Use of computational fluid dynamics to compare upper airway pressures and airflow resistance in brachycephalic, mesocephalic, and dolichocephalic dogs
This study evaluated air pressure and airflow resistance in the upper airways and trachea in nine sedated, sternally recumbent dogs of different skull types (dolichocephalic, n = 3; mesocephalic, n = 3; brachycephalic, n = 3). CT images were acquired from the nostrils to the caudal border of the lungs and geometrical reconstruction of the upper airway and trachea was performed. Analysis of computational fluid dynamics was performed using inspiratory flow adapted to bodyweight for each dog. Flow (L/min) and pressure (cmH2O) were computed for the entire upper airway and trachea. Resi...
Source: The Veterinary Journal - September 29, 2019 Category: Veterinary Research Source Type: research

Short-term surgical outcomes and histomorphological evaluation of thermal injury following palatoplasty performed with diode laser or air plasma device in dogs with brachycephalic airway obstructive syndrome
Publication date: Available online 25 September 2019Source: The Veterinary JournalAuthor(s): R. Tamburro, B. Brunetti, L.V. Muscatello, C. Mantovani, D. De LorenziAbstractBrachycephalic obstructive airway syndrome (BOAS) is a common disorder presenting enlarged soft palate, stenotic nares and abnormal turbinate growth. Surgical correction of BOAS abnormalities with caudal palatoplasty is an elective therapy. This prospective study aimed to compare the effect of an air plasma device and diode laser in dogs undergoing palatoplasty. Outcome measures were as follows: 1) intra-operative and immediate post-operative complication...
Source: The Veterinary Journal - September 27, 2019 Category: Veterinary Research Source Type: research

Thoracic computed tomographic interpretation for clinicians to aid in the diagnosis of dogs and cats with respiratory disease
Publication date: Available online 23 September 2019Source: The Veterinary JournalAuthor(s): Isabelle Masseau, Carol R. ReineroAbstractIn humans, high-resolution computed tomography (CT) is a key diagnostic modality for pulmonary disorders. Its success likely lies in excellent correlation of lung diseases with associated subgross anatomic changes, as assessed by histopathology, and because of a multidisciplinary approach between clinicians, radiologists and pathologists. Although thoracic CT studies have been performed in dogs and cats for nearly three decades, there is a lack of uniformity in both protocols for acquisitio...
Source: The Veterinary Journal - September 24, 2019 Category: Veterinary Research Source Type: research

Editorial Board
Publication date: October 2019Source: The Veterinary Journal, Volume 252Author(s): (Source: The Veterinary Journal)
Source: The Veterinary Journal - September 24, 2019 Category: Veterinary Research Source Type: research

Chemiluminescent ELISA with multi-epitope proteins to improve the diagnosis of canine visceral leishmaniasis
In this study, we adapted a chemiluminescent enzyme-linked immunosorbent assay (CL ELISA), using two multi-epitope recombinant proteins (PQ10 and PQ20) and a crude Leishmania antigen produced using promastigotes of L. infantum, as antigens to detect CVL infection in animals from Belo Horizonte. To investigate cross-reactions, samples from dogs with other infections (babesiosis, ehrlichiosis and Trypanosoma cruzi) were tested. Assay performance validations were conducted to analyse parameters such as variability, reproducibility, and stability.CL ELISA sensitivity/specificity with PQ10 antigen was 93.1%/80.0%; with the PQ20...
Source: The Veterinary Journal - September 23, 2019 Category: Veterinary Research Source Type: research

Discrimination between respiratory and non-respiratory sound waveforms in dogs using acoustic wave recordings: An objective metric of cough
Publication date: Available online 20 September 2019Source: The Veterinary JournalAuthor(s): M. Grobman, T. Lever, C.R. ReineroAbstractCough is an important respiratory protective mechanism, which when persistent also contributes to disease pathology. It is therefore both a marker for and a target of therapeutic intervention. In dogs, assessment of cough is subjective, generally based on owner’s perceptions of clinical signs. In humans, acoustic cough monitoring provides objective data on cough frequency by examining acoustic waveforms. We hypothesized that healthy mesocephalic dogs would demonstrate characteristic c...
Source: The Veterinary Journal - September 21, 2019 Category: Veterinary Research Source Type: research

