Acceptability of Single-Dose Clindamycin Gel for Bacterial Vaginosis: A Randomized Controlled Trial
Clin Ther. 2023 Apr 23:S0149-2918(23)00130-3. doi: 10.1016/j.clinthera.2023.04.001. Online ahead of print.ABSTRACTPURPOSE: The goal of this study was to assess the acceptability of a single-dose bioadhesive 2% clindamycin vaginal gel for bacterial vaginosis (BV).METHODS: This double-blind, placebo-controlled, randomized study compared a new clindamycin gel with placebo gel (2:1 ratio). The primary objective was efficacy; secondary objectives were safety and acceptability. Subjects were evaluated at screening, days 7 to 14 (Day 7-14), and days 21 to 30 (test-of-cure [TOC]). An acceptability questionnaire with 9 questions wa...
Source: Clinical Therapeutics - April 25, 2023 Category: Drugs & Pharmacology Authors: Christine Mauck Sharon L Hillier Judy Gendreau Clint Dart Hongsheng Wu Steven Chavoustie Valerie Sorkin-Wells Clifton Scott Nicholson-Uhl Brandon Perez Mark Jacobs Nadene Zack David Friend Source Type: research
Acceptability of Single-Dose Clindamycin Gel for Bacterial Vaginosis: A Randomized Controlled Trial
Clin Ther. 2023 Apr 23:S0149-2918(23)00130-3. doi: 10.1016/j.clinthera.2023.04.001. Online ahead of print.ABSTRACTPURPOSE: The goal of this study was to assess the acceptability of a single-dose bioadhesive 2% clindamycin vaginal gel for bacterial vaginosis (BV).METHODS: This double-blind, placebo-controlled, randomized study compared a new clindamycin gel with placebo gel (2:1 ratio). The primary objective was efficacy; secondary objectives were safety and acceptability. Subjects were evaluated at screening, days 7 to 14 (Day 7-14), and days 21 to 30 (test-of-cure [TOC]). An acceptability questionnaire with 9 questions wa...
Source: Clinical Therapeutics - April 25, 2023 Category: Drugs & Pharmacology Authors: Christine Mauck Sharon L Hillier Judy Gendreau Clint Dart Hongsheng Wu Steven Chavoustie Valerie Sorkin-Wells Clifton Scott Nicholson-Uhl Brandon Perez Mark Jacobs Nadene Zack David Friend Source Type: research
Oxytocin versus prostaglandins for labour Induction of women with an unfavourable cervix after 24 hours of cervical ripening (OPIC): protocol for an open multicentre randomised non-inferiority trial
Introduction
It remains uncertain whether the most appropriate management for women with an unfavourable cervix after 24 hours of cervical ripening is repeating the ripening procedure or proceeding directly to induction by oxytocin. No adequately powered trial has compared these strategies. We hypothesise that induction of labour with oxytocin among women who have just undergone an ineffective first ripening procedure is not associated with a higher risk of caesarean delivery than a repeated cervical ripening with prostaglandins.
Methods and analysis
We will conduct a multicentre, non-inferiority, open-label, randomised c...
Source: BMJ Open - April 17, 2023 Category: General Medicine Authors: De Berti, M., Le Gouge, A., Monmousseau, F., Gallot, D., Sentilhes, L., Winer, N., Legendre, G., Desbriere, R., Girault, A., Pozzi, J., Gachon, B., Barjat, T., Perrotin, F., Brunet-Houdard, S., Diguisto, C., Groupe de Recherche en Gynecologie Obstetrique Tags: Open access Obstetrics and gynaecology Source Type: research
Vaginal progesterone gel vs. capsule for preterm birth prevention: an indirect comparison meta-analysis
To evaluate the effectiveness of vaginal progesterone in preventing preterm birth in women with a singleton gestation and short cervical length and to determine which of the two formulations, micronized progesterone vaginal capsule versus vaginal gel is more effective for preventing preterm birth. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2023 Category: OBGYN Authors: Doron Kabiri, Yael Hamou, Gali Gordon, Roei Alter, Einav Kremer, Ilan Matok Tags: Poster Session IV Source Type: research
Sperm-blocking vaginal gel could be a reliable contraceptive method
A gel that has prevented almost all of 1 billion sperm getting past the cervix in sheep could become an alternative to hormonal birth control methods but without the side effects (Source: New Scientist - Health)
Source: New Scientist - Health - November 30, 2022 Category: Consumer Health News Source Type: research
Evaluation of the safety and efficacy of wormwood vaginal gel in improving sexual function and sexual satisfaction in women of reproductive age: A randomized, triple-blinds, placebo-controlled clinical trial
CONCLUSIONS: Based on the findings of this trial, it seems that the wormwood vaginal gel can be used as a topical supplement to improve sexual function and sexual satisfaction in women of reproductive age who have sexual dysfunction and low sexual satisfaction.PMID:36368248 | DOI:10.1016/j.ejogrb.2022.11.002 (Source: Reproductive Biology)
Source: Reproductive Biology - November 11, 2022 Category: Reproduction Medicine Authors: Hajatpour Niloofar Babazadeh Raheleh Salari Roshanak Jamali Jamshid Source Type: research
Evaluation of the safety and efficacy of wormwood vaginal gel in improving sexual function and sexual satisfaction in women of reproductive age: A randomized, triple-blinds, placebo-controlled clinical trial
CONCLUSIONS: Based on the findings of this trial, it seems that the wormwood vaginal gel can be used as a topical supplement to improve sexual function and sexual satisfaction in women of reproductive age who have sexual dysfunction and low sexual satisfaction.PMID:36368248 | DOI:10.1016/j.ejogrb.2022.11.002 (Source: Reproductive Biology)
Source: Reproductive Biology - November 11, 2022 Category: Reproduction Medicine Authors: Hajatpour Niloofar Babazadeh Raheleh Salari Roshanak Jamali Jamshid Source Type: research
Evaluation of the safety and efficacy of Wormwood vaginal gel in improving sexual function and sexual satisfaction in women of reproductive age: a Randomized, Triple-Blinds, Placebo-Controlled Clinical Trial
Sexual dysfunction in women is a growing problem in the world, which according to studies, affects 10-52% of men and 25-63% of women [1,2]. In a systematic study and meta-analysis (2016), the prevalence of female sexual dysfunction in 215,740 women of reproductive age was reported at 41% [3]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 5, 2022 Category: OBGYN Authors: Hajatpour Niloofar, Babazadeh Raheleh, Salari Roshanak, Jamali Jamshid Tags: Full length article Source Type: research
Molecules, Vol. 27, Pages 4916: Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms
arii Kobyliak
Phytoestrogen resveratrol (R) has been demonstrated to benefit human reproductive health. However, R bioavailability and pharmacokinetics are still problematic under oral supplementation. We used an experimental vaginal gel with R and hyaluronic acid (HA) to improve bioavailability and pharmacokinetic properties. The study aimed to assess the impact of vaginal R-HA gel on the reproductive system in ovariectomized rats. Methods: The study was carried out on Wistar female rats. It investigated the body weight, tail temperature, vaginal pH, estrogen and progesterone blood levels, and immunohistochemical biom...
