Fight Aging! Newsletter, December 7th 2020
In this study, except for the reduction in body weight, the aging characteristics related to epidermal and muscle tissue in mice were significantly ameliorated in the CR group compared with the control group. Additional studies have indicated that not stem cells themselves but the stem cell microenvironment is the key factor mediating stem cell activation, proliferation and differentiation.
Mitochondrial dysfunction is an important factor leading to age-related muscular atrophy. Considering the dependence of skeletal muscle on ATP, loss of mitochondrial function, which can lead to a decrease in strength and enduranc...
Source: Fight Aging! - December 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Control Over the Dynamic Equilibrium of Bone Tissue Maintenance
Bone loses mass and strength with age, leading to the condition called osteoporosis. The extracellular matrix of bone is dynamically remodeled throughout life, built up osteoblast cells and broken down by osteoclast cells. Osteoporosis is the result of a growing imbalance in cell activity and cell creation that favors osteoclasts. There are many contributing causes, and some uncertainty of which of these causes are more or less important. The chronic inflammation that accompanies aging does appear to be important, particularly that connected to the senescence-associated secretory phenotype (SASP) of senescent cells.
...
Source: Fight Aging! - December 2, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 16th 2020
This study conclusively demonstrates the long-speculated relationship between aging, gene regulation, and somatic damage. The results open up new avenues of research with practical implications. If the same level of coordination reduction between genes is indeed a leading cause for aging phenomena, there may be a need to change course in current efforts to develop aging treatments.
Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis
https://www.fightaging.org/archives/2020/11/using-oligodendrocyte-extracellular-vesicles-to-induce-tolerance-to-myelin-...
Source: Fight Aging! - November 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis
In multiple sclerosis, the immune system becomes intolerant towards myelin, the sheathing around nerves that is essential to nervous system function. One class of approach to treating autoimmune diseases of this nature is to produce immune tolerance by delivering more of the problem molecule into the body. The challenge in multiple sclerosis is that it is unclear as to which of the many possible protein sequences is the problem in any given patient, and indeed to build a comprehensive list of such sequences in the first place. Researchers here report on the discovery that the oligodendrocyte cells responsible for building ...
Source: Fight Aging! - November 11, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Does lupus or arthritis affect your prognosis if you get COVID-19?
Soon after the coronavirus pandemic began, we learned that older adults and people with certain chronic conditions, such as high blood pressure or diabetes, are at increased risk for severe COVID-19. One condition on that list is an immunocompromised state (a weakened immune system). This can be due to a number of conditions, including having had an organ transplant, having HIV, or taking medications that suppress the immune system.
If you have an autoimmune condition such as rheumatoid arthritis or lupus (also called systemic lupus erythematosus), you may wonder how this affects your risk. It’s thought that these condit...
Source: Harvard Health Blog - November 9, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Autoimmune diseases Bones and joints Coronavirus and COVID-19 Source Type: blogs
Fight Aging! Newsletter, November 2nd 2020
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings.
In Vivo Reprogramming Improves Cognitive Function in Old Mice
https://www.fightaging.org/archives/2020/10/in-vivo-reprogramming-improves-cognitive-function-in-old-mi...
Source: Fight Aging! - November 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Antibody Binding Changes with Age and Can be Used to Build an Immune Aging Clock
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings. (Source: Fight Aging!)
Source: Fight Aging! - October 30, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Illness-related fatigue: More than just feeling tired
A common refrain during the COVID-19 pandemic is, “I’m so tired.” After months of adjusted living and anxiety, people are understandably weary. Parents who haven’t had a break from their kids are worn out. Those trying to juggle working from home with homeschooling are stretched thin. Between concerns about health, finances, and isolation, everyone is feeling some level of additional stress during this unusual time, and that’s tiring. We all could use a good, long nap — or better yet, a vacation.
But while a break would be nice, most people — except those who are actually sick with COVID-19 or other illnesses...
