Preferences for HIV Preexposure Prophylaxis Products Among Black Women in the U.S.
AbstractIn a nationwide sample of Black women in the U.S., we assessed preferences for HIV preexposure prophylaxis (PrEP) products, including long-acting injectable (LAI) PrEP and once-daily oral PrEP. Among 315 respondents, 32.1% were aware of PrEP and 40.6% were interested in using it; interest increased to 62.2% if PrEP were provided for free. Oral PrEP was the preferred option (51.1%), followed by LAI PrEP (25.7%), vaginal gel (16.5%), and vaginal ring (6.7%). When examining oral and LAI PrEP alone, most (62.7%) preferred oral PrEP. LAI PrEP was more likely to be preferred among respondents with concerns about healthca...
Source: AIDS and Behavior - January 5, 2022 Category: Infectious Diseases Source Type: research
A Pre-Phase III Efficacy Trial of the Spermicide/Contraceptive Effect of the Invisible Condom ®, a Non-Hormonal Vaginal Gel, in Women from Canada
CONCLUSION: Based on our results, the vaginal gel demonstrated important spermicidal and contraceptive effect. A larger phase III contraceptive efficacy trial is warranted. The vaginal gel may represent a non-hormonal spermicide/contraceptive option for women.PMID:34656768 | DOI:10.1016/j.jogc.2021.09.018 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - October 17, 2021 Category: OBGYN Authors: Rabeea F Omar Mathieu Leboeuf Madeleine Lemyre Isabelle Chabot Sylvie Trottier Andr é Ulmann Michel G Bergeron Source Type: research
Evaluation of the novel vaginal contraceptive agent PPCM in preclinical studies using sperm hyaluronan binding and acrosome status assays
ConclusionPPCM vaginal gel may provide contraceptive protection as well as help with STI prevention. HBA may be a sensitive and much needed biomarker for sperm activity in future contraceptive development. (Source: Andrology)
Source: Andrology - October 5, 2021 Category: Urology & Nephrology Authors: Barbara B. North,
Mary B. Weitzel,
Donald P. Waller,
William X. Birch,
Kenneth A. Feathergill,
Lynn A. Birch,
Christopher J. De Jonge,
Gail S. Prins Tags: ORIGINAL ARTICLE Source Type: research
GSE141478 Results of the phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel
Contributors : Natalia Teleshova ; Hong HurSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGriffithsin (GRFT) is an anti-viral lectin with potent anti-HIV activity. GRFT ’s preclinical safety, lack of systemic absorption after topical administration, and lack of cross-resistance with existing products prompted its development for topical HIV pre-exposure prophylaxis. We evaluated safety, pharmacokinetics and pharmacodynamics of PC-6500 (0.1% GRFT in a carrageenan (CG) gel) in healthy, HIV-negative, non-pregnant women following once daily vaginal gel administration for 14 days. No ...
Source: GEO: Gene Expression Omnibus - October 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Evaluation of the novel vaginal contraceptive agent PPCM in preclinical studies using sperm hyaluronan binding and acrosome status assays
ConclusionPPCM vaginal gel may provide contraceptive protection as well as STI prevention. HBA may be a sensitive and much needed biomarker for sperm activity in future contraceptive development.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - September 21, 2021 Category: Urology & Nephrology Authors: B.B. North,
M.B. Weitzel,
D.P. Waller,
W.X. Birch,
K. A. Feathergill,
L. A. Birch,
C.J. De Jonge,
G. S. Prins Tags: ORIGINAL ARTICLE Source Type: research
Determination of progesterone (steroid drug) in the semi - solid dosage form (vaginal gel) using a stability - indicating method by RP-HPLC/PDA detector
Biomed Chromatogr. 2021 Sep 15:e5246. doi: 10.1002/bmc.5246. Online ahead of print.ABSTRACTA simple stability-indicating method was developed and validated for the determination of progesterone (a steroid drug) in the semi-solid dosage form. All the impurities were separated from the main compound with simple stationary phase (Eclipse XDB, C8, 150 mm × 4.6 mm, 5μm). The mobile phase-A contains phosphate buffer and acetonitrile in the ratio of 90:10 v/v and mobile phase-B contains purified water and acetonitrile in the ratio of 10:90 v/v. The optimized chromatographic conditions were flow rate 1.0 ml/min, UV detection at ...
Source: Biomedical Chromatography : BMC - September 15, 2021 Category: Biomedical Science Authors: Naresh Konduru Vijay Babu Kethe Rambabu Gundla Naresh Kumar Katari Ravindra Mallavarapu Source Type: research
Determination of progesterone (steroid drug) in the semi - solid dosage form (vaginal gel) using a stability - indicating method by RP-HPLC/PDA detector
Biomed Chromatogr. 2021 Sep 15:e5246. doi: 10.1002/bmc.5246. Online ahead of print.ABSTRACTA simple stability-indicating method was developed and validated for the determination of progesterone (a steroid drug) in the semi-solid dosage form. All the impurities were separated from the main compound with simple stationary phase (Eclipse XDB, C8, 150 mm × 4.6 mm, 5μm). The mobile phase-A contains phosphate buffer and acetonitrile in the ratio of 90:10 v/v and mobile phase-B contains purified water and acetonitrile in the ratio of 10:90 v/v. The optimized chromatographic conditions were flow rate 1.0 ml/min, UV detection at ...
Source: Biomedical Chromatography : BMC - September 15, 2021 Category: Biomedical Science Authors: Naresh Konduru Vijay Babu Kethe Rambabu Gundla Naresh Kumar Katari Ravindra Mallavarapu Source Type: research
Determination of progesterone (steroid drug) in the semi - solid dosage form (vaginal gel) using a stability - indicating method by RP-HPLC/PDA detector
Biomed Chromatogr. 2021 Sep 15:e5246. doi: 10.1002/bmc.5246. Online ahead of print.ABSTRACTA simple stability-indicating method was developed and validated for the determination of progesterone (a steroid drug) in the semi-solid dosage form. All the impurities were separated from the main compound with simple stationary phase (Eclipse XDB, C8, 150 mm × 4.6 mm, 5μm). The mobile phase-A contains phosphate buffer and acetonitrile in the ratio of 90:10 v/v and mobile phase-B contains purified water and acetonitrile in the ratio of 10:90 v/v. The optimized chromatographic conditions were flow rate 1.0 ml/min, UV detection at ...
Source: Biomedical Chromatography : BMC - September 15, 2021 Category: Biomedical Science Authors: Naresh Konduru Vijay Babu Kethe Rambabu Gundla Naresh Kumar Katari Ravindra Mallavarapu Source Type: research
Determination of progesterone (steroid drug) in the semi - solid dosage form (vaginal gel) using a stability - indicating method by RP-HPLC/PDA detector
Biomed Chromatogr. 2021 Sep 15:e5246. doi: 10.1002/bmc.5246. Online ahead of print.ABSTRACTA simple stability-indicating method was developed and validated for the determination of progesterone (a steroid drug) in the semi-solid dosage form. All the impurities were separated from the main compound with simple stationary phase (Eclipse XDB, C8, 150 mm × 4.6 mm, 5μm). The mobile phase-A contains phosphate buffer and acetonitrile in the ratio of 90:10 v/v and mobile phase-B contains purified water and acetonitrile in the ratio of 10:90 v/v. The optimized chromatographic conditions were flow rate 1.0 ml/min, UV detection at ...
Source: Biomedical Chromatography : BMC - September 15, 2021 Category: Biomedical Science Authors: Naresh Konduru Vijay Babu Kethe Rambabu Gundla Naresh Kumar Katari Ravindra Mallavarapu Source Type: research
