-01014-3. Online ahead of print.ABSTRACTPancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC in two prospective studies. We measured 904 lipid species and 252 fatty acids across 15 lipid classes in pre-diagnostic serum (up to 24 years) in a PDAC nested-case control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, NCT00002540) with 332 matched case-control sets including 272 having ...
Source: Cancer Control - May 11, 2023 Category: Cancer & Oncology Authors: Sabine Naudin Joshua N Sampson Steven C Moore Demetrius Albanes Neal D Freedman Stephanie J Weinstein Rachael Stolzenberg-Solomon Source Type: research

Viruses, Vol. 15, Pages 1085: Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19
Conclusions: Vaccination against SARS-CoV-2 virus infection prevented the reduction of platelet mitochondrial respiration and energy production. The mechanism of suppression of CoQ10 levels by SARS-CoV-2 virus is not fully known. Methods for the determination of CoQ10 and HRR can be used for monitoring of mitochondrial bioenergetics and targeted therapy of patients with post-acute COVID-19. (Source: Viruses)
Source: Viruses - April 28, 2023 Category: Virology Authors: Gvozdj áková Kucharsk á Rausov á Lop éz-Lluch Navas Palacka Bartol čičová Sumbalov á Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3714: Essential Oil Composition and Antioxidant Activity of Oregano and Marjoram as Affected by Different Light-Emitting Diodes
In this study, different spectra of LED light, namely blue, red, white, blue-red, and natural ambient light as a control, were applied to assess the essential oil content, composition, flavonoid, phenolic, and antioxidant capacity of oregano and marjoram. GC-MS analysis revealed thymol, terpinen-4-ol, sabinene, linalool, p-cymene, and &gamma;-terpinene as the main compounds. In oregano, the thymol content ranged from 11.91% to 48.26%, while in marjoram it varied from 17.47% to 35.06% in different samples. In oregano and marjoram, the highest phenolic contents were in blue (61.26 mg of tannic acid E/g of DW) and in ...
Source: Molecules - April 25, 2023 Category: Chemistry Authors: Danial Sarfaraz Mehdi Rahimmalek Mohammad R. Sabzalian Shima Gharibi Adam Matkowski Antoni Szumny Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3618: Solubility and Stability of Carotenoids in Ammonium- and Phosphonium-Based Ionic Liquids: Effect of Solvent Nature, Temperature and Water
This study provides some guidance for screening suitable solvents for carotenoid extraction and storage. (Source: Molecules)
Source: Molecules - April 21, 2023 Category: Chemistry Authors: Wanting Cheng Feng Xian Zhanluo Zhou Kun Hu Jing Gao Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3519: Direct Solar Oven with and without UV Filter vs. Traditional Oven: Effect on Polyphenolic Antioxidants, Vitamins and Carotenoids of Food
iela Tofani The use of efficient solar ovens can be a way for progressing ecofriendly technologies in the field of food preparation. In most performing direct solar ovens, the sun rays reach the foods directly, therefore, it becomes essential to check whether, in these conditions, foods can retain theirnutraceutical properties (antioxidants, vitamins and carotenoids). In the present research work, to investigate this issue, several foods (vegetables, meats, and a fish sample) were analyzed before and after cooking (traditional oven, solar oven, and solar oven with a UV filter). The content of lipophilic vitamins and ca...
Source: Molecules - April 17, 2023 Category: Chemistry Authors: Seyed Sepehr Moeini Chiara Dal Bosco Elena Mattoni Tecla Gasperi Alessandra Gentili Daniela Tofani Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3505: Photoinduced Dynamics of 13,13 & prime;-Diphenylpropyl- & beta;-carotene
Molecules, Vol. 28, Pages 3505: Photoinduced Dynamics of 13,13′-Diphenylpropyl-β-carotene Molecules doi: 10.3390/molecules28083505 Authors: Sangho Koo Yeong Hun Kim Oliver Flender Mirko Scholz Kawon Oum Thomas Lenzer Carotenoids are ubiquitous pigment systems in nature which are relevant to a range of processes, such as photosynthesis, but the detailed influence of substitutions at the polyene backbone on their photophysics is still underexplored. Here, we present a detailed experimental and theoretical investigation of the carotenoid 13,13&prime;-diphenylpropyl-&beta;-c...
Source: Molecules - April 16, 2023 Category: Chemistry Authors: Sangho Koo Yeong Hun Kim Oliver Flender Mirko Scholz Kawon Oum Thomas Lenzer Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3474: Chemical Characterization and Determination of the Antioxidant Properties of Phenolic Compounds in Three Scutellaria sp. Plants Grown in Colombia
Stashenko Plants of the genus Scutellaria (Lamiaceae) have a wide variety of bioactive secondary metabolites with diverse biological properties, e.g., anti-inflammatory, antiallergenic, antioxidant, antiviral, and antitumor activities. The chemical composition of the hydroethanolic extracts, obtained from dried plants of S. incarnata, S. coccinea, and S. ventenatii &times; S. incarnata, was determined by UHPLC/ESI-Q-Orbitrap-MS. The flavones were found in a higher proportion. Baicalin and dihydrobaicalein-glucuronide were the major extract components in S. incarnata (287.127 &plusmn; 0.005 mg/g and 140....
Source: Molecules - April 14, 2023 Category: Chemistry Authors: Silvia M. Porras Rogerio A. Saavedra Lady J. Sierra Robert T. Gonz ález Jairo R. Mart ínez Elena E. Stashenko Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3429: Dry Nutrition Delivery System Based on Defatted Soybean Particles and Its Application with & beta;-Carotene
Molecules, Vol. 28, Pages 3429: Dry Nutrition Delivery System Based on Defatted Soybean Particles and Its Application with β-Carotene Molecules doi: 10.3390/molecules28083429 Authors: Chunyu Wu Xuewen Ouyang Xiaoya Zhou Xiaofei Li Hongbo Li Wenying Li Cuixiang Wan Bo Yu Sobhy El-Sohaimy Zhihua Wu Many nutrition delivery systems (NDSs) have been developed for the encapsulation, protection, and delivery of bioactive compounds, such as &beta;-carotene. Most of those systems were prepared in solution, which is inconvenient for transportation and storage in the food industry. In the pr...
Source: Molecules - April 13, 2023 Category: Chemistry Authors: Chunyu Wu Xuewen Ouyang Xiaoya Zhou Xiaofei Li Hongbo Li Wenying Li Cuixiang Wan Bo Yu Sobhy El-Sohaimy Zhihua Wu Tags: Communication Source Type: research