ABCB1 c.-6-180T > G polymorphism and clinical risk factors in a multi-breed cohort of dogs with refractory idiopathic epilepsy
Publication date: November 2019Source: The Veterinary Journal, Volume 253Author(s): T. Gagliardo, G. Gandini, A. Gallucci, M. Menchetti, E. Bianchi, M.E. Turba, A. Cauduro, D.S. Corlazzoli, S. Gianni, M. Baroni, M. Bernardini, F. GentiliniAbstractEpilepsy is the most common chronic neurological disorder in dogs. Approximately 20–30% of dogs do not achieve satisfactory seizure control with two or more anti-epileptic drugs at appropriate dosages. This condition, defined as refractory epilepsy, is a multifactorial condition involving both acquired and genetic factors. The P glycoprotein might play and important role in ...
Source: The Veterinary Journal - September 21, 2019 Category: Veterinary Research Source Type: research

Placebo-controlled pilot study of the effects of an eggshell membrane-based supplement on mobility and serum biomarkers in dogs with osteoarthritis
Publication date: Available online 13 September 2019Source: The Veterinary JournalAuthor(s): C. Muller, M. Enomoto, A. Buono, J.M. Steiner, B.D.X. LascellesAbstractOsteoarthritis (OA) is a debilitating disease in dogs. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat OA; however, many dogs do not obtain adequate pain relief with an NSAID alone. This pilot study evaluated the systemic anti-inflammatory and mobility enhancing effects of an eggshell membrane-based nutritional supplement in dogs with OA-associated pain and mobility impairment. Twenty-seven dogs with OA-associated pain were enrolled int...
Source: The Veterinary Journal - September 15, 2019 Category: Veterinary Research Source Type: research

Retrospective evaluation of prazosin and diazepam after thoracolumbar hemilaminectomy in dogs
Publication date: Available online 13 September 2019Source: The Veterinary JournalAuthor(s): K.H. Barnes, K.S. Aulakh, C. LiuAbstractManagement of urinary retention after spinal cord injury in dogs is often needed and can include use of medications to relax the urethral sphincter. This was a retrospective study evaluating two such medications, prazosin and diazepam, and whether dogs treated with these medications had different lengths of hospitalization, urinary continence levels, or development of bacteriuria compared to dogs not receiving these medications after thoracolumbar hemilaminectomy for intervertebral disc herni...
Source: The Veterinary Journal - September 15, 2019 Category: Veterinary Research Source Type: research

ABCB1 c.-6-180 T > G polymorphism and clinical risk factors in a multi-breed cohort of dogs with refractory idiopathic epilepsy
Publication date: Available online 12 September 2019Source: The Veterinary JournalAuthor(s): T. Gagliardo, G. Gandini, A. Gallucci, M. Menchetti, E. Bianchi, M.E. Turba, A. Cauduro, D.S. Corlazzoli, S. Gianni, M. Baroni, M. Bernardini, F. GentiliniAbstractEpilepsy is the most common chronic neurological disorder in dogs. Approximately 20-30% of dogs do not achieve satisfactory seizure control with two or more anti-epileptic drugs at appropriate dosages. This condition, defined as refractory epilepsy, is a multifactorial condition involving both acquired and genetic factors. The P glycoprotein might play and important role ...
Source: The Veterinary Journal - September 13, 2019 Category: Veterinary Research Source Type: research

Diffusion of fluoroquinolones into equine fetal fluids did not induce fetal lesions after enrofloxacin treatment in early gestation
Publication date: Available online 7 September 2019Source: The Veterinary JournalAuthor(s): R.E. Ellerbrock, I.F. Canisso, G. Podico, P.J. Roady, E. Uhl, F.S. Lima, Z. LiAbstractWhile recent work has suggested enrofloxacin and ciprofloxacin reach the fetoplacental unit without causing obvious lesions in the 9-month-old equine fetus or resulting foal, many practitioners still hesitate to prescribe a fluoroquinolone during pregnancy. Since early gestation is a critical time for fetal skeletal development, if fluoroquinolones are chondrotoxic to the fetus at any point during gestation, this period would be important. The aim ...
Source: The Veterinary Journal - September 9, 2019 Category: Veterinary Research Source Type: research

Interobserver agreement of an electronic von Frey device for measuring mechanical sensory thresholds in normal dogs
Publication date: Available online 4 September 2019Source: The Veterinary JournalAuthor(s): A.T. Kerns, L.B. Cook, N. Kieves, S.A. MooreAbstractElectronic von Frey aesthesiometry (VFA) has been previously reported as a useful method of mechanical quantitative sensory testing (QST) for evaluating neuropathic pain in dogs. Intraobserver agreement has been shown to be good to excellent; however, interobserver agreement has not been evaluated and is vital to the use of this technique in multicenter veterinary clinical trials in neuropathic pain. The goal of this study was to evaluate the interobserver agreement of sensory thre...
Source: The Veterinary Journal - September 6, 2019 Category: Veterinary Research Source Type: research

