Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children
Since the start of global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), at least four waves have occurred as mutations and variant strains have developed. During the first waves, adults were the primary target, but the highly infectious delta variant has been infecting children and unvaccinated adults with a vengeance.On this go-round, the delta variant is predominately infecting children. I am seeing reports of high school football games being canceled, schools deciding to go virtual, and occasional reports of teachers dying of COVID. I have never seen anything like this pandemic ...
Source: M2E Too! Mellick's Multimedia EduBlog - October 1, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, August 30th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out mo...
Source: Fight Aging! - August 29, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Christina Applegate reveals multiple sclerosis diagnosis
Award-winning actress Christina Applegate revealed on social media that she had been diagnosed with multiple sclerosis (MS). “It’s been a tough road. But as we all know, the road keeps going,” wrote Applegate in a tweet. Multiple sclerosis is a neurological autoimmune disease that has puzzled patients and health care providers for decades. The diseaseRead more …Christina Applegate reveals multiple sclerosis diagnosis originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 25, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/yasir-jassam" rel="tag" > Yasir Jassam, MD < /a > < /span > Tags: Conditions Neurology Source Type: blogs
Age-Related Dysfunction in Cellular Metabolism Substantially Impacts the Immune System
Most of what to my eyes are less promising lines of research into the treatment of aging are focused on manipulation of cellular metabolism. These approaches, such as targeting the mTOR pathway, largely derive from the study of calorie restriction and the cellular response to stress that is brought on by lack of nutrients. Calorie restriction extends average and maximum life span considerably in short-lived species, up to 40% in mice, for example. It increases the efficiency of cellular maintenance processes and makes cells more frugal in other ways. The impact of aging is slowed, as molecular damage accumulates less rapid...
Source: Fight Aging! - August 23, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Immune System Should be a High Priority Target in the Development of Rejuvenation Therapies
The immune system has many roles. It doesn't just destroy invading pathogens, but also hunts and kills potentially harmful cells, such as those that have become senescent or potentially cancerous. Further, immune cells are intricately involved in the processes of tissue maintenance. Regeneration from injury is a complicated dance of signals and changed states carried out between stem cells, immune cells, and somatic cells. In the central nervous system, immune cells take on additional responsibilities related to maintaining and changing synaptic connections between neurons.
The immune system fails with age. Its fail...
Source: Fight Aging! - August 19, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Improved Manipulation of " Eat Me " and " Don't Eat Me " Markers in the Context of Cancer
One of the more interesting discoveries of the past few decades in cancer research has been the identity of surface markers such as CD47 that normally act to protect important cells from being attacked and destroyed by immune cells - a "don't eat me" signal. Cancers abuse such mechanisms in a variety of ways, both directly, in cancerous cells, and indirectly, via subversion of regulatory immune cells that are protected by such surface markers, in order to suppress the immune response to the cancer. Targeting CD47 has proven a promising approach to the treatment of cancer, but it has side-effects. There are always necessary...
Source: Fight Aging! - August 19, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Srs with T1D; Medicare + Lack of Good Enrollment Info from Diabetes Nonprofits
Not long ago, my friend Riva Greenberg wrote a compelling diabetes blog post which actually ran on Diabetes Minehttps://www.healthline.com/diabetesmine/nearly-50-years-with-type-1-diabetes-a-long-haulers-report although she also posted news of it on her own personal bloghttps://diabetesstories.com/2021/06/16/the-untold-story-49-years-of-type-1-diabetes/.Riva, like me, is today considered a T1D " Long Hauler " . She is now in her 49th year of living with Type 1 diabetes, meaning she ' ll soon be eligible for a Joslin 50 year medal if she chooses to claim it. I think Riva and my older sister share a common diagnosis year (I ...