Molecules, Vol. 28, Pages 3371: Chemometrics of the Composition and Antioxidant Capacity of Hyptis crenata Essential Oils from Brazil
B. Figueiredo Hyptis crenata (Pohl) ex Benth is used in traditional medicine as an analgesic to treat general pain. Six Hyptis crenata samples (Hc-1 to Hc-6) were collected in Par&aacute; state, Brazil. The leaf essential oils were obtained by hydrodistillation, and GC-MS and GC-FID were used to analyze their chemical compositions. The antioxidant capacity was measured in vitro using DPPH and carotene/linoleic acid assays. Chemometrics analysis (PCA, HCA, and clustered heat map) were used to identify the sample relationships between those collected in this study and those from the literature (Hc-7 to Hc-16) sam...
Source: Molecules - April 11, 2023 Category: Chemistry Authors: Maria Nancy N. de Lima Jamile Silva da Costa Bruna A. Guimar ães Jofre Jacob S. Freitas William N. Setzer Joyce Kelly R. da Silva Jos é Guilherme S. Maia Pablo Luis B. Figueiredo Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3267: Carotenoids Composition of Green Algae Caulerpa racemosa and Their Antidiabetic, Anti-Obesity, Antioxidant, and Anti-Inflammatory Properties
ndeho Bonglee Kim Green alga Caulerpa racemosa is an underexploited species of macroalgae, even though it is characterized by a green color that indicates an abundance of bioactive pigments, such as chlorophyll and possibly xanthophyll. Unlike chlorophyll, which has been well explored, the composition of the carotenoids of C. racemosa and its biological activities have not been reported. Therefore, this study aims to look at the carotenoid profile and composition of C. racemose and determine their biological activities, which include antidiabetic, anti-obesity, anti-oxidative, anti-inflammatory, and cytotoxicity in v...
Source: Molecules - April 6, 2023 Category: Chemistry Authors: Rudy Kurniawan Fahrul Nurkolis Nurpudji Astuti Taslim Dionysius Subali Reggie Surya William Ben Gunawan Darmawan Alisaputra Nelly Mayulu Netty Salindeho Bonglee Kim Tags: Article Source Type: research

Chitosan fabricated biogenic silver nanoparticles (Ch@BSNP) protectively modulate the defense mechanism of tomato during bacterial leaf spot (BLS) disease
Plant Physiol Biochem. 2023 Mar 11;197:107637. doi: 10.1016/j.plaphy.2023.03.014. Online ahead of print.ABSTRACTHerein, the impact of chitosan fabricated biogenic silver nanoparticles (Ch@BSNP) has been evaluated for the protective management of bacterial leaf spot (BLS) disease in tomatoes caused by Xanthomonas campestris (NCIM5028). The Ch@BSNP originated by the Trichoderma viride (MTCC5661) derived extracellular compounds and subsequent chitosan hybridization. Spherical-shaped Ch@BSNP (30-35 nm) treated diseased plants were able to combat the biotic stress, as evidenced by the decreased elevated response of stress marke...
Source: Physiological Research - March 18, 2023 Category: Physiology Authors: Ved Prakash Giri Shipra Pandey Sonal Srivastava Pallavi Shukla Navinit Kumar Madhuree Kumari Ratna Katiyar Shiv Singh Aradhana Mishra Source Type: research