EVO100 prevents chlamydia and gonorrhea in women at high risk of infection
According to the Centers for Disease Control and Prevention, rates of infection for Chlamydia trachomatis and Neisseria gonorrhoeae are increasing in the United States. EVO100 is an investigational antimicrobial, pH-modulating, vaginal gel with active ingredients L-lactic acid, citric acid, and potassium bitartrate that is being evaluated for the prevention of sexually transmitted infections. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 7, 2021 Category: OBGYN Authors: B. Todd Chappell, Leandro A. Mena, Basem Maximos, Scott Mollan, Kelly Culwell, Brandon Howard Tags: Original Research Source Type: research
EVO100 Prevents Chlamydia and Gonorrhea in Women At High-Risk For Infection
According to the Centers for Disease Control and Prevention, rates of infection for Chlamydia trachomatis and Neisseria gonorrhea are increasing in the United States. EVO100 is an investigational antimicrobial, pH-modulating, vaginal gel with active ingredients L-lactic acid, citric acid, and potassium bitartrate that is being evaluated for the prevention of sexually transmitted infections. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 7, 2021 Category: OBGYN Authors: B. Todd CHAPPELL, Leandro A. MENA, Basem MAXIMOS, Scott MOLLAN, Kelly CULWELL, Brandon HOWARD Tags: Original Research: Gynecology Source Type: research
Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study
Among the multitude of complaints related to the lowering of estrogen in the menopause, those affecting the genitourinary tract are reported by at least 50% of menopausal women [1 –4]. The most common signs and symptoms of vulvovaginal atrophy (VVA) are dryness, dyspareunia, redness, itching, with occasional discharge and/or bleeding [5]. Recently, genitourinary syndrome of menopause (GSM) is a new definition to encompass even other sexual and urinary symptoms associated wi th VVA[6]. (Source: Maturitas)
Source: Maturitas - March 4, 2021 Category: Primary Care Authors: Francesco De Seta, Salvatore Caruso, Giovanni Di Lorenzo, Federico Romano, Mariateresa Mirandola, Rossella E. Nappi Source Type: research
Efficacy and safety of an adsorbent and anti-oxidative vaginal gel on CIN1 and 2, on high-risk HPV, and on p16/Ki-67: a randomized controlled trial
ConclusionSAM vaginal gel enhances the regression of cervical lesions and clears hr-HPV and p16/Ki-67 in smears significantly, thus offering an active non-destructive management to prevent cervical cancer.Trial registration numberISRCTN11009040, date of registration: 10/12/2019;https://doi.org/10.1186/ISRCTN11009040; retrospectively registered. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - February 1, 2021 Category: OBGYN Source Type: research
Correction to: Efficacy and safety of an adsorbent and anti-oxidative vaginal gel on CIN1 and 2, on high-risk HPV, and on p16/Ki-67: a randomized controlled trial
In the original article published, there was an error in the Fig. 2 (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - January 7, 2021 Category: OBGYN Source Type: research
Therapeutic Efficacy of a Coriolus versicolor -Based Vaginal Gel in Women with Cervical Uterine High-Risk HPV Infection: A Retrospective Observational Study
ConclusionsThe use of aCoriolus versicolor-based vaginal gel in high-risk HPV patients is safe and effective based on all examined tests. (Source: Advances in Therapy)
Source: Advances in Therapy - December 26, 2020 Category: Drugs & Pharmacology Source Type: research
Progesterone Intramuscularly or Vaginally Administration May Not Change Live Birth Rate or Neonatal Outcomes in Artificial Frozen-Thawed Embryo Transfer Cycles
ConclusionsRelatively higher serum progesterone level induced by intramuscular regimen did not change live birth rate or neonatal outcomes compared to vaginal regimen. Monitoring serum progesterone level and optimizing progesterone dose of intramuscular progesterone as needed in HRT-FET cycles has a role in improving live birth rate without impact on neonatal outcomes. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 4, 2020 Category: Endocrinology Source Type: research
Advances in contraception research and development
Purpose of review
In the past few years, there have been great advances in contraceptive technology and development. Here we review advances in contraception over the past two years including new medications, and technologies.
Recent findings
Contraception must be discussed within the context of individual goals and context. New contraceptive options approved by the FDA in the past two years include a year-long vaginal ring, a progestin-only pill that is as effective as combined oral contraceptive pills, a new hormonal patch and a vaginal gel that may also help prevent sexually transmitted infections.
There a...
