Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats.
CONCLUSIONS Chrysophanol improved cardiac functions and protected against myocardial damage, apoptosis, OS, and inflammation by inhibiting activation of the JNK1/2 pathway in AHF rat models. These finding indicate that chrysophanol may be a promising approach for treatment of AHF. PMID: 33044948 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Safety implications of combining ACE inhibitors with thiazides for the treatment of hypertensive patients.
Authors: Borghi C, Soldati M, Bragagni A, Cicero AFG Abstract INTRODUCTION: ACE-inhibitors (ACEI) and diuretics are the typical first-line antihypertensive drugs with complementary mechanisms of action. The present paper is summarizing the evidence supporting the efficacy of their combination in a broad range of hypertensive patients. AREAS COVERED: This source of data are different trials investigating the use of ACEI and diuretics in different populations of patients. The available evidence supports some advantage for thiazide-type compounds (chlortalidone-CHT and indapamide-IND) in the prevention of major CV...
Source: Expert Opinion on Drug Safety - October 15, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Postnatal renin-angiotensin system inhibition prevents renal damage from prenatal inflammation in rats.
CONCLUSION: Together with our previous findings that postnatal inhibition of nuclear factor-kappa B activation blocks intra-renal renin-angiotensin system activation, our current data demonstrate that intra-renal activation of the renin-angiotensin system interacts with nuclear factor-kappa B activation to cause renal damage in adulthood following prenatal inflammation. PMID: 32744032 [PubMed - in process] (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - July 31, 2020 Category: Complementary Medicine Authors: Guo W, Ji Y, Han Q, Yang Y, Wang F, Yang Y, Deng Y, Sun X, Li X Tags: J Tradit Chin Med Source Type: research

Wenyang Lishui Decoction Ameliorates Podocyte Injury in Membranous Nephropathy Rat and Cell Models by Regulating p53 and Bcl-2.
In conclusion, WYD could reduce proteinuria and ameliorate podocyte injury by regulating the expression of p53 and Bcl-2. The study is registered in the Chinese Clinical Trial Registry (ChiCTR-OCH-14005137). PMID: 32454867 [PubMed - as supplied by publisher] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 27, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

DELay of appearance of sYmptoms of canine degenerative mitral valve disease treated with spironolactone and benazepril: The DELAY study
Publication date: Available online 10 January 2020Source: Journal of Veterinary CardiologyAuthor(s): M. Borgarelli, L. Ferasin, K. Lamb, C. Bussadori, D. Chiavegato, G. D’Agnolo, F. Migliorini, M. Poggi, R.A. Santilli, E. Guillot, C. Garelli-Paar, Pharm.D, R. Toschi Corneliani, F. Farina, A. Zani, M. Dirven, P. Smets, C. Guglielmini, P. Oliveira, M. Di Marcello, F. PorcielloAbstractIntroductionEfficacy of renin-angiotensin-aldosterone system (RAAS) blockade using angiotensin converting enzyme inhibitors (ACEi) in dogs with preclinical myxomatous mitral valve disease (MMVD) is controversial.HypothesisAdministration of...
Source: Journal of Veterinary Cardiology - January 11, 2020 Category: Veterinary Research Source Type: research

Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition.
In conclusion, TXL attenuates MF after AMI by inhibiting EndMT and through activating the NRG-1/ErbB- PI3K/AKT signalling cascade. PMID: 31317035 [PubMed - indexed for MEDLINE] (Source: Biomed Res)
Source: Biomed Res - December 21, 2019 Category: Research Authors: Yin Y, Zhang Q, Zhao Q, Ding G, Wei C, Chang L, Li H, Bei H, Wang H, Liang J, Jia Z Tags: Biomed Res Int Source Type: research

Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF- κB, TGF-β and TRPC6.
Conclusion: The combination use of leflunomide and benazepril could improve the renal function and reduce the renal injury of DN rats and could reduce the levels of NF-κb, TGF-β and TRPC6 in both DN rats and high-glucose induced RMCs. PMID: 31552773 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - September 27, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Efficacy of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Preventative Treatment of Episodic Migraine in Adults
AbstractPurpose of ReviewSystematic review of angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARB) in the prophylactic treatment of adults with migraine. To identify gaps in research and provide guidance for future clinical trials.Recent FindingsA search was completed using PubMed, MEDLINE, Embase, and the Cochrane Library January 1, 1990 through December 31, 2017. The following are keywords used in the search: migraine, migraine prophylaxis/prevention, renin-angiotensin-aldosterone system, RAAS, ACE inhibitors, angiotensin-converting enzyme inhibitors: quinapril, perindopril, r...
Source: Current Pain and Headache Reports - September 11, 2019 Category: Neurology Source Type: research

Influence of Side-Chain Length on Long-Term Release Kinetics from Poly(2-oxazoline)-Drug Conjugate Networks
Publication date: Available online 29 August 2019Source: European Polymer JournalAuthor(s): Jong-Ryul Park, Joachim F.R. Van Guyse, Annelore Podevyn, Eleonore Bolle, Nathalie Bock, Erik Linde, Mathew Celina, Richard Hoogenboom, Tim R. DargavilleAbstractFour drug-conjugated poly(2-alkyl-2-oxazoline) (PAOx) networks with different hydrophobicity were synthesized via copolymerization of either 2-methyl-, 2-ethyl-, 2-propyl- or 2-butyl-2-oxazoline with the functional monomer, 2-dec-9-enyl-2-oxazoline. The incorporation of a labile ester linkage between the polymer and the drug benazepril allowed for sustained drug release over...
Source: European Polymer Journal - September 5, 2019 Category: Chemistry Source Type: research

Zhengganxifeng Decoction Affects Gut Microbiota and Reduces Blood Pressure via Renin-Angiotensin System.
This study investigated the composition of gut microbiota in spontaneously hypertensive rats (SHR) treated with ZGXFD. ZGXFD was shown to cause similar effects in the treatment group as benazepril: both were able to reduce in SHR the microbial diversity, Firmicutes to Bacteroidetes (F/B) ratio and coccus to bacillus (C/B) ratio. Meanwhile, ZGXFD can maintain the integrity of intestinal mechanistic barrier and elevate the percentage of bacteria producing short chain fatty acids (SCFA). By investigating renin-angiotensin system (RAS) system, we found that ZGXFD can decrease the expression of angiotensin-converting-enzyme (AC...
Source: Biological and Pharmaceutical Bulletin - September 3, 2019 Category: Drugs & Pharmacology Authors: Yu X, Zhang X, Jin H, Wu Z, Yan C, Liu Z, Xu X, Liu S, Zhu F Tags: Biol Pharm Bull Source Type: research

Effect of shenyan xiaobai granule on nephrin and podocin of adriamycin-induced renal injury: A randomised controlled trial
ConclusionsThe therapeutic effect of ShenYanXiaoBai high dose group was better than the two other treated groups from the 5th week to the 7th week, the comparison had a significant difference. The therapeutic effect of benazepril group was better than the ShenYanXiaoBai low dose group in the 7 weeks and the comparison had a significant difference.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

IGF-1/IGF-1R blockade ameliorates diabetic kidney disease through normalizing Snail1 expression in a mouse model.
This study investigated the role of insulin-like growth factor-1/insulin-like growth factor-1 receptor (IGF-1/IGF-1R) in the genesis and progression of diabetic kidney disease (DKD) in a streptozocin (STZ)-induced mouse diabetes model. We show elevated IGF-1 expression in the DKD kidneys after 16 weeks of diabetic onset. Intraperitoneal administration of IGF-1R inhibitor (GSK4529) from weeks 8 to 16 post-diabetes induction ameliorated urinary albumin excretion and kidney histological changes due to diabetes, including amelioration of glomerulomegaly, inflammatory infiltration, and tubulointerstitial fibrosis. The GSK4529 t...
Source: Am J Physiol Endocri... - July 29, 2019 Category: Endocrinology Authors: Dong R, Yu J, Yu F, Yang S, Qian Q, Zha Y Tags: Am J Physiol Endocrinol Metab Source Type: research

