Fight Aging! Newsletter, December 16th 2019
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - December 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An excerpt from the Revised & Expanded Edition of Wheat Belly
The original Wheat Belly book rocked the nutritional world with its revolutionary ideas. But, as time has passed, I’ve added new strategies and concepts that have expanded the overall program and taken the health, weight, and youth-preserving benefits even further. I have therefore collected all this new material into a new Revised & Expanded Edition. The new Revised & Expanded Edition of Wheat Belly is now available at all major bookstores.
Here is a brief excerpt from the new foreword:
Wheat Belly began as my modest effort to help people with heart disease stop relying on the revolving door of angiop...
Source: Wheat Belly Blog - December 14, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open autoimmune blood sugar bowel flora cholesterol diabetes Dr. Davis Gliadin gluten-free grain-free grains Inflammation low-carb microbiota prebiotic probiotic wheat belly Source Type: blogs
Corpora Amylacea in the Clearance of Metabolic Waste from the Brain via Cerebrospinal Fluid Drainage
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - December 12, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
“ Wheat Belly hit like a bomb ” : Author Dana Carpender reviews the Revised & Expanded Edition of Wheat Belly
Dana Carpender, friend and author of many low-carb cookbooks, provided this review of my new Revised & Expanded Wheat Belly, below.
For more of Dana’s signature wit and conversation, you can join her on her engaging Facebook page “Hold the toast press” or visit her Amazon page that lists all her wonderful low-carb cookbooks.
It’s funny how things happen. Nine years ago I had already been eating a low carbohydrate diet for 16 years. During that time I had occasionally eaten low carb tortillas and low carb bread. These things were hardly a staple of my diet, but I kept ’em around for the oc...
Source: Wheat Belly Blog - December 8, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open autoimmune joint pain wheat belly Source Type: blogs
Fight Aging! Newsletter, December 9th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - December 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Tryptophan Metabolism and Inflammaging
Today's open access research on tryptophan and its role in age-related immune dysfunction is particularly interesting in the context of ongoing research into the changes that take place in gut microbiota with age. Other recent work has examined the way in which tryptophan production by gut microbes declines precipitously with age, as this is one of a number of compounds produced by bacteria, such as butyrate, indole, and proprionate, that are influential on long term health. It is a slow process, but researchers are uncovering the specific mechanisms linking age-related changes in gut microbe populations with declining hea...
Source: Fight Aging! - December 6, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The new Revised & Expanded Edition of Wheat Belly being released!
The complete updated Wheat Belly program is now available in the Revised & Expanded Edition of Wheat Belly! (For availability, see below.)
In the original Wheat Belly, I recounted how agribusiness and geneticists altered traditional strains of wheat, yielding the high-yield semi-dwarf strain that now dominates supermarket shelves. Consuming modern foods made from this plant yields peculiar, sometimes crippling, health effects, while dramatic benefits develop upon removing it from the diet. If you’ve been following the Wheat Belly conversations, you are no stranger to the huge successes people have shared on this...
Source: Wheat Belly Blog - December 6, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open autoimmune bowel flora cholesterol diabetes gluten-free grain-free joint pain microbiota prebiotic probiotic Thyroid Weight Loss wheat belly Source Type: blogs
The new Revised & Expanded Edition of Wheat Belly released!
The complete updated Wheat Belly program is now available in the Revised & Expanded Edition of Wheat Belly! (For availability, see below.)
In the original Wheat Belly, I recounted how agribusiness and geneticists altered traditional strains of wheat, yielding the high-yield semi-dwarf strain that now dominates supermarket shelves. Consuming modern foods made from this plant yields peculiar, sometimes crippling, health effects, while dramatic benefits develop upon removing it from the diet. If you’ve been following the Wheat Belly conversations, you are no stranger to the huge successes people have shared on this...
Source: Wheat Belly Blog - December 6, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open autoimmune bowel flora cholesterol diabetes gluten-free grain-free joint pain microbiota prebiotic probiotic Thyroid Weight Loss wheat belly Source Type: blogs
The Catalytic Antibody Approach to Amyloid Aggregation
Today's paper is authored by the Covalent Bioscience science team, and is an overview of the science underlying their catalytic antibody (or catabody) approach to clearing amyloids of various sorts from aged tissues. It isn't open access, unfortunately, but the paper is, as usual, available to the world thanks to the ethical civil disobedience of the Sci-Hub team. Amyloids are solid deposits formed by one of the very small number of proteins in the body that can become misfolded or otherwise altered in ways that cause other molecules of the same protein to also alter in the same way. These errant proteins aggregate into st...
Source: Fight Aging! - December 2, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 2nd 2019
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications.
To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence?
https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/
Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable proces...
Source: Fight Aging! - December 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Common Mechanisms of Blood-Brain Barrier Dysfunction to Underlie Many Forms of Damage to the Brain
Researchers here note a signature of blood-brain barrier dysfunction that is common in many forms of damage and injury to the brain, suggesting it to be more broadly relevant to pathology than suspected. There is already good evidence for dysfunction of the blood-brain barrier to be an early feature of neurodegenerative diseases. The specialized cells of the blood-brain barrier line blood vessels that pass through the central nervous system, managing the passage of molecules and cells. When the barrier fails, unwanted molecules such as fibrogen can enter the brain to cause inflammation - and chronic inflammation in the bra...
Source: Fight Aging! - November 27, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Block an Enzyme, Save a Life
Vern Schramm, professor of biochemistry at Albert Einstein College of Medicine, Bronx, New York. Credit: Albert Einstein College of Medicine.
Enzymes drive life. Without them, we couldn’t properly digest food, make brain chemicals, move—or complete myriad other vital tasks. Unfortunately, in certain cases, enzymes also can trigger a host of health problems, including cancer, bacterial infections, and hypertension (high blood pressure).
Understanding how enzymes work has been the research focus of Vern Schramm for more than 4 decades.
“When we started our work, we were driven not by the desire to find...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 26, 2019 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cellular Processes Diseases Precision Medicine Source Type: blogs
Fight Aging! Newsletter, November 25th 2019
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis.
Against Senolytics
https://www.fightaging.org/archives/2019/11/against-senolytics/
There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a...
Source: Fight Aging! - November 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence May Contribute to Rheumatoid Arthritis in Younger Patients
Senescent cells are a cause of aging, and much of the present focus in the study of cellular senescence is thus on targeting and destroying these unwanted cells in order to treat aging. However, a comparatively recent and intriguing finding is that at least some autoimmune diseases, such as type 1 diabetes, involve cellular senescence. The question at present is whether or not this true for all forms of autoimmunity.
An autoimmune condition must have a trigger, something that prompts the immune system to attack healthy tissues, and it is possible that many different triggers converge on the generation of senescent c...
Source: Fight Aging! - November 19, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Wheat Belly: Revised & Expanded!
In the original Wheat Belly, I recounted how agribusiness and geneticists altered modern wheat from traditional strains, yielding the high-yield semi-dwarf strain that now dominates supermarket shelves. Consuming modern foods made from this plant yields peculiar health effects, while dramatic benefits develop upon removing it from the diet. If you’ve been following the Wheat Belly conversations, you are no stranger to the huge successes people have shared on this lifestyle.
But lessons have been learned along the way in the marvelous worldwide grain-eliminating experience, lessons shared in subsequent books: Wheat Be...
Source: Wheat Belly Blog - November 8, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open Dr. Davis gluten-free grain-free grains wheat belly Source Type: blogs
