Molecules, Vol. 29, Pages 1743: Experimental and Theoretical Insights into the Intermolecular Interactions in Saturated Systems of Dapsone in Conventional and Deep Eutectic Solvents
This study also analyzed the intermolecular interactions, not only in the studied eutectic systems, but also in a wide range of systems found in the literature, determined using the COSMO-RS framework. The intermolecular interactions were quantified as affinity values, which correspond to the Gibbs free energy of pair formation of dapsone molecules with constituents of regular solvents and choline chloride-based deep eutectic solvents. The patterns of solute–solute, solute–solvent, and solvent–solvent interactions that affect solubility were recognized using Orange data mining soft...
Source: Molecules - April 11, 2024 Category: Chemistry Authors: Cysewski Jeli ński Przyby łek Tags: Article Source Type: research
Increased Risk of Nocardia Infection with Atovaquone Prophylaxis in Cardiac Transplant Patients: A Critical Analysis
Purpose: Prophylactic measures are essential to minimize the risk of opportunistic infections in transplant recipients. Traditionally, sulfamethoxazole-trimethoprim (Bactrim) has been the preferred prophylactic agent for pneumocystis jirovecii pneumonia (PJP). However, use comes with risk of hyperkalemia and caution in patients with kidney impairment or sulfa allergy. Use of alternative agents, such as atovaquone and dapsone, may not offer as broad of protection against other infections. Nocardia infections are a rare but serious complication in heart transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Robbins, J. Conway, R. Singh, Source Type: research
UCOMB-real life data: treatment strategies for chronic urticaria patients with comorbidities
CONCLUSIONS: Combining treatment modalities for chronic urticaria and comorbidities are available and feasible with a good safety profile.PMID:38508226 | DOI:10.1080/09546634.2024.2329784 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 20, 2024 Category: Dermatology Authors: Petra Staubach Benedikt Bilo Joachim W Fluhr Karoline Krause Kanokvalai Kulthanan Andac Salman Connie Katelaris Jonathan A Bernstein Marcus Maurer Caroline Mann Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Red crusty plaques in a young man
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562411.ABSTRACTPemphigus foliaceus is a superficial blistering disorder characterized by erosions and scaling in a seborrheic distribution. The condition typically occurs in healthy individuals but issues arise from delayed diagnosis. Many cases remain undiagnosed or misdiagnosed due to the lack of awareness of the condition. With use of common diagnostic tools, pemphigus foliaceus can be easily identified and monitored. Histological analysis exhibits "chicken wire" patterning along keratinocytes in the upper epidermis, whereas immunofluorescence study displays subcorn...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mishma Farsi Cassandra M Johnson Kelly Segars Jonathan Rhim Source Type: research
Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment.PMID:38478644 | DOI:10.5070/D329562408 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Maraya Semblano Bittencourt Tally Serruya Luana De Oliveira Loureiro Aline Dias Coelho De Souza Camilla Correa Neri Ana Thais Machado Moutinho Caren Dos Santos Lima Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Red crusty plaques in a young man
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562411.ABSTRACTPemphigus foliaceus is a superficial blistering disorder characterized by erosions and scaling in a seborrheic distribution. The condition typically occurs in healthy individuals but issues arise from delayed diagnosis. Many cases remain undiagnosed or misdiagnosed due to the lack of awareness of the condition. With use of common diagnostic tools, pemphigus foliaceus can be easily identified and monitored. Histological analysis exhibits "chicken wire" patterning along keratinocytes in the upper epidermis, whereas immunofluorescence study displays subcorn...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mishma Farsi Cassandra M Johnson Kelly Segars Jonathan Rhim Source Type: research
Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment.PMID:38478644 | DOI:10.5070/D329562408 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Maraya Semblano Bittencourt Tally Serruya Luana De Oliveira Loureiro Aline Dias Coelho De Souza Camilla Correa Neri Ana Thais Machado Moutinho Caren Dos Santos Lima Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Red crusty plaques in a young man
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562411.ABSTRACTPemphigus foliaceus is a superficial blistering disorder characterized by erosions and scaling in a seborrheic distribution. The condition typically occurs in healthy individuals but issues arise from delayed diagnosis. Many cases remain undiagnosed or misdiagnosed due to the lack of awareness of the condition. With use of common diagnostic tools, pemphigus foliaceus can be easily identified and monitored. Histological analysis exhibits "chicken wire" patterning along keratinocytes in the upper epidermis, whereas immunofluorescence study displays subcorn...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mishma Farsi Cassandra M Johnson Kelly Segars Jonathan Rhim Source Type: research
Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment.PMID:38478644 | DOI:10.5070/D329562408 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Maraya Semblano Bittencourt Tally Serruya Luana De Oliveira Loureiro Aline Dias Coelho De Souza Camilla Correa Neri Ana Thais Machado Moutinho Caren Dos Santos Lima Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Red crusty plaques in a young man
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562411.ABSTRACTPemphigus foliaceus is a superficial blistering disorder characterized by erosions and scaling in a seborrheic distribution. The condition typically occurs in healthy individuals but issues arise from delayed diagnosis. Many cases remain undiagnosed or misdiagnosed due to the lack of awareness of the condition. With use of common diagnostic tools, pemphigus foliaceus can be easily identified and monitored. Histological analysis exhibits "chicken wire" patterning along keratinocytes in the upper epidermis, whereas immunofluorescence study displays subcorn...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mishma Farsi Cassandra M Johnson Kelly Segars Jonathan Rhim Source Type: research