[Effect of traditional Chinese medicine for replenishing qi, nourishing yin and activating blood on renal Notch/Hes1 signaling in rats with diabetic nephropathy].
CONCLUSIONS: The Traditional Chinese medicine (TCM) capsule for replenishing qi, nourishing yin and activating blood can reduce Hes1, CD34 and CD144 in kidney tissue of model rats, play a protective role on kidney function and delay the development of DN. PMID: 31340921 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - July 27, 2019 Category: Universities & Medical Training Authors: Zhou X, Xu C, Wang K, Chu Q, Dong C, Wu C, Zhao J, Li L, Wang L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

A new strategy for taste masking on bitter drug by other combined drug in fixed ‐dose combination: bitterness of Amlodipine besylate could be masked efficiently by Valsartan
ConclusionsIt was suggested that when VAL was mixed with AML, the electrostatic interactions between positive charged amino group of AML and negative charged tetrazole group of VAL were caused, and thereby led the suppression the bitterness of AML. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 4, 2019 Category: Drugs & Pharmacology Authors: Honami Kojima, Saki Nakamura, Tamami Haraguchi, Miyako Yoshida, Masaaki Habara, Hidekazu Ikezaki, Takahiro Uchida Tags: Research Paper Source Type: research

High-Mobility Group Nucleosome-Binding Protein 1 Mediates Renal Fibrosis Correlating with Macrophages Accumulation and Epithelial-to-Mesenchymal Transition in Diabetic Nephropathy Mice Model
Conclusion: HMGN1 may promote macrophages accumulation and EMT, suggesting a potential therapeutic target for preventing renal fibrosis development in DN.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 14, 2019 Category: Urology & Nephrology Source Type: research

Real-World Data Approaches for Early Detection of Potential Safety and Effectiveness Signals for Generic Substitution: A Metoprolol Extended-Release Case Study.
This study used metoprolol succinate extended release as a historic case example from which to develop an analytic framework. The US Food and Drug Administration Adverse Event Reporting System was utilized for disproportionality analyses and to identify outcomes of interest. Claims data were analyzed for generic uptake, proportion of prescriptions with "dispense as written" orders, time to discontinuation or switching, and relative rates of clinical events. Adverse Event Reporting System data showed that the Medical Dictionary for Regulatory Activities terms for product quality were higher for generic metoprolol ...
Source: The Journal of Clinical Pharmacology - May 13, 2019 Category: Drugs & Pharmacology Authors: Brown JD, Henriksen C, Vozmediano V, Schmidt S Tags: J Clin Pharmacol Source Type: research

Surgical valvulotomy for tricuspid valve stenosis in a dog
Publication date: Available online 26 April 2019Source: Journal of Veterinary CardiologyAuthor(s): P. Bristow, A. Kurosawa, V.L. Fuentes, L. Rutherford, D. BrockmanAbstractA 2-year, 4-month-old neutered female Labrador retriever was brought for evaluation of right-sided congestive heart failure. Echocardiographic examination revealed tricuspid valve dysplasia with only two small orifices in the valve resulting in severe tricuspid stenosis. The dog underwent a right fifth lateral intercostal thoracotomy and surgical tricuspid valvulotomy, under cardiopulmonary bypass. The stenosis was relieved by dividing the valve leaflets...
Source: Journal of Veterinary Cardiology - May 13, 2019 Category: Veterinary Research Source Type: research

Surgical management of tricuspid valve stenosis in a dog
Publication date: Available online 26 April 2019Source: Journal of Veterinary CardiologyAuthor(s): Poppy Bristow, Anne Kurosawa, Virginia Luis Fuentes, Lynda Rutherford, Dan BrockmanAbstractA 2 year 4 month old female neutered Labrador retriever was presented for evaluation right sided congestive heart failure. Echocardiographic examination revealed tricuspid valve dysplasia with only two small orifices in the valve resulting in severe tricuspid stenosis. The dog underwent a right fifth lateral intercostal thoracotomy and surgical tricuspid valvulotomy, under cardiopulmonary bypass. The stenosis was relieved by dividing th...
Source: Journal of Veterinary Cardiology - April 27, 2019 Category: Veterinary Research Source Type: research