Editorial Board
Publication date: September 2019Source: The Veterinary Journal, Volume 251Author(s): (Source: The Veterinary Journal)
Source: The Veterinary Journal - September 4, 2019 Category: Veterinary Research Source Type: research

Publisher's Note
Publication date: September 2019Source: The Veterinary Journal, Volume 251Author(s): (Source: The Veterinary Journal)
Source: The Veterinary Journal - September 4, 2019 Category: Veterinary Research Source Type: research

A randomised controlled comparison of aspiration and non-aspiration fine-needle techniques for obtaining ultrasound-guided cytological samples from canine livers
Publication date: Available online 31 August 2019Source: The Veterinary JournalAuthor(s): K.L. Fleming, E.J. Howells, E.J. Villiers, T.W. MaddoxAbstractUltrasound-guided fine-needle sampling to obtain cytological samples is a well-established technique. However, the application of suction during sampling is controversial. Evidence from the human literature and one previous veterinary study suggest that non-aspiration may superior for a number of organs. This prospective study compared the quality and diagnostic value of cytological samples from canine livers obtained by fine-needle aspiration (FNA) and non-aspiration (FN-N...
Source: The Veterinary Journal - September 1, 2019 Category: Veterinary Research Source Type: research

Measurement of chronic pain in companion animals: Priorities for future research and development based on discussions from the Pain in Animals Workshop (PAW) 2017
Publication date: Available online 28 August 2019Source: The Veterinary JournalAuthor(s): B.D.X. Lascelles, D.C. Brown, M. Conzemius, M. Gill, M.L. Oshinsky, M. SharkeyAbstractThe estimation of long-standing pain in companion animals through the measurement of different dimensions impacted by pain is a fundamental requirement if pain management, and pain therapeutic development, are to advance. Although pain management in veterinary medicine has advanced considerably in the last 20 years, there is much critical work to do in the area of measurement of chronic pain. To date, most work has centered on musculoskeletal pain, a...
Source: The Veterinary Journal - August 29, 2019 Category: Veterinary Research Source Type: research

Red light at night permits the nocturnal rise of melatonin production in horses
Publication date: Available online 22 August 2019Source: The Veterinary JournalAuthor(s): B.A. Murphy, C. O’Brien, J.A. ElliottAbstractExposure to white light at night suppresses melatonin production, impacts circadian rhythms and contributes to ill-health in humans. Human interaction with horses frequently occurs at night. We tested the hypothesis that dim red light would not suppress the nightly rise in serum melatonin levels in horses. In a crossover design, six horses were maintained for consecutive 48 h periods under a Light:Red (LR) and a Light:Dark (LD) photo-schedule. Transitions from light (>200&th...
Source: The Veterinary Journal - August 24, 2019 Category: Veterinary Research Source Type: research

Serum concentration of homocysteine in spontaneous feline chronic kidney disease
Publication date: Available online 22 August 2019Source: The Veterinary JournalAuthor(s): M. Giraldi, S. Paltrinieri, C. Curcio, P. ScarpaAbstractSerum homocysteine (Hcy) increases in people and dogs with chronic kidney disease (CKD). Hyperhomocysteinemia (HHcy) has also been associated with CKD-related hypertension and proteinuria. The aims of this study were to: (1) validate an enzymatic method for quantification of Hcy in feline serum; (2) evaluate whether HHcy was associated with the presence and severity of CKD, proteinuria or hypertension; and (3) determine whether HHcy could predict disease progression.The intra- an...
Source: The Veterinary Journal - August 24, 2019 Category: Veterinary Research Source Type: research

Precision and accuracy of a point-of-care glucometer in horses and the effects of sample type
The objectives of this study were to determine the accuracy of glucometry in adult horses and the precision of duplicate measurements. Blood samples were collected from 62 horses into one plain syringe, one EDTA tube and three fluoride oxalate (FO) tubes. Immediately after collection, glucose concentrations in whole blood were determined, in duplicate, by glucometry from the syringe (plain whole blood [WB] group), EDTA tube (EDTA group) and one FO tube (FO group). One FO sample was used to measure plasma glucose concentration by a laboratory chemistry analyser (LAB group) ≤1 h after collection. The third FO tube ...
Source: The Veterinary Journal - August 24, 2019 Category: Veterinary Research Source Type: research

