Development of a multivariate predictive model for dapsone adverse drug events in people with leprosy under standard WHO multidrug therapy
ConclusionWe propose a clinical model that could become a helpful tool for physicians in predicting ADEs in DDS-treated leprosy patients. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 25, 2024 Category: Tropical Medicine Authors: Ana Carolina Galv ão dos Santos de Araujo Source Type: research
Case Report: Borderline Lepromatous Leprosy Therapy Complicated by Type 1 Leprosy Reaction and Adverse Reactions with Dapsone and Clofazimine
Am J Trop Med Hyg. 2024 Jan 23:tpmd220637. doi: 10.4269/ajtmh.22-0637. Online ahead of print.ABSTRACTLeprosy is a global health issue, causing long-term functional morbidity and stigma. Rapid diagnosis and appropriate treatment are important; however, early diagnosis is often challenging, especially in nonendemic areas. Here, we report a case of borderline lepromatous leprosy accompanied by dapsone-induced (neutropenia, anemia, and methemoglobinemia) and clofazimine-induced (skin discoloration and ichthyosis) side effects and type 1 leprosy reactions during administration of the multidrug therapy. The patient completely re...
Source: Am J Trop Med Hyg - January 24, 2024 Category: Infectious Diseases Authors: Takashi Matono Shotaro Suzuki Shuichi Mori Manabu Ato Source Type: research
Case Report: Borderline Lepromatous Leprosy Therapy Complicated by Type 1 Leprosy Reaction and Adverse Reactions with Dapsone and Clofazimine
Am J Trop Med Hyg. 2024 Jan 23:tpmd220637. doi: 10.4269/ajtmh.22-0637. Online ahead of print.ABSTRACTLeprosy is a global health issue, causing long-term functional morbidity and stigma. Rapid diagnosis and appropriate treatment are important; however, early diagnosis is often challenging, especially in nonendemic areas. Here, we report a case of borderline lepromatous leprosy accompanied by dapsone-induced (neutropenia, anemia, and methemoglobinemia) and clofazimine-induced (skin discoloration and ichthyosis) side effects and type 1 leprosy reactions during administration of the multidrug therapy. The patient completely re...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2024 Category: Tropical Medicine Authors: Takashi Matono Shotaro Suzuki Shuichi Mori Manabu Ato Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Momin, Bahar Source Type: research
Photochemical Synthesis of a Cubyl Derivative of Dapsone
Synfacts 2024; 20: 0201- DOI: 10.1055/s-0043-1763860 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Synfacts)
Source: Synfacts - January 16, 2024 Category: Chemistry Tags: Innovative Drug Discovery and Development Source Type: research
Treatment of Pyoderma Gangrenosum
Pyoderma gangrenosum is a rare neutrophilic dermatosis that results in painful cutaneous ulcers and is frequently associated with underlying hematologic disorders, inflammatory bowel disease, or other autoimmune disorders. Pathogenesis involves an imbalance between proinflammatory and anti-inflammatory mediators, leading to tissue damage from neutrophils. First-line treatment options with the greatest evidence include systemic corticosteroids, cyclosporine, and tumor necrosis factor alpha inhibitors. Other steroid-sparing therapies such as dapsone, mycophenolate mofetil, intravenous immunoglobulin, and targeted biologic or...
Source: Dermatologic Clinics - December 29, 2023 Category: Dermatology Authors: Marcus G. Tan, Stanislav N. Tolkachjov Source Type: research
Evaluation of dapsone and its synthetic derivative DDS ‑13 in cancer < em > in vitro < /em >
The objectives of the present study were to evaluate the anticancer activity of both DDS and DDS-13 and to identify the physicochemical and pharmacokinetic properties of DDS-13. The results showed that DDS-13 presented a cytotoxic effect in the DU145 cell line (IC50=19.06 µM), while DDS showed a cytotoxic effect on both the DU145 (IC50=11.11 µM) and HeLa (IC50=13.07 µM) cell lines. DDS-13 appears to be a good cytotoxic candidate for the treatment of prostate cancer, while DDS appears to be a good candidate for both cervical and prostate cancer. Neither candidate showed a cytotoxic effect in non-cancerous cells. The diff...
Source: Experimental and Therapeutic Medicine - December 25, 2023 Category: General Medicine Authors: Griselda A Cabral-Pacheco Virginia Flores-Morales Idalia Garza-Veloz Miriam Dami án-Sandoval Rosa B Mart ínez-Flores Mar ía C Martínez-Vázquez Iv án Delgado-Enciso Iram P Rodriguez-Sanchez Margarita L Martinez-Fierro Source Type: research