Danggui Shaoyao San Ameliorates Renal Fibrosis via Regulation of Hypoxia and Autophagy.
In this study, we evaluated the effect of DSS on unilateral ureteral obstruction- (UUO-) induced renal fibrosis in rats and investigated the mechanisms underlying the effect. Sprague Dawley (SD) rats were randomized to UUO or Sham operation. After 1 day, the rats that underwent UUO were randomized to treatment for four experimental groups (n=10 each group): Sham, UUO only, UUO+ benazepril (Bena), and UUO+DSS. After 4 weeks, we demonstrated that DSS significantly suppressed UUO-induced renal hypertrophy by gravimetric. In addition, DSS obviously prevented UUO-induced disorder in renal structure and renal function by HE and ...
Source: Evidence-based Complementary and Alternative Medicine - April 24, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Qiaoling Li, Jie Tu, Benhong ZhouAbstractTotal tannins from Punica granatum L (TPG) was obtained by aqueous-acetone extraction and was abundant in punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, this study was to investigate the protective role of TPG on the kidney in focal segmental glomerulosclerosis (FSGS) rats. In the present study, the glomerulosclerosis model was established by nephrectomy and injection of Adriamycin. The rats were treated with TPG and...
Source: Journal of Functional Foods - April 22, 2019 Category: Nutrition Source Type: research

Comparative effectiveness of generic and brand-name medication use: A database study of US health insurance claims
ConclusionsIn this study, we observed that use of generics was associated with comparable clinical outcomes to use of brand-name products. These results could help in promoting educational interventions aimed at increasing patient and provider confidence in the ability of generic medicines to manage chronic diseases. (Source: PLoS Medicine)
Source: PLoS Medicine - March 12, 2019 Category: Internal Medicine Authors: Rishi J. Desai Source Type: research

JYYS Granule Mitigates Renal Injury in Clinic and in Spontaneously Hypertensive Rats by Inhibiting NF- κB Signaling-Mediated Microinflammation.
Conclusion: JYYS is a promising prescription of Chinese medicine for patients with hypertension and hypertensive renal damage. PMID: 30598687 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - January 3, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Iridium/f-Amphox-Catalyzed Asymmetric Hydrogenation of Styrylglyoxylamides
We report an iridium-catalyzed asymmetric hydrogenation reaction for the preparation of chiral homophenylalanine derivatives. Catalyzed by an iridium/f-amphox complex, the asymmetric hydrogenation of styrylglyoxylamides was conducted smoothly with turnover numbers of up to 10,000 and up to 98% ee. This method was successfully applied in a synthesis of a fragment of benazepril, a drug used for the treatment of high blood pressure. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Synlett)
Source: Synlett - August 20, 2018 Category: Chemistry Authors: Wang, Simin Yu, Yuena Wen, Jialin Zhang, Xumu Tags: letter Source Type: research

Simultaneous ultraperformance liquid chromatography/tandem mass spectrometry determination of four antihypertensive drugs in human plasma using hydrophilic-lipophilic balanced reversed phase sorbents sample preparation protocol.
In conclusion, the present study revealed method selectivity and sensitivity; it can be applied for estimation of ACEI and HCT in human plasma for dose adjustment and therapeutic drug monitoring. PMID: 30109716 [PubMed - as supplied by publisher] (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - August 14, 2018 Category: Biomedical Science Authors: Mahrouse MA Tags: Biomed Chromatogr Source Type: research

