& #8220;Turban PUVAsol: & #8221; A simple, novel, effective, and safe treatment option for advanced and refractory cases of alopecia areata
Conclusion: We found topical Turban PUVAsol to be a very cost-effective and safe treatment option for AA. (Source: International Journal of Trichology)
Source: International Journal of Trichology - June 20, 2018 Category: Dermatology Authors: Banashree Majumdar Abhishek De Soumyodhriti Ghosh Amrita Sil Aarti Sarda Koushik Lahiri Gobinda Chatterjee Sudip Das Source Type: research
Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients
Conclusion: In our patients, tofacitinib successfully alleviated AU in the absence of significant adverse side effects. We recommend that further controlled studies be required to establish safety and confirm efficacy. (Source: International Journal of Trichology)
Source: International Journal of Trichology - June 20, 2018 Category: Dermatology Authors: Chandrashekar Byalekere Shivanna Chaithra Shenoy R Arti Priya Source Type: research
Mesalazine in the treatment of extensive alopecia areata: A new therapeutic option ?
Conclusions: In extensive and refractory AA cases, the topical treatment combined with mesalazine may provide excellent results, reducing the need for extended oral corticosteroids courses. Besides that, mesalazine seems to minimize relapses on discontinuation of oral steroids. Controlled studies are needed to confirm the effectiveness of this combination. (Source: International Journal of Trichology)
Source: International Journal of Trichology - June 20, 2018 Category: Dermatology Authors: Ana Elisa Kiszewski Mariele Bevilaqua Luciana Boff De Abreu Source Type: research
Risk of sun ‐induced skin cancers in patients with alopecia areata, alopecia totalis and alopecia universalis
Journal of the European Academy of Dermatology and Venereology, EarlyView. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - May 28, 2018 Category: Dermatology Authors: R.R.Z. Conic
,
R. Miller
,
M. Piliang
,
W. Bergfeld
,
N. Atanaskova Mesinkovska Source Type: research
Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A critically appraised topic.
This article is protected by copyright. All rights reserved.
PMID: 29777625 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 19, 2018 Category: Dermatology Authors: Browne R, Stewart L, Williams HC Tags: Br J Dermatol Source Type: research
Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A critically appraised topic
British Journal of Dermatology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - May 19, 2018 Category: Dermatology Authors: R. Browne
,
L. Stewart
,
H.C. Williams Source Type: research
Topical 2% tofacitinib for children with alopecia areata, alopecia totalis, and alopecia universalis
To the Editor: Alopecia areata (AA) is an autoimmune condition with limited treatment options, particularly in pediatric populations. There are no Food and Drug Administration –approved treatments for children with AA, and medications used for alopecia totalis (AT) and alopecia universalis (AU) lack large, controlled studies.1 The mainstays of treatment are topical or intralesional steroids and irritant therapy. Some families opt for systemic therapies, including oral c orticosteroids or off-label use of immunosuppressive drugs, such as methotrexate, cyclosporine A, mycophenolate mofetil, or azathioprine. (Source: Journa...
Source: Journal of the American Academy of Dermatology - May 11, 2018 Category: Dermatology Authors: Elana Putterman, Leslie Castelo-Soccio Tags: Research letter Source Type: research
An unusual case of hamartomatous polyposis with malignancy complication in a patient with ulcerative colitis treated with golimumab.
We report an unusual case of hamartomatous polyposis with malignant complications in a patient with ulcerative colitis on golimumab and previous thiopurine therapy. This patient was evaluated for iron deficiency anemia and underwent hemicolectomy for extensive right-side predominant inflammatory pseudopolyps. Anemia persisted post-colectomy and subsequent gastroscopy showed a fungating polypoid lesion along with numerous carpet-like strawberry appearing polyps in the stomach extending from the gastro-esophageal junction to the distal part of the antrum, necessitating a gastrectomy. Histology showed extensive hamartomatous-...
