T223. real world effectiveness of antipsychotic drugs in patients with schizophrenia: a 10-years retrospective study
The objective of present study is to determine which antipsychotic medication is highly effective in a real-world clinical setting considering adjuvant pharmacotherapy over a 10-year follow-up period.MethodsA total of 2300 patients with schizophrenia were recruited at the Seoul National University Hospital, and participants received amisulpride, aripiprazole, clozapine, haloperidol, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone for up to 10-years. Time-to-discontinuation of antipsychotic medications was analyzed using Kaplan-Meier survival analyses. Group differences were compared using log-rank tests.Resu...
Source: Schizophrenia Bulletin - April 1, 2018 Category: Psychiatry Source Type: research
Pharmacological interventions for treating sialorrhea associated with neurological disorders: A mixed treatment network meta-analysis of randomized controlled trials
Publication date: Available online 21 February 2018 Source:Journal of Clinical Neuroscience Author(s): Kannan Sridharan, Gowri Sivaramakrishnan Sialorrhea is a common distress associated with certain neurological disorders. The aim of this study is to compare the pharmacological agents used for treating sialorrhea by network meta-analysis. Electronic databases were searched for randomized clinical trials comparing active drugs with either placebo or other active drugs. Total drooling scores was the primary outcome measure. Inverse variance heterogeneity model was used for both direct and mixed treatment comparison anal...
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research
Replacement treatment during extinction training with the atypical dopamine uptake inhibitor, JHW-007, reduces relapse to methamphetamine seeking
Publication date: 3 April 2018 Source:Neuroscience Letters, Volume 671 Author(s): Ashlea F. Dassanayake, Juan J. Canales There are currently no approved medications to effectively counteract the effects of methamphetamine (METH), reduce its abuse and prolong abstinence from it. Data accumulated in recent years have shown that a range of N-substituted benztropine (BZT) analogues possesses psychopharmacological features consistent with those of a potential replacement or “substitute” treatment for stimulant addiction. On the other hand, the evidence that antidepressant therapy may effectively prevent relapse to stimu...
Source: Neuroscience Letters - February 16, 2018 Category: Neuroscience Source Type: research
Anticholinergic medication for antipsychotic-induced tardive dyskinesia.
CONCLUSIONS: Based on currently available evidence, no confident statement can be made about the effectiveness of anticholinergics to treat people with antipsychotic-induced tardive dyskinesia. The same applies for the withdrawal of such medications. Whether the withdrawal of anticholinergics may benefit people with antipsychotic-induced TD should be evaluated in a parallel-group, placebo-controlled randomised trial, with adequate sample size and at least 6 weeks of follow-up.
PMID: 29341071 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - January 17, 2018 Category: General Medicine Authors: Bergman H, Soares-Weiser K Tags: Cochrane Database Syst Rev Source Type: research
Behavioral economic analysis of the effects of N-substituted benztropine analogs on cocaine self-administration in rats
ConclusionsThe current findings, obtained using a behavioral economic assessment, suggest that BZT analogs selectively decrease the reinforcing effectiveness of cocaine. (Source: Psychopharmacology)
Source: Psychopharmacology - January 1, 2018 Category: Psychiatry Source Type: research
Reducing Anticholinergic Medication Burden in Patients With Psychotic or Bipolar Disorders.
CONCLUSIONS: In this interdisciplinary, collaborative QI project, patients whose anticholinergic burden was reduced experienced a significant improvement in side effects, memory, and quality of life.
PMID: 29178683 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Drugs for Parkinson's Disease
Date: November 20, 2017
Issue #:
1534Summary:
The motor symptoms of Parkinson ' s disease (PD) are
caused primarily by degeneration of dopaminergic
neurons in the substantia nigra. The nonmotor
symptoms of the disease are thought to be caused by
degeneration of other neurotransmitter systems. (Source: The Medical Letter)
Source: The Medical Letter - November 1, 2017 Category: Drugs & Pharmacology Authors: admin Tags: Alertec Amantadine Antidepressants Antipsychotics Apokyn Apomorphine Aricpet armadofinil azilect benserazide Benztropine Bydureon Byetta Carbidopa Carbidopa/levodopa Clozapine Clozaril Cogentin Comtan Deep Brain stimu Source Type: research
Precursors to the PANSS: The BPRS and its progenitors
Conclusion
One definition of value is when a trademark is used as a generic; Kleenex and Jello come to mind. From that perspective, the BPRS became the name for numerous scales that went far beyond the original. Perhaps the distinction of the PANSS is that it changed the terrain by creating both a new name and a brand. With its remarkable utility in the development of new antipsychotic medications and other treatments in schizophrenia and psychotic disorders today, the PANSS will help to shape the future of assessment tools, and ultimately psychiatric research.
