Su328 A SUSPECTED CASE OF BENAZEPRIL-HYDROCHLOROTHIAZIDE INDUCING AUTOIMMUNE HEPATITIS
(Source: Gastroenterology)
Source: Gastroenterology - May 1, 2021 Category: Gastroenterology Authors: Shaleen Vasavada, Sadhna Dhingra, Rise Stribling, Neeraj Agrawal Tags: AASLD Abstracts Source Type: research
Combination of LCZ696 and ACEI further improves heart failure and myocardial fibrosis after acute myocardial infarction in mice.
CONCLUSIONS: LCZ696 in combination with benazepril showed better positive effects in modulating heart failure and myocardial fibrosis after acute AMI in mice and affect some inflammatory markers.
PMID: 33378988 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 1, 2021 Category: Drugs & Pharmacology Authors: Liu Y, Fan Y, Li J, Chen M, Chen A, Yang D, Guan X, Cao Y Tags: Biomed Pharmacother Source Type: research
A sensitive and efficient LC-MS/MS method for the bioanalysis of Fosinopril diacid from human plasma and its application for a bioequivalence study in humans.
Abstract
Fosinopril diacid is an ACE inhibitor with efficient anti-hypertensive action. It is the active metabolic product formed in the body on hydrolysis of its prodrug Fosinopril. A sensitive, rapid method with high recovery for Fosinopril diacid from human plasma was developed. Solid phase extraction technique employing Waters Oasis SPE cartridges gave clean samples with very high recovery of 97%. The analyte along with its internal standard (Benazepril hydrochloride) were chromatographed on XTerra RP8 column (4.6 x 50 mm, 5μm) using Methanol- Ammonium acetate buffer (10 mM) (90:10, v/v) as the mobile...
Source: Biomedical Chromatography : BMC - December 22, 2020 Category: Biomedical Science Authors: Bhende SD, Varanasi MB, Abbulu K Tags: Biomed Chromatogr Source Type: research
Cardiovascular Benefits of Angiotensin Converting Enzyme Inhibition plus Calcium Channel Blockade in Patients Achieving Tight Blood Pressure Control and with Resistant Hypertension.
CONCLUSIONS: Combination therapy adding a calcium channel blocker, rather than hydrochlorothiazide, to an angiotensin converting enzyme inhibitor was more effective in preventing composite cardiovascular events even in hypertensive patients achieving aggressive systolic blood pressure targets as well as in those with apparent resistant hypertension. Our findings add support that most patients, including those following contemporary clinical guidelines, will benefit from this combination.
TRIAL REGISTRATION: ClinicalTrials.gov, NCT00170950.
PMID: 33216879 [PubMed - as supplied by publisher] (Source: American...
Source: American Journal of Hypertension - November 20, 2020 Category: Cardiology Authors: Brook RD, Kaciroti N, Bakris G, Dahlöf B, Pitt B, Velazquez E, Weber MA, Jamerson KA, ACCOMPLISH investigators Tags: Am J Hypertens Source Type: research
Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats.
CONCLUSIONS Chrysophanol improved cardiac functions and protected against myocardial damage, apoptosis, OS, and inflammation by inhibiting activation of the JNK1/2 pathway in AHF rat models. These finding indicate that chrysophanol may be a promising approach for treatment of AHF.
PMID: 33044948 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Safety implications of combining ACE inhibitors with thiazides for the treatment of hypertensive patients.
Authors: Borghi C, Soldati M, Bragagni A, Cicero AFG
Abstract
INTRODUCTION: ACE-inhibitors (ACEI) and diuretics are the typical first-line antihypertensive drugs with complementary mechanisms of action. The present paper is summarizing the evidence supporting the efficacy of their combination in a broad range of hypertensive patients.
AREAS COVERED: This source of data are different trials investigating the use of ACEI and diuretics in different populations of patients. The available evidence supports some advantage for thiazide-type compounds (chlortalidone-CHT and indapamide-IND) in the preventio...
Source: Expert Opinion on Drug Safety - October 15, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Postnatal renin-angiotensin system inhibition prevents renal damage from prenatal inflammation in rats.
CONCLUSION: Together with our previous findings that postnatal inhibition of nuclear factor-kappa B activation blocks intra-renal renin-angiotensin system activation, our current data demonstrate that intra-renal activation of the renin-angiotensin system interacts with nuclear factor-kappa B activation to cause renal damage in adulthood following prenatal inflammation.
PMID: 32744032 [PubMed - in process] (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - July 31, 2020 Category: Complementary Medicine Authors: Guo W, Ji Y, Han Q, Yang Y, Wang F, Yang Y, Deng Y, Sun X, Li X Tags: J Tradit Chin Med Source Type: research
Wenyang Lishui Decoction Ameliorates Podocyte Injury in Membranous Nephropathy Rat and Cell Models by Regulating p53 and Bcl-2.
In conclusion, WYD could reduce proteinuria and ameliorate podocyte injury by regulating the expression of p53 and Bcl-2. The study is registered in the Chinese Clinical Trial Registry (ChiCTR-OCH-14005137).
PMID: 32454867 [PubMed - as supplied by publisher] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 27, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
DELay of appearance of sYmptoms of canine degenerative mitral valve disease treated with spironolactone and benazepril: The DELAY study
ConclusionsThis study failed in demonstrating that combined administration of spironolactone and benazepril delays onset of HF in dogs with preclinical MMVD. However, such treatment induces beneficial effects on cardiac remodeling and these results could be of clinical relevance. (Source: Journal of Veterinary Cardiology)
Source: Journal of Veterinary Cardiology - January 11, 2020 Category: Veterinary Research Source Type: research
Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition.
In conclusion, TXL attenuates MF after AMI by inhibiting EndMT and through activating the NRG-1/ErbB- PI3K/AKT signalling cascade.
PMID: 31317035 [PubMed - indexed for MEDLINE] (Source: Biomed Res)
Source: Biomed Res - December 21, 2019 Category: Research Authors: Yin Y, Zhang Q, Zhao Q, Ding G, Wei C, Chang L, Li H, Bei H, Wang H, Liang J, Jia Z Tags: Biomed Res Int Source Type: research
Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF- κB, TGF-β and TRPC6.
Conclusion: The combination use of leflunomide and benazepril could improve the renal function and reduce the renal injury of DN rats and could reduce the levels of NF-κb, TGF-β and TRPC6 in both DN rats and high-glucose induced RMCs.
PMID: 31552773 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Efficacy of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Preventative Treatment of Episodic Migraine in Adults
AbstractPurpose of ReviewSystematic review of angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARB) in the prophylactic treatment of adults with migraine. To identify gaps in research and provide guidance for future clinical trials.Recent FindingsA search was completed using PubMed, MEDLINE, Embase, and the Cochrane Library January 1, 1990 through December 31, 2017. The following are keywords used in the search: migraine, migraine prophylaxis/prevention, renin-angiotensin-aldosterone system, RAAS, ACE inhibitors, angiotensin-converting enzyme inhibitors: quinapril, perindopril, r...
Source: Current Pain and Headache Reports - September 11, 2019 Category: Neurology Source Type: research