The Effect and Mechanism of Chinese Herbal Formula Sini Tang in Heart Failure after Myocardial Infarction in Rats.
Authors: Zhu Y, Zhao J, Han Q, Wang Z, Wang Z, Dong X, Li J, Liu L, Shen X Abstract Objective: To investigate the effectiveness and mechanism of the Chinese herbal formula Sini Tang (SNT) which consists of Aconitum carmichaelii (Fuzi), Zingiber officinale (Gan Jiang), and Glycyrrhiza uralensis (Gancao) in heart failure after myocardial infarction in rats. Methods: We established the heart failure after myocardial infarction in model of SD rats by ligating the anterior descending branch of left coronary artery. Rats were randomly divided into six experimental groups: Sham operation group, HF group, Benazepril gr...
Source: Evidence-based Complementary and Alternative Medicine - July 30, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Transient myocardial thickening in a Bartonella henselae–positive cat
Publication date: June 2018Source: Journal of Veterinary Cardiology, Volume 20, Issue 3Author(s): J.L. Joseph, E.M. Oxford, R.A. SantilliAbstractA 3-year-old castrated male domestic shorthair presented to the Cornell University Hospital for Animals for acute onset respiratory distress. Thoracic radiographs, echocardiogram, and electrocardiogram (ECG) revealed left-sided congestive heart failure, myocardial thickening with left atrial dilation, and sinus rhythm conducted with a left bundle branch block, respectively. Cardiac troponin I was elevated and continued to increase over 36 h (1.9 ng/mL, 3.1 ng/mL, an...
Source: Journal of Veterinary Cardiology - July 10, 2018 Category: Veterinary Research Source Type: research

Transient myocardial thickening in a Bartonella henselae –positive cat
Publication date: Available online 2 May 2018 Source:Journal of Veterinary Cardiology Author(s): J.L. Joseph, E.M. Oxford, R.A. Santilli A 3-year-old castrated male domestic shorthair presented to the Cornell University Hospital for Animals for acute onset respiratory distress. Thoracic radiographs, echocardiogram, and electrocardiogram (ECG) revealed left-sided congestive heart failure, myocardial thickening with left atrial dilation, and sinus rhythm conducted with a left bundle branch block, respectively. Cardiac troponin I was elevated and continued to increase over 36 h (1.9 ng/mL, 3.1 ng/mL, and 3.5&n...
Source: Journal of Veterinary Cardiology - May 29, 2018 Category: Veterinary Research Source Type: research

Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat.
Authors: Geng J, Yu X, Liu C, Sun C, Guo M, Li Z, Jin Y, Zou Y, Yu J Abstract Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout the world; until now there is no specific drug available. In this work, we use herba artemisiae capillaris extract (HACE) to alleviate renal fibrosis characterized by the excessive accumulation of extracellular matrix (ECM) in rats, aiming to investigate the protective effect of the HACE on DN. We found that the intragastric treatment of high-dose HACE could reverse the effect of streptozotocin not only to decrease the level of blood glucose and blood lipid i...
Source: Evidence-based Complementary and Alternative Medicine - April 11, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of benazepril and pimobendan on serum angiotensin ‐converting enzyme activity in dogs
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 2, 2018 Category: Veterinary Research Source Type: research

Effect of benazepril and pimobendan on serum angiotensin ‐converting enzyme activity in dogs
In conclusion, 0.25–0.5 mg/kg benazepril administered BID produced noninferior inhibition of serum ACE activity compared to 0.5–1.0 mg/kg benazepril dosed SID. Pimobendan had no significant effect on benazepril's action on serum ACE activity. The results support the use of benazepril BID in dogs and in combination with pimobendan. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - February 1, 2018 Category: Veterinary Research Authors: J. N. King, C. Christinaz, G. Strehlau, J. Hornfeld Tags: SHORT COMMUNICATION Source Type: research

IGF-1R Inhibitor Ameliorates Diabetic Nephropathy with Suppressed HMGN1/TLR4 Pathway.
CONCLUSION: IGF-1R inhibitor might have therapeutic potential in DN through inhibition of HMGN1/TLR4 pathway. PMID: 29384065 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 30, 2018 Category: Endocrinology Authors: Jiali Y, Jingjing D, Rong D, Yi S, Yingjie N, Fuxun Y, Lima Z, Yan Z Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Astragaloside IV inhibits ventricular remodeling and improves fatty acid utilization in rats with chronic heart failure.
In conclusion, our study shows that AS-IV inhibits ventricular remodeling, improves cardiac function, and decreases FFA concentration of CHF model rats. Our findings suggest a therapeutic potential of using AS-IV in CHF. PMID: 29301869 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - January 4, 2018 Category: Biomedical Science Authors: Tang B, Zhang JG, Tan HY, Wei XQ Tags: Biosci Rep Source Type: research

