Simultaneous ultraperformance liquid chromatography/tandem mass spectrometry determination of four antihypertensive drugs in human plasma using hydrophilic-lipophilic balanced reversed phase sorbents sample preparation protocol.
In conclusion, the present study revealed method selectivity and sensitivity; it can be applied for estimation of ACEI and HCT in human plasma for dose adjustment and therapeutic drug monitoring.
PMID: 30109716 [PubMed - as supplied by publisher] (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - August 14, 2018 Category: Biomedical Science Authors: Mahrouse MA Tags: Biomed Chromatogr Source Type: research
The Effect and Mechanism of Chinese Herbal Formula Sini Tang in Heart Failure after Myocardial Infarction in Rats.
Conclusions: The Chinese herbal formula SNT could improve left ventricular systolic function in heart failure after myocardial infarction in rats and decreased the level of Plasma Renin, Angiotensin II, and Aldosterone, as well as downregulating the protein and gene level of ACE and AT1R. Therefore, SNT has potential benefits of improving cardiac function by inhibiting the excessive activation of Renin-Angiotensin-Aldosterone system in heart failure after myocardial infarction in rats.
PMID: 30050591 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 30, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Transient myocardial thickening in a Bartonella henselae–positive cat
Publication date: June 2018Source: Journal of Veterinary Cardiology, Volume 20, Issue 3Author(s): J.L. Joseph, E.M. Oxford, R.A. SantilliAbstractA 3-year-old castrated male domestic shorthair presented to the Cornell University Hospital for Animals for acute onset respiratory distress. Thoracic radiographs, echocardiogram, and electrocardiogram (ECG) revealed left-sided congestive heart failure, myocardial thickening with left atrial dilation, and sinus rhythm conducted with a left bundle branch block, respectively. Cardiac troponin I was elevated and continued to increase over 36 h (1.9 ng/mL, 3.1 ng/mL, and 3.5 ng/mL...
Source: Journal of Veterinary Cardiology - July 10, 2018 Category: Veterinary Research Source Type: research
Transient myocardial thickening in a Bartonella henselae –positive cat
Publication date: Available online 2 May 2018 Source:Journal of Veterinary Cardiology Author(s): J.L. Joseph, E.M. Oxford, R.A. Santilli A 3-year-old castrated male domestic shorthair presented to the Cornell University Hospital for Animals for acute onset respiratory distress. Thoracic radiographs, echocardiogram, and electrocardiogram (ECG) revealed left-sided congestive heart failure, myocardial thickening with left atrial dilation, and sinus rhythm conducted with a left bundle branch block, respectively. Cardiac troponin I was elevated and continued to increase over 36 h (1.9 ng/mL, 3.1 ng/mL, and 3.5 ng/mL, s...
Source: Journal of Veterinary Cardiology - May 29, 2018 Category: Veterinary Research Source Type: research
Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat.
Authors: Geng J, Yu X, Liu C, Sun C, Guo M, Li Z, Jin Y, Zou Y, Yu J
Abstract
Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout the world; until now there is no specific drug available. In this work, we use herba artemisiae capillaris extract (HACE) to alleviate renal fibrosis characterized by the excessive accumulation of extracellular matrix (ECM) in rats, aiming to investigate the protective effect of the HACE on DN. We found that the intragastric treatment of high-dose HACE could reverse the effect of streptozotocin not only to decrease the level of blood glucose and bloo...
Source: Evidence-based Complementary and Alternative Medicine - April 11, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Effect of benazepril and pimobendan on serum angiotensin ‐converting enzyme activity in dogs
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 2, 2018 Category: Veterinary Research Source Type: research
Effect of benazepril and pimobendan on serum angiotensin ‐converting enzyme activity in dogs
In conclusion, 0.25–0.5 mg/kg benazepril administered BID produced noninferior inhibition of serum ACE activity compared to 0.5–1.0 mg/kg benazepril dosed SID. Pimobendan had no significant effect on benazepril's action on serum ACE activity. The results support the use of benazepril BID in dogs and in combination with pimobendan. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 1, 2018 Category: Veterinary Research Authors: J. N. King, C. Christinaz, G. Strehlau, J. Hornfeld Tags: SHORT COMMUNICATION Source Type: research
IGF-1R Inhibitor Ameliorates Diabetic Nephropathy with Suppressed HMGN1/TLR4 Pathway.