Hair or salivary cortisol analysis to identify chronic stress in piglets?
Publication date: Available online 17 August 2019Source: The Veterinary JournalAuthor(s): S. Prims, C. Van den Hole, S. Van Cruchten, C. Van Ginneken, X. Van Ostade, C. CasteleynAbstractHair cortisol might better represent chronic stress than salivary cortisol in piglets. To test this hypothesis, 24 female, 7-day old piglets were allocated to two groups and artificially reared. The piglets in the stressed group were exposed to overcrowding (0.10 m2/piglet) and frequent mixing with unfamiliar piglets until the age of 28 days. The control group remained in an unchanging group at a density of 0.29 m2/piglet. Aft...
Source: The Veterinary Journal - August 19, 2019 Category: Veterinary Research Source Type: research

Comparison of activity levels derived from two accelerometers in dogs with osteoarthritis: Implications for clinical trials
This study was conducted to evaluate a novel accelerometer that allows for remote download of data via Wi-Fi (Heyrex), to compare automatically generated parameters quantifying activity levels to previously established cut-points (Actical) and to describe the variability of accelerometer data in dogs with osteoarthritis. Twelve client-owned dogs with osteoarthritis were fitted with a collar with two accelerometers (Heyrex and Actical). Accelerometer data were recorded for 28 days. Pearson bivariate correlations and coefficient of variation (CV%) were calculated for accelerometer data.There was a strong correlation between ...
Source: The Veterinary Journal - August 16, 2019 Category: Veterinary Research Source Type: research

Estimation of perinatal mortality in dairy calves: A review
Publication date: Available online 16 August 2019Source: The Veterinary JournalAuthor(s): Emma Cuttance, Richard LavenAbstractDairy calf mortality is of interest worldwide as animal welfare continues to increase in importance to the consumer. This review summarises overall estimations of perinatal mortality from published literature, then further explores the limitations of each publication as well as its applicability, and challenges faced in use of the generated data for comparisons. The first limitation is the definition of perinatal mortality. There is no agreed definition of the period over which perinatal mortality c...
Source: The Veterinary Journal - August 16, 2019 Category: Veterinary Research Source Type: research

Associations between neutering and idiopathic epilepsy in Labrador retrievers and Border collies under primary veterinary care in the UK
This study aimed to explore the timing of neutering with respect to onset of seizures in dogs with idiopathic epilepsy. Associations between neutering and both age of onset of seizures and the occurrence of cluster seizures or status epilepticus were examined. Survival analysis investigated the effects of sex-neuter categories. The median survival time of Border collies was compared with data previously reported in literature.The study included veterinary primary-care clinical data on 117 Labrador retrievers and 57 Border collies diagnosed with idiopathic epilepsy from the VetCompass project in the UK. The majority (74.2%;...
Source: The Veterinary Journal - August 15, 2019 Category: Veterinary Research Source Type: research

An equine cadaver study investigating the relationship between cervical flexion, nuchal ligament elongation and pressure at the first and second cervical vertebra
In this study, ten equine head and neck specimens with one side of the soft tissues over the cervical vertebral spine removed were placed in lateral recumbency on a table in neutral, mildly flexed, and hyperflexed head and neck positions. Angulations of the neck were measured using markers placed on the nuchal ligament and drilled into the skull, vertebrae and withers. In six specimens, the pressure between the nuchal ligament and the atlas and the axis was measured using an inflatable air pouch.Hyperflexion was associated with the highest nuchal ligament length and with the highest pressure values at the site of the nucha...
Source: The Veterinary Journal - August 9, 2019 Category: Veterinary Research Source Type: research

Relationships between failure of passive transfer and subsequent mortality, bodyweights and lactation performance in 12-36 month old heifers on pasture-based, seasonal calving dairy farms in New Zealand
This study examined the long-term effects of failure of passive transfer of immunity (FPT; diagnosed at 1-8 days of age) on subsequent milk production, growth, reproduction, and lactation performance in dairy heifers from 12 to 36 months of age. A total of 34 farms from the Waikato and Canterbury regions of New Zealand were enrolled in 2015. Each farm was visited on three occasions during the seasonal calving period (early, middle, and late). Blood samples were collected at each visit from 20 replacement heifer calves aged between 1 and 7 days to test for FPT. These heifers (n=1879) were monitored from birth until the end ...
Source: The Veterinary Journal - August 6, 2019 Category: Veterinary Research Source Type: research

