Towards Control of Inflammation as an Important Goal in the Treatment of Aging
Today I'll point out a review article that laments the present state of progress towards the control of inflammation in the human body. While acknowledging that great strides have been made in ways to interfere in inflammatory signaling, benefiting many patients, present tools are crude in comparison to the technologies that will most likely be needed in order to truly control unresolved, chronic inflammation and eliminate its contribution to age-related disease. True control of inflammation would imply the ability to (a) trigger resolution mechanisms with specificity, avoiding impairment of the operation of inflammation w...
Source: Fight Aging! - April 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Malpractice: an officer of the court
Tony (not his real name) was one of those patients who came to be a friend. I was his doctor for 11 years, guiding him through some very difficult times with a chronic autoimmune disease. He was a handyman, a fly fisherman, a husband, a father and a man of deep faith. His condition wasRead more …Malpractice: an officer of the court originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 20, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/brian-sayers" rel="tag" data-wpel-link="internal" > Brian Sayers, MD < /a > < /span > Tags: Physician Malpractice Source Type: blogs
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Envisaging Alzheimer's Disease as Innate Autoimmunity
There is no shortage of theorizing in the Alzheimer's disease community. The lengthy failure of therapies targeting amyloid-β, first the failure to clear amyloid-β meaningfully, and then the failure to produce benefits in patients after clearance was achieved, has led to a great deal of frustration and the search for new views of the condition that might lead to different therapeutic strategies. Many of these viewpoints should probably be taken with a grain of salt (e.g. that modern painkillers play an important role), while others are quite compelling (e.g. persistent viral infection, or the burden of cellular senescenc...
Source: Fight Aging! - April 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How to Navigate Life with a Chronic Disease Like T1D and High-Deductible Insurance - Redux
Last February (2021), I wrote a blog post called " How to Navigate Life with a Chronic Disease Like T1D and High-Deductible Insurance Plans " (read my post athttps://blog.sstrumello.com/2021/02/how-to-navigate-life-with-chronic.html for details).I still stand by all of the recommendations I made in that blog post because I actually used (and still use some) the methods described effectively and saved a lot of money by doing so. But times change, and sometimes strategies need to evolve with changes that happen in the world around us.Intro of " Authorized Generic " Insulins, plus Branded/Unbranded BiosimilarsFor example, in ...
Source: Scott's Web Log - April 7, 2022 Category: Endocrinology Tags: 2022 high-deductible insurance plans insulin Source Type: blogs
A Viral Risk Factor for Multiple Sclerosis
Several new lines of evidence suggest that Epstein-Barr virus infection may be a risk factor for the development of multiple sclerosis. (Source: virology blog)
Source: virology blog - April 7, 2022 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey autoimmune disease autoimmunity B cell receptor b cells EBNA1 EBV Epstein-Barr virus GlialCAM herpesvirus kinase molecular mimicry monoclonal antibody multiple sclerosis somatic hypermutation Source Type: blogs
The Vitamin Deficiency Linked To Autoimmune Disorders
A vitamin that reduces autoimmune disease risk by almost one-quarter. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 10, 2022 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Nutrition Source Type: blogs
AndHealth, the Digital Health Company for Reversing Migraine and Autoimmune Diseases Raises $57 Million in Financing for Growth
AndHealth today announced the company’s closure of more than $57 million in financing by leading technology investor Francisco Partners, with participation from the American Medical Association’s venture capital arm Health 2047, Kirkland & Ellis and Twofold Ventures. AndHealth is led by former CoverMyMeds co-founder and CEO Matt Scantland and the team that helped grow healthcare […] (Source: EMR and HIPAA)
Source: EMR and HIPAA - February 11, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT AMA AMA Venture Capital AndHealth Autoimmune Diseases Chris Adams CoverMyMeds Digital Health Dr. Robert Sheeler Francisco Partners Health 2047 Health2047 ICHD-3 Kirkland & Ellis Matt Scantland Source Type: blogs
Magnetic-Plasmonic Hybrid Nanoparticles Isolate Lysosomes from Cells
Researchers at the Japan Advanced Institute of Science and Technology have developed a method to isolate intact lysosomes from cells. The technique is rapid and produces samples of high purity. Lysosomes are the garbage-disposal organelles within a cell, and they are involved in numerous diseases, from lysosomal storage diseases to autoimmune disorders, certain cancers, and neurodegenerative diseases. However, they are difficult to study, as current techniques to isolate lysosomes from cells result in samples with poor purity and damaged or altered lysosomes. This new approach uses nanotechnology to rapidly extract a high-...
Source: Medgadget - January 13, 2022 Category: Medical Devices Authors: Conn Hastings Tags: etc. Genetics Nanomedicine Pathology Source Type: blogs
Lower Hemoglobin Levels Correlate with Raised Mortality in Older People
Anemia is a lowered level of red blood cells and hemoglobin, leading to a diminished supply of oxygen to tissues and thus degraded function throughout the body. The anemia of aging, like all issues in later life, is a gradual onset, a sliding scale of dysfunction with an arbitrary line in the sand as how low hemoglobin must fall for it to be formally considered a medical condition. There are consequences prior to that point of course, as the study data here illustrates. The relationship between lower hemoglobin levels and higher mortality is linear. It is, however, an open question as to how much of this relates to downstr...
Source: Fight Aging! - December 27, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Delivering Catalase to Treat Sepsis
Sepsis is a state of runaway inflammation in response to infection, a condition that is more serious and more often fatal in older individuals. With age, the immune system becomes every more overactive and inflammatory, reacting to signals created by the damaged environment of the body. This background of chronic inflammation makes it ever less likely that any given incident of greatly raised inflammatory signaling will successfully resolve. Instead inflammation can rage to the point of causing serious harm and organ failure.
At present, treatments for sepsis are largely palliative, or focus on removing the infectio...
Source: Fight Aging! - December 21, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Suppression of Inflammatory Signaling as a Treatment for Frailty
Age-related frailty is accompanied by marked chronic inflammation, and indeed much of the physical weakness of frailty is likely caused by long-term inflammation and the ways in which it disrupts muscle tissue maintenance. The tools presently available to suppress inflammation are somewhat blunt, interfering in the necessary signaling needed to maintain a normal immune response, as well as in the unwanted overactivation of the immune system found in older people. Nonetheless, such tools are slowly becoming better and more selective over time, and some are now being tested as treatments for frailty.
Earlier this ye...
Source: Fight Aging! - December 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Top 10 Digital Health News Of 2021
From the approval of a new prescription VR treatment to renewed privacy concerns, 2021 has been full of digital health developments. Indeed, some news might have gone under the radar or might require a quick refresher; so we’re wrapping up 2021 with a round-up of 10 of the most important digital health news of this year.
1. FDA-approved prescription VR treatment for chronic back pain
In mid-November, the FDA authorised a virtual reality (VR) system as a prescription treatment for chronic back pain. Called EaseVRx, it combines cognitive behaviour therapy techniques and breathing exercises to help relax, distract...
Source: The Medical Futurist - December 16, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Covid-19 3D Printing Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy Telemedicine & Smartphones apple telehealth blood pressure A.I. 23andme news remote care 2021 Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
