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Utilization of dapsone and hemoglobin in the epithelial skin regeneration therapy of cutaneous loxoscelism: A case report and integrative literature review
CONCLUSIONS: The administration of dapsone and heparin for the management of cutaneous loxoscelism demonstrated success in this case, with no sequelae observed. In general, the literature review indicated favorable outcomes in patients treated with antimicrobials and corticosteroids, with continuous healing of skin lesions.SYSTEMATIC REVIEW REGISTRATION: PROSPERO ID CRD42023422424 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023422424).PMID:38422241 | PMC:PMC10885633 | DOI:10.1590/1516-3180.2023.0151.04012023 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - February 29, 2024 Category: General Medicine Authors: Omar Azuara-Antonio Mario Isidoro Ortiz Karla Daniela Jim énez-Oliver Marco Castillo-Cabrera Ana Karen M éndez-Salinas Luz Hern ández-Ramírez Source Type: research

Fabrication and characterization of a Bi < sub > 2 < /sub > O < sub > 3 < /sub > -modified chitosan@ZIF-8 nanocomposite for enhanced drug loading-releasing efficacy
In this study, a simple novel hybrid mesoporous nanomaterial derived from a metal-organic framework (ZIF-8) and chitosan, which were coated on green bismuth oxide, has been successfully synthesized, characterized, and applied to investigate its dapsone loading-releasing capability in the aqueous media. This suggested nanocomposite showed promise for drug loading from water b using hydrogen bonds, pi-pi, and electrostatic interactions. Structural and morphological analyses were performed on the proposed green synthesized nanocomposite through scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectr...
Source: International Journal of Biological Macromolecules - February 21, 2024 Category: Biochemistry Authors: Zahra Khalili Negar Moatakef Kazemi Zahra Jafari Azar Zahra Mosavi Mehdi Hasanzadeh Source Type: research

Clinical Features of Paediatric Inflammatory Epidermolysis Bullosa Acquisita: A Case Series Study
In conclusion, EBA in childhood may be unique, and thus distinct from its adult counterpart. Specific treatment and follow-up protocols are required for therapy of this rare autoimmune skin disease in children.PMID:38270257 | PMC:PMC10831865 | DOI:10.2340/actadv.v104.11917 (Source: Acta Derm Venereol A...)
Source: Acta Derm Venereol A... - January 25, 2024 Category: Dermatology Authors: Yuexin Zhang Jingyang Dang Ruoyu Li Xixue Chen Xuejun Zhu Mingyue Wang Source Type: research

Clinical Features of Paediatric Inflammatory Epidermolysis Bullosa Acquisita: A Case Series Study
In conclusion, EBA in childhood may be unique, and thus distinct from its adult counterpart. Specific treatment and follow-up protocols are required for therapy of this rare autoimmune skin disease in children.PMID:38270257 | PMC:PMC10831865 | DOI:10.2340/actadv.v104.11917 (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 25, 2024 Category: Dermatology Authors: Yuexin Zhang Jingyang Dang Ruoyu Li Xixue Chen Xuejun Zhu Mingyue Wang Source Type: research

Development of a multivariate predictive model for dapsone adverse drug events in people with leprosy under standard WHO multidrug therapy
ConclusionWe propose a clinical model that could become a helpful tool for physicians in predicting ADEs in DDS-treated leprosy patients. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 25, 2024 Category: Tropical Medicine Authors: Ana Carolina Galv ão dos Santos de Araujo Source Type: research

Case Report: Borderline Lepromatous Leprosy Therapy Complicated by Type 1 Leprosy Reaction and Adverse Reactions with Dapsone and Clofazimine
Am J Trop Med Hyg. 2024 Jan 23:tpmd220637. doi: 10.4269/ajtmh.22-0637. Online ahead of print.ABSTRACTLeprosy is a global health issue, causing long-term functional morbidity and stigma. Rapid diagnosis and appropriate treatment are important; however, early diagnosis is often challenging, especially in nonendemic areas. Here, we report a case of borderline lepromatous leprosy accompanied by dapsone-induced (neutropenia, anemia, and methemoglobinemia) and clofazimine-induced (skin discoloration and ichthyosis) side effects and type 1 leprosy reactions during administration of the multidrug therapy. The patient completely re...
Source: Am J Trop Med Hyg - January 24, 2024 Category: Infectious Diseases Authors: Takashi Matono Shotaro Suzuki Shuichi Mori Manabu Ato Source Type: research

Case Report: Borderline Lepromatous Leprosy Therapy Complicated by Type 1 Leprosy Reaction and Adverse Reactions with Dapsone and Clofazimine
Am J Trop Med Hyg. 2024 Jan 23:tpmd220637. doi: 10.4269/ajtmh.22-0637. Online ahead of print.ABSTRACTLeprosy is a global health issue, causing long-term functional morbidity and stigma. Rapid diagnosis and appropriate treatment are important; however, early diagnosis is often challenging, especially in nonendemic areas. Here, we report a case of borderline lepromatous leprosy accompanied by dapsone-induced (neutropenia, anemia, and methemoglobinemia) and clofazimine-induced (skin discoloration and ichthyosis) side effects and type 1 leprosy reactions during administration of the multidrug therapy. The patient completely re...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2024 Category: Tropical Medicine Authors: Takashi Matono Shotaro Suzuki Shuichi Mori Manabu Ato Source Type: research

Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Momin, Bahar Source Type: research