A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain
This clinical trial evaluated the independent and combined effects of a tricyclic antidepressant (desipramine) and cognitive behavioral therapy (CBT) for chronic back pain relative to an active placebo treatment. Participants (n = 142) were patients experiencing daily chronic back pain at an intensity of ≥4/10 who were randomized to a single-center, double-blind, 12-week, 4-arm, parallel groups controlled clinical trial of (1) low concentration desipramine titrated to reach a serum concentration level of 15 to 65 ng/mL; (2) CBT and active placebo medication (benztropine mesylate, 0.125 mg); (3) low concentration desipram...
Source: Pain - May 21, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research
Dispensing patterns of emergency medicines prescribed by Australian dentists from 1992 to 2018 – a pharmacoepidemiology study
ConclusionThis study highlights the dispensing patterns of medicines prescribed by dentists for emergency scenarios. Although this study did not assess the appropriateness of use of the emergency medicines, further investigation may be required to ensure the future safety of patients when encountering emergency scenarios. (Source: International Dental Journal)
Source: International Dental Journal - March 16, 2020 Category: Dentistry Authors: Joon Soo Park,
Estie Kruger,
Marc Tennant Tags: SCIENTIFIC RESEARCH REPORT Source Type: research
Cancers, Vol. 12, Pages 523: Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3
In conclusion, we propose the repurposing of benztropine for anticancer research and therapeutics that can suppress tumor progression, CTC, and metastasis of aggressive cancers by reducing key pro-tumorigenic factors. (Source: Cancers)
Source: Cancers - February 23, 2020 Category: Cancer & Oncology Authors: Chiharu Sogawa Takanori Eguchi Manh Tien Tran Masayuki Ishige Kilian Trin Yuka Okusha Eman Ahmed Taha Yanyin Lu Hotaka Kawai Norio Sogawa Masaharu Takigawa Stuart K. Calderwood Kuniaki Okamoto Ken-ichi Kozaki Tags: Article Source Type: research
Psychotropics in Your Medicine Cabinet: A Case Study of Dimenhydrinate Use
We present a case of a woman in her forties, with a psychiatric history of bipolar disorder, and complex concurrent medical history including familial Mediterranean fever (FMF), and fibromyalgia, admitted for withdrawal management of her intravenous dimenhydrinate use. As a result of her FMF, there were numerous hospital admissions and treatment which required intravenous access. Hence, a physician-inserted intravenous access port was placed on her chest. The port was maintained monthly with the help of a community agency. In this port, she was injecting 100 to 200 mg of dimenhydrinate hourly for its euphoric and calming...
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Case Reports Source Type: research
Molecules, Vol. 24, Pages 2747: Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents with Potential Inhibitory Effect on Human CES1
In conclusion, the binding site of CES1 is relatively flexible and can adapt its conformation to different types of ligands. Combining ensemble docking and machine learning approaches improves the prediction of CES1 inhibitors compared to a docking study using only one crystal structure. (Source: Molecules)
Source: Molecules - July 28, 2019 Category: Chemistry Authors: Eliane Briand Ragnar Thomsen Kristian Linnet Henrik Berg Rasmussen S øren Brunak Olivier Taboureau Tags: Article Source Type: research
Acute dystonic reaction induced by a single dose of clebopride: A case report
Rationale:
Clebopride is known as a dopamine antagonist used for alleviating emetic symptoms with minimal side effects. Herein, we report a case of acute dystonic reaction possibly caused by administration of clebopride in a young male.
Patient concerns:
A 19-year-old with no special medical conditions, visited a local clinic complaining of abdominal discomfort, associated with nausea and vomiting. The patient was prescribed with tiropramide, clebopride, simethicone, and mosapride citrate, only to visit the emergency department for abrupt neck pain followed with dystonic reactions upon oral administration of the drugs...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Low-Dose Amitriptyline for Chronic Low Back Pain
To the Editor We read the article “Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial” by Urquhart and colleagues, in which the authors found a significant reduction in disability at 3 months following treatment with amitriptyline but not at 6 months. The other outcome parameters, such as p ain intensity and work absence and hindrance, were not significantly different between the amitriptyline and the control groups. Adverse effects of a drug are an important outcome measure. A drug may be effective but may not be used because of its severe adverse effects, such as reserpine for h...
