Comparison of benazepril and losartan on endothelial function and vascular stiffness in patients with Type 2 diabetes mellitus and hypertension: A randomized controlled trial
Conclusions:
Hypertensive diabetic patients using benazepril had a greater reduction in C-reactive protein, and a slight improvement in FMD, than those taking losartan. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 23, 2015 Category: Biomedical Science Authors: Gismondi, R. A., Oigman, W., Bedirian, R., Pozzobon, C. R., Ladeira, M. C. B., Neves, M. F. Tags: Original Articles Source Type: research
Effects of high doses of enalapril and benazepril on the pharmacologically activated renin-angiotensin-aldosterone system in clinically normal dogs.
CONCLUSIONS AND CLINICAL RELEVANCE In this study, administration of high doses of enalapril and benazepril significantly inhibited ACE activity, yet did not prevent increases in mean urine and serum aldosterone concentrations resulting from furosemide activation of RAAS. This suggested that aldosterone breakthrough from ACE inhibition was a dose-independent effect of ACE inhibitors.
PMID: 26618728 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - December 1, 2015 Category: Veterinary Research Authors: Ames MK, Atkins CE, Lee S, Lantis AC, zumBrunnen JR Tags: Am J Vet Res Source Type: research
Azithromycin‐Induced, Biopsy‐Proven Acute Interstitial Nephritis in an Adult Successfully Treated with Low‐Dose Corticosteroids
We describe the case of a 59‐year‐old white male who developed AIN that required hemodialysis following azithromycin treatment. He presented to the hospital with complaints of nausea, vomiting, malaise, and fever over the past 3 days, along with no urine output in the preceding 24 hours. Two weeks earlier, he had completed a 5‐day course of azithromycin 500 mg on day 1 followed by 250 mg/day on days 2–5 (total dose 1.5 g) for an upper respiratory tract infection. On admission, the patient's serum creatinine (Scr) concentration was 7.4 mg/dl (baseline = 1.3 mg/dl). He reported a similar episode of kidney fa...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 23, 2015 Category: Drugs & Pharmacology Authors: Ashley E. Woodruff, Calvin J. Meaney, Elizabeth A. Hansen, Gina M. Prescott Tags: Case Report Source Type: research
The appropriate dose of angiotensin‐converting‐enzyme inhibitors or angiotensin receptor blockers in patients with dilated cardiomyopathy. The higher, the better?
Abstract
Heart failure is a major public issue, and dilated cardiomyopathy (DCM) is one of the common etiologies of heart failure. DCM is generally progressive, and some patients with DCM need heart transplant despite optimal medical and mechanical therapy. Current guidelines recommend inhibitors of renin–angiotensin–aldosterone system, namely angiotensin‐converting‐enzyme (ACE) inhibitor, angiotensin receptor blocker (ARB), and mineralocorticoid receptor antagonist as well as beta‐blockers for the medical treatment of heart failure with reduced ejection fraction, including DCM. Furthermore, because they have ben...
Source: ESC Heart Failure - November 17, 2015 Category: Cardiology Authors: Junichi Ishida, Masaaki Konishi, Stephan Haehling Tags: Editorial Source Type: research
Modulation of acute transient exercise-induced hypertension after oral administration of four angiotensin-converting enzyme inhibitors in normotensive horses
In conclusion, administration of PO benazepril at a dose of 0.5 mg/kg modulated physiological hypertension induced by exercise in horses that were otherwise normotensive. (Source: The Veterinary Journal)
Source: The Veterinary Journal - October 23, 2015 Category: Veterinary Research Source Type: research
Comparison of Efficacy of Long‐term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic Kidney Disease
Conclusion and Clinical ImportanceBoth telmisartan and benazepril were well tolerated and safe. Telmisartan proved to be noninferior to benazepril and significantly decreased proteinuria relative to baseline at all assessment points whereas benazepril did not. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - October 16, 2015 Category: Veterinary Research Authors: U. Sent, R. Gössl, J. Elliott, H. M. Syme, T. Zimmering Tags: Standard Article Source Type: research
Benazepril in dogs with asymptomatic mitral valve disease
BestBETs for Vets are generated by the Centre for Evidence-based Veterinary Medicine at the University of Nottingham to help answer specific questions and assist in clinical decision making. Although evidence is often limited, they aim to find, present and draw conclusions from the best available evidence, using a standardised framework. A more detailed description of how BestBETs for Vets are produced was published in Veterinary Record earlier this year (VR, April 4, 2015, vol 176, pp 354-356) (Source: Veterinary Record)
Source: Veterinary Record - October 16, 2015 Category: Veterinary Research Tags: Clinical Decision Making Source Type: research
Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned?
Abstract
Congestive heart failure (CHF) is a primary cause of morbidity and mortality with an increasing prevalence in human and canine populations. Recognition of the role of renin-angiotensin-aldosterone system (RAAS) overactivation in the pathophysiology of CHF has led to significant medical advances. By decreasing systemic vascular resistance and angiotensin II (AII) production, angiotensin-converting enzyme (ACE) inhibitors such as benazepril improve cardiac hemodynamics and reduce mortality in human and dog CHF patients. Although several experiments have pointed out that efficacy of ACE inhibitors de...