Source: Current Opinion in Obstetrics and Gynecology - November 11, 2020 Category: OBGYN Tags: FAMILY PLANNING: Edited by Paul D. Blumenthal Source Type: research
P71 Characterization of women according to pregnancy status following treatment with VPR during the AMPOWER study
Objectives: The investigational vaginal pH regulator (VPR) is a non-hormonal, woman-controlled contraceptive vaginal gel. This analysis describes the characteristics of women in the phase 3 AMPOWER trial who became pregnant vs. those who did not. (Source: Contraception)
Source: Contraception - October 1, 2020 Category: OBGYN Authors: B. Maximos, K. Culwell, C. Dart, B. Howard Source Type: research
P41 Impact of product adherence and condom use on rates of urogenital re-infection with chlamydia trachomatis or neisseria gonorrhoeae in the amprevence phase 2B/3 clinical trial
The objectives of this analysis were to assess the effects of adherence and condom use during the phase 2b/3 AMPREVENCE study on urogenital re-infection with Chlamydia trachomatis (CT) or Neisseria gonorrhoeae (GC). (Source: Contraception)
Source: Contraception - October 1, 2020 Category: OBGYN Authors: L. Mena, K. Culwell, S. Mollan, J. Brumfield, B. Howard Source Type: research
Characterization and in vitro evaluation of a vaginal gel containing lactobacillus crispatus for the prevention of gonorrhea
Publication date: Available online 5 August 2020Source: International Journal of PharmaceuticsAuthor(s): K.C. N'Guessan Gnaman, S. Bouttier, A. Yeo, A.A.S. Aka Any-Grah, S. Geiger, N. Huang, V. Nicolas, S. Villebrun, H. Faye-Kette, G. Ponchel, A.A. Koffi, F. Agnely (Source: International Journal of Pharmaceutics)
Source: International Journal of Pharmaceutics - August 31, 2020 Category: Drugs & Pharmacology Source Type: research
Safety of misoprostol for near-term and term induction in small-for-gestational-age pregnancies compared to dinoprostone and primary cesarean section: results of a retrospective cohort study
ConclusionOral misoprosol is a safe method for labor induction in SGA near-term and term pregnancies and, concerning the neonatal outcome, comparable with other methods of labor induction or primary CS. Our study showed no adverse neonatal outcomes related to the use of oral misoprostol. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - August 4, 2020 Category: OBGYN Source Type: research
The effect of Quercus (Oak Gal) vaginal cream versus metronidazole vaginal gel on bacterial vaginosis: A double ‑blind randomized controlled trial.
CONCLUSION: Oak Gall could be recommended for women in reproductive age who are uncomfortable with the potential side effects of synthetic drugs.
PMID: 32951746 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - July 31, 2020 Category: Complementary Medicine Authors: Afzali E, Siahposh A, Haghighi-Zadeh MH, Farajzadeh A, Abbaspoor Z Tags: Complement Ther Med Source Type: research
Phexxi - A Nonhormonal Contraceptive Gel
Date: August 24, 2020
Issue #:
1605Summary:
The FDA has approvedPhexxi (Evofem), a
nonhormonal prescription-only vaginal gel containing
lactic acid, citric acid, and potassium bitartrate, for
prevention of pregnancy. The gel is intended for on-demand
contraception; it is not effective when used
after intercourse. It was previously approved for
use as a vaginal lubricant(Amphora), but was never
marketed. (Source: The Medical Letter)
Source: The Medical Letter - July 21, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Annovera cervical cap Condom Contraceptives Depo-Provera Diaphragm EluRyng Flexi-T IUD Kyleena Levonorgestrel Liberte Liletta Medroxyprogesterone Mirena Mona Lisa Nexplanon NuvaRing Oral contraceptives ParaGard Phex Source Type: research
The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: a proof-of-concept study
AbstractIn vitro studies suggest that certain probiotic bacterial strains have potential activity against opportunistic infections such asCandida. There are few in vivo trials using probiotics as a single treatment for acuteCandida vulvovaginitis (CV). In this open-label, proof-of-concept study, selectedLactobacillus strains were tested in women with acuteCandida vaginitis. Twenty women diagnosed with proven, symptomatic CV were instructed to administer a vaginal probiotic gel withL. plantarum YUN-V2.0,L. pentosus YUN-V1.0 andL. rhamnosus YUN-S1.0 for 10 consecutive days. Vaginal rinsing fluid, vaginal culture swab and vag...
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 8, 2020 Category: Microbiology Source Type: research
