Development of a Digital Interface for Personalized Dosing in Renal Impaired Patients: A Case-Study Using the ACE-Inhibitor Benazepril
CONCLUSION: The use of the models via a practical user interface can help inform clinical decisions and design optimal dosing based on the individual anthropometric characteristics and stage of renal impairment.PMID:37172168 | DOI:10.3233/SHTI230027 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - May 12, 2023 Category: Information Technology Authors: Valerie Reinisch Amrit Paudel Joana T Pinto Source Type: research
Metabolomics reveal the mechanism for anti-renal fibrosis effects of an < em > n < /em > -butanol extract from < em > Amygdalus mongolica < /em >
Acta Pharm. 2022 Apr 13;72(3):437-448. doi: 10.2478/acph-2022-0023. Print 2022 Sep 1.ABSTRACTTo reveal the mechanism of anti-renal fibrosis effects of an n-butanol extract from Amygdalus mongolica, renal fibrosis was induced with unilateral ureteral obstruction (UUO) and then treated with an n-butanol extract (BUT) from Amygdalus mongolica (Rosaceae). Sixty male Sprague-Dawley rats were randomly divided into the sham-operated, renal fibrosis (RF) model, benazepril hydrochloride-treated model (1.5 mg kg-1) and BUT-treated (1.75, 1.5 and 1.25 g kg-1) groups and the respective drugs were administered intragastrically for 21 d...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Chen Gao Hong Chang Hong-Bing Zhou Qing Liu Ying-Chun Bai Quan-Li Liu Wan-Fu Bai Song-Li Shi Source Type: research