Comparison of fasted basal insulin with the combined glucose-insulin test in horses and ponies with suspected insulin dysregulation
This study aimed to compare FI with the combined glucose-insulin test (CGIT) in horses suspect for ID. We hypothesised that FI would have poor sensitivity for detecting ID compared to CGIT using conventional cut-offs. Records were retrieved from CGITs performed in horses fasted for approximately 8 h. Serum insulin and glucose concentrations were measured before and for 150 min following an IV bolus of glucose followed by insulin. Correlations between FI and CGIT values were assessed. Youden’s index analysis was used to determine the optimal cut-off for FI. Logistic regression and Mann-Whitney U tests we...
Source: The Veterinary Journal - August 6, 2019 Category: Veterinary Research Source Type: research

Effects of general anaesthesia in dorsal recumbency with and without vatinoxan on bronchoalveolar lavage cytology of healthy horses
In this study, anaesthesia in dorsal recumbency resulted in no clinically relevant changes in airway cytology that could be differentiated from the effect of repeated BALF sampling. No differences in BALF matrix metalloproteinase gelatinolytic activity could be detected between the two treatments or the control series. Marked increase in serum amyloid A was detected in some animals. Vatinoxan as premedication did not consistently affect lung cytology or blood inflammatory markers after anaesthesia. (Source: The Veterinary Journal)
Source: The Veterinary Journal - August 6, 2019 Category: Veterinary Research Source Type: research

Editorial Board
Publication date: August 2019Source: The Veterinary Journal, Volume 250Author(s): (Source: The Veterinary Journal)
Source: The Veterinary Journal - August 3, 2019 Category: Veterinary Research Source Type: research

Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele
Publication date: Available online 31 July 2019Source: The Veterinary JournalAuthor(s): J.A. Jaffey, M. Pavlick, C.R. Webster, G.E. Moore, K.A. McDaniel, S.L. Blois, E.M. Brand, C.F. Reich, L. Motschenbacher, E. Hostnik, D. Su, J.A. Lidbury, O. Raab, S.V. Carr, K.E. Mabry, W. Fox-Alvarez, S. Townsend, S. Palermo, Y. Nakazono, K. OhnoAbstractGallbladder mucocele (GBM) is a common extra-hepatic biliary syndrome in dogs with death rates ranging from 7-45%. Therefore, the aim of this study was to identify the association of survival with variables that could be utilized to improve clinical decisions. A total of 1194 dogs with ...
Source: The Veterinary Journal - August 2, 2019 Category: Veterinary Research Source Type: research

Clinical manifestations, laboratory findings, treatment and outcome of acute organophosphate or carbamate intoxication in 102 dogs: A retrospective study
Publication date: Available online 31 July 2019Source: The Veterinary JournalAuthor(s): S. Klainbart, M. Grabernik, E. Kelmer, O. Chai, O. Cuneah, G. Segev, I. ArochAbstractOrganophosphates (OP) and carbamates are commonly used insecticides and important intoxication sources of humans and animals. Nevertheless, large scale studies of these intoxications in dogs are unavailable. The medical records of dogs presented to a veterinary hospital were reviewed retrospectively. The study included 102 dogs definitely diagnosed with acute OP or carbamate intoxication.The most common presenting clinical signs included muscle tremor, ...
Source: The Veterinary Journal - August 2, 2019 Category: Veterinary Research Source Type: research

Pulmonary hypertension secondary to respiratory disease and/or hypoxia in dogs: Clinical features, diagnostic testing and survival
Publication date: Available online 30 July 2019Source: The Veterinary JournalAuthor(s): J.A. Jaffey, K. Wiggen, S.B. Leach, I. Masseau, R.E. Girens, C.R. ReineroAbstractPulmonary hypertension (PH) is associated with substantial morbidity and if untreated, mortality. The human classification of PH is based on pathological, hemodynamic characteristics, and therapeutic approaches. Despite being a leading cause of PH, little is known about dogs with respiratory disease and/or hypoxia (RD/H)-associated PH. Therefore, our objectives were to retrospectively describe clinical features, diagnostic evaluations, final diagnoses and i...
Source: The Veterinary Journal - July 31, 2019 Category: Veterinary Research Source Type: research