References
Kay SR, Fiszbein A, Opler LA. The positive and ne...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review 7-point Likert scale BPRS factor analysis of data PANSS psychometrics schizophrenia symptom assessment the Brief Psychiatric Rating Scale The Positive and Negative Syndrome Scale Source Type: research
Molecular dynamics of conformation-specific dopamine transporter-inhibitor complexes
Publication date: Available online 11 July 2017 Source:Journal of Molecular Graphics and Modelling Author(s): Bernandie Jean, Christopher K. Surratt, Jeffry D. Madura The recreational psychostimulant cocaine inhibits dopamine reuptake from the synapse, resulting in excessive stimulation of postsynaptic dopamine receptors in brain areas associated with reward and addiction. Cocaine binds to and stabilizes the outward- (extracellular-) facing conformation of the dopamine transporter (DAT) protein, while the low abuse potential DAT inhibitor benztropine prefers the inward- (cytoplasmic-) facing conformation. A correlatio...
Source: Journal of Molecular Graphics and Modelling - July 12, 2017 Category: Molecular Biology Source Type: research
Molecules, Vol. 22, Pages 808: The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus
We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that the expression of genes involved in antigen processing and presentation in astrocytes are significantly upregulated upon IFNγ exposure, emphasizing the critical role of this cytokine in the redirection of immune response towards self-antigens. Data reported herein support previous observations that the IFNγ-induced JAK-STAT signaling pathwa y may be regarded as a valuable target for pharmaceutical interventions. (Source: Molecules)
Source: Molecules - May 15, 2017 Category: Chemistry Authors: Anna Kudriaeva Vladimir Galatenko Diana Maltseva Nadezhda Khaustova Ekaterina Kuzina Alexander Tonevitsky Alexander Gabibov Alexey Belogurov Tags: Article Source Type: research
Sudan black: a fast, easy and non ‐toxic method to assess myelin repair in demyelinating diseases
ConclusionOur adapted sudan black staining can be used to rapidly and non‐toxically screen for remyelinating therapies in demyelinating diseases. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - March 9, 2017 Category: Neurology Authors: Benjamin V. Ineichen, Oliver Weinmann, Nicolas Good, Patricia S. Plattner, Carla Wicki, Elisabeth J. Rushing, Michael Linnebank, Martin E. Schwab Tags: Original Article Source Type: research
Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes
Conclusion and ImplicationsThe tools established in this study can be widely used to identify new transport inhibitors. Using these tools, we were able to identify compounds that can be used to study epithelial transport, to induce protein restriction, or be developed further through medicinal chemistry. This article is protected by copyright. All rights reserved. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - January 31, 2017 Category: Drugs & Pharmacology Authors: Qi Cheng, Nishank Shah, Angelika Br öer, Stephen Fairweather, Yang Jiang, Dieter Schmoll, Ben Corry, Stefan Bröer Tags: RESEARCH PAPER Source Type: research
Further delineation between typical and atypical dopamine uptake inhibitors: effects on food-maintained behavior and food consumption
The present studies compared the acute effects of benztropine analogs (4-Cl-BZT, JHW 007, AHN 1-055), which are atypical dopamine uptake inhibitors, with those of the standard dopamine uptake inhibitors GBR 12909 and cocaine, on the reinforcing efficacy of food and food intake in male Sprague-Dawley rats. Repeated drug effects of JHW 007 on food intake were also determined. The number of ratios completed under a progressive-ratio schedule of food delivery was used as an index of reinforcing efficacy. Food intake was determined by measuring powdered laboratory-chow consumption during daily 40 min food-availability time pe...
Source: Behavioural Pharmacology - January 14, 2017 Category: Drugs & Pharmacology Tags: Research Reports Source Type: research
Sudan black: a fast, easy, and non ‐toxic method to assess myelin repair in demyelinating diseases
ConclusionOur adapted sudan black staining can be used to rapidly and non‐toxically screen for remyelinating therapies in demyelinating diseases.This article is protected by copyright. All rights reserved. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - December 22, 2016 Category: Neurology Authors: Benjamin. V. Ineichen, Oliver Weinmann, Nicolas Good, Patricia Plattner, Carla Wicki, Elisabeth J. Rushing, Michael Linnebank, Martin E. Schwab Tags: Original Article Source Type: research
New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.
This study also provides a screening platform for identification of additional anti-CSC agents.
PMID: 27894093 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - November 29, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