24 Danggui shaoyao powder improves diabetic nephropathy without altering blood glucose in streptozotocin-induced diabetic rats
ConclusionThis study suggests that DSS could improve renal function in streptozotocin-induced DN model rats. The mechanism may be related to regulating the Th1/Th2 cell balance and improved lipid metabolism in DN rats.AcknowledgmentSupported by a project grant from The National Natural Science Foundation of China (Grant No. 81603527), Science and technology project of Henan Province (Grant No. 162102310466), Key scientific research projects of Henan Province Colleges and Universities (Grant No. 16A360010), Henan University of Traditional Chinese Medicine Scientific and technological innovation talent support program (Grant...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Li, X., Li, Z., Zhang, L., Zhang, Y., Liu, X., Zhao, X., Liu, W., Gao, A. Tags: Abstracts Source Type: research

24 Danggui shaoyao powder improves diabetic nephropathy without altering blood glucose in streptozotocin-induced diabetic rats
Conclusion This study suggests that DSS could improve renal function in streptozotocin-induced DN model rats. The mechanism may be related to regulating the Th1/Th2 cell balance and improved lipid metabolism in DN rats. Acknowledgment Supported by a project grant from The National Natural Science Foundation of China (Grant No. 81603527), Science and technology project of Henan Province (Grant No. 162102310466), Key scientific research projects of Henan Province Colleges and Universities (Grant No. 16A360010), Henan University of Traditional Chinese Medicine Scientific and technological innovation talent support program (G...
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Li, X., Li, Z., Zhang, L., Zhang, Y., Liu, X., Zhao, X., Liu, W., Gao, A. Tags: Abstracts Source Type: research

Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression
This study aimed to investigate the effects of benazepril hydrochloride (BH) on proteinuria and ANGPTL-4 expression in a diabetic nephropathy (DN) rat model. (Source: BMC Nephrology)
Source: BMC Nephrology - October 4, 2017 Category: Urology & Nephrology Authors: Lingyu Xue, Xiaoqing Feng, Chuanhai Wang, Xuebin Zhang, Wenqiang Sun and Kebo Yu Tags: Research article Source Type: research

A positive association between the human tissue kallikerin gene A2233C polymorphism and blood pressure response to benazepril.
CONCLUSION: Our findings suggest that the A2233C polymorphism of KLK1 may be a marker of evaluation of hypertensive subjects' responses to angiotensin I converting enzyme inhibitors benazepril. PMID: 28621557 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - June 16, 2017 Category: Cardiology Authors: Hong Z, Pan L, Fei J, Ma Z, Hong Z Tags: Clin Exp Hypertens Source Type: research

Safety of a benazepril and pimobendan combination tablet in adult healthy dogs
In conclusion, Fortekor PLUS® tablets were well tolerated in healthy adult dogs when administered at one, two, and four times the highest recommended dosage for 6 months. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - June 1, 2017 Category: Veterinary Research Authors: E. A. Kuntz, G. Strehlau, J. M. Giraudel, J. N. King Tags: ORIGINAL ARTICLE Source Type: research

Clinical and Pathological Findings in 2 Rats (Rattus norvegicus) With Dilated Cardiomyopathy
Two 2-year-old intact female rats (Rattus norvegicus) were presented with severe dyspnea and tachypnea. In rat 1, radiographic evaluation of the thorax revealed severe pleural effusion, and cardiomegaly was suspected, suggesting a severe congestive heart failure. Echocardiography and computed tomography (CT) revealed bilateral pleural effusion, severe dilated cardiomyopathy (DCM), hepatomegaly, and mild abdominal effusion. Thoracocentesis and cytological examination revealed a chylous effusion. The patient was treated with a low-fat diet, octreotide, and medication to treat heart disease (furosemide, benazepril, pimobendan...
Source: Journal of Exotic Pet Medicine - May 6, 2017 Category: Veterinary Research Authors: Sara Dias, Carlo Anselmi, Maria Casanova, Marta Planellas, Jaume Martorell Tags: Brief Communication Source Type: research