Source: Pharmacological Reviews - October 2, 2015 Category: Drugs & Pharmacology Authors: Mochel JP, Danhof M Tags: Rev Physiol Biochem Pharmacol Source Type: research
Short-term follow-up of exercise training program and beta-blocker treatment on quality of life in dogs with naturally acquired chronic mitral valve disease.
This study aimed to evaluate the effects of carvedilol treatment and a regimen of supervised aerobic exercise training on quality of life and other clinical, echocardiographic, and biochemical variables in a group of client-owned dogs with chronic mitral valve disease (CMVD). Ten healthy dogs (control) and 36 CMVD dogs were studied, with the latter group divided into 3 subgroups. In addition to conventional treatment (benazepril, 0.3-0.5 mg/kg once a day, and digoxin, 0.0055 mg/kg twice daily), 13 dogs received exercise training (subgroup I; 10.3±2.1 years), 10 dogs received carvedilol (0.3 mg/kg twice daily) and exercise...
Source: Braz J Med Biol Res - October 1, 2015 Category: Research Authors: Marcondes-Santos M, Mansur AP, Fragata FS, Strunz CM Tags: Braz J Med Biol Res Source Type: research
Enhanced elution of angiotensin converting enzyme inhibitors in ion chromatography: Application to their simultaneous quantitation in formulations and human plasma
Publication date: January 2016 Source:Microchemical Journal, Volume 124 Author(s): Fawzi Elsebaei, Yan Zhu In this paper, ion chromatography is utilized as a superior alternative to HPLC for analysis of angiotensin converting enzyme (ACE) inhibitors. A low-capacity weak cation exchanger functionalized with carboxylic acid groups (Dionex IonPac SCS1) is used in which the cation exchange separation mechanism predominates over the hydrophobic interactions that happen in most HPLC columns. This leads to much improvement of studied drugs peak profiles, which permits their analysis at normal temperature and ordinary pH w...
Source: Microchemical Journal - September 11, 2015 Category: Chemistry Source Type: research
Attenuation of the pressor response to exogenous angiotensin by angiotensin receptor blockers and benazepril hydrochloride in clinically normal cats.
CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that telmisartan administration may have advantages over benazepril administration for cats with renal or cardiovascular disease.
PMID: 26309109 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - August 29, 2015 Category: Veterinary Research Authors: Jenkins TL, Coleman AE, Schmiedt CW, Brown SA Tags: Am J Vet Res Source Type: research
Short-term follow-up of exercise training program and beta-blocker treatment on quality of life in dogs with naturally acquired chronic mitral valve disease.
This study aimed to evaluate the effects of carvedilol treatment and a regimen of supervised aerobic exercise training on quality of life and other clinical, echocardiographic, and biochemical variables in a group of client-owned dogs with chronic mitral valve disease (CMVD). Ten healthy dogs (control) and 36 CMVD dogs were studied, with the latter group divided into 3 subgroups. In addition to conventional treatment (benazepril, 0.3-0.5 mg/kg once a day, and digoxin, 0.0055 mg/kg twice daily), 13 dogs received exercise training (subgroup I; 10.3±2.1 years), 10 dogs received carvedilol (0.3 mg/kg twice daily) and exercise...
Source: Brazilian Journal of Medical and Biological Research - August 15, 2015 Category: Research Tags: Braz J Med Biol Res Source Type: research
Development of a new benazepril hydrochloride chewable tablet and evaluation of its bioequivalence for treatment of heart failure in dogs
The aim of the study was to develop a new chewable benazepril hydrochloride(BH) tablet, investigate its physical properties, and evaluate its bioequivalence with the branded formulation (Fortekor®). A corrective agent was included in the formula to improve its palatability and convenience for administration to dogs. The tablet remained stable in light, heat, and humidity tests, and its physical properties such as hardness, uniformity of content, and dissolution rate were highly consistent with the technical standards. After single and repeated administrations to eight beagles and single dose to 14 mongrel dogs (0.5 mg/kg...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 30, 2015 Category: Veterinary Research Authors: M. Qian, T. Chen, D. Zhou, Z. Zhang, Q. Zhang, S. Tang, X. Xiao Tags: Short Communication Source Type: research
Mycophenolate mofetil ameliorates diabetic nephropathy through epithelial mesenchymal transition in rats.
Authors: Xiao X, Wang J, Chang X, Zhen J, Zhou G, Hu Z
Abstract
Recent studies in animal models have revealed that mycophenolate mofetil (MMF) has certain protective effects against experimental diabetic nephropathy. The present study therefore aimed to investigate the hypothesis that diabetic nephropathy may be ameliorated by mycophenolate mofetil and benazepril treatment alone or in combination, and identify the potential underlying mechanisms in a rat model. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin. Rats were subsequently treated with benazepril, MMF or a comb...
Source: Molecular Medicine Reports - June 19, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Application of quantitative NMR for purity determination of standard ACE inhibitors
This study investigated the accuracy of the quantitative NMR method for purity determination of ACE inhibitors reference standards and the discovery of two pairs of new diastereoisomers. Six types of ACE inhibitors, imidapril hydrochloride, benazepril hydrochloride, lisinopril, enalapril maleate, quinapril hydrochloride, and captopril were quantificated and validated for the qNMR method by discussing factors that affect parameters of the qNMR experiment, internal standards, integration, pH-effect, and uncertainty. The results were compared with data obtained by the mass balance method. The study found that maleic acid infl...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 12, 2015 Category: Drugs & Pharmacology Source Type: research