Intranasal dexmedetomidine in healthy beagles: An echocardiographic and pharmacokinetic/pharmacodynamic study
Publication date: Available online 27 July 2019Source: The Veterinary JournalAuthor(s): B. Santangelo, M. Harel, I. Fourel, F. Micieli, M. Cataldi, E. Segard-Weisse, K. PortierAbstractThe aim of this study was to compare the sedative and cardiovascular effects of dexmedetomidine (DEX) administrated via intranasal (IN) and intramuscular (IM) routes. This masked, randomised, crossover study used six male beagle dogs, receiving 0.02 mg/kg dexmedetomidine either IN (DEX-IN) or IM (DEX-IM), and an equal volume of saline by the alternative route. Dexmedetomidine plasma concentration was measured before (TB) and at time po...
Source: The Veterinary Journal - July 28, 2019 Category: Veterinary Research Source Type: research

Diagnosis of spontaneous hyperadrenocorticism in dogs. Part 2: Adrenal function testing and differentiating tests
Publication date: Available online 27 July 2019Source: The Veterinary JournalAuthor(s): Michael Bennaim, Robert E. Shiel, Carmel T. MooneyAbstractHyperadrenocorticism is a relatively common endocrine disorder in dogs that has been extensively described. However, its diagnosis remains challenging because there is no true reference standard test, and a myriad of factors can affect the diagnostic performance of the commonly used adrenal function tests. Ultimately, the diagnosis is based on a combination of signalment, history and clinical findings, and a variety of diagnostic test results. The second part of this review aims ...
Source: The Veterinary Journal - July 28, 2019 Category: Veterinary Research Source Type: research

Aerodigestive disorders in dogs evaluated for cough using respiratory fluoroscopy and videofluoroscopic swallow studies
In conclusion, canine aerodigestive disorders can manifest as cough without alimentary signs. VFSS is a useful diagnostic to determine the contribution of esophageal/gastrointestinal pathology in dogs with cough. (Source: The Veterinary Journal)
Source: The Veterinary Journal - July 28, 2019 Category: Veterinary Research Source Type: research

Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine
In conclusion, premedication with vatinoxan induced hypotension, thus its use in anesthetized horses warrants further studies. Even though heart rate and arterial blood pressures remained clinically acceptable with MED, cardiac performance and oxygen delivery were lower than with MED+V. (Source: The Veterinary Journal)
Source: The Veterinary Journal - July 28, 2019 Category: Veterinary Research Source Type: research

Diagnosis of spontaneous hyperadrenocorticism in dogs. Part 1: Pathophysiology, aetiology, clinical and clinicopathological features
Publication date: Available online 23 July 2019Source: The Veterinary JournalAuthor(s): Michael Bennaim, Robert E. Shiel, Carmel T. MooneyAbstractHyperadrenocorticism is a relatively common endocrine disorder in dogs. It occurs as a result of a functional pituitary or adrenal tumour, although other causes have been rarely reported. Canine hyperadrenocorticism has been extensively described but diagnosing this disease remains challenging. Few studies have investigated the clinical and clinicopathological features helpful in differentiating dogs with hyperadrenocorticism from dogs in which the disease is suspected but eventu...
Source: The Veterinary Journal - July 25, 2019 Category: Veterinary Research Source Type: research

A short-term evaluation of a thermoplastic polyurethane implant for osteochondral defect repair in an equine model
Publication date: Available online 20 July 2019Source: The Veterinary JournalAuthor(s): N.M. Korthagen, H. Brommer, G. Hermsen, S.G.M. Plomp, G. Melsom, K. Coeleveld, S.C. Mastbergen, H. Weinans, W. van Buul, P.R. van WeerenAbstractCartilage repair remains a major challenge and treatment of (osteo)chondral defects generally results in poor quality fibrous repair tissue. Our approach aims to address some of the major biomechanical issues encountered in scaffold-based cartilage repair, such as insufficient stiffness of the scaffolds, step formation at the interface with the native tissue and inadequate integration with the o...
Source: The Veterinary Journal - July 21, 2019 Category: Veterinary Research Source Type: research

A high protein meal affects plasma insulin concentrations and amino acid metabolism in horses with equine metabolic syndrome
The objective was therefore to assess insulin and amino acid responses following intake of a high protein meal in healthy horses and those with EMS. Six mature horses diagnosed with EMS and six age-matched control horses without EMS were used. Horses were fed 2 g/kg body mass (BM) of a high protein pellet (31% crude protein) at time 0 and 30 min, for a total of 4 g/kg BM, following an overnight fast. Blood samples collected during a 4 h period were analysed for plasma glucose, insulin, amino acids and urea concentrations.Glucose concentrations were not different between groups (P =&thinsp...
Source: The Veterinary Journal - July 21, 2019 Category: Veterinary Research Source Type: research

