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Red crusty plaques in a young man
Pemphigus foliaceus is a superficial blistering disorder characterized by erosions and scaling in a seborrheic distribution. The condition typically occurs in healthy individuals but issues arise from delayed diagnosis. Many cases remain undiagnosed or misdiagnosed due to the lack of awareness of the condition. With use of common diagnostic tools, pemphigus foliaceus can be easily identified and monitored. Histological analysis exhibits "chicken wire" patterning along keratinocytes in the upper epidermis, whereas immunofluorescence study displays subcorneal acantholysis. Pemphigus foliaceus is confirmed via ELISA studies r...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Farsi, Mishma Source Type: research

Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Bittencourt, Maraya Semblano Source Type: research

Cost-effectiveness analysis of HLA-B*13:01 screening for the prevention of co-trimoxazole-induced severe cutaneous adverse reactions among HIV-infected patients in Thailand
This study aims to evaluate the cost-effectiveness of HLA-B*13:01 screening before co-trimoxazole initiation in HIV-infected patients in Thailand. A combination of a decision tree model and a Markov model was used to estimate lifetime costs and outcomes of two strategies including 1) HLA-B*13:01 screening before co-trimoxazole initiation and 2) usual practice from a societal perspective. Alternative drugs are not considered because dapsone (the second-line drug) also presents a genetic risk. Input parameters were obtained from literature, government documents, and part of the TREAT Asia HIV Observational Database (TAHOD). ...
Source: Journal of Medical Economics - October 13, 2023 Category: Health Management Authors: Warittakorn Kategeaw Nontaya Nakkam Sasisopin Kiertiburanakul Chonlaphat Sukasem Wichittra Tassaneeyakul Nathorn Chaiyakunapruk Source Type: research

Overview and Current Advances in Dapsone Hypersensitivity Syndrome
AbstractPurpose of ReviewAs a sulfone antibacterial agent, dapsone has been widely used to treat leprosy. Moreover, dapsone is also used in many immune diseases such as herpetic dermatitis because of its anti-inflammatory and immunomodulatory effects. However, dapsone can cause several adverse effects, the most serious being dapsone hypersensitivity syndrome. Dapsone hypersensitivity syndrome is characterized by a triad of eruptions, fever, and organ involvement, which limits the application of dapsone to some extent.Recent FindingsIn this article, we review current research about the interaction model between HLA-B*13:01,...
Source: Current Allergy and Asthma Reports - October 7, 2023 Category: Allergy & Immunology Source Type: research

Fragment-based and structure-guided discovery of perforin inhibitors
In this study, by screening a fragment library using NMR and surface plasmon resonance, we identified 4,4-diaminodiphenyl sulfone (dapsone) as a perforin ligand. We also found that dapsone has modest (mM) inhibitory activity of perforin lytic activity in a red blood cell lysis assay in vitro. Sequential modification of this lead fragment, guided by structural knowledge of the ligand binding site and binding pose, and supported by SPR and ligand-detected 19F NMR, enabled the design of nanomolar inhibitors of the cytolytic activity of intact NK cells against various tumour cell targets. Interestingly, the ligands we develope...
Source: European Journal of Medicinal Chemistry - September 16, 2023 Category: Chemistry Authors: Jiney Jose Ruby H P Law Eleanor W W Leung Dorothy C C Wai Hedieh Akhlaghi Indu R Chandrashekaran Tom T Caradoc-Davies Ilia Voskoboinik John Feutrill David Middlemiss Devadharshini Jeevarajah Tanya Bashtannyk-Puhalovich Anna C Giddens Tet Woo Lee Stephen M Source Type: research

Management of Rhinosporidiosis: by Coblation
AbstractRhinosporidiosis is a granulomatous disease commonly affecting the mucous membrane. It is caused by Rhinosporidium seeberi, an aquatic parasite& seen affecting the nose, paranasal sinuses most commonly. A retrospective study was conducted at a tertiary care hospital situated in Indian peninsula and five patients who were diagnosed and treated for rhinosporidiosis were analysed. Surgical excision by coblator along with medical management using Dapsone 100 mg once daily for 6 months given promising results in view of reducing recurrence. Combined approach of management including surgical excision using coblator...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - September 5, 2023 Category: ENT & OMF Source Type: research

Editors ’ Picks
Systemic corticosteroids are the mainstay treatment for Sweet syndrome, an acute febrile neutrophilic dermatosis with unclear pathogenesis; however, such therapy is often accompanied by considerable morbidity. Alternative therapies, such as colchicine, dapsone, and potassium iodide, have been used for treatment; however, many patients have experienced refractory disease. Bhattacharya et al. (2023) reported identification of a gain-of-function mutation in PIK3R1 in neutrophils from a patient with systemic Sweet syndrome who required chronic use of systemic corticosteroids and exhibited IL-1β–dominant inflammation. (Sou...
Source: Journal of Investigative Dermatology - August 21, 2023 Category: Dermatology Tags: Editors ’ Picks Source Type: research

Amicrobial pustulosis of the folds: long-term remission achieved with low dose dapsone and topical pimecrolimus
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361443.NO ABSTRACTPMID:37591283 | DOI:10.5070/D329361443 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Chrysa Brinia Aikaterini Tsiogka Eftychia Platsidaki Vasiliki Markantoni Stamatios Gregoriou Dimitris Rigopoulos Georgios Kontochristopoulos Source Type: research