Fight Aging! Newsletter, November 25th 2019

This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ridiculous argument given the present evidence. To make it one has to declare the existing results showing extension of healthy life span in mice to be something other than credible data, which just isn't the case. Further, it seems shaky on theoretical grounds to suggest that removal of something like 1% of cells will put onerous stress on the remaining 99%, particularly given that the 1% were contributing to declining stem cell activity via inflammatory signaling. All told, it is hard to take seriously the idea that loss of senescent cells can possibly produce greater degrees of dysfunction in tissue than is caused by the inflammatory signaling of senescent cells. Your new review on senolytics suggests that senolytics may cause more harm than good. Can you summarize your objections and concerns? Here is the argument: 1) theoretically, senol...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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ConclusionSubstantial agreement exists among experts regarding many strong recommendations for the improvement of practice concerning the use of muscle relaxants and reversal agents during anaesthesia. In particular, the French Society of Anaesthesia and Intensive Care (SFAR) recommends the use of a device to monitor neuromuscular blockade throughout anaesthesia.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Date: Friday, 01 24, 2020; Speaker: Diane L. Bolton, Ph.D., Chief, Animal Models&Pathogenesis Section, US Military HIV Research Program; 33; 1N09
Source: NIH Calendar of Events - Category: American Health Source Type: events
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
ConclusionsStudents with ID are at increased risk of developing depressive symptoms when exposed to negative social relationships (i.e., peer victimization or TSR conflict). For these students, the benefits of TSR warmth were far less important than the consequences of conflict.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: Available online 16 January 2020Source: Stem Cell ReportsAuthor(s): Weiwei Yang, G. Devon Trahan, Elizabeth D. Howell, Nancy A. Speck, Kenneth L. Jones, Austin E. Gillen, Kent Riemondy, Jay Hesselberth, David Bryder, Patricia ErnstSummaryThe Mixed Lineage Leukemia (MLL1, KMT2A) gene is critical for development and maintenance of hematopoietic stem cells (HSCs), however, whether this protein is limiting for HSC development is unknown due to lack of physiologic model systems. Here, we develop an MLL1-inducible embryonic stem cell (ESC) system and show that induction of wild-type MLL1 during ESC di...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
In conclusion, we succeeded in generating an iPSC-based RAG2-SCID model, which enabled the identification of previously unrecognized disorder-related T cell developmental roadblocks.Graphical Abstract
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 16 January 2020Source: Stem Cell ReportsAuthor(s): Insoo Hyun, Megan Munsie, Martin F. Pera, Nicolas C. Rivron, Janet RossantOver the past few years, a number of research groups have reported striking progress on the generation of in vitro models from mouse and human stem cells that replicate aspects of early embryonic development. Not only do these models reproduce some key cell fate decisions but, especially in the mouse system, they also mimic the spatiotemporal arrangements of embryonic and extraembryonic tissues that are required for developmental patterning and implantation in ...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
This article describes a model of human induced pluripotent stem cell cardiomyocyte-derived engineered heart tissues (hiPSC-CM EHTs) transduced with the calcium sensor GCaMP6f followed by sequential analysis of force and CaT. Average peak analysis demonstrated the temporal sequence of the CaT preceding the contraction twitch. The pharmacological relevance of the test system was demonstrated with inotropic indicator compounds. Force-frequency relationship was analyzed in the presence of ivabradine (300 nM), which reduced spontaneous frequency and unmasked a positive correlation of force and CaT at physiological human h...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 17 January 2020Source: Stem Cell ResearchAuthor(s): Xiaomeng Yang, Beibei Yan, Haiyan Zhang, Yanyan Ma, Qi Zhou, Yue Li, Jingyun Guan, Dong Wang, Yi Liu, Zhongtao GaiAbstractAn induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells of a 3-day-old boy with 47,XXY and Ornithine Transcarbamylase Deficiency carrying hemizygote mutation (c.663+2T>G (sliping)) in OTC. The iPSCs had original 47,XXY, and mutation in OTC, expressing pluripotency markers and bearing differentiation potential in vitro.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 16 January 2020Source: Stem Cell ResearchAuthor(s): Rachelle Balez, Tracey Berg, Monique Bax, Sonia Sanz Muñoz, Mauricio C. Cabral-da-Silva, Martin Engel, Dzung Do-Ha, Claire H. Stevens, Dominic Rowe, Shu Yang, Ian P. Blair, Lezanne OoiAbstractDermal fibroblasts were donated by a 43 year old male patient with clinically diagnosed familial amyotrophic lateral sclerosis (ALS), carrying the SOD1E101G mutation. The induced pluripotent stem cell (iPSC) line UOWi007-A was generated using repeated mRNA transfections for pluripotency transcription factors Oct4, Klf4, Sox2, c-Myc, Lin28 and...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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