Source: Molecules - August 2, 2022 Category: Chemistry Authors: Ganna Zaychenko Olena Stryga Oksana Sinitsyna Anna Doroshenko Oksana Sulaieva Tetyana Falalyeyeva Nazarii Kobyliak Tags: Article Source Type: research
Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial
CONCLUSION: A new, single-dose clindamycin vaginal gel was highly effective, with excellent safety, in women disproportionately affected by bacterial vaginosis, with Nugent scores of 7-10 at study entry.FUNDING SOURCE: The study was funded by Daré Bioscience, Inc.CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov, NCT04370548.PMID:35675606 | DOI:10.1097/AOG.0000000000004805 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 8, 2022 Category: OBGYN Authors: Christine Mauck Sharon L Hillier Judy Gendreau Clint Dart Steven Chavoustie Valerie Sorkin-Wells Clifton Nicholson-Uhl Brandon Perez Mark Jacobs Nadene Zack David Friend Source Type: research
Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial
CONCLUSION: A new, single-dose clindamycin vaginal gel was highly effective, with excellent safety, in women disproportionately affected by bacterial vaginosis, with Nugent scores of 7-10 at study entry.FUNDING SOURCE: The study was funded by Daré Bioscience, Inc.CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov, NCT04370548.PMID:35675606 | DOI:10.1097/AOG.0000000000004805 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 8, 2022 Category: OBGYN Authors: Christine Mauck Sharon L Hillier Judy Gendreau Clint Dart Steven Chavoustie Valerie Sorkin-Wells Clifton Nicholson-Uhl Brandon Perez Mark Jacobs Nadene Zack David Friend Source Type: research
Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial
CONCLUSION: A new, single-dose clindamycin vaginal gel was highly effective, with excellent safety, in women disproportionately affected by bacterial vaginosis, with Nugent scores of 7-10 at study entry.FUNDING SOURCE: The study was funded by Daré Bioscience, Inc.CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov, NCT04370548.PMID:35675606 | DOI:10.1097/AOG.0000000000004805 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 8, 2022 Category: OBGYN Authors: Christine Mauck Sharon L Hillier Judy Gendreau Clint Dart Steven Chavoustie Valerie Sorkin-Wells Clifton Nicholson-Uhl Brandon Perez Mark Jacobs Nadene Zack David Friend Source Type: research
Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial
CONCLUSION: A new, single-dose clindamycin vaginal gel was highly effective, with excellent safety, in women disproportionately affected by bacterial vaginosis, with Nugent scores of 7-10 at study entry.FUNDING SOURCE: The study was funded by Daré Bioscience, Inc.CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov, NCT04370548.PMID:35675606 | DOI:10.1097/AOG.0000000000004805 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 8, 2022 Category: OBGYN Authors: Christine Mauck Sharon L Hillier Judy Gendreau Clint Dart Steven Chavoustie Valerie Sorkin-Wells Clifton Nicholson-Uhl Brandon Perez Mark Jacobs Nadene Zack David Friend Source Type: research
Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial
CONCLUSION: A new, single-dose clindamycin vaginal gel was highly effective, with excellent safety, in women disproportionately affected by bacterial vaginosis, with Nugent scores of 7-10 at study entry.FUNDING SOURCE: The study was funded by Daré Bioscience, Inc.CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov, NCT04370548.PMID:35675606 | DOI:10.1097/AOG.0000000000004805 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 8, 2022 Category: OBGYN Authors: Christine Mauck Sharon L Hillier Judy Gendreau Clint Dart Steven Chavoustie Valerie Sorkin-Wells Clifton Nicholson-Uhl Brandon Perez Mark Jacobs Nadene Zack David Friend Source Type: research
Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial
CONCLUSION: A new, single-dose clindamycin vaginal gel was highly effective, with excellent safety, in women disproportionately affected by bacterial vaginosis, with Nugent scores of 7-10 at study entry.FUNDING SOURCE: The study was funded by Daré Bioscience, Inc.CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov, NCT04370548.PMID:35675606 | DOI:10.1097/AOG.0000000000004805 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 8, 2022 Category: OBGYN Authors: Christine Mauck Sharon L Hillier Judy Gendreau Clint Dart Steven Chavoustie Valerie Sorkin-Wells Clifton Nicholson-Uhl Brandon Perez Mark Jacobs Nadene Zack David Friend Source Type: research
