Fight Aging! Newsletter, December 9th 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents The Catalytic Antibody Approach to Amyloid Aggregation This Giving Tuesday, Support Rejuvenation Research at the SENS Research Foundation The Prospects for Restoring Neurogenesis in the Aging Brain Mesodermal Progenitor Cells Enable the Generation of Vascularized Organoids Tryptophan Metabolism and Inflammaging More Aggressive Control of Blood Pressure Modestly Extends Life in Older People Potentially Significant Gut Microbiome Changes Occur in Younger Adult Life IL-15 as an Exercise Mimetic that Improves Wound Healing in Old Mice Fibrosis as an Important Contributing Cause of Atrial Fibrillation A Demonstration of Small Molecule Inhibition of Tau Aggregation Discovering New Mechanisms of Action for Metformin On Making Philanthropy in Support of Rejuvenation Research Att...

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Source: Fight Aging! - December 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

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Constructional variation with two near-synonymous verbs: the case of schicken and senden in present-day German

Publication date: January 2021Source: Language Sciences, Volume 83Author(s): Hilde De Vaere, Ludovic De Cuypere, Klaas Willems

Source: Language Sciences - August 4, 2020 Category: Speech-Language Pathology Source Type: research

The prediction of children's accident proneness based on attention deficit hyperactivity disorder and sluggish cognitive tempo symptoms: the mediating role of sensitivity to reward and punishment - Khanjani Z, Mohammadi E, Shadbafi M.

Background and Purpose: Accidents, both intentional and unintentional, are one of the leading causes of death and disability for children around the world and impose a heavy financial burden on the health care system of societies. The aim of the present st...

Source: SafetyLit - August 4, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Prioritization of black spots in hilly road segment using road engineering data - Pandey S, Singh Bura G.

Road accidents are one of the causes of disability, injury and death. As per the latest road accident data released by the Ministry of Road Transport&Highways (MoRTH), the total number of accidents increased by 2.5 percent from 4,89,400 in 2014 to 5,01,4...

Source: SafetyLit - August 4, 2020 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

A new version of the Behaviour of Young Novice Drivers Scale (BYNDS). Insights from a randomised sample of 700 German young novice drivers - Jannusch T, V öller M, Murphy F, Mullins M.

This study aims to address t...

Source: SafetyLit - August 4, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Gene expression profiling in dorsolateral prostates of prepubertal and adult Sprague-Dawley rats dosed with estradiol benzoate, estradiol, and testosterone.

In this study, microarray analysis was used for gene expression profiling in rat prostate tissue after exposure to EDCs and sex hormones over multiple time points (prepubertal through adulthood). We used dorsolateral prostate tissues from Sprague-Dawley rats (male offspring) and postnatally administered estradiol benzoate (EB) on postnatal days (PNDs) 1, 3, and 5, followed by treatment with additional hormones [estradiol (E) and testosterone (T)] on PNDs 90-200, as described by Ho et al. Microarray analysis was performed for gene expression profiling in the dorsolateral prostate, and the results were validated via qRT-PCR....

Source: Journal of Toxicological Sciences - August 4, 2020 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Analysis of microRNA expression profiling during paraquat-induced injury of murine lung alveolar epithelial cells.

Authors: Zhao HW, Liu H, Liu LY, Liu Z, Dong XS Abstract Paraquat (PQ) as a non-selective heterocyclic herbicide, has been applied worldwide for over a few decades. But PQ is very harmful to humans and rodents. The lung is the main target organ of PQ poisoning. It is an important event that lung epithelial cells are injured during PQ-induced acute lung injury and pulmonary fibrosis. As a regulator of mRNA expression, microRNA (miRNA) may play an important role in the progress. Our study was to investigate the mechanisms of PQ-induced injury of pulmonary epithelial cells through analyzing the profiling of miRNAs and...

Source: Journal of Toxicological Sciences - August 4, 2020 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Estimation of Generalized Impact Fraction and Population Attributable Fraction of Hypertension Based on JNC-IV and 2017 ACC/AHA Guidelines for Cardiovascular Diseases Using Parametric G-Formula: Tehran Lipid and Glucose Study (TLGS)

Source: Risk Management and Healthcare Policy - August 4, 2020 Category: Health Management Tags: Risk Management and Healthcare Policy Source Type: research

Awareness, treatment rates, and compliance to treatment in patients with serum LDL cholesterol higher than 250 mg/dl, and possible, probable or definite familial hypercholesterolemia.

CONCLUSION: A significant proportion of patients with LDL-C≥250 mg/dL were not taking lipid-lowering drugs. Similar with many other studies, diagnosis and treatment rates of FH patients were very low in our study. Further national studies are required to increase awareness of the disease in both physicians and patients. PMID: 32744105 [PubMed - as supplied by publisher]

Source: Postgraduate Medicine - August 4, 2020 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Optimization of Electronically Monitored Non-Adherence in Highly Adherent Renal Transplant Recipients by Reducing the Dosing Frequency & ndash; A Prospective Single-Center Observational Study

Source: Patient Preference and Adherence - August 4, 2020 Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research

Overall and cause-specific mortality in patients with type 1 diabetes mellitus: Population-based cohort study in Taiwan between 1998 and 2014.

CONCLUSIONS: Type 1 diabetes in both genders and all ages was associated with significantly elevated SMRs for all-cause and mostly for diabetes per se and renal disease. PMID: 32741854 [PubMed - as supplied by publisher]

Source: Journal of Epidemiology - August 4, 2020 Category: Epidemiology Tags: J Epidemiol Source Type: research