Clinical and pathological findings in two rats (rattus norvegicus) with dilated cardiomyopathy
Two 2-year-old intact female rats (Rattus norvegicus) were presented with severe dyspnea and tachypnea. In rat 1, radiographic evaluation of the thorax revealed chronic pleural effusion, and cardiomegaly was suspected, suggesting a severe congestive heart failure. Echocardiography and computed tomography (CT) revealed bilateral pleural effusion, severe dilated cardiomyopathy, hepatomegaly, and mild abdominal effusion. Thoracocentesis and cytological examination revealed a chylous effusion. The patient was treated with a low fat diet, octreotide, and medication to treat heart disease (furosemide, benazepril, pimobendan, and...
Source: Journal of Exotic Pet Medicine - May 6, 2017 Category: Veterinary Research Authors: Sara C. Dias, Carlo Anselmi, Maria I. Casanova, Marta Planellas, Jaume M. Martorell Source Type: research

Effects of Benazepril on Survival of Dogs with Chronic Kidney Disease: A Multicenter, Randomized, Blinded, Placebo ‐Controlled Clinical Trial
Conclusions and Clinical RelevanceBenazepril significantly reduced proteinuria in dogs with CKD. Insufficient numbers of dogs were recruited to allow conclusions on survival time. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - May 1, 2017 Category: Veterinary Research Authors: J.N. King, A. Font, J. ‐F. Rousselot, R.A. Ash, U. Bonfanti, C. Brovida, I.D. Crowe, D. Lanore, D. Pechereau, W. Seewald, G. Strehlau Tags: Standard Article Source Type: research

Systemic arterial hypertension secondary to chronic kidney disease in two captive-born large felids
We describe here the first two cases of spontaneous SHT in large felids, i.e. one 18-year old, 34.4 kg, male North-Chinese leopard (Panthera pardus japonensis, case #1) and one 20-year old, 28.7 kg, female snow leopard (Panthera uncia, case #2), both captive-bred and previously diagnosed with CKD. Both animals underwent complete echocardiographic examination under general anesthesia due to abnormal cardiac auscultation (heart murmur and/or gallop sound), and recurrent lethargy in case #1. The combination of left ventricular remodeling with moderate aortic regurgitation of high velocity was highly suggestive ...
Source: Journal of Veterinary Cardiology - April 21, 2017 Category: Veterinary Research Source Type: research

Protective effects of tacrolimus on podocytes in early diabetic nephropathy in rats.
Authors: Peng T, Chang X, Wang J, Zhen J, Yang X, Hu Z Abstract The aim of the present study was to investigate the protective effect of tacrolimus on early podocyte damage in rats with diabetic nephropathy (DN). A total of 38 normal male Sprague‑Dawley rats were randomly divided into four groups: Normal control group (group N; n=8), DN group (n=10), tacrolimus (FK506) treatment group (group F; n=10), benazepril (Lotensin) treatment group (group L; n=10). The rats in groups DN, F and L were administered with streptozotocin (STZ; 60 mg/kg) by intraperitoneal injection to establish the diabetic rat model. Afte...
Source: Molecular Medicine Reports - March 27, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Effect of triptolide on expression of oxidative carbonyl protein in renal cortex of rats with diabetic nephropathy
This study aimed to provide experimental evidence for triptolide treatment on DN through its effect on the expression of OCP, in order to investigate the effects of triptolide on the expression of OCP in rats with DN. Sixty SD rats were randomly divided into five groups: control group, high-dose triptolide (Th) group, low-dose triptolide (Tl) group, DN model group, and positive control (benazepril) group. The DN model was established using streptozotocin. Urinary protein excretion, fasting blood glucose (FBG), superoxide dismutase (SOD) in renal homogenate, malondialdehyde (MDA) in renal homogenate and renal nitrotyrosine ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 31, 2017 Category: Research Source Type: research

