Delay in the Diagnosis of APECED: A Case Report and Review of Literature from Iran.
In this study, we report an Iranian patient who presented with Addison disease, chronic mucocutaneous candidiasis, alopecia totalis, keratopathy and asplenia treated as an isolated endocrinopathy for 25 years. In the adulthood, the diagnosis of APECED was made by genetic analysis which demonstrated homozygous nonsense p.R257* (c.769C>T) mutation of AIRE. APECED has been shown to be frequent in some ethnicities including Iranian Jews. Therefore, we reviewed 39 Iranian APECED patients published in the literature. We found that most of the Iranian patients were of Jewish ethnic background and presented hypoparathyroidism, ...
Source: Immunological Investigations - October 8, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Tofacitinib therapy for the treatment of alopecia areata: Report of 11 patients
Background: Alopecia areata (AA) is a chronic disorder characterized by patchy loss of hair. Sometimes disease can be severe leading to loss of entire scalp and body hair. Management of these patients is very difficult with the available options of topical and systemic immunosuppressant agents. Tofacitinib, JAK3 inhibitor, is emerging as a promising drug for the management of severe and resistant cases of AA/totalis/universalis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research
Epidemiology of alopecia areata, ophiasis, totalis and universalis: A systematic review and meta-analysis
Alopecia areata (AA) is a common, autoimmune, alopecia with heterogeneous severity and distribution. Previous studies found conflicting results about AA epidemiology. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 18, 2019 Category: Dermatology Authors: Harrison H. Lee, Eran Gwillim, Kevin R. Patel, Tammy Hua, Supriya Rastogi, Erin Ibler, Jonathan I. Silverberg Source Type: research
Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis
Alopecia areata (AA) is a common autoimmune alopecia with heterogeneous severity and distribution. Previous studies found conflicting results about AA epidemiology. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 18, 2019 Category: Dermatology Authors: Harrison H. Lee, Eran Gwillim, Kevin R. Patel, Tammy Hua, Supriya Rastogi, Erin Ibler, Jonathan I. Silverberg Tags: Original article Source Type: research
Impact of alopecia areata on psychiatric disorders: A retrospective cohort study
To the Editor: Alopecia areata (AA) is a common inflammatory condition presenting as round or oval patches of nonscarring hair loss. Although AA is not life threatening, psychiatric comorbidities are especially common, and the effect of these comorbidities is considerable in severe cases, such as alopecia totalis or alopecia universalis.1,2 However, a relationship between AA and psychiatric disorders (PDs) and the effect of disease severity and duration are not well known. Therefore, we performed a retrospective cohort study to investigate the risk of various PDs in patients with AA using data from the National Health Insu...
Source: Journal of the American Academy of Dermatology - July 2, 2019 Category: Dermatology Authors: Jin Cheol Kim, Eun-So Lee, Jee Woong Choi Tags: Letter Source Type: research
Incidence and prevalence of alopecia areata according to subtype: A nationwide, population-based study in South Korea (2006-2015).
This article is protected by copyright. All rights reserved.
PMID: 31102412 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 17, 2019 Category: Dermatology Authors: Lee JH, Kim HJ, Han KD, Han JH, Bang CH, Park YM, Lee JY, Lee SJ, Park YG, Lee YB Tags: Br J Dermatol Source Type: research
Patients with alopecia areata show signs of insulin resistance
AbstractAlopecia areata (AA) is an autoimmune disease associated with high levels of proinflammatory cytokines. Since chronic inflammation plays a major role in the pathogenesis of insulin resistance, AA can theoretically increase the risk of diabetes. We sought to investigate this theory by conducting a case –control study. Sixty patients with alopecia areata and 60 healthy volunteers (matched for age, sex, and body mass index) were evaluated. Fasting blood glucose (FBS), C-peptide, plasma insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured for each individual. Pla sma levels of insu...