Comparison of vertical force redistribution in the pads of dogs with elbow osteoarthritis and healthy dogs
Publication date: Available online 8 July 2019Source: The Veterinary JournalAuthor(s): L. Braun, A. Tichy, C. Peham, B. BockstahlerAbstractKinetic analyses are becoming increasingly important for biomechanical research in veterinary medicine and as a diagnostic tool for orthopaedic examinations in dogs. Such analysis enables accurate evaluation of the vertical force distribution (VFD) in canine paw pads. The aim of this study was to assess peak vertical force (PFz) as a percent of total force (%TF), vertical impulse (IFz, %TF) and time of occurrence of PFz (TPFz) as a percent of the stance phase (%SP) in the pads of all fo...
Source: The Veterinary Journal - July 9, 2019 Category: Veterinary Research Source Type: research

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial
Publication date: Available online 5 July 2019Source: The Veterinary JournalAuthor(s): S. Sanchis-Mora, Y.M. Chang, S.M. Abeyesinghe, A. Fisher, N. Upton, H.A. Volk, L. PelligandAbstractPregabalin is the first-line treatment for neuropathic pain (NeP) in humans. Dogs with Chiari-like malformation and syringomyelia (CM/SM) associated with NeP could benefit from pregabalin. The aim of this study was to evaluate the efficacy of pregabalin for NeP in dogs with CM/SM. Eight dogs with symptomatic CM/SM were included in a double-masked, randomised, crossover placebo–controlled clinical trial. All dogs received anti-inflamma...
Source: The Veterinary Journal - July 6, 2019 Category: Veterinary Research Source Type: research

The influence of trimming of the hoof wall on the damage of laminar tissue after loading: An in vitro study
Publication date: Available online 4 July 2019Source: The Veterinary JournalAuthor(s): S. Moeller, B. Patan-Zugaj, T. Daeullary, A. Tichy, T.F. LickaAbstractLaminitis is associated with failure of the suspensory apparatus of the distal phalanx (SADP) connecting the distal phalanx to the hoof wall. The specific aim of this study was to examine in vitro whether thinning of the hoof wall leading to increased deformability influences the damage of the laminar tissue created by loading of the hoof. Paired cadaver forelimbs from twelve horses were used. For each pair, the hoof wall from one hoof was thinned by 25%; this was asce...
Source: The Veterinary Journal - July 6, 2019 Category: Veterinary Research Source Type: research

Measurement of chronic pain in companion animals: Discussions from the Pain in Animals Workshop (PAW) 2017
Publication date: Available online 3 July 2019Source: The Veterinary JournalAuthor(s): B.D.X. Lascelles, D.C. Brown, M.G. Conzemius, M. Gill, M.L. Oshinsky, M. SharkeyAbstractIn the face of increasing recognition and interest in treating chronic pain in companion animals, we struggle with a lack of therapeutic options. A significant barrier to the development of new therapeutics, or the critical evaluation of current therapies, is our inability to accurately measure chronic pain and its impact on companion animals. Over the last 20 years, much progress has been made in developing methods to measure chronic pain via subject...
Source: The Veterinary Journal - July 4, 2019 Category: Veterinary Research Source Type: research

Bacterial osteomyelitis in veterinary orthopaedics: Pathophysiology, clinical presentation and advances in treatment across multiple species
Publication date: Available online 25 June 2019Source: The Veterinary JournalAuthor(s): Fabian Gieling, Sarah Peters, Christoph Erichsen, R. Geoff Richards, Stephan Zeiter, T. Fintan MoriartyAbstractBacterial osteomyelitis in veterinary patients can be challenging to diagnose and treat, given limited therapeutic options and reported success rates. Osteomyelitis is frequently associated with surgical implant devices, including those required to optimise stability and healing of fractures. However, management of osteomyelitis sometimes necessitates the removal of these surgical implant devices in order to eradicate infection...
Source: The Veterinary Journal - June 27, 2019 Category: Veterinary Research Source Type: research