Source: Acta Gastro-Enterologica Belgica - March 23, 2018 Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Diphencyclopropenone (DPCP) for alopecia areata: a UK survey.
This article is protected by copyright. All rights reserved.
PMID: 29480935 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 26, 2018 Category: Dermatology Authors: Karanovic S, Harries M, Kaur MR Tags: Br J Dermatol Source Type: research
An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis
Alopecia areata (AA) is a common autoimmune disease with a lifetime risk of ∼2%. In AA, the immune system targets the hair follicle, resulting in clinical hair loss. The prognosis of AA is unpredictable, and currently there is no definitive treatment. Our previous whole genome expression studies identified active immune circuits in AA lesions, including common γ-chain cy tokine and IFN pathways. Because these pathways are mediated through JAK kinases, we prioritized clinical exploration of small molecule JAK inhibitors. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - February 13, 2018 Category: Dermatology Authors: A. Jabbari, F. Sansaricq, J. Cerise, J.C. Chen, A. Bitterman, G. Ulerio, J. Borbon, R. Clynes, A.M. Christiano, J. Mackay-Wiggan Tags: Original Article Source Type: research
An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch Type Alopecia Areata, Totalis and Universalis
Alopecia areata (AA) is a common autoimmune disease, with a lifetime risk of ∼2%. In AA, the immune systems targets the hair follicle, resulting in clinical hair loss. AA prognosis is unpredictable, and currently there is no definitive treatment. Our previous whole genome expression studies identified active immune circuits in AA lesions, including common γ-chain cytokine and IFN pathways. Since these pathways are mediated through JAK kinases, we prioritized clinical exploration of small molecule JAK inhibitors. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - February 13, 2018 Category: Dermatology Authors: A. Jabbari, F. Sansaricq, J. Cerise, J.C. Chen, A. Bitterman, G. Ulerio, J. Borbon, R. Clynes, A.M. Christiano, J. Mackay-Wiggan Tags: Original Article Source Type: research
An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis
Alopecia areata (AA) is a common autoimmune disease with a lifetime risk of ∼2%. In AA, the immune system targets the hair follicle, resulting in clinical hair loss. The prognosis of AA is unpredictable, and currently there is no definitive treatment. Our previous whole genome expression studies identified active immune circuits in AA lesions, including common γ-chain cy tokine and IFN pathways. Because these pathways are mediated through JAK kinases, we prioritized clinical exploration of small molecule JAK inhibitors. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - February 13, 2018 Category: Dermatology Authors: A. Jabbari, F. Sansaricq, J. Cerise, J.C. Chen, A. Bitterman, G. Ulerio, J. Borbon, R. Clynes, A.M. Christiano, J. Mackay-Wiggan Tags: Original Article Source Type: research
Diphencyclopropenone (DPCP) for alopecia areata: a UK survey
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 1, 2018 Category: Dermatology Authors: S. Karanovic, M. Harries, M.R. Kaur Tags: Research Letter Source Type: research
Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation
Germline heterozygous NFKB2 variants that result in an unprocessable NF-κB2 (nuclear factor-kappa-B) p100 subunit have been identified as a cause of primary immunodeficiency.1 Patients often present with clinical and immunological features consistent with common variable immunodeficiency (CVID); however, additional defects in T and natural killer cells have been reported, widening the immunological phenotype. Multisystem autoimmunity is also frequently present in patients with damaging NFKB2 variants, causing endocrinopathies including central adrenal insufficiency, growth hormone deficiency, and hypothyroidism, as we l...
Source: Journal of Allergy and Clinical Immunology - December 7, 2017 Category: Allergy & Immunology Authors: Kesava A. Ramakrishnan, William Rae, Gabriela Barcenas-Morales, Yifang Gao, Reuben J. Pengelly, Sanjay V. Patel, Dinakantha S. Kumararatne, Sarah Ennis, Rainer D öffinger, Saul N. Faust, Anthony P. Williams Tags: Letter to the Editor Source Type: research