Source: JAMA Internal Medicine - March 1, 2019 Category: Internal Medicine Source Type: research
Drug-induced Sialorrhoea
Summary
Sialorrhoea is a common adverse effect of a range of medicines, primarily clozapine. At least a third of patients treated with clozapine suffer from sialorrhoea, and the consequences of this can be socially stigmatising and lead to non-adherence. The treatment options are limited and primarily centered around muscarinic antagonism. We suggest non-pharmacological interventions followed by locally applied atropine or glycopyrrolate. If systemic treatment is necessary, amisulpride, benztropine, or terazosin may be attempted. (Source: Adverse Drug Reaction Bulletin)
Source: Adverse Drug Reaction Bulletin - November 30, 2018 Category: Drugs & Pharmacology Tags: Invited Review Article Source Type: research
A Prospective Study of the Safety and Effectiveness of Droperidol in Children for Prehospital Acute Behavioural Disturbance.
CONCLUSIONS: The use of droperidol in children for acute behavioural disturbance in the prehospital setting is both safe and effective.
PMID: 30380965 [PubMed - as supplied by publisher] (Source: Prehospital Emergency Care)
Source: Prehospital Emergency Care - November 3, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
A Significant Injury with Just a Speck of Pain
BY ARJUN BHARADWAJ & KHALID MALIK, MDA 58-year-old man who lived at a nursing facility came to the emergency department complaining of abdominal pain for three days. His pain was localized to the epigastrium and periumbilical regions. The nursing home staff indicated that he was hypotensive and possibly hypoxic.The patient said he never had similar pain before, which he said pain was mild and constant in severity and did not radiate to the chest, back, pelvis, or shoulders. He also reported nausea but no trauma, falls, vomiting, fever, chills, dizziness, chest pain, shortness of breath, trouble walking, or change in...
Source: The Case Files - October 16, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Pneumatosis Intestinalis with a Curious Etiology
BY ALISON BROOMFIELD; ARJUN BHARADWAJ; KHALID MALIK, MDA 68-year-old woman was brought to the emergency department from a nursing home with a complaint of abdominal distention. The patient had no focal pain, just overall diffuse discomfort in her abdomen and upper pelvis. She and the nursing home staff did not know when her symptoms started. The patient had taken acetaminophen, but it had no effect on her discomfort.The discomfort did not radiate to her chest, back, or shoulders. The patient and nursing home indicated no recent trauma or falls, but the patient reported two episodes of non-bilious, non-bloody vomiting...
Source: The Case Files - September 25, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Identification of the benztropine analog [125I]GA II 34 binding site on the human dopamine transporter
Publication date: Available online 17 August 2018Source: Neurochemistry InternationalAuthor(s): Michael J. Tomlinson, Danielle Krout, Akula Bala Pramod, John R. Lever, Amy Hauck Newman, L. Keith Henry, Roxanne A. VaughanAbstractThe dopamine transporter (DAT) is a neuronal membrane protein that is responsible for reuptake of dopamine (DA) from the synapse and functions as a major determinant in control of DA neurotransmission. Cocaine and many psychostimulant drugs bind to DAT and block reuptake, inducing DA overflow that forms the neurochemical basis for euphoria and addiction. Paradoxically, however, some ligands such as ...
Source: Neurochemistry International - August 17, 2018 Category: Neuroscience Source Type: research
Antipsychotic-Related Movement Disorders: Drug-Induced Parkinsonism vs. Tardive Dyskinesia —Key Differences in Pathophysiology and Clinical Management
ConclusionsIt is important for clinicians to be able to recognize DIP and TD in patients using antipsychotics so that they can minimize the impact of these adverse events on their patients ’ quality of life. Accurate diagnosis will drive the selection of the correct treatment.Plain Language SummaryPlain language summary available for this article. (Source: Neurology and Therapy)
Source: Neurology and Therapy - July 19, 2018 Category: Neurology Source Type: research
Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study
Conclusions
This observational study demonstrates a harmful association between the incidence of Parkinson disease or associated EPSs and use of the antidepressants duloxetine, mirtazapine, citalopram, escitalopram, paroxetine, sertraline, venlafaxine, bupropion, and fluoxetine. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - June 28, 2018 Category: Psychiatry Tags: Original Contributions Source Type: research
