Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice
ConclusionTXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 22, 2024 Category: Internal Medicine Source Type: research

Effect of azilsartan on myocardial remodeling after acute myocardial infarction
ConclusionsAzilsartan can improve myocardial remodeling after acute myocardial infarction. CTRP1 may become an effective target for the prevention and treatment of myocardial remodeling after acute myocardial infarction. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 22, 2023 Category: Drugs & Pharmacology Source Type: research

Re-Purposing FDA-Approved Drugs for Opioid Use Disorder
CONCLUSION: These results provide medication options that may be useful in treating OUD as well as integrated therapies to treat comorbid mental illness.PMID:37584436 | DOI:10.1080/10826084.2023.2247071 (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - August 16, 2023 Category: Addiction Authors: Krishna Patel David Waldron Nicholas Graziane Source Type: research

Molecules, Vol. 28, Pages 5938: Utilizing Proteomic Approaches to Uncover the Neuroprotective Effects of ACE Inhibitors: Implications for Alzheimer & rsquo;s Disease Treatment
Molecules, Vol. 28, Pages 5938: Utilizing Proteomic Approaches to Uncover the Neuroprotective Effects of ACE Inhibitors: Implications for Alzheimer’s Disease Treatment Molecules doi: 10.3390/molecules28165938 Authors: Ming-Hui Yang Tzu-Chuan Ho Chin-Chuan Chang Yuh-Shan Su Cheng-Hui Yuan Kuo-Pin Chuang Yu-Chang Tyan Two types of angiotensin-converting enzyme (ACE) inhibitors, lisinopril and benazepril HCl, were tested in neuroblastoma cells and found to upregulate low-density lipoprotein-receptor-related protein 1B (LRP1B) and 14-3-3 protein zeta/delta. Additionally, benazepril HCl was found t...
Source: Molecules - August 8, 2023 Category: Chemistry Authors: Ming-Hui Yang Tzu-Chuan Ho Chin-Chuan Chang Yuh-Shan Su Cheng-Hui Yuan Kuo-Pin Chuang Yu-Chang Tyan Tags: Article Source Type: research

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease
CONCLUSIONS: There is currently insufficient evidence to determine the effectiveness of ACEi or ARB in patients with stage 1 to 3 CKD who do not have DM. The available evidence is overall of very low certainty and high risk of bias. We have identified an area of large uncertainty for a group of patients who account for most of those diagnosed as having CKD.PMID:37466151 | DOI:10.1002/14651858.CD007751.pub3 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - July 19, 2023 Category: General Medicine Authors: Tess E Cooper Claris Teng David J Tunnicliffe Brydee A Cashmore Giovanni Fm Strippoli Source Type: research

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease
CONCLUSIONS: There is currently insufficient evidence to determine the effectiveness of ACEi or ARB in patients with stage 1 to 3 CKD who do not have DM. The available evidence is overall of very low certainty and high risk of bias. We have identified an area of large uncertainty for a group of patients who account for most of those diagnosed as having CKD.PMID:37466151 | PMC:PMC10355090 | DOI:10.1002/14651858.CD007751.pub3 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - July 19, 2023 Category: General Medicine Authors: Tess E Cooper Claris Teng David J Tunnicliffe Brydee A Cashmore Giovanni Fm Strippoli Source Type: research

Baicalin Reduces Renal Inflammation in Mesangial Proliferative Glomerulonephritis through Activation of Nrf2/ARE and PI3K/AKT Pathways
CONCLUSIONS: Baicalin can mitigate MPGN by impeding the proliferation and inflammation of mesangial cells by activating Nrf2/ARE and PI3K/AKT pathways.PMID:37272104 | DOI:10.24976/Discov.Med.202335176.38 (Source: Discovery Medicine)
Source: Discovery Medicine - June 5, 2023 Category: Research Authors: Xiaoyuan Ning Dongping Luo Yong Chen Yeqing Shao Jiayun Xu Source Type: research