Fight Aging! Newsletter, December 7th 2020

In this study, except for the reduction in body weight, the aging characteristics related to epidermal and muscle tissue in mice were significantly ameliorated in the CR group compared with the control group. Additional studies have indicated that not stem cells themselves but the stem cell microenvironment is the key factor mediating stem cell activation, proliferation and differentiation. Mitochondrial dysfunction is an important factor leading to age-related muscular atrophy. Considering the dependence of skeletal muscle on ATP, loss of mitochondrial function, which can lead to a decrease in strength and endurance, is especially obvious in skeletal muscle. CR can preserve the integrity and function of mitochondrial structure via reducing oxidative damage. Previous studies have shown that CR reduces proton leakage and ROS generation in mitochondria in skeletal muscle while enhancing the expression of ROS scavenging-related genes. In addition, CR may alter the fatty acid composition of the mitochondrial membrane, reduce lipid oxidation, and reduce proton leakage. Accumulating evidence suggests that apoptosis may constitute a fundamental mechanism driving the onset and progression of sarcopenia. There are two main pathways of apoptosis: activation of the apoptotic enzyme caspase through extracellular signaling and activation of caspases through the release of mitochondrial apoptosis activators. These activated caspases can degrade important proteins in cells and...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

Conclusions This study demonstrated a limited role of continuous passive motion in patients operated with total knee arthroplasty. Thus, there is at this stage no indication for continuous passive motion procedures in patients operated with total knee arthroplasty as a standard postoperative care.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
Background Many nonconclusive studies have been conducted on low back pain (LBP) in adolescents and associated factors. Objective The aim was to assess the lifetime prevalence and associated factors of LBP in adolescents. Materials and Methods A questionnaire was administered in high school students (14–19-yr-old participants) in Veneto region (Italy). The self-administered, structured questionnaire included anthropometric data; psychologic factors and lifestyle; presence, intensity, and family history of LBP; referral to professional health care for LBP; and a short version of the International Phy...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
Every-other-day fasting is effective for a variety of major human diseases, but the safety of these interventions is uncertain for patients with spinal cord injury. A randomized controlled study was conducted to investigate the safety of every-other-day fasting in patients with spinal cord injury. Participants who met the diagnostic inclusion and exclusion criteria were randomly divided into the control and every-other-day fasting groups. In the every-other-day fasting group, fasting lasted from 09:00 p.m. on day 1 to 06:00 p.m. on the following day (day 2). Dinner on day 2 was restricted to approximately 30% of the averag...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
No abstract available
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: RFS – Teaching Images Source Type: research
No abstract available
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Letters to the Editor Source Type: research
Hi everyone, I'm currently active duty and working on a plan to go to medical school after I get out. My ETS is May 2023. As of now, I'm not sure if I will stay in or not; if I do, I'd be in for another 4 years doing a software development program. I only recently learned about VR&E and I'm not sure if I will even qualify but I hope so. I don't know what my disability rating will be. I have a bad knee, sleep problems, and possible mild PTSD from a sexual assault on deployment but it's not... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Veterans' Benefits Source Type: forums
Link to case here: Liver Failure [Medication-Induced] This case has an expert witness opinion from a GI doc. Patient was started on Depakote, LFTs were initially fine. Within 5 weeks she had a liver transplant. The expert notes that she had positive ASMA and ANA titers and homozygous positive for H63D hemochromatosis. Do these results suggest that there may be an alternative cause for her liver failure?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Gastroenterology Source Type: forums
Although hemodialysis treatment is one of the main treatment methods in chronic kidney failure, it also causes many health problems. A variety of complementary and integrative therapies are used to relieve or minimize hemodialysis symptoms. Fatigue (60%-97%) is also one of these problems. Therefore, we have conducted a systematic review to determine the effect of complementary and integrative therapies on fatigue in hemodialysis patients. Relevant studies published from 2005 to 2019, in PubMed, EBSCOhost, ScienceDirect, and Cochran Library databases have been reviewed. In the study, initially, 21 039 pieces of data were ob...
Source: Holistic Nursing Practice - Category: Nursing Tags: FEATURES Source Type: research
Conclusions: Two-way messaging and standardized documentation increased rates. Declinations persisted despite education. Reasons included fear of side effects, and rarely leaving home due to the COVID-19 pandemic. Nursing interventions can increase influenza vaccination quality measures for primary care home telehealth patients.
Source: Journal of Nursing Care Quality - Category: Nursing Tags: Articles Source Type: research
Conclusions: The majority of reported cardiac telemetry downtime events were unplanned and without documented contingency plans. A robust contingency plan with defined staff roles and responsibilities will serve to lessen anxiety during downtimes and mitigate potential risk of patient harm.
Source: Journal of Nursing Care Quality - Category: Nursing Tags: Articles Source Type: research
More News: Academia | Actos | Adenoviruses | AIDS Vaccine | Antidoxidants | Anxiety | Arthritis | Autoimmune Disease | Avandia | Biotechnology | Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer Vaccines | Cardiology | Chemistry | Chemotherapy | Clinical Trials | Databases & Libraries | Depression | Diabetes | Diabetic Ulcers | Dietary Protein | Diets | Disability | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epidemiology | Eyes | Fortamet | Funding | Ganglions | Gastroenterology | Gastroschisis Repair | Genetics | Glaucoma | Glimepiride | Government | Grants | Heart | Heart Disease | HIV AIDS | Hormones | Hospitals | Hypertension | Insulin | Laboratory Medicine | Liver | Liver Disease | Metformin | Mitochondria | Mitochondrial Disease | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Nutrition | Obesity | Orthopaedics | Osteoarthritis | Osteoporosis | Paget's Disease | Pancreas | Pancreatic Cancer | Pathology | Pneomococcal Vaccine | Pneumonia | Politics | Pressure Sores | Prostate Cancer | Psychology | Rehabilitation | Research | Respiratory Medicine | Rheumatoid Arthritis | Rheumatology | Science | Skin | Sleep Disorders | Sleep Medicine | Spinal Cord Injury | Sports Medicine | Statistics | Stem Cell Therapy | Stem Cells | Stroke | Study | Toxicology | Transplants | Universities | Urology & Nephrology | Vaccines | Venture Capital | Veterinary Vaccinations | Vitamin A | Vitamin B3 | Weight Loss | Xgeva