CONCLUSION: IGF-1R inhibitor might have therapeutic potential in DN through inhibition of HMGN1/TLR4 pathway.
PMID: 29384065 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 30, 2018 Category: Endocrinology Authors: Jiali Y, Jingjing D, Rong D, Yi S, Yingjie N, Fuxun Y, Lima Z, Yan Z Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Astragaloside IV inhibits ventricular remodeling and improves fatty acid utilization in rats with chronic heart failure.
In conclusion, our study shows that AS-IV inhibits ventricular remodeling, improves cardiac function, and decreases FFA concentration of CHF model rats. Our findings suggest a therapeutic potential of using AS-IV in CHF.
PMID: 29301869 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - January 4, 2018 Category: Biomedical Science Authors: Tang B, Zhang JG, Tan HY, Wei XQ Tags: Biosci Rep Source Type: research
24 Danggui shaoyao powder improves diabetic nephropathy without altering blood glucose in streptozotocin-induced diabetic rats
ConclusionThis study suggests that DSS could improve renal function in streptozotocin-induced DN model rats. The mechanism may be related to regulating the Th1/Th2 cell balance and improved lipid metabolism in DN rats.AcknowledgmentSupported by a project grant from The National Natural Science Foundation of China (Grant No. 81603527), Science and technology project of Henan Province (Grant No. 162102310466), Key scientific research projects of Henan Province Colleges and Universities (Grant No. 16A360010), Henan University of Traditional Chinese Medicine Scientific and technological innovation talent support program (Grant...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Li, X., Li, Z., Zhang, L., Zhang, Y., Liu, X., Zhao, X., Liu, W., Gao, A. Tags: Abstracts Source Type: research
24 Danggui shaoyao powder improves diabetic nephropathy without altering blood glucose in streptozotocin-induced diabetic rats
Conclusion
This study suggests that DSS could improve renal function in streptozotocin-induced DN model rats. The mechanism may be related to regulating the Th1/Th2 cell balance and improved lipid metabolism in DN rats.
Acknowledgment
Supported by a project grant from The National Natural Science Foundation of China (Grant No. 81603527), Science and technology project of Henan Province (Grant No. 162102310466), Key scientific research projects of Henan Province Colleges and Universities (Grant No. 16A360010), Henan University of Traditional Chinese Medicine Scientific and technological innovation talent support program (G...
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Li, X., Li, Z., Zhang, L., Zhang, Y., Liu, X., Zhao, X., Liu, W., Gao, A. Tags: Abstracts Source Type: research
Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression
This study aimed to investigate the effects of benazepril hydrochloride (BH) on proteinuria and ANGPTL-4 expression in a diabetic nephropathy (DN) rat model. (Source: BMC Nephrology)
Source: BMC Nephrology - October 4, 2017 Category: Urology & Nephrology Authors: Lingyu Xue, Xiaoqing Feng, Chuanhai Wang, Xuebin Zhang, Wenqiang Sun and Kebo Yu Tags: Research article Source Type: research
A positive association between the human tissue kallikerin gene A2233C polymorphism and blood pressure response to benazepril.
CONCLUSION: Our findings suggest that the A2233C polymorphism of KLK1 may be a marker of evaluation of hypertensive subjects' responses to angiotensin I converting enzyme inhibitors benazepril.
PMID: 28621557 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 16, 2017 Category: Cardiology Authors: Hong Z, Pan L, Fei J, Ma Z, Hong Z Tags: Clin Exp Hypertens Source Type: research
Safety of a benazepril and pimobendan combination tablet in adult healthy dogs
In conclusion, Fortekor PLUS® tablets were well tolerated in healthy adult dogs when administered at one, two, and four times the highest recommended dosage for 6 months. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - June 1, 2017 Category: Veterinary Research Authors: E. A. Kuntz, G. Strehlau, J. M. Giraudel, J. N. King Tags: ORIGINAL ARTICLE Source Type: research
