Experiences from the adverse drug event manager
Summary
The current report briefly summarizes the experiences and statistics of the Adverse Drug Event Manager (ADEM) covering the Capital Region of Denmark, Denmark, during the period 1 January 2013 to 31 December 2020. During this 8-year period, the ADEM function has reported a total of 4262 adverse drug reactions (ADRs) to the Danish Medicines Agency, and of these, 141 had a fatal outcome (3.3%). The most commonly reported drugs were vaccines, antihypertensive agents, anticoagulants, and antiosteoporosis drugs. Fatal ADRs were predominantly related to anticoagulants. In 2020, the ADEM reported more than two-thirds o...
Source: Adverse Drug Reaction Bulletin - September 28, 2022 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Will the new treatment recommendations for asthma increase adverse events?
In conclusion, the new treatment with as-needed ICS/formoterol only is at least as safe as the previously recommended treatment, regarding adverse effects. ICS/formoterol used as needed and maintenance might give an increased risk of candidiasis and dysphonia, though the absolute risk remains low. (Source: Adverse Drug Reaction Bulletin)
Source: Adverse Drug Reaction Bulletin - August 1, 2022 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Drug-induced optic neuropathy
This study revealed a weak association between optic neuropathy and amiodarone; however, we were unable to confirm any association with ciprofloxacin, sildenafil, and disulfiram. (Source: Adverse Drug Reaction Bulletin)
Source: Adverse Drug Reaction Bulletin - June 1, 2022 Category: Drugs & Pharmacology Tags: Invited Review Article Source Type: research
Medication-related osteonecrosis of the jaw – a scoping review
Summary
Medication-related osteonecrosis of the jaw [MRONJ] is a rare, often intractable, and debilitating condition that is associated with multiple therapies. The condition can be asymptomatic or become chronic adversely affecting the patient's quality of life. Case definitions of MRONJ have been given by the American Association of Oral and Maxillofacial Surgeons [AAOMS] and the American Society for Bone and Mineral Research [ASBMR] and history of use [or current] of anti-resorptive agents and anti-angiogenic agents form a key component of the definition. The exact pathophysiology of this condition remains unclear t...
Source: Adverse Drug Reaction Bulletin - April 1, 2022 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Cardiotoxicity in relation to treatment with aromatase inhibitors in breast cancer
Summary
With the success of modern cancer therapy, breast cancer survival has steadily improved over the last decades. Treatment with aromatase inhibitors has become the preferred endocrine treatment in postmenopausal women with estrogen receptor-positive breast cancer. However, concerns have been raised over a possible cardiotoxic potential. The aim of the current paper is to review the evidence regarding cardiotoxicity with aromatase inhibitors in breast cancer.
Weighing benefits vs. risks, the improved effect of aromatase inhibitors vs. tamoxifen on breast cancer recurrence in most patients outweighs the potentia...
Source: Adverse Drug Reaction Bulletin - February 1, 2022 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
SUBJECT AND DRUG INDEXES TO ADVERSE DRUG REACTION BULLETIN: Nos 326–331 February 2021 – December 2021
No abstract available (Source: Adverse Drug Reaction Bulletin)
Source: Adverse Drug Reaction Bulletin - December 1, 2021 Category: Drugs & Pharmacology Tags: INDEX Source Type: research
Adverse drug reactions to herbal medicines
Summary
Herbal medicines may cause adverse drug reactions (ADRs) due to effects of known constituent(s), substitution with other herbal ingredients, or contamination or adulteration with additional substances. Healthcare professionals (HCPs) should always take a full medicines history, including use of herbal medicines and other complementary products (e.g., food supplements and other dietary supplements).
A range of resources are available to inform HCPs and the public/patients/ carers about possible ADRs associated with herbal medicines. HCPs and the public/patients also need to be made aware of the importance of ...
Source: Adverse Drug Reaction Bulletin - December 1, 2021 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Prevalence and characteristics of drug-drug interactions among hospitalised patients in the Capital Region of Denmark
Summary
Previous studies on the prevalence of drug-drug interactions (DDIs) have largely been restricted to specific hospital departments. We identified common drug combinations and potential drug-drug interactions (pDDIs) in an entire hospital population throughout 1 year. Frequently administered drug combinations involved analgesics, cardiovascular medicines and gastrointestinal medicines. The prevalence of pDDIs among newly hospitalised patients was 2.6%. The most common pDDIs were ibuprofen – paracetamol, pantoprazole – paracetamol and morphine – paracetamol. Critical pDDIs were rare and only accounted for 0....
