Evaluation of dapsone and its synthetic derivative DDS ‑13 in cancer < em > in  vitro < /em >

The objectives of the present study were to evaluate the anticancer activity of both DDS and DDS-13 and to identify the physicochemical and pharmacokinetic properties of DDS-13. The results showed that DDS-13 presented a cytotoxic effect in the DU145 cell line (IC50=19.06 µM), while DDS showed a cytotoxic effect on both the DU145 (IC50=11.11 µM) and HeLa (IC50=13.07 µM) cell lines. DDS-13 appears to be a good cytotoxic candidate for the treatment of prostate cancer, while DDS appears to be a good candidate for both cervical and prostate cancer. Neither candidate showed a cytotoxic effect in non-cancerous cells. The different pharmacokinetic properties of DDS-13 make it a new candidate for evaluation in preclinical models for the treatment of cancer.PMID:38144918 | PMC:PMC10739155 | DOI:10.3892/etm.2023.12335

Source: Experimental and Therapeutic Medicine - December 25, 2023 Category: General Medicine Authors: Griselda A Cabral-Pacheco Virginia Flores-Morales Idalia Garza-Veloz Miriam Dami án-Sandoval Rosa B Mart ínez-Flores Mar ía C Martínez-Vázquez Iv án Delgado-Enciso Iram P Rodriguez-Sanchez Margarita L Martinez-Fierro Source Type: research