Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report
Indian J Pathol Microbiol. 2023 Oct-Dec;66(4):852-854. doi: 10.4103/IJPM.IJPM_879_20.ABSTRACTPemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA depos...
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Rawat Kavita Azad Sheenam Bahal Neelima Bisht S Jitender Source Type: research
Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report
Indian J Pathol Microbiol. 2023 Oct-Dec;66(4):852-854. doi: 10.4103/IJPM.IJPM_879_20.ABSTRACTPemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA depos...
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Rawat Kavita Azad Sheenam Bahal Neelima Bisht S Jitender Source Type: research
Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report
Indian J Pathol Microbiol. 2023 Oct-Dec;66(4):852-854. doi: 10.4103/IJPM.IJPM_879_20.ABSTRACTPemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA depos...
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Rawat Kavita Azad Sheenam Bahal Neelima Bisht S Jitender Source Type: research
Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report
Indian J Pathol Microbiol. 2023 Oct-Dec;66(4):852-854. doi: 10.4103/IJPM.IJPM_879_20.ABSTRACTPemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA depos...
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Rawat Kavita Azad Sheenam Bahal Neelima Bisht S Jitender Source Type: research
Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report
Indian J Pathol Microbiol. 2023 Oct-Dec;66(4):852-854. doi: 10.4103/IJPM.IJPM_879_20.ABSTRACTPemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA depos...
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Rawat Kavita Azad Sheenam Bahal Neelima Bisht S Jitender Source Type: research
Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report
Indian J Pathol Microbiol. 2023 Oct-Dec;66(4):852-854. doi: 10.4103/IJPM.IJPM_879_20.ABSTRACTPemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA depos...
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Rawat Kavita Azad Sheenam Bahal Neelima Bisht S Jitender Source Type: research
Combination therapy for management of pemphigus patients with unexpected therapeutic response to rituximab: A report of five cases
This study aimed to evaluate the efficacy and safety of using a combination treatment of mycophenolate mofetil or dapsone and methotrexate in case of nonresponse, exacerbation or development of allergic reactions following rituximab therapy in pemphigus patients. In this case series, archive files of pemphigus patient in a tertiary care hospital from 2016 to 2021 who were treated with rituximab were reviewed and those with failure in treatment process including nonresponsiveness, exacerbation or development of allergic reactions to rituximab were identified and assessed. The study includes five patients out of 1245 RTX-tre...
Source: Clinical Case Reports - November 25, 2023 Category: General Medicine Authors: Zeinab Aryanian,
Insha Zainab Riyaz,
Kamran Balighi,
Ali Ahmadzade,
Hamid Reza Mahmoudi,
Arghavan Azizpour,
Parvaneh Hatami Tags: CASE REPORT Source Type: research
Superior efficacy of combination antibiotic therapy versus monotherapy in a mouse model of Lyme disease
Lyme disease (LD) results from the most prevalent tick-borne infection in North America, with over 476,000 estimated cases annually. The disease is caused by Borrelia burgdorferi (Bb) sensu lato which transmits through the bite of Ixodid ticks. Most cases treated soon after infection are resolved by a short course of oral antibiotics. However, 10–20% of patients experience chronic symptoms because of delayed or incomplete treatment, a condition called Post-Treatment Lyme Disease (PTLD). Some Bb persists in PTLD patients after the initial course of antibiotics and an effective treatment to eradicate the persistent Bb is n...
Source: Frontiers in Microbiology - November 21, 2023 Category: Microbiology Source Type: research
Dapsone to Treat Moderate-to-Severe Hidradenitis Suppurativa: A Retrospective Case-Series
CONCLUSIONS: Dapsone may have some efficacy for moderate-to-severe HS and seems well-tolerated. J Drugs Dermatol. 2023;22(11):e12-e16 doi:10.36849/JDD.4936e.PMID:37943259 | DOI:10.36849/JDD.4936 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 9, 2023 Category: Dermatology Authors: Brittany Baroudi Arjun M Bashyam Steven R Feldman Rita O Pichardo Source Type: research