Source: Adverse Drug Reaction Bulletin - September 29, 2021 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
The rule of 3
Summary
In this paper, we critically review the information distributed to patients and doctors regarding adverse drug reactions. One major concern is that frequencies reported in the summary of product characteristics are not adjusted for the nocebo effect, leading to an exaggerated concern of adverse drug reactions. Previous research has found that the understanding of health hazards related to pharmacotherapy can be significantly improved by providing information on the frequencies of adverse drug reactions in both the active- and placebo-treated group. (Source: Adverse Drug Reaction Bulletin)
Source: Adverse Drug Reaction Bulletin - July 30, 2021 Category: Drugs & Pharmacology Tags: Invited Review Article Source Type: research
Chemotherapy-induced nausea and vomiting in children – the missing evidence
No abstract available (Source: Adverse Drug Reaction Bulletin)
Source: Adverse Drug Reaction Bulletin - June 1, 2021 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Adverse effects from selected antidotes commonly used in poisonings
Summary
The number of specific antidotes available is low compared to the wide range of substances, of natural or synthetic origin, able to produce toxic symptoms in the human body. Some of these antidotes being very specific in target and effect, e.g., antagonism at the μ-opioid receptors by naloxone in an opioid overdose, other antidotes being unspecific, e.g., glucagon or atropine in the case of betablocker poisoning or activated charcoal with its ability reduce absorption of a wide range of toxic substances. In the following, we present four important antidotes (N-acetylcysteine, deferoxamine, methylene blue and p...
Source: Adverse Drug Reaction Bulletin - April 1, 2021 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Drug interactions with herbal medicines: mechanisms and implications
Summary
Interactions between herbal and conventional medicines can occur by either pharmacodynamic or pharmacokinetic mechanisms, resulting in a reduction or increase in the effects of the conventional medicine. Healthcare professionals (HCPs) should always take a full medicines history, including herbal medicines use as well as other complementary products (e.g., food supplements and other dietary supplements), and be aware that they may sometimes affect the efficacy or safety of other medicines the patient receives. A range of resources are available to inform HCPs and patients/carers about potential drug/herb intera...
Source: Adverse Drug Reaction Bulletin - February 1, 2021 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
SUBJECT AND DRUG INDEXES TO ADVERSE DRUG REACTION BULLETIN: Nos 320–325 February 2020 – December 2020
No abstract available (Source: Adverse Drug Reaction Bulletin)
Source: Adverse Drug Reaction Bulletin - December 1, 2020 Category: Drugs & Pharmacology Tags: INDEX Source Type: research
Bisphosphonate use and the risk of atypical fractures: A narrative review
Summary
Bisphosphonates (BPs) have been in the market for the past 40 years and proven beneficial especially for patients with osteoporosis and prevention of hypercalcemic in malignancy. However, their long-term use raises safety concerns like Atypical femoral fracture and Osteonecrosis of the Jaw whose pathophysiology still remains unclear. Atypical femoral fracture is more commonly seen among BP users with at least six years of therapy and concomitant use of drugs such as glucocorticoids. The most common treatment for atypical femoral fracture is to withdraw the therapy with monitoring of bone resorption markers but ...
Source: Adverse Drug Reaction Bulletin - December 1, 2020 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Adverse drug reactions: five historical scandals
Summary
It is estimated that eight percentage of all acute medical admissions are due to adverse drug reactions, and three percentage of all approved new medical entities are later withdrawn from the market due to safety issues. Adverse drug reactions are of public health concern and this paper reviews five selected adverse drug reaction scandals that all caused significant stir and had a huge impact on our way of thinking, drug development and legislation. (Source: Adverse Drug Reaction Bulletin)
Source: Adverse Drug Reaction Bulletin - October 1, 2020 Category: Drugs & Pharmacology Tags: Review Article Source Type: research
