CNN myocarditis fact check by a Cardiologist (me)
BY ANISH KOKA
A recent CNN article discusses approval of the Moderna Covid-19 vaccine for people ages 6-17. The CDC director acted after its vaccine advisers on the Advisory Committee on Immunization Practices voted unanimously to support the two dose Moderna COVID-19 vaccine for kids in this age group. The goal per CDC director Walensky was to “protect our children and teens from the complications of severe COVID-19 disease”
The elephant in the room that the CDC advisory group addressed is the risk of myocarditis from the vaccines that has been widely reported since April of 2021 by multipl...
Source: The Health Care Blog - August 10, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health CNN myocarditis Source Type: blogs
TORdx LUNG Test for Donor Lung Assessment: Interview with Eric Brouwer, Chief Scientific Officer at SQI Diagnostics
SQI Diagnostics, a medtech company based in Canada, is developing the TORdx LUNG Test. The technology is intended to assist clinicians in assessing donor lungs in their suitability for transplantation. At present, clinicians typically assess donor lungs using qualitative variables, such as donor health and lung size. One of the most important factors, lung inflammation, is difficult to assess, and clinicians will often play it safe and reject an organ if there is any doubt about it.
This means that lungs that might actually be suitable for transplantation are often rejected, further compounding the lack of donor organs....
Source: Medgadget - July 18, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Exclusive Medicine Thoracic Surgery lung transplant sqi diagnostics Source Type: blogs
Fight Aging! Newsletter, July 18th 2022
In conclusion, we show that PVS morphology in mice is variable and that the structure and function of pia suggests a previously unrecognized role in regulating CSF transport and amyloid clearance in aging and disease.
Reversing Ovarian Fibrosis in Mice
https://www.fightaging.org/archives/2022/07/reversing-ovarian-fibrosis-in-mice/
Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibro...
Source: Fight Aging! - July 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Does Systemic Inflammation in the Body Cause Neuroinflammation in the Brain?
The chronic inflammation of aging is harmful, disruptive of tissue structure and function, altering cell behavior for the worse. The immune system reacts to many of the varied signs of molecular damage that become prevalent in old tissues, such as DNA debris from dying cells, and the result is unresolved inflammatory signaling. Neurodegenerative conditions in particular appear to be driven by inflammation, but given that the brain is separated from the body by the blood-brain barrier, and the immune systems of brain and body are also distinct and separate, how is it that inflammation in the body generates neuroinflammation...
Source: Fight Aging! - July 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Contribution of Retroviral Transposable Elements to Aging
A growing body of academic work is focused on the activity of transposable elements in degenerative aging, and some of these projects may produce approaches to therapy based on suppressing this activity. Transposable elements are DNA sequences capable of copying themselves within the genome, thought to be the result of ancient viral infections, but which contribute to evolution by providing a ready path to mutational change. Transposable elements are suppressed in youth, but with age the regulation of gene expression becomes more ragged, and transposable elements exhibit ever greater activity. This is supposed by many rese...
Source: Fight Aging! - July 5, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Innate Immune Activation as a Contributing Cause of Inflammaging, Reduced by Calorie Restriction
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree
Towards Scaffold-Based Regeneration of Dental Pulp
https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/
Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth ...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lyfspn Working on Clinical Trials of Plasmapheresis
Parabiosis studies involve connecting the circulatory systems of two genetically identical mice, resulting in modest rejuvenation in the older mouse of the pair. The path from those animal studies to age-modifying therapies in humans has been one of twists and turns. At first, the research community focused on potentially beneficial factors in young blood. Elevian's work on GDF11 is still ongoing as an outcome of that research. Over the same period of time, plasma transfusions from young to old humans have produced a lack of convincing data.
Later experiments strongly suggested that the real benefit was dilution of ...
Source: Fight Aging! - June 17, 2022 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Inflammaging as a Contributing Factor in the Development of Cardiovascular Disease
Inflammaging is the name given to the decline of the aging immune system into a state of constant, unresolved inflammation. Inflammatory signaling in the aged body arises in part because of an increased burden of senescent cells. These cells secrete a potent mix of pro-inflammatory signals, disrupting tissue function. This is one of the reasons why removal of lingering senescent cells produces such rapid rejuvenation, as these errant cells actively maintain a portion of the degradation of function and environment in aged tissues. Beyond senescent cells, the broad molecular damage and cellular dysfunction of aging produces ...
Source: Fight Aging! - June 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Is this Myo-pericarditis? Or OMI with subsequent pericarditis? Does the angiogram always explain the ECG findings?
Conclusion: Although at 1st glance, it looked like the ECG picture in Figure-1 might be suggestive of acute pericarditis — on further inspection, there are significant ECG features against the diagnosis of acute uncomplicated pericarditis.As per the superb discussion above by Dr. Smith — evolution of this case (including the ECG picture on serial tracings) — are consistent with what probably occurred in today ' s case, namely the combination of acute OMI from LCx occlusion, followed by development of post-infarction regional per...
Source: Dr. Smith's ECG Blog - June 11, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs
The immune system
It occurs to me that right now, a great deal of trouble results from public misunderstanding of the immune system. It would actually be impossible for most of the public to understand very much about the immune system because it is extremely complicated. It depends on elaborate correlation of literally dozens of different kinds of cells, along with complicated features of all other human cells and of pathogens. Understanding how all of this works further depends on fairly deep understanding of basic biology, which believe me very few people have.Into this immense gulf of ignorance wade opportunistic charlatans who want to ...
Source: Stayin' Alive - June 2, 2022 Category: American Health Source Type: blogs
The Power of Honest Medicine, My New Book on LDN
My new book, The Power of Honest Medicine, has just been published and is available in paperback and Kindle eBook editions from Amazon.com
The book, written with Don Schwartz, introduces readers to Low Dose Naltrexone—or LDN—an effective, inexpensive alternative to the costly, toxic treatments doctors routinely prescribe for autoimmune and other diseases.
The Power of Honest Medicine contains contributions from eighteen people from around the world—from the US, the UK, and Europe—all of whom are eager to spread the word about this innovative treatment that has helped them, and has become a “people’s moveme...
Source: HONEST MEDICINE: My Dream for the Future - May 25, 2022 Category: Consumer Health News Authors: JuliaS1573 at aol.com (Julia Schopick) Tags: Books HONEST MEDICINE Low Dose Naltrexone autoimmune autoimmune disease autoimmunity LDN Source Type: blogs
Underfunding Research Of Female Health Leaves Huge Amounts Of Money On The Table
“Did you know that at least one-third of women have lower back pain before their periods every month, and yet, nobody seems to fully understand why?” – asked a Medical Futurist team member a little while ago. The question led to a discussion about the differences in research, funding and understanding of male-only and female-only health issues, and consequently, to this article.
It is a well-known fact that some diseases or conditions dominantly affect one gender or the other. There are the trivial ones, like prostate cancer or ovarian, cervical, uterine cancers. But there is a long list of diseases and condit...
Source: The Medical Futurist - May 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Healthcare Policy Medical Education women female health under-reseached gender gap in healthcare Source Type: blogs
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