Urine 5-hydroxyindoleacetic acid in Cavalier King Charles spaniels with preclinical myxomatous mitral valve disease
Publication date: Available online 26 June 2019Source: The Veterinary JournalAuthor(s): L.B. Christiansen, S.E. Cremer, A. Helander, Tine Madsen, M.J. Reimann, J.E. Møller, K. Höglund, I. Ljungvall, J. Häggström, L. Høier OlsenAbstractHigher concentrations of circulating serotonin have been reported in Cavalier King Charles spaniels (CKCS) compared to other dog breeds. The CKCS is also a breed highly predisposed to myxomatous mitral valve disease (MMVD). The aim of this study was to determine urine concentrations of 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite and excretion product...
Source: The Veterinary Journal - June 27, 2019 Category: Veterinary Research Source Type: research

Editorial Board
Publication date: July 2019Source: The Veterinary Journal, Volume 249Author(s): (Source: The Veterinary Journal)
Source: The Veterinary Journal - June 24, 2019 Category: Veterinary Research Source Type: research

Footbathing, formalin and foot trimming: The 3Fs associated with granulomas and shelly hoof in sheep
Publication date: Available online 21 June 2019Source: The Veterinary JournalAuthor(s): M.C. Reeves, N.S. Prosser, E.M. Monaghan, L.E. GreenAbstractGranulomas and shelly hoof (SH), are lesions of sheep feet. Our objective was to use data from four questionnaires on lameness sent to English sheep farmers in 2004, 2013, 2014 and 2015 to further understanding of the risks and aetiologies of both lesions.Granulomas were more likely in flocks where routine foot trimming (odds ratio [OR] = 3.17; 95% confidence intervals [CI] 1.11–11.47) and routine footbathing (OR = 2.38; 95% CI 1.19–4.83)...
Source: The Veterinary Journal - June 23, 2019 Category: Veterinary Research Source Type: research

Erratum to: “Clinical presentation, diagnostic findings, and outcome of adult horses with equine coronavirus infection at a veterinary teaching hospital: 33 cases (2012–2018)” [Vet. J. 248 (2019) 95–100]
Publication date: August 2019Source: The Veterinary Journal, Volume 250Author(s): E.H. Berryhill, K.G. Magdesian, M. Aleman, N. Pusterla (Source: The Veterinary Journal)
Source: The Veterinary Journal - June 14, 2019 Category: Veterinary Research Source Type: research

Risk factors associated with excessive negative energy balance in commercial United Kingdom dairy herds
This study assessed risk factors associated with excessive negative energy balance (eNEB) in UK dairy cows between April 2006 and March 2015. Blood samples were analysed for β-hydroxybutyrate (BHB), non-esterified fatty acids (NEFA) and glucose. Following removal of all potential duplicate cows, a final dataset of 69,161 unique individual cows was obtained including biochemical results, individual cow and feed data.Generalised linear mixed-effect models and multivariable classification tree-based models showed that individual cow risk factors for eNEB included: (1) days relative to predicted calving date (dry cows); (...
Source: The Veterinary Journal - June 12, 2019 Category: Veterinary Research Source Type: research

Race-day performance of horses with epiglottic entrapment, and following surgical correction using intra-oral curved bistoury hook in anaesthetised horses
The objective of the current study was to assess the race-day performance of horses racing with epiglottic entrapment and the effect of surgical correction on performance outcomes using an intra-oral technique in anaesthetised horses. A case-control study was conducted at the Singapore Turf Club from 2008 to 2011. Controls were selected 1:1 to cases, based on Malaysian Racing Authority number. The performance of horses racing with epiglottic entrapment was recorded and post-surgery race performance was described. Further, post-surgery race performance was compared between cases and with non-case controls.Twenty horses race...
Source: The Veterinary Journal - June 8, 2019 Category: Veterinary Research Source Type: research

Canine papillomavirus types 1 and 2 in classical papillomas: High abundance, different morphological associations and frequent co-infections
Publication date: Available online 4 June 2019Source: The Veterinary JournalAuthor(s): C.E. Lange, S.H. Jennings, A. Diallo, J. LyonsAbstractCanine papillomatosis is mainly attributed to papillomavirus infection. Papillomavirus DNA is also frequently identified in healthy skin, and evidence of high papillomavirus diversity complicates this simplistic view of causality. The aim of this study was to determine how frequently canine papillomas contain papillomavirus DNA and express viral protein, and how these factors correlate to the histology and anatomic location. Fifty-three archived, formalin-fixed samples of canine papil...
Source: The Veterinary Journal - June 5, 2019 Category: Veterinary Research Source Type: research