Source: Scott's Web Log - August 8, 2021 Category: Endocrinology Tags: Abbott CGM CMS Dexcom Eversense FDA Freestyle Libre Medicare Seniors Senseonics Source Type: blogs
Srs with T1D; Medicare + Lack of Good Enrollment Info from Diabetes Nonprofits
Not long ago, my friend Riva Greenberg wrote a compelling diabetes blog post which actually ran on Diabetes Minehttps://www.healthline.com/diabetesmine/nearly-50-years-with-type-1-diabetes-a-long-haulers-report although she also posted news of it on her own personal bloghttps://diabetesstories.com/2021/06/16/the-untold-story-49-years-of-type-1-diabetes/.Riva, like me, is today considered a T1D " Long Hauler " . She is now in her 49th year of living with Type 1 diabetes, meaning she ' ll soon be eligible for a Joslin 50 year medal if she chooses to claim it. I think Riva and my older sister share a common diagnosis year (I ...
Source: Scott's Web Log - August 8, 2021 Category: Endocrinology Tags: Abbott CGM CMS Dexcom Eversense FDA Freestyle Libre Medicare Seniors Senseonics Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstrea...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Disruption of Naive T Cell Quiescence in Immune Aging
This open access paper discusses a secondary issue in the aging of the adaptive immune system. Of primary concern is that the supply of new T cells diminishes over time, due to the atrophy of the thymus where such cells mature, as well as due to issues in the hematopoietic system of the bone marrow where such cells are produced. As noted here, a secondary concern is that the population of unspecialized naive T cells needed to respond effectively to novel threats begins to have issues maintaining itself in readiness. So not only is the supply of new naive T cells reduced to a tiny fraction of youthful levels, but the popula...
Source: Fight Aging! - August 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Senescent T Cells in the Context of Cancer
Cells become senescent in response to potentially cancer-inducing stresses and damage, to tissue injury, or when they reach the Hayflick limit on cellular replication. Senescent cells cease to replicate and secrete pro-inflammatory, pro-growth signals. They are cleared by the immune system or via programmed cell death mechanisms. Their presence is beneficial in the short term, an important part of the panoply of mechanisms devoted to, separately, cancer suppression and regeneration. When senescent cells begin to linger, however, their secretions become highly disruptive to normal tissue function. Senescent cell accumulatio...
Source: Fight Aging! - August 4, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Future Treatment For Autoimmune Diseases
New digital health tech targeted to fight autoimmune diseases or their symptoms are diverse and creative. These often completely different illnesses, like type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis, indicate an immune system dysfunction. Immune cells and mechanisms target the body’s own cells and structures, deconstructing it bit by bit and inducing inflammation.
An estimated 24-50 million people in the US alone are living with autoimmune conditions. It affects their day-to-day life, but scientists suggest people living with chronic conditions could also be more suscepti...
Source: The Medical Futurist - July 29, 2021 Category: Information Technology Authors: szandra Tags: Biotechnology Future of Medicine Portable Medical Diagnostics Telemedicine & Smartphones chatbot diabetes digital health sleep optimization chronic pain chronic illness skin coronavirus autoimmune disease Source Type: blogs
Vaccine associated myocarditis revisited with COVID-19 mRNA vaccines
When I had reviewed the topic of vaccine associated myocarditis for an editorial in the BMH Medical Journal in 2017, most of the cases were associated with small pox vaccination [1]. There were also reports of streptococcal pneumonia vaccine and influenza vaccine associated myocarditis. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) used in the vaccine were also implicated in some cases [2,3].
While the large scale vaccination for small pox in an attempt to prepare for potential bioterrorism was the association in 2003 [4], COVID-19 mRNA vaccines are currently in the limelight for vaccine induced myocarditis...
Source: Cardiophile MD - July 22, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Reports of the Death of Diamyd's T1D Intervention Have Been Greatly Exaggerated
Remember Diamyd Medical? I wrote about the company and even interviewed one of the company execs (Peter Zerhouni, who was then Director of Business Development) back in 2010 (see that post athttps://blog.sstrumello.com/2010/05/interview-with-diamyd-medical-ab.html). A year later, I wrote another post about it not being dead yet (seehttps://blog.sstrumello.com/2011/06/teplizumab-and-dpt-1-not-dead-yet.html), but it later appeared to actually be dead, and I basically lost interest.As it turns out, the Swedish biotech firm known as Diamyd Medical isn ' t dead after all! Diamyd Medical was founded by the Swedish entrepre...
Source: Scott's Web Log - June 14, 2021 Category: Endocrinology Source Type: blogs