Source: Archives of Dermatological Research - May 13, 2019 Category: Dermatology Source Type: research
231 Epidemiology of alopecia areata, totalis, universalis, and ophiasis: A systematic review and meta-analysis
Alopecia areata (AA) is a common autoimmune alopecia with heterogeneous severity and distribution. Previous studies found conflicting results about the epidemiology of AA. We performed a systematic review of all published cohort and cross-sectional studies that analyzed AA, and excluded other types of alopecia.MEDLINE, EMBASE, LILACS, Scopus, Cochrane library and GREAT were searched. The pooled prevalence of AA, alopecia totalis (AT), ophiasis (AO), and universalis (AU) were determined and stratified by population source, study region, study year and age. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: H.H. Lee, K. Patel, T. Hua, E.C. Gwillim, S. Rastogi, J. Silverberg Tags: Epidemiology Source Type: research
Alopecia areata is characterised by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease-associated psychological morbidity.
CONCLUSION: Our data highlight changes in both type 17 and 2 cytokines, suggesting that complex systemic cytokine profiles may contribute both to the pathogenesis of AA and to the associated depression This article is protected by copyright. All rights reserved.
PMID: 30980732 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2019 Category: Dermatology Authors: Bain KA, McDonald E, Moffat F, Tutino M, Castelino M, Barton A, Cavanagh J, Ijaz UZ, Siebert S, McInnes IB, Astrand A, Holmes S, Milling SWF Tags: Br J Dermatol Source Type: research
Are Preferred Scalp Locations for Alopecia Areata Patches a Clue to Neuronal Etiology?
Conclusion: AA patches most commonly present on the occiput of the scalp in both female and male patients. Cervical spine nerves C3 and C2 supply sensory innervation and the occipital artery supplies blood to this area.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - March 22, 2019 Category: Dermatology Source Type: research
GSE111061 An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch Type Alopecia Areata, Totalis and Universalis
This study was an open-label, clinical trial to investigate tofacitinib 5 mg to 10 mg PO twice daily in the treatment of moderate/severe alopeica areata and to identify if gene expression of the scalp correlates with clinical response. Gene expression profiling was performed on scalp biopsies of alopecia areata patients taken at baseline and up to 24 weeks of treatment of tofacitinib. We applied both na ïve and supervised clustering to this dataset in order to assess two features: the overall molecular effect of tofacitinib treatment on patient samples, and the concordant molecular response of the disease. The former was ...
Source: GEO: Gene Expression Omnibus - February 28, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Familial Vitamin D-dependent rickets Type 2A: A report of two cases with alopecia and oral manifestations
We report two cases of familial VDDR2A, with alopecia and oral manifestations. (Source: Journal of Oral and Maxillofacial Pathology)
Source: Journal of Oral and Maxillofacial Pathology - February 22, 2019 Category: ENT & OMF Authors: Moni Thakur Source Type: research
Serum interleukin-15 is a marker of alopecia areata severity
Conclusion: Serum IL-15 may be a marker of AA severity. (Source: International Journal of Trichology)
Source: International Journal of Trichology - February 13, 2019 Category: Dermatology Authors: Adel Ali Ebrahim Rehab Mohammed Salem Asmaa Adel El Fallah Esraa Taha Younis Source Type: research
Efficacy of diphenylcyclopropenone in alopecia areata: a comparison of two treatment regimens.
Conclusions: Treatment at longer intervals may be safer and more comfortable for patients; however, further research is required.
PMID: 30618524 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - January 10, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Severity of disease and quality of life in parents of children with alopecia areata, totalis, and universalis: a prospective, cross-sectional study
•Chronic disease impacts parent’s quality of life. Awareness of the impact of alopecia areata on the emotional health of parents should lead to more family centered care for this disease. Parent needs support systems as much as children do. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 9, 2019 Category: Dermatology Authors: Elana Putterman, Deepa P. Patel, Gabriela Andrade, Katya L. Harfmann, Marcia Hogeling, Carol E. Cheng, Carolyn Goh, Rachel S. Rogers, Leslie Castelo-Soccio Source Type: research