Rapid analysis of drug dissolution by paper spray ionization mass spectrometry
Publication date: 20 March 2017 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 136 Author(s): Yang Liu, Ning Liu, Ya-nan Zhou, Lan Lin, Lan He With a great quantity of solid dosage tested by dissolution technology, developing a rapid and sensitive method to access the content of drug within dissolution media is highly desired by analysts and scientists. Traditionally, dissolution media is not compatible with mass spectrometry since the inorganic salts in the media might damage the mass spectrometer. Here, paper spray ionization mass spectrometry (PSI-MS), one of the ambient mass spectrometry technologies...
Source: Journal of Pharmaceutical and Biomedical Analysis - January 6, 2017 Category: Drugs & Pharmacology Source Type: research

Collagen type III glomerulopathy: case report and review of the literature.
Abstract To summarize the clinical and pathological features of collagen type III glomerulopathy, the present report describes a case of collagen type III glomerulopathy and reviewed more than 60 cases recorded by other groups in English literature over the last few years. A 24-year-old female patient was admitted because of lower limbs edema, without any other discomforts. The lab examination of the patient reported proteinuria (2.42 g/24 h urine), microscopic hematuria, and the serum creatinine was 71 μmol/L. She received renal biopsy. The immunofluorescence staining results showed that collagen type III expr...
Source: Clinical Nephrology - November 29, 2016 Category: Urology & Nephrology Authors: Chen X, Wang H, Xu W, Zhu J Tags: Clin Nephrol Source Type: research

Unilateral absence of the right pulmonary artery with associated aortopulmonary collaterals and bullous lung lesions in a dog
Publication date: Available online 8 September 2016 Source:Journal of Veterinary Cardiology Author(s): S. Birch, D. Casamian-Sorrosal, S. Fonfara, G. Chanoit, C. Warren-Smith This case report describes a combination of congenital cardiopulmonary abnormalities found in a 1-year-old Labrador Retriever. To the authors' knowledge this combination of cardiopulmonary abnormalities has not been previously reported in veterinary medicine. Unilateral absence of the right pulmonary artery associated with unilateral right-sided aortopulmonary collaterals was observed. These aortopulmonary collaterals preserved the blood supply to th...
Source: Journal of Veterinary Cardiology - September 8, 2016 Category: Veterinary Research Source Type: research

Effect of benazepril, robenacoxib and their combination on glomerular filtration rate in cats
The objective of this invest... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - June 23, 2016 Category: Veterinary Research Authors: Jonathan N. King, Alessandro Panteri, Melanie Graille, Wolfgang Seewald, Gabriele Friton and Cyril Desevaux Source Type: research

Effect of benazepril and robenacoxib and their combination on glomerular filtration rate in dogs
The objective of this investigation was to evaluate the effect of benazepril, robenacoxib and their combination in healthy dogs. In each of two studies (studies 1 and 2), 32 beagle dogs were randomized into one of four groups in a parallel‐group design. Groups received once‐daily oral treatment for 7 days with placebo, benazepril, robenacoxib or benazepril plus robenacoxib. In study 2, all dogs received additionally 2 mg/kg furosemide orally twice daily. The primary endpoint was the glomerular filtration rate (GFR) estimated from the plasma clearance of iohexol. Secondary endpoints included standard clinical ...
Source: Journal of Veterinary Pharmacology and Therapeutics - May 31, 2016 Category: Veterinary Research Authors: A. Panteri, A. Kukk, C. Desevaux, W. Seewald, J. N. King Tags: Scientific Paper Source Type: research

Long‐term Outcome of Irish Wolfhound Dogs with Preclinical Cardiomyopathy, Atrial Fibrillation, or Both Treated with Pimobendan, Benazepril Hydrochloride, or Methyldigoxin Monotherapy
Conclusions and Clinical ImportanceIn IW dogs with preclinical DCM, AF or both, pimobendan monotherapy significantly prolonged time to onset of CHF or sudden death than did monotherapy with benazepril HCl or methyldigoxin. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - March 3, 2016 Category: Veterinary Research Authors: A.C. Vollmar, P.R. Fox Tags: Standard Article Source Type: research