Source: Harvard Health Blog - October 21, 2020 Category: Consumer Health News Authors: Jennifer Crystal, MFA Tags: Autoimmune diseases Fatigue Source Type: blogs
The tragedy of the post-COVID “ long haulers ”
Suppose you are suddenly are stricken with COVID-19. You become very ill for several weeks. On awakening every morning, you wonder if this day might be your last.
And then you begin to turn the corner. Every day your worst symptoms — the fever, the terrible cough, the breathlessness — get a little better. You are winning, beating a life-threatening disease, and you no longer wonder if each day might be your last. In another week or two, you’ll be your old self.
But weeks pass, and while the worst symptoms are gone, you’re not your old self — not even close. You can’t meet your responsibilities at home or at wor...
Source: Harvard Health Blog - October 15, 2020 Category: Consumer Health News Authors: Anthony Komaroff, MD Tags: Brain and cognitive health Coronavirus and COVID-19 Fatigue Source Type: blogs
Antigen vs antibody – what is the difference?
3D illustration of antigen in the human body
What is the difference between antigen vs antibody, and what role do they play in creating an effective vaccine? With the recent focus on the development of a COVID-19 vaccine there has been much talk of antigens and antibodies, often interchangeably, and little clarity on what they are – or the role they play in creating an effective vaccine. In this blog, we’ll cut through the jargon and discover the facts together.
Antigen
An antigen is any substance or organism that is unrecognized by our immune system. It could be anything from bacteria to chemicals, to v...
Source: GIDEON blog - October 1, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Examples News Therapy Source Type: blogs
If EF% is a most flawed LV functional parameter,.. why we Insist HF to be classified based on it ?
Heart failure has been classified in many ways, with prevailing levels of our knowledge and ignorance. It is based on a variety of factors like rapidity of onset, etiology, chambers involved, hemodynamics, etc.
Forward vs backward failure
Acute vs chronic failure
RV/LV or Biventicular failure
Systolic vs diastolic heart failure
High output vs low out failure
Ischemic vs non-ischemic failure
Reversible vs Refractory HF
None of them have really helped at the bedside though it helped us understand the condition. Now, in the last decade, we have crash-landed on our favorite obsession to classify HF ie based...
Source: Dr.S.Venkatesan MD - September 25, 2020 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized ase esc acc csi echo cariteria definition of heart failure diastolic heart failure ejection fraction limitation forward vs backward failure hf with normal GLS HFpEF HFrEF rv vs lv failure systolic vs diastolic heart failu Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Theophylline Produces Accelerated Remyelination in the Central Nervous System of Mice
The myelin sheathing around axons is necessary for the proper function of nervous system tissue. Demyelinating conditions such as multiple sclerosis, an autoimmune disease in which the immune system attacks myelin, well illustrate the severe consequences that result from a sizable loss of myelin. Unfortunately, the integrity of myelin sheathing declines with age for everyone, most likely the result of disruption and damage in the oligodendrocyte cell population responsible for maintaining these structures. Evidence suggests that this contributes to cognitive decline and other issues. Thus it is worth keeping an eye on prog...
Source: Fight Aging! - September 1, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit.
Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
On Stress, Yoga Meditation, and The Evolution Revolution
In the Tale of Two Cities, Charles Dickens wrote:
“It was the best of times, it was the worst of times. It was the age of wisdom, it was the age of foolishness…. It was the season of light, it was the season of darkness. It was the spring of hope, it was the winter of despair”
Yes, the period of which Dickens wrote is a lot like the present day.
We are living through extraordinary times in a complicated world. In my 74 ½ years, I’ve never seen anything like it — from the virus to political strife to protests, stress is rampant.
Stress may impact negatively virtually every system of our body, from the immune sy...
Source: SharpBrains - August 14, 2020 Category: Neuroscience Authors: Dr. Dharma Singh Khalsa at Alzheimer's Research & Prevention Foundation Tags: Cognitive Neuroscience Health & Wellness anxiety chronic-stress depression immune system insomnia Kirtan-Kriya lower cognitive ability mbsr meditation mental health Mindfulness-Based-Stress-Reduction telomere Transcendental Med Source Type